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| 1 | Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model显示文摘AIM:To investigate the effect of E3-methyl-1-phenyl-2-pyrazolin-5-one (Edr) on hepatic ischemia-reperfusion (I/R) injury and liver regeneration in a porcine hepatectomy model.METHODS:One hour ischemia was induced by occluding the vessels and the bile duct of the right and median lobes.A 40% left hepatectomy was performed after reperfusion.Six animals received Edr (3 mg/kg per hour) intravenously and six control animals received saline just before reperfusion.Remnant liver volume,hemodynamics,aspartate aminotransferase (AST),alanine aminotransferase,lactate dehydrogenase and lactic acid,were compared between the groups.The expression of transforming growth factor (TGF1) and toll-like receptor (TRL) mRNA in hepatic tissues was examined using reverse transcription polymerase chain reaction.Apoptosis was demonstrated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining,respectively.RESULTS:Serum AST (P = 0.029),and toll like receptor 4 level (P = 0.043) were significantly lower after 3 h in animals receiving Edr.In addition,TUNEL staining in Edr-treated pigs showed significantly fewer hepatocytes undergoing apoptosis compared with control pigs.After 1 mo,all factors were non-significantly different between the two groups.CONCLUSION:Edr is considered to reduce hepatic injury in the early stage of I/R injury in a porcine model. | Mitsugi Shimoda Yoshimi Iwasaki Toshie Okada Keiichi Kubota | 2012 | World Journal of Gastroenterology2012，18，27： | 8 |
| 2 | Ectopic hepatocellular carcinoma arising from pancreas: A case report and review of the literature显示文摘A 56-year-old man was found to have a pancreatic tail tumor. His blood chemistry showed no infection with hepatitis B or C virus and no elevations of tumor markers or pancreatic hormones. Abdominal ultrasound showed an encapsulated, rather heterogeneous, hypoechoic tumor, 6.5 cm in maximum diameter, with a beak sign. Helical dynamic CT revealed an irregularly enhanced tumor with pooling of contrast medium in the delayed phase. Abdominal angiography showed a hypervascular tumor. With a tentative diagnosis of non-functional islet-cell tumor, the patient underwent resection of the pancreatic body and tail with splenectomy. The contour of the liver and its surface were normal. In microscopic examination, tumor cells arranged in a trabecular pattern with focal bile pigment resembling hepatocellular carcinoma (HCC). Immunohistochemically, these tumor cells were positivefor HEPPAR-1, CAM5.2, cytokeratin 18 and COX-2, but negative for MUC-1, and cytokeratins 7, 20 and 8. These results supported a diagnosis of HCC without any adenocarcinoma component. The patient is currently doing well without any signs of recurrence in either the remaining pancreas or liver three years after surgery. We report the rare case with ectopic HCC in the pancreas with a review of the literature. | Keiichi Kubota Junji Kita Kyu Rokkaku Yoshimi Iwasaki Tokihiko Sawada Johji Imura Takahiro Fujimori | 2007 | World Journal of Gastroenterology2007，13，31： | 7 |
| 3 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 4 | Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse显示文摘AIM: To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS: The multi-herbal medicine Juzentaihoto (JTX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism (T-RFLP) method was used. To identify the changed bacteria, DNA sequencing was performed. RESULTS: Heat shock protein gene expression,documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver. | Miho Kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe | 2007 | World Journal of Gastroenterology2007，13，16： | 5 |
| 5 | 发电不确定性条件下电动汽车对智能家居能量管理的贡献(英文)显示文摘光伏、风电等可再生能源的大规模接入给电力系统的运行带来了诸多问题,如由发电过剩引起的电网反向潮流、电网频率和节点电压调节容量的不足。作为解决可再生能源出力波动性引起的不确定性问题的方法之一,采用电动汽车作为储能装置,即所谓的V2H(vehicle to house)或者V2G(vehicle to grid),将发挥重要作用,因此有必要建立电动汽车应用评估方法。以配有光伏发电装置和一辆电动汽车的某智能家居为例,定量评估了电动汽车电池充放电对光伏发电输出功率的家庭内部使用比例、家庭用电成本和CO2排放量的影响。分析结果表明,通过光伏发电装置和电功汽车电池的有效配合使用,可以减少反向潮流和CO2排放。最后,通过仿真分析论证了多辆电动汽车对含有多栋智能家居的智能化小区能量管理的贡献。 | Ryuichi YOKOYAMA Kouichirou YOSHIMI Takahiko MASUDA Haruhiko KONDOU | 2011 | 电力系统自动化2011，35，22： | 4 |
| 6 | Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study显示文摘AIM To identify certain clinical factors other than the type of gastrectomy which affect the postoperative quality of life(QOL) of patients after gastrectomy.METHODS The postgastrectomy syndrome assessment scale(PGSAS)-45 was designed to assess the severity of symptoms, the living status and the QOL of gastrectomized patients. It consists of 45 items, of which 22 are original items while 23 were retrieved from the SF-8 and Gastrointestinal Symptoms Rating Scale questionnaires with permission. A nationwide surveillance study to validate PGSAS was conducted and 2368 gastric cancer patients who underwent various types of gastrectomy at 52 medical institutions were enrolled. Of these, 1777 patients who underwent total gastrectomy(TG) reconstructed with Roux-Y(n = 393), distal gastrectomy(DG) reconstructed with Billroth-I(n = 909), or DG reconstructed with Roux-Y(n = 475) were evaluated in the current study. The influence of the type of gastrectomy and other clinical factors such as age, sex, duration after surgery, the symptom severity, the degree of weight loss, dietary intake, and the ability for working on the postoperative QOL(i.e., dissatisfaction for daily life subscale, physical component summary and mental component summary of the SF-8) were examined by multiple regression analysis(MRA). In addition, importance of various symptoms such as esophageal reflux, abdominal pain, meal-related distress, indigestion, diarrhea, constipation and dumping on the postoperative living status and QOL were also appraised by MRA.RESULTS The postoperative QOL were significantly deteriorated in patients who underwent TG compared to those after DG. However, the extent of gastrectomy was not an influential factor on patients' QOL when adjusted by the MRA. Among various clinical factors, the symptom severity, ability for working, and necessity for additional meals were the most influential factorsto the postoperative QOL. As for the individual symptoms, meal-related distress, dumping, abdominal pain, and esophageal reflux significantly affected the postoperative QOL in that order, while the influence of indigestion, diarrhea and constipation was insignificant. CONCLUSION Several clinical factors such as the symptom severity(especially in meal-related distress and dumping), ability for working and necessity for additional meals were the main factors which affected the patients' wellbeing after gastrectomy. | Koji Nakada Masazumi Takahashi Masami Ikeda Shinichi Kinami Masashi Yoshida Yoshikazu Uenosono Yoshiyuki Kawashima Sayumi Nakao Atsushi Oshio Yoshimi Suzukamo Masanori Terashima Yasuhiro Kodera | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 7 | The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells显示文摘 | Kaoru Mitsui Yoshimi Tokuzawa Hiroaki Itoh Kohichi Segawa Mirei Murakami Kazutoshi Takahashi Masayoshi Maruyama Mitsuyo Maeda Shinya Yamanaka | 2003 | Cell2003，，5： | 3 |
| 8 | Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review显示文摘Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements and coinfected with Epstein-Barr virus (EBV) infection presenting with various endoscopic findings. A 38-yearold homosexual man who presented with anemia and was diagnosed with an human immunodeficiency virus infection for the first time. GI endoscopy revealed multiple dish-like lesions, ulcerations, bloody spots, nodular masses with active bleeding in the stomach, erythematous flat lesions in the duodenum, and multiple nodular masses in the colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Biopsy specimens from the stomach, duodenum, colon, and rectum revealed diffuse large B-cell lymphoma concomitant with EBV infection that was detected by high tissue EBV-polymerase chain reaction levels and Epstein-Barr virus small RNAs in situ hybridization. Fluorescence in situ hybridization analysis revealed a fusion between the immunoglobulin heavy chain (IgH) and c-MYC genes, but not between the IgH and BCL2 loci. After 1-mo of treatment with HAART and R-CHOP, endoscopic appearance improved remarkably, and the histological features of the biopsy specimens revealed no evidence of lymphoma. However, he died from multiple organ failure on the 139 th day after diagnosis. The cause of his poor outcome may be related to MYC rearrangement. The GI tract involvement in ARL is rarely reported, and its endoscopic findings are various and may be different from those in non-AIDS GI lymphoma; thus, we also conducted a literature review of GI-ARL cases. | Shohei Tanaka Naoyoshi Nagata Sohtaro Mine Toru Igari Taiichiro Kobayashi Jun Sugihara Haruhito Honda Katsuji Teruya Yoshimi Kikuchi Shinichi Oka Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，29： | 3 |
| 9 | ECAP加工工艺对Al-Si-Cu合金耐腐蚀性能的影响显示文摘用电化学极化法研究了ECAP加工工艺对Al-7%Si-1.5%Cu(质量分数)合金在含氯离子的硼砂-硼酸弱碱性溶液中的点腐蚀行为。采用ECAP的工艺路线Bc在室温下对Al-Si-Cu合金进行了连续大变形处理后,合金组织中Si颗粒的分布更加均匀。极化实验表明,ECAP变形处理后的合金试样的点腐蚀电压明显增加。但是随着加工次数的增加,点腐蚀电压的变化不明显。分析表明,ECAP变形过程中Si颗粒的均匀分布是Al-Si-Cu合金耐腐蚀性能提高的主要原因。 | 张作贵 周冰 Watanabe Yoshimi | 2008 | 材料导报(纳米与新材料专辑)2008，22，2： | 3 |
| 10 | Effects of calcium antagonists on hepatic and systemic hemodynamics in awake portal hypertensive rats显示文摘 | Masamichi Nagasawa Tsunehisa Kawasaki Teruya Yoshimi | 1996 | Journal of Gastroenterology1996，，3： | 2 |
| 11 | Effect of oxidation due to ultraviolet-light irradiation on diamond thin films synthesized by hot-filament chemical vapor deposition显示文摘 | Ishikawa Y Yoshimi H Hirose Y | 1995 | Jpn J Appl Phys1995，34，： | 2 |
| 12 | The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells显示文摘 | Kaoru Mitsui Yoshimi Tokuzawa Hiroaki Itoh Kohichi Segawa Mirei Murakami Kazutoshi Takahashi Masayoshi Maruyama Mitsuyo Maeda Shinya Yamanaka | 2003 | Cell2003，，5： | 2 |
| 13 | Efficacy of preoperative endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘 | Norikazu Arakura Mari Takayama Yayoi Ozaki Masafumi Maruyama Yoshimi Chou Ryou Kodama Yasuhide Ochi Hideaki Hamano Takenari Nakata Shouji Kajikawa Eiji Tanaka Shigeyuki Kawa | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，4： | 2 |
| 14 | Long-Term Follow-Up of Autoimmune Pancreatitis: Characteristics of Chronic Disease and Recurrence显示文摘 | Shigeyuki Kawa Hideaki Hamano Yayoi Ozaki Tetsuya Ito Ryou Kodama Yoshimi Chou Mari Takayama Norikazu Arakura | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 2 |
| 15 | SUPER TOUGH GELS WITH A DOUBLE NETWORK STRUCTURE显示文摘Living tissues work with fantastic functions in soft and wet gel-like state.Thus,hydrogels have attracted much attention as excellent soft and wet materials,suitable tot making artificial organs for medical treatments.However, conventional hydrogels are mechanically too weak for practical uses.We have created double network (DN) hydrogels with extremely high mechanical strength in order to overcome this problem.DN gels are interpenetrating network (IPN) hydrogels consisting of rigid polyelectrolyte and s... | Tasuku Nakajima Takayuki Kurokawa Hidemitsu Furukawa Yoshimi Tanaka Yoshihito Osada 龚剑萍 | 2009 | Chinese Journal of Polymer Science2009，27，1： | 2 |
| 16 | Achieving the Goals of Healthy China 2030 Depends on Increasing Smoking Cessation in China:Comparative Findings from the ITC Project in China,Japan,and the Republic of Korea显示文摘Summary Tobacco smoking is the number one preventable cause of disease and death in China as it is globally.Indeed,the toll of smoking in China is much greater than its status as the world’s most populous country.There is a persistent and continuing need for China to implement the measures specified in the global tobacco control treaty,the World Health Organization(WHO)Framework Convention on Tobacco Control(FCTC),which China ratified in 2005. | Geoffrey T.Fong Jiang Yuan Lorraine V.Craig Steve Shaowei Xu Gang Meng Anne C.K.Quah Hong-Gwan Seo Sungkyu Lee Itsuro Yoshimi Kota Katanoda Takahiro Tabuchi | 2021 | China CDC weekly2021，3，22： | 2 |
| 17 | Hepatoid adenocarcinoma of the stomach显示文摘 | Satoshi Inagawa Jiro Shimazaki Masao Hori Fuyo Yoshimi Shinya Adachi Toru Kawamoto Katashi Fukao Masayuki Itabashi | 2001 | Gastric Cancer2001，，1： | 2 |
| 18 | Postoperative recurrence of hepatocellular carcinoma显示文摘 | Nagao T Inoue S Yoshimi F | 1990 | Ann Surg1990，211，1： | 2 |
| 19 | Self-care practices and health-seeking behavior among older persons in a developing country:Theories-based research显示文摘Purpose:The aim of this study was to examine the self-care practices and health-seeking behaviours of older adults in urban Indonesia.Methods:The cross-sectional study was performed from January to March 2014 in the Tammua sub-district of Indonesia.At the time of the study,273 older adults resided in Tammua,and half of them(51.2%)participated in this study.Data collection was carried out including self-care practices,health literacy,self-efficacy and basic conditioning factors.Results:It was found that most respondents(124;88.6%)always ate various protein sources daily.However,many participants never limited consumption of sugar(55;39.3%)or salt(40;28.6%),and more than half of respondents(96;68.6%)did not regularly visit MHCs.Health status(p<0.05),health maintenance(p<0.01)and salt limitation(p<0.05)were all significantly associated with salt limitation.It was found that respondents with higher selfefficacy,those who did not want to get information,and those of younger ages are less likely to visit MHCs regularly.Conclusion:An understanding of self-care practices and self-efficacy is needed to improve health care in developing countries.High self-efficacy should be promoted along with adequate health literacy.Older persons should learn the importance of regular health examinations to promote health,prevent diseases,and slow the progress of chronic diseases.The number of respondents who never limit their sugar and salt intake was especially surprising.An intervention program should be developed to limit salt and sugar intake of Indonesian elderly and to motivate older persons to use primary health services. | Andi Masyitha Irwan Mayumi Kato Kazuyo Kitaoka Teruhiko Kido Yoshimi Taniguchi Miho Shogenji | 2016 | International Journal of Nursing Sciences2016，3，1： | 2 |
| 20 | LI Language socialization as a variable in the use ofne by L2 learners of Japanese显示文摘 | Yoshimi D | 1999 | Journal of Pragmatics1999，，31： | 1 |
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