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| 1 | Stability assessment and feature analysis of slope in Nanfen Open Pit Iron Mine显示文摘Under the combined influences of special topography and the long term mining in Nanfen Open Pit Iron Mine, many large scale landslide masses appeared in heading side of stope, and tens of millions of iron mine is buried underside, making great economic losses. In order to guide the safety mining and increase the supply quantity, this paper through the use of MSARMA-method and the ''MSARMA evaluation and analytical system for slope stability analysis'' based on this method, which aimed at the quantitative evaluating of the slope stability before and after the actual mining below the slip mass, and the sensitivity analysis for the main influencing factor, providing scientific proof for the parameter optimization of open mine surface slope, the security and sustainable exploitation. | Yang Jun Tao Zhigang Li Baoliang Gui Yang Li Haifeng | 2012 | International Journal of Mining Science and Technology2012，22，3： | 10 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 4 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 5 | Methane formation from CaCO_3 reduction catalyzed by high pressure显示文摘在用热水的钻石铁砧房间的几 giga-pascals 的高压下面,在排队黄金的房间从 CaCO3 减小直接产生的甲烷在拉曼光谱学在 550 ° C 的温度测量的 situ。减少的代理人包括 FeO, SiO 和天赋铁橄榄石(Fe2SiO4 ) ,和氢的资源是水和天赋蛇(Mg3Si2O5 (哦) 4 ) 。学习在地球的内部在高压下面表明甲烷的源於生物的形成的存在并且多催化部件反应是的高压的申请一个很有希望的方法。 | Jin Yang Chen Lu Jiang Jin Jun Ping Dong Hai Fei Zheng Gui Yang Liu | 2008 | Chinese Chemical Letters2008，19，4： | 5 |
| 6 | Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China显示文摘Objective Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria(NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. Methods Four macrolides, including clarithromycin(CLAR), azithromycin(AZM), roxithromycin(ROX), and erythromycin(ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method. Two resistance mechanisms, 23 S r RNA and erm, were analyzed with nucleotide sequence analysis. Results Varied effectiveness of macrolides and species-specific resistance patterns were observed. Most Mycobacterium abscessus subsp. massiliense were susceptible and all M. fortuitum were highly resistant to macrolides. All the drugs, except for erythromycin, exhibited excellent activities against slow-growing mycobacteria, and drug resistance rates were below 22.2%. Only four highly resistant strains harbored 2,058/2,059 substitutions on rrl and none of other mutations were related to macrolide resistance. G2191 A and T2221 C on rrl were specific for the M. abscessus complex(MABC). Seven sites, G2140 A, G2210 C, C2217 G, T2238 C, T2322 C, T2404 C, and A2406 G, were specifically carried by M. avium and M. intracellulare. Three sites, A2192 G, T2358 G, and A2636 G, were observed only in M. fortuitum and one site G2152 A was specific for M. gordonae. The genes erm(39) and erm(41) were detected in M. fortuitum and M. abscessus and inducible resistance was observed in relevant sequevar. Conclusion The susceptibility profile of macrolides against NTM was demonstrated. The well-known macrolide resistance mechanisms, 23 S r RNA and erm, failed to account for all resistant NTM isolates, and further studies are warranted to investigate macrolide resistance mechanisms in various NTM species. | LI Fu LI Gui Lian PANG Hui LIU Hai Can XIAO Tong Yang LI Shuang Jun LUO Qiao JIANG Yi WANG Rui Bai WAN Kang Lin | 2018 | Biomedical and Environmental Sciences2018，31，4： | 3 |
| 7 | Coupling phase field with creep damage to study γ’evolution and creep deformation of single crystal superalloys显示文摘A phase-field model coupling with elastoplastic de fo rmation and creep damage has been built to study the micro structural evolution and deformation behavior for Ni-Al single crystal alloy during the whole creep processing.The relevant experiments were conducted to verify the model validity.The simulation re sults show that under the tensile creep at 1223 K/100 MPa,cubic γ’phases coarsen along the direction parallel to the axis of tensile stress during the first two creep stages;and spindle-shaped and wavy γ’phases are fo rmed during tertiary creep,similar to the experimental results.The evolution mechanism of γ’phases is analyzed from the perspective of changes of stress and strain fields.The'is land-like'γ phase is observed and its formation mechanism is discussed.With the increase of creep stress,the directional coarsening of γ’phase is accelerated,the steady-state creep rate is increased and the creep life is decreased.The comparison between simulated and experimental creep curves shows that this phase-field model can effectively simulate the performance changes during the first two creep stages and predict the influence of creep stresses on creep properties.Our work provides a potential approach to synchronously simulate the creep microstructure and property of superalloys strengthened by γ’precipitates. | Min Yang Jun Zhang Weimin Gui Songsong Hu Zhuoran Li Min Guo Haijun Su Lin Liu | 2021 | Journal of Materials Science & Technology2021，，12： | 3 |
| 8 | Prized edible Asian mushrooms: ecology, conservation and sustainability显示文摘Mushrooms can be found in forests worldwide and have long been exploited as resources in developed economies because of their important agro-industrial,medicinal and commercial uses.For less developed countries,such as those within the Greater Mekong Subregion,wild harvesting and mushroom cultivation provides a much-needed alternative source of income for rural households.However,this has led to over-harvesting and ultimately environmental degradation in certain areas,thus management guidelines allowing for a more sustained approach to the use of wild mushrooms is required.This article addresses a selection of the most popular and highly sought after edible mushrooms from Greater Mekong Subregion:Astraeus hygrometricus,Boletus edulis,Morchella conica,Ophiocordyceps sinensis,Phlebopus portentosus,Pleurotus giganteus,Termitomyces eurhizus,Thelephora ganbajun,Tricholoma matsuake,and Tuber indicum in terms of value,ecology and conservation.The greatest threat to these and many other mushroom species is that of habitat loss and over-harvesting of wild stocks,thus,by creating awareness of these issues we wish to enable a more sustainable use of these natural products.Thus our paper provides baseline data for these fungi so that future monitoring can establish the effects of continued harvesting on mushroom populations and the related host species. | Peter E.Mortimer Samantha C.Karunarathna Qiaohong Li Heng Gui Xueqing Yang Xuefei Yang Jun He Lei Ye Jiayu Guo Huili Li Phongeun Sysouphanthong Dequn Zhou Jianchu Xu Kevin D.Hyde | 2012 | Fungal Diversity2012，，5： | 3 |
| 9 | Simultaneous elimination of cancer stem cells and bulk cancer cells by cationic-lipid-assisted nanoparticles for cancer therapy显示文摘有说服力的证据显示在恶意的肿瘤以内的癌症干细胞(CSC ) 的存在为化疗的失败主要负责。因此而不是仅仅指向体积癌症房间, CSC 和体积癌症房间的同时的消除是必要的改进治疗学的结果。此处,我们设计了 cationic-lipid-assisted nanoparticles DTXL NP 为常规化学疗法的 agentdocetaxel (DTXL ) 和指向 BMI-1 (siBMI-1 ) 的小介入 RNA (siRNA ) 的同时的封装的 siRNA 。我们证实了那 nanoparticles DTX LNP siBMI-1 有效地交付两个治疗学的代理人进 CSC 和体积癌症房间。体积癌症房间被在 DTX LNP siBMI-1 。在胸 CSC, BMI-1 表示是显著地由 DTX LNP siBMI-1 ;因而, stemness 被减少,到 DTXL 的 CSC 的 chemosensitivity 被提高,导致 CSC 的消除。因此,经由 DTX LNP siBMI-1 , siBMI-1 和 DTXL 的联合完全禁止了肿瘤生长并且由在一个 MDA-MB-231 orthotropic 肿瘤的一个鼠科的模型 CSC 和体积癌症房间杀死的 synergistic 阻止了恶化。 | Kaige Chen Song Shen Gui Zhao Zhiting Cao Xianzhu Yang Jun Wang | 2018 | Nano Research2018，11，8： | 2 |
| 10 | Studies on the Preparation and the Stability of SOD Modified by Lauric Acid显示文摘Tkls paper reported that a way or Preparlng superoxlde dlsmutase (SoD) modiried by lauric acid(LA-SoD) and study on stablllty of LA-SoD. The resultS showed that LA-SoD had high speclfic actlvlty,highstablllty and high rate of recovery. The stabiliy or LA-SoD ln temperature, pH and kuman gastrlc juice wasmuch higher than that of natural SOD. Because LA-SOD ls kept for a long tlme at room temperature, it canwiden the appIled range of SoD and brlng out conslderable benirlclaI results both in society and economy. | Gui Xingfeu, Yang Ping, Qiu Yanxia, Liu Jun(Henan Medical College for Health Staff, Zhengzhou 450003,China)Zou Guolin(College of Life Sciences,Wuhan University, Wuhan 430072,China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 2 |
| 11 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 12 | Effects of simvastatin on early oxidative stress and endothelial function in apolipoprotein E-deficient mice显示文摘Objective:To investigate the mechanisms that Simvastatin,a 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibitor,plays an important role in primary prevention of atherosclerosis independently of its lipid-lowering effect in Apolipoprotein E-deficient mice in the early stage of atherosclerosis.Methods:Twenty-four 6-week old male apoE-deficient mice were randomly divided into two groups:control group(normal saline) and treatment group[simvastatin(5 mg/(kg·d))].Simvastatin was administered to treatment group mice by gavage and the same volume of normal saline was administered to control group mice by the same method for 2 or 4 weeks.Total cholesterol(TC),super-oxide dismutase(SOD),malondialdehyde(MDA) and serum nitric oxide(NO) were measured by bio-chemical analysis.Results:There was no significant difference in serum TC between control and treatment groups.Compared with the control's,the effects of simvastatin were more significant in decreasing serum MDA level(P < 0.01 vs control's at 2-week;P < 0.006 vs control's at 4-week),increasing serum SOD level(P < 0.03 vs control's at 2-week;P < 0.003 vs control's at 4-week) and NO level(P < 0.01 control's at 2-week;P < 0.001 vs control's at 4-week) either at 2 or 4 weeks.Conclusion:Simvastatin attenuates oxidative stress and protects endothelial function by the mechanisms of decreasing serum MDA level,increasing serum SOD level and NO level ,which were inconsistent with its cholesterol-lowering effect.It may play an important role in primary(if not all) prevention of atherosclerosis and might be independent of lipid-regulation mechanism. | Donghua Yin Meng Liu Guoping Yang Jun Huang Ming Gui | 2007 | Journal of Nanjing Medical University2007，21，6： | 2 |
| 13 | Cytotoxic terpenes from Abies sibirica显示文摘新的和 16 已知的混合物被孤立从受苦 sibirica。他们的结构主要根据 NMR 和 MS 被分配分光镜的数据。在为对四个人的肿瘤房间的 anti-proliferative 活动的生物鉴定,与 0.9 g/mL 的 IC50 价值对 COLO-205 肿瘤房间加重 7 展出选择 anti-proliferative 活动。 | Gui Rong Wang Yong Li Li Wei Dong Zhang Xian Wen Yang Wen Cong Liu Ji Ye Zhi Jun Zhu Hong Chen | 2012 | Chinese Chemical Letters2012，23，11： | 2 |
| 14 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 15 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 16 | Genetic Characteristics and Antimicrobial Susceptibility of Arcobacter butzleri Isolates from Raw Chicken Meat and Patients with Diarrhea in China显示文摘Arcobacter is an emerging foodborne pathogen worldwide.In this study,the prevalence,antimicrobial susceptibility and genetic characteristics of Arcobacter from different sources were investigated.Eighteen A.butzleri isolates were obtained from 60 raw chicken meat samples(16/60,27%)and 150 patients with diarrhea(2/150,1.3%).The resistance ratios to nalidixic acid,ciprofloxacin,clindamycin,chloramphenicol,and florfenicol were 83.33%(15/18),38.89%(7/18),38.89%(7/18),33.33%(6/18)and 33.33%(6/18),respectively.We performed whole genome sequencing of the 18 isolates,and we predicted antibiotic resistance genes and virulence factors by using assembled genomes through blastx analysis.Two resistance genes,blaOXA-464 and tet(H),and the C254T mutation in gyrA,were identified in the genomes of some resistant isolates.Furthermore,virulence genes,such as flgG,flhA,flhB,fliI,fliP,motA,cadF,cjl349,ciaB,mviN,pldA and tlyA,were found in all strains,whereas hecA,hecB and iroE were found in only some strains.Phylogenetic tree analysis of A.butzleri isolates on the basis of the core-genome single nucleotide polymorphisms showed that two isolates from patients with diarrhea clustered together,separately from the isolates from raw chicken and the chicken strains.This study is the first comprehensive analysis of Arcobacter isolated in Beijing. | WANG Yuan Yuan ZHOU Gui Lan LI Ying GU Yi Xin HE Mu ZHANG Shuang JI Guo Qiang YANG Jie WANG Miao MA Hong Mei ZHANG Mao Jun | 2021 | Biomedical and Environmental Sciences2021，34，12： | 1 |
| 17 | Progress in nanoparticle-based regulation of immune cells显示文摘Immune cells are indispensable defenders of the human body,clearing exogenous pathogens and toxicities or endogenous malignant and aging cells.Immune cell dysfunction can cause an inability to recognize,react,and remove these hazards,resulting in cancers,inflammatory diseases,autoimmune diseases,and infections.Immune cells regulation has shown great promise in treating disease,and immune agonists are usually used to treat cancers and infections caused by immune suppression.In contrast,immunosuppressants are used to treat inflammatory and autoimmune diseases.However,the key to maintaining health is to restore balance to the immune system,as excessive activation or inhibition of immune cells is a common complication of immunotherapy.Nanoparticles are efficient drug delivery systems widely used to deliver small molecule inhibitors,nucleic acid,and proteins.Using nanoparticles for the targeted delivery of drugs to immune cells provides opportunities to regulate immune cell function.In this review,we summarize the current progress of nanoparticle-based strategies for regulating immune function and discuss the prospects of future nanoparticle design to improve immunotherapy. | Ya-Nan Fan Gui Zhao Yue Zhang Qian-Ni Ye Yi-Qun Sun Song Shen Yang Liu Cong-Fei Xu Jun Wang | 2023 | Medical Review2023，3，2： | 1 |
| 18 | Esti- mation of subpixel land surface temperature using the end member index base technique: a ease examination on ASTER and MODIS products over a heterogeneous area 显示文摘 | YANG GUI JUN PU RUILIANG ZHAO CHUNJIANG | 2011 | Remote Sensing of Environ- ment2011，115，： | 1 |
| 19 | Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China显示文摘Objective There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein (CRP), soluble intracellular adhesion molecule1-1 (sICAM-1), and angiotensin Ⅱ (Ang Ⅱ), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China. Methods A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants. Results The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one, two or three biomarkers were 0.94 (0.72-1.22), 1.42 (0.93-2.16), and 11.08 (1.45-84.80), respectively, compared with subjects with no increase in any biomarker. Conclusion Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population. | ZHU Xiao Hong JIAO Yang LI Hong Mei WANG Ai Li WANG Gui Yan TONG Wei Jun ZHANG Yong Hong | 2012 | Biomedical and Environmental Sciences2012，25，5： | 1 |
| 20 | Simultaneous Determination of Gold and Platinum by Double Artificial Neural Network Analysis with Flow-injection Chemiluminescence显示文摘A highly sensitive double artificial neural network (DANN) analysis with flow-injection chemiluminescence (FI-CL) has been developed to simultaneously determine the trace amounts of the gold and platinum in simulated mixed samples, without the boring process. | Ming Yang LIU Hai Tao ZHANG Jun Feng LI Shu Gui CHEN Hong Yan WANG | 2006 | Chinese Chemical Letters2006，17，10： | 1 |
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