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| 1 | 辛伐他汀减轻载脂蛋白E^(-/-)小鼠氧化应激及小窝蛋白1的表达显示文摘背景氧化应激损伤内皮是动脉粥样硬化的始动因素,他汀对于动脉粥样硬化的干预主要集中在粥样硬化斑块形成之后,而对于粥样硬化斑块形成之前的研究较少。目的观察辛伐他汀对载脂蛋白(apo)E^(-/-)小鼠氧化应激及主动脉内皮小窝蛋白l的影响,探讨辛伐他汀在动脉粥样硬化一级预防中保护内皮功能的机制。方法24只6周龄雄性 apoE^(-/-)小鼠,随机等分为两组:对照组、辛伐他汀[5 mg/(kg·d)]治疗组,4周后处死动物。常规生物化学法测定血总胆固醇(TC)、超氧化物歧化酶活性(SOD)、丙二醛(MDA)和血清一氧化氮(N0)含量。采用苏木素伊红(HE)染色法观察小鼠主动脉内皮组织,免疫组织化学法分析小鼠主动脉内皮的小窝蛋白1的表达。结果两组间血脂水平无显著性差异。辛伐他汀治疗组主动脉内皮组织的损伤减轻(损伤阳性率33.3%比对照组:75%,P<0.05)。治疗4周后,辛伐他汀治疗组 SOD[(135.3±5.5)U/L 比对照组:(97.2±7.6)U/L,P<0.01)和 NO[(28.4±4.1)μmol/L 比对照组:(12.3±2.1)μmol/L,P<0.01]均明显升高,MDA 显著减低[(10.5±0.5)nmol/L 比对照组:(17.3±1.0)nmol/L,P<0.01]。辛伐他汀治疗组主动脉内皮上小窝蛋白1的表达(表达阳性率41.67%比对照组:83.33%,P<0.05)明显降低。结论辛伐他汀在不影响血脂水平情况下,抑制主动脉内皮的小窝蛋白1的表达,减轻 apoE^(-/-)小鼠氧化应激,增加 NO 水平,起到改善内皮功能、抗动脉粥样硬化作用,在动脉粥样硬化的一级预防中可能发挥重要作用。 | 尹冬华 桂鸣 刘猛 黄峻 | 2008 | 中华高血压杂志2008，16，8： | 1 |
| 2 | Effects of Simvastatin on adiponectin and endothelial function in apolipoprotein E-deficient mice显示文摘Objective:To investigate the effects of simvastatin,a 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibitor,on adiponectin and markers of endothelial function in apolipoprotein E-deficient mice at an early stage of atherosclerosis. Methods:Twenty-four 6-week old male apoE-deficient mice were randomly divided into two groups: control group(normal saline) and treatment group simvastatin(5 mg/(kg·d). Simvastatin was administered to treatment group mice by gavage and the same volume of normal saline was administered to control group mice by the same method for 4 weeks. Total cholesterol(TC),superoxide dismutase(SOD),malondialdehyde (MDA),and nitric oxide(NO) were measured by biochemical analysis,and adiponectin was measured by an ABC-ELISA method. Results: There was no significant difference in serum TC between control and treatment groups. Compared with the control animals,simvastatin-treated animals exhibited a significant increase in serum levels of adponectin,SOD and NO,and decrease in serum MDA(P < 0.01). Conclusion: Simvastatin protects endothelial function by increasing serum adiponectin,which may increase serum SOD and NO,and decrease serum MDA. This study suggests that simvastatin has therapeutic advantages,unrelated to its cholesterol-lowering effect,that are mediated by adiponectin. | Meng Liu Donghua Yin Ming Gui Kejiang Cao | 2009 | Journal of Nanjing Medical University2009，23，1： | 1 |
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