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| 1 | Late Miocene Red River submarine fan,northwestern South China Sea显示文摘A huge submarine fan is discovered through the research of the seismic and borehole data in the binding site of Yinggehai basin and Qiongdongnan basin in northwestern South China Sea.The fan,mainly formed during Late Miocene (Huangliu period) has an area over 10000 km 2 and maximum thickness of over 2000 m.It is characterized by a wedge-shaped oblique progradation configuration on the dip profile and a hummocky bidirectional progradation configuration on the strike profile.The core and Logging data from the well YC35-1-2 located in the front side of the fan indicate that sandy gravity flow deposits are predominant in lower Huangliu Formation and change to interbeds of sand and mud in upper Huangliu Formation.The fan is interpreted as a sand/mud-rich submarine fan in combination with the bathyal geological background of Huangliu period.A preliminary analysis of provenance indicates that neither the Guiren Uplift in the west nor the Hainan Uplift in the north can serve as the major provenance for the submarine fan.The provenance is considered to be from the Red River,based on the sedimentary facies study of the Huangliu Formation in Yinggehai basin.The fan is thus named as 'Red River submarine fan'.The Red River depositional system consists of the Red River submarine fan,the Red River delta,and associated submarine canyons.The discovery of the Red River submarine fan provides important information for the research of the uplift of Tibetan Plateau and the evolvement of Red River Fault Zone.Furthermore,it also points out a new direction for the deepwater hydrocarbon exploration in the northern South China Sea. | WANG YingMin XU Qiang LI Dong HAN JianHui LU Ming WANG YongFeng LI WeiGuo WANG HaiRong | 2011 | Chinese Science Bulletin2011，56，14： | 28 |
| 2 | Effect of electroacupuncture on expression of Ang/Tie-2 mRNA and protein in rats with acute cerebral infarction显示文摘OBJECTIVE: To identify the intervention mechanism of the effect of electroacupuncture on the expression of Ang/Tie-2 m RNA and protein in rats with acute cerebral infarction induced by middle cerebral artery occlusion(MCAO).METHODS: Altogether 120 Wistar rats were subjected to MCAO by inserting a nylon filament, andthen divided into 3 groups: control group, injured group and electroacupuncture group. The injured and electroacupuncture groups were further divided into the following 7 subgroups according to the time after MCAO: 3, 6, 12, 24 h, 3, 7 and 12 d, with 8 rats in each subgroup. The electroacupuncture group was given electroacupuncture treatment at Shuigou(GV 26) instantly after operation. The rats were killed at different time points according to their groups, and then the expression levels of Ang/Tie-2 m RNA and protein were detected using Real-Time polymerase chain reaction and immunohistochemical staining.RESULTS: The m RNA and protein expression levels of Ang/Tie-2 in the electroacupuncture group were significant higher than that in the injured group.CONCLUSION: The results suggested that electroacupuncture could significantly regulate the expression of Ang/Tie-2 m RNA and protein in the rats with acute cerebral infarction induced by MCAO, and enhance angiogenesis after ischemic penumbra. | Li Jing Bai Zonglu Du Yuanhao Li Yongfeng Zhang Xuezhu Pang Bo Zhang Jingjing | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 17 |
| 3 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 4 | Palaeogeomorphology and its control on the development of sequence stratigraphy and depositional systems of the Early Silurian in the Tarim Basin显示文摘The Silurian in the Tarim Basin was deposited on the basement deformed by the Caledonian tectonic movements at the end of the Late Ordovician. The development and distribution of sedimentary sequences of the Early Silurian have been clearly controlled by the palaeogeomorphology of the Late Ordovician. Based on unconformity characteristics and distribution of erosion, several zones can be differentiated including a high uplifted erosion zone, a transitional slope zone and a depression zone. The central and west Tabei Uplift zones show high angular unconformity and intense erosion. The Tarim Basin in the late Ordovician shows characteristics of higher in the west, lower in the east while higher in the south, lower in the north. The Early Silurian mainly developed transgressive and highstand systems tracts on the whole, while the lowstand systems tract only developed partly below the slope break. The palaeogeomorphology controlled the clastic source supply and deposit distribution. Braided delta system and tidal flat–estuary system were deposited. The duration of uplifting of the Tazhong paleouplift was longer than that of the Tabei paleo-uplift, and deposition was later. This led to the lower and middle members of the Kepingtage Formation missing in that area. As a large-scale transgression occurred during the deposition period of the upper member of the Kepingtage Formation, sediment from the west of the basin was transported and deposited by tides and waves, forming tidal–marine debris systems above the uplift. Proximal alluvial fan and fan delta coarse clastic deposits developed in proximal uplift zone in the east and southeast of the basin, and braided delta put forward to the transitional zone between the edge of uplift and the sea. Large-scale tidal channel, sub-distributary channel and mouth bar of the delta front can form favorable reservoirs, and they are primary targets for oil and gas exploration. This research on sequence–depositional systems development and distribution controlled by palaeogeomorphology is significant in guiding the prediction of reservoir sandstones. | Liu Jingyan Lin Changsong Cai Zhenzhong Zhu Yongfeng Yang Yongheng Peng Li Si Baoling Huang Zhen Li Huanpu Xu Yingcai Su Zhenzhen | 2010 | Petroleum Science2010，7，3： | 13 |
| 5 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
| 6 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 7 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 8 | Study on Ecological Risk of Land Use in Urbanization Watershed Based on RS and GIS:A Case Study of Songhua River Watershed in Harbin Section显示文摘By using RS and GIS technology,the ecological risk index ( ERI) was constructed based on the analysis of land use change and structural characteristics in urbanization watershed of Songhua River in Harbin section. Afterwards,the spatial distribution and change characteristics maps of ERI obtained by using block Kriging were analyzed to reveal the spatial and temporal evolution characteristics,change rules and formation mechanisms of ecological risk based on land use under the background of urbanization,and to minimize land use risk during urbanization process. The results showed that during the past 18 years,moderate ecological risk level was major,while proportion of high ecological risk was the lowest,and the area of higher and lower ecological risk region changed most greatly; high and higher ecological risk were focused on urban region and the transition zone from urban to suburban region,while low and lower ecological risk mainly distributed in forestland with higher vegetation coverage,water bodies,grassland,shrub land and so on. Meanwhile,the transition zone from high to low ecological risk was very obvious. In addition,ecological risk became slightly worse in some region due to the transformation from cropland to residential and urban land,while it became slightly better in other regions because of the transformation from cropland to forestland; the center of gravity in lower ecological risk region shifted most greatly,while the shift was the smallest in high ecological risk region,namely 12. 31 and 0. 57 km respectively. | Li YUAN Wenfeng GONG Yongfeng DANG Zexu LONG | 2013 | Asian Agricultural Research2013，5，3： | 7 |
| 9 | The early-middle Miocene submarine fan system in the Pearl River Mouth Basin, South China Sea显示文摘Based on a large amount of seismic, drilling and core data, the characteristics of the earlymiddle Miocene submarine fans in the Baiyun Sag, northern South China Sea are investigated. By analyzing the sedimentary processes of submarine fans in SQ21 (SQ21 refers to the 3rd-order sequence with its bottom boundary 21 Ma), a sedimentary model of the sand-rich fans is established and the main factors controlling fan deposition are detailed. The results indicate that from early to middle Miocene the Pearl River Mouth Basin developed seven 3rd-order sequences in all, with each lowstand systems tract (LST) of the sequence corresponding to submarine fans. However, only the fans in SQ13.8 and SQ21 are sand-rich fans, the others being mud-rich fans. The cores reveal that the submarine fans in the Pearl River Mouth Basin developed five lithofacies: (1) mud clast-bearing sandstone, interpreted as channel deposits; (2) typical turbidite sandstones, also interpreted as channel deposits; (3) thin-bedded sandstone and mudstone, interpreted as channel-levee complex deposits; (4) massive sandstones, interpreted as lobe deposits; (5) massive mudstone, interpreted as hemipelagic mud. The sand-rich submarine fans in the Pearl River Mouth Basin mainly developed in LST, and in LST reverse faults were active, which led to the formation of accommodation on the shelf. Different from the theory of classic sequence stratigraphy, the accommodation on the shelf captures terrigenous debris transported by the Pearl River, and the uplift at the edge of shelf serves as a 'Linear Source' for the deep water area instead of the Pearl River. Therefore, the fans mainly derived from the eroded debris from the uplift. Factors controlling fan deposition include the basin's tectonic framework, the evolution of the slope break, relative sea-level changes as well as the evolution of the fault system, and the fans are formed under the combination of the above factors. | Wang Yongfeng Wang Yingmin Xu Qiang Li Dong Zhuo Haiteng Zhou Wei | 2012 | Petroleum Science2012，9，1： | 7 |
| 10 | SHRIMP Zircon U-Pb and Molybdenite Re-Os Datings of the Superlarge Donggou Porphyry Molybdenum Deposit in the East Qinling,China,and Its Geological Implications显示文摘摘要:在东方 Qinling 铝带的东方部分定位了, Donggou 存款是在最近的年里发现的 superlarge 斑岩铝存款。作者执行了在 Donggou 铝存款的使矿物化的斑岩和矿石的高度精确的标明日期。Donggou 铝土的 A 类型花岗石斑岩标明日期的虾 U-Pb 锆石给了 112 楬瑡摥 ? 的形成岩石的年龄 ??????? | YE Huishou MAO Jingwen LI Yongfeng GUO Baojian ZHANG Changqing LIU Jun YAN Quanren LIU Guoyin | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 6 |
| 11 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 12 | An Effective SDN Controller Scheduling Method to Defence DDoS Attacks显示文摘Distributed Denial of Service(DDoS)attack is a difficult issue which needs to be addressed in Software defined networking(SDN). In order to help the controller to weather out the DDoS attack, an efficient controller scheduling method is proposed. The proposed controller scheduling method uses the normalized waiting time, length and extent of the switch being attacked to choose the request that needs to be processed by the controller. The evaluation results validate that compared with the polling based controller scheduling method, the proposed one can significantly reduce the connection failure ratio and delay. | LI Saifei CUI Yunhe NI Yongfeng YAN Lianshan | 2019 | Chinese Journal of Electronics2019，28，2： | 5 |
| 13 | Review:Recent advances in multisensor multitarge11racking using random finite set显示文摘In this study,we provide an overview of recent advances in multisensor multitarget tracking based on the random finite set(RFS)approach.The fusion that plays a fundamental role in multisensor filtering is classified into data-level multitarget measurement fusion and estimate-level multitarget density fusion,which share and fuse local measurements and posterior densities between sensors,respectively.Important properties of each fusion rule including the optimality and sub-optimality are presented.In particulax,two robust multitarget density-averaging approaches,arithmetic-and geometric-average fusion,are addressed in detail for various RFSs.Relevant research topics and remaining challenges are highlighted. | Kai DA Tiancheng LI Yongfeng ZHU Hongqi FAN Qiang FU | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，1： | 5 |
| 14 | Simulation and Experiment for Oxygen-enriched Combustion Engine Using Liquid Oxygen to Solidify CO2显示文摘For capturing and recycling of CO_2 in the internal combustion engine, Rankle cycle engine can reduce the exhaust pollutants effectively under the condition of ensuring the engine thermal efficiency by using the techniques of spraying water in the cylinder and optimizing the ignition advance angle. However, due to the water spray nozzle need to be installed on the cylinder, which increases the cylinder head design difficulty and makes the combustion conditions become more complicated. In this paper, a new method is presented to carry out the closing inlet and exhaust system for internal combustion engines. The proposed new method uses liquid oxygen to solidify part of cooled CO_2 from exhaust system into dry ice and the liquid oxygen turns into gas oxygen which is sent to inlet system. The other part of CO_2 is sent to inlet system and mixed with oxygen, which can reduce the oxygen-enriched combustion detonation tendency and make combustion stable. Computing grid of the IP52 FMI single-cylinder four-stroke gasoline-engine is established according to the actual shape of the combustion chamber using KIVA-3V program. The effects of exhaust gas recirculation(EGR) rate are analyzed on the temperatures, the pressures and the instantaneous heat release rates when the EGR rate is more than 8%. The possibility of enclosing intake and exhaust system for engine is verified. The carbon dioxide trapping device is designed and the IP52 FMI engine is transformed and the CO_2 capture experiment is carried out. The experimental results show that when the EGR rate is 36% for the optimum EGR rate. When the liquid oxygen of 35.80–437.40 g is imported into the device and last 1–20 min, respectively, 21.50–701.30 g dry ice is obtained. This research proposes a new design method which can capture CO_2 for vehicular internal combustion engine. | LIU Yongfeng JIA Xiaoshe PEI Pucheng LU Yong YI Li SHI Yan | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 5 |
| 15 | Effects of Cu^(2+)and humic acids on degradation and fate of TBBPA in pure culture of Pseudomonas sp.strain CDT显示文摘Soil contamination with tetrabromobisphenol A(TBBPA) has caused great concerns;however, the presence of heavy metals and soil organic matter on the biodegradation of TBBPA is still unclear. We isolated Pseudomonas sp. strain CDT, a TBBPA-degrading bacterium, from activated sludge and incubated it with ^(14)C-labeled TBBPA for 87 days in the absence and presence of Cu^(2+)and humic acids(HA). TBBPA was degraded to organic-solvent extractable(59.4% ± 2.2%) and non-extractable(25.1% ± 1.3%) metabolites,mineralized to CO_2(4.8% ± 0.8%), and assimilated into cells(10.6% ± 0.9%) at the end of incubation. When Cu^(2+)was present, the transformation of extractable metabolites into non-extractable metabolites and mineralization were inhibited, possibly due to the toxicity of Cu^(2+)to cells. HA significantly inhibited both dissipation and mineralization of TBBPA and altered the fate of TBBPA in the culture by formation of HA-bound residues that amounted to 22.1% ± 3.7% of the transformed TBBPA. The inhibition from HA was attributed to adsorption of TBBPA and formation of bound residues with HA via reaction of reactive metabolites with HA molecules, which decreased bioavailability of TBBPA and metabolites in the culture. When Cu^(2+)and HA were both present, Cu^(2+)significantly promoted the HA inhibition on TBBPA dissipation but not on metabolite degradation. The results provide insights into individual and interactive effects of Cu^(2+)and soil organic matter on the biotransformation of TBBPA and indicate that soil organic matter plays an essential role in determining the fate of organic pollutants in soil and mitigating heavy metal toxicity. | Yini Ma Yingying Zhao Yongfeng Wang Xiangzhen Li Feifei Sun Phillippe Francois-Xavier Corvini Rong Ji | 2017 | Journal of Environmental Sciences2017，29，12： | 5 |
| 16 | Economic Benefits and Environmental Costs of China's Exports: A Comparison with the USA Based on Network Analysis显示文摘 | Ya Liu Yuhuan Zhao Hao Li Song Wang Yongfeng Zhang Ye Cao | 2018 | China & World Economy2018，26，4： | 4 |
| 17 | Simultaneous removal and oxidation of arsenic from water byδ-MnO 2 modified activated carbon显示文摘The ubiquitous arsenic in groundwater poses a great risk to human health due to its environmental toxicity and carcinogenicity.In the present work,a new adsorbent,δ-MnO2 modified activated carbon,was prepared,and its performance for the uptake of arsenate and arsenite species from aqueous solutions was investigated by batch experiments.Various techniques,including FESEM-EDX,p-XRD,XPS and BET surface area analysis,were employed to characterize the properties of the adsorbent and the arsenic adsorption mechanisms.The results showed thatδ-MnO2 covered on the surface and padded in the pores of the activated carbon.Adsorption kinetic studies revealed that approximately 90.1%and 76.8%of As(Ⅲ)and As(V),respectively,were removed by the adsorbent in the first 9 hr,and adsorption achieved equilibrium within 48 hr.The maximum adsorption capacities of As(V)and As(Ⅲ)at pH 4.0 calculated from Langmuir adsorption isotherms were 13.30 and 12.56 mg/g,respectively.The effect of pH on As(Ⅴ)and As(Ⅲ)removal was similar,and the removal efficiency significantly reduced with the increase of solution pH.Arsenite oxidation and adsorption kinetics showed that the As(Ⅴ)concentration in solution due to As(Ⅲ)oxidation and reductive dissolution of MnO2 increased rapidly during the first 12 min,and then gradually decreased.Based on the XPS analysis,nearly 93.3%of As(Ⅲ)had been oxidized to As(V)on the adsorbent surface and around 38.9%of Mn(Ⅳ)had been reduced to Mn(Ⅱ)after As(Ⅲ)adsorption.This approach provides a possible method for the purification of arsenic-contaminated groundwater. | Yulong Wang Hupeng Liu Shaofeng Wang Xuhui Li Xin Wang Yongfeng Jia | 2020 | Journal of Environmental Sciences2020，32，8： | 4 |
| 18 | Impact of external carbon source on A2/O system and its biological phosphorus and nitrogen removal efficiency before and after restoration显示文摘以啤酒废水作为外加碳源,研究了不同浓度外加碳源对A2/O系统的冲击情况,并通过调节工艺参数对系统进行修复,对比了修复前后系统的脱氮除磷效果。结果表明,投加低浓度(COD为50mg/L)外加碳源没有影响系统的正常运行,且有助于提高系统的脱氮除磷效率;用COD为150mg/L的啤酒废水对系统进行冲击时,总氮、氨氮、总磷和COD的去除率均有所下降,依次下降了31.53、16.38、7.61、10.19百分点;经过修复后,与冲击前相比较,各分析指标的去除率略有降低。用高浓度(COD为250nag/L)的啤酒废水冲击A2/O系统,冲击期间各分析指标显著下降,且产生轻微的污泥膨胀,修复后各分析指标去除率依次降低了11.75、9.56、21.20、20.79百分点。实验表明,啤酒废水可以作为外加碳源用以调节系统的C/N,且A0/o系统对浓度变化的冲击具有一定的抵抗力。 | LIU Fangjing DUAN Yitong ZHAO Jianhui CHENG Guoling LI Yongfeng | 2014 | 环境污染与防治2014，36，4： | 4 |
| 19 | Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication显示文摘Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus(HCV) with unknown mechanism. Here, we showed that bicyclol significantly inhibited HCV replication in vitro and in hepatitis C patients. Using bicyclol as a probe, we identified glycolipid transfer protein(GLTP) to be a novel restrictive factor for HCV replication. The GLTP preferentially bound host vesicle-associated membrane protein-associated protein-A(VAP-A) in competition with the HCV NS5 A, causing an interruption of the complex formation between VAP-A and HCV NS5 A. As the formation of VAP-A/NS5 A complex is essential for viral RNA replication, up-regulation of GLTP by bicyclol reduced the level of VAP-A/NS5 A complex and thus inhibited HCV replication. Bicyclol also exhibited an inhibition on HCV variants resistant to direct-acting antiviral agents(DAAs) with an efficacy identical to that on wild type HCV. In combination with bicyclol, DAAs inhibited HCV replication in a synergistic fashion. GLTP appears to be a newly discovered host restrictive factor for HCV replication, Up-regulation of GLTP causes spontaneous restriction of HCV replication. | Meng-Hao Huang Hu Li Rong Xue Jianrui Li Lihua Wang Junjun Cheng Zhouyi Wu Wenjing Li Jinhua Chen Xiaoqin Lv Qiang Li Pei Lan Limin Zhao Yongfeng Yang Zonggen Peng Jiandong Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 20 | Hybrid superhydrophilic-superhydrophobic micro/nanostructures fabricated by femtosecond laserinduced forward transfer for sub-femtomolar Raman detection显示文摘Raman spectroscopy plays a crucial role in biochemical analysis.Recently,superhydrophobic surface-enhanced Raman scattering(SERS)substrates have enhanced detection limits by concentrating target molecules into small areas.However,due to the wet transition phenomenon,further reduction of the droplet contact area is prevented,and the detection limit is restricted.This paper proposes a simple method involving femtosecond laser-induced forward transfer for preparing a hybrid superhydrophilic–superhydrophobic SERS(HS-SERS)substrate by introducing a superhydrophilic pattern to promote the target molecules to concentrate on it for ultratrace detection.Furthermore,the HS-SERS substrate is heated to promote a smaller concentrated area.The water vapor film formed by the contact of the solution with the substrate overcomes droplet collapse,and the target molecules are completely concentrated into the superhydrophilic region without loss during evaporation.Finally,the concentrated region is successfully reduced,and the detection limit is enhanced.The HS-SERS substrate achieved a final contact area of 0.013mm2,a 12.1-fold decrease from the unheated case.The reduction of the contact area led to a detection limit concentration as low as 10−16 M for a Rhodamine 6G solution.In addition,the HS-SERS substrate accurately controlled the size of the concentrated areas through the superhydrophilic pattern,which can be attributed to the favorable repeatability of the droplet concentration results.In addition,the preparation method is flexible and has the potential for fluid mixing,fluid transport,and biochemical sensors,etc. | Xiaodan Ma Lan Jiang Xiaowei Li Bohong Li Ji Huang Jiaxing Sun Zhi Wang Zhijie Xu Liangti Qu Yongfeng Lu Tianhong Cui | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
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