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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 3 | A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells显示文摘 | He B You L Uematsu K | 2004 | Neoplasia2004，6，1： | 1 |
| 4 | Effect of gas bubbling and impeller agitation on degassing kinetics during magnesium alloy (AZ91D) melt recycling-water model approach 显示文摘 | Han J W Kim D J You B D | 2003 | Materials Science Forum2003，439，： | 1 |
| 5 | Anti-EGFR monoelonal antibodies for treat- ment of colorectal cancers : development of cetuximab and panitu- mumab显示文摘 | You B Chen EX | 2012 | J Clin Pharmacol2012，52，： | 1 |
| 6 | Solidification of AZ31 magnesium alloy plate in a horizontal continuous casting process 显示文摘 | YOU B S YIM C D KIM S H | 2005 | Materials Science and Engineering A2005，，： | 1 |
| 7 | Regulation of antioxidant system, lipids and fatty acid 13 -oxidation contributes to the eardioproteetive effect of sodium tanshinone IIA sulphonate in isoproterenol - induced my-ocardial infarction in rats 显示文摘 | Wei B You MG Ling JJ | 2013 | Atherosclerosis2013，230，1： | 1 |
| 8 | MicroRNA-449a inhibits cell growth in lung cancer and regulates long noncoding RNA nuclear enriched abundant transcript 1 显示文摘 | You J Zhang Y Liu B | 2014 | Indian J Cancer2014，3，： | 1 |
| 9 | A hydrated ethylenediammonium salt of a new polymeric polyoxoanion (H2en)4·3H2O显示文摘 | LUAN G Y WANG E B YOU W S | 2000 | Acta Cryst2000，56，： | 1 |
| 10 | Spectroelectrochemistry of solid in-dirubin and its sulfdnated form显示文摘 | Hu X W He J B You Y H | 2011 | Electrochim Acta2011，56，3： | 1 |
| 11 | Large-scale Synthesis of Few-layered Graphene Using CVD显示文摘 | Wang X B You H J Liu F M | | 0，，： | 1 |
| 12 | Evaluation of low-tem- perature binder properties of warm-mix asphalt, extracted and recovered RAP and RAS,and bioasphalt显示文摘 | YOU Z P MILLS B J FINI E | 2011 | Journal of Mate- rials in Civil Engineering2011，23，11： | 1 |
| 13 | Solidification of AZ31 magnesium alloy plate in a horizontal continuous casting process显示文摘 | You B S Yim Ch D Kim S H | 2005 | Material Science and Engineering A2005，，413414： | 1 |
| 14 | Prevalence,characteristics,and publication of discontinued randomized trials显示文摘 | Kasenda B von Elm E You J | 2014 | JAMA2014，311，10： | 1 |
| 15 | Highly photoactive, low bandgap TiOz nanoparticles wrapped by graphene显示文摘 | LEE J S YOU K H PARK C B | 2012 | Advanced Materials2012，24，8： | 1 |
| 16 | Synthesis and Structure of 4-Nitrobenzaldehyde Thiosemicarbazone显示文摘SynthesisandStructureof4-NitrobenzaldehydeThiosemicarbazoneTianYu-Peng;DuanChun-Ying;LuZhong-Lin;YouXiao-Zeng(CoordinationChe... | Tian Yu-Peng Duan Chun-Ying Lu Zhong-Lin You Xiao-Zeng(Coordination Chemistry Institute, State Key Laboratory of Coordinatton Chemistry,Nanjing Univuersity, Centre for Advanced Studies in Science and Technology of Microstructure, Hanjing, 210093) Luo B | 1996 | Chinese Journal of Structural Chemistry1996，15，4： | 1 |
| 17 | A Compact Monopulse Radial Line Slot Array Antenna at Millimeter Wavelengths显示文摘 | Don W B | 2007 | Int J Infrared Milli Waves2007，28，10： | 1 |
| 18 | Effect of gas bubbling and impeller agitation on degassing kinetics during magnesium alloy (AZ91D) melt recycling-Water model approach显示文摘 | HAN J W KIM D J YOU B D ENGH T A | 2003 | Materials Science Forum2003，439，： | 1 |
| 19 | Donor lymphocyte infusion induced acute hepatitis显示文摘 | YOU J Y YU Y B CHEN P C | 2004 | J Chin Med Assoc2004，67，： | 1 |
| 20 | Texture an d microstmcture changes in asymmetrically hot rolled AZ31 magnesium alloy sheets显示文摘 | KIM S H YOU B S YIM C D | 2005 | Materials Letters2005，59，2930： | 1 |
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