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| 1 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 2 | A MULTI-GROUP SVEIR EPIDEMIC MODEL WITH DISTRIBUTED DELAY AND VACCINATION显示文摘 | JINLIANG WANG YASUHIRO TAKEUCHI SHENGQIANG LIU | 2012 | International Journal of Biomathematics2012，5，3： | 2 |
| 3 | Modeling the effect of time delay in budget allocation to control an epidemic through awareness显示文摘 | A. K. Misra Rajanish Kumar Rai Yasuhiro Takeuchi | 2018 | International Journal of Biomathematics2018，11，2： | 2 |
| 4 | Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma显示文摘 | Hideaki Kinugasa Kazuhiro Nouso Yasuto Takeuchi Tetsuya Yasunaka Hideki Onishi Shin-ichiro Nakamura Hidenori Shiraha Kenji Kuwaki Hiroaki Hagihara Fusao Ikeda Yasuhiro Miyake Akinobu Takaki Kazuhide Yamamoto | 2012 | Journal of Gastroenterology2012，，4： | 2 |
| 5 | SVIR epidemic models with vaccination strategies显示文摘 | Xianning Liu Yasuhiro Takeuchi Shingo Iwami | 2007 | Journal of Theoretical Biology2007，，1： | 2 |
| 6 | A Delayed HIV Infection Model with the Homeostatic Proliferation of CD4^(+)T Cells显示文摘In this paper,we investigate a delayed HIV infection model that considers the homeostatic prolif-eration of CD4^(+)T cells.The existence and stability of uninfected equilibrium and infected equilibria(smaller and larger ones)are studied by analyzing the characteristic equation of the system.The intracellular delay does not affect the stability of uninfected equilibrium,but it can change the stability of larger positive equilibrium and Hopf bifurcation appears inducing stable limit cycles.Furthermore,direction and stability of Hopf bifur-cation are well investigated by using the central manifold theorem and the normal form theory.The numerical simulation results show that the stability region of larger positive equilibrium becomes smaller as the increase of time delay.Moreover,when the maximum homeostatic growth rate is very small,the larger positive equilibrium is always stable.On the contrary,when the rate of supply of T cells is very small,the larger positive equilibrium is always unstable. | Qiang-hui XU Ji-cai HUANG Yue-ping DONG Yasuhiro TAKEUCHI | 2022 | Acta Mathematicae Applicatae Sinica2022，38，2： | 2 |
| 7 | SVIR epidemic models with vaccination strategies显示文摘 | LIU X N YASUHIRO Takeuchi SHINGO Iwami | 2008 | Journal of Theoretical Biology2008，253，： | 1 |
| 8 | SVIR epidemic models with vaccination strategies显示文摘 | Xianning Liu Yasuhiro Takeuchi Shingo Iwami | 2007 | Journal of Theoretical Biology2007，，1： | 1 |
| 9 | Avian-human influenza epidemic model 显示文摘 | SHINGO IWAMI A YASUHIRO TAKEUCHI | 2007 | Mathematical Biosciences2007，2007，： | 1 |
| 10 | Effect of surface pre-treatment on durability of resin-based cements bonded to titanium显示文摘 | TSUCHIMOTO YOUHEI YOSHIDA YASUHIRO TAKEUCHI MAHO | 2006 | Dental Materials2006，22，6： | 1 |
| 11 | Predator-prey dynamics in models of prey dispersal in two-patch environments显示文摘 | YANG Kuang YASUHIRO Takeuchi | 1994 | Math Biosci1994，120，： | 1 |
| 12 | Construction of Lyapunov functionals for delay differential equations in virology and epidemiology显示文摘 | Tsuyoshi Kajiwara Toru Sasaki Yasuhiro Takeuchi | 2011 | Nonlinear Analysis: Real World Applications2011，，4： | 1 |
| 13 | Long term changes in platelet counts after H. pylori eradication in non-ITP patients显示文摘 | Yoshihiro Matsukawa Maho Iwamoto Kimitoshi Kato Shigeaki Mizuno Yasuhiro Gon Akihiro Hemmi Natalia Shirinskaya Jin Takeuchi Shigemasa Sawada | 2010 | Platelets2010，，8： | 1 |
| 14 | Core Protein of Hepatitis C Virus Induces Cardiomyopathy显示文摘 | Takashi Omura Minoru Yoshiyama Tetsuya Hayashi Shuhei Nishiguchi Masahiko Kaito Shinichiro Horiike Katsuhiko Fukuda Sakiko Inamoto Yasushi Kitaura Yasuhiro Nakamura Masakazu Teragaki Takeshi Tokuhisa Hiroshi Iwao Kazuhide Takeuchi Junichi Yoshikawa | 2005 | Circulation Research2005，，2： | 1 |
| 15 | Role of nitric oxide in pathogenesis of aspirin-induced gastric mucosal damage in rats显示文摘 | Takeuchi K Yasuhiro T Asada Y | 1998 | Digestion1998，59，4： | 1 |
| 16 | 显示文摘 | Youhei Tsuchimoto Yasuhiro Yoshida Maho Takeuchi | 2006 | Dental Materials2006，22，： | 1 |
| 17 | DOES PROLONGED BILIARY OBSTRUCTIVE JAUNDICE SENSITIZE THE LIVER TO ENDOTOXEMIA?显示文摘 | Ayako Iida Hiroyuki Yoshidome Takashi Shida Fumio Kimura Hiroaki Shimizu Masayuki Ohtsuka Yasuhiro Morita Dan Takeuchi Masaru Miyazaki | 2009 | Shock2009，，4： | 1 |
| 18 | Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5显示文摘 | Tetsuya Tanigawa Toshio Watanabe Koji Otani Yuji Nadatani Fumikazu Ohkawa Mitsue Sogawa Hirokazu Yamagami Masatsugu Shiba Kenji Watanabe Kazunari Tominaga Yasuhiro Fujiwara Koji Takeuchi Tetsuo Arakawa | 2013 | 2013 (1-3)2013，，1： | 1 |
| 19 | The Burning Carousel and the Carni- valesque: Subversion and Transcendence at the Close of The Catcher 显示文摘 | Takeuchi Yasuhiro | | Studies in the Novel0，34，3： | 1 |
| 20 | Global properties of virus dynamics model with Beddington-DeAngelis functional response显示文摘 | Gang Huang Wanbiao Ma Yasuhiro Takeuchi | | Applied Mathematics Letters0，，： | 1 |
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