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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Expression of basic fibroblast growth factor and its receptor in human pancreatic carcinomas显示文摘 | Ohta T Yamamoto M Numata M | 1995 | B J Cancer1995，72，4： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | 初产妇和经产妇妊娠期间的诊室和家庭血压显示文摘妊娠高血压可导致分娩时产生严重的并发症,如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法:入选初产妇和经产妇共575名,评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值,参与者妊娠期间每日清晨在家自测血压。 | Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K Sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori S Suzuki M Kuriyama S Imai Y 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，6： | 2 |
| 6 | Metallothionein expression correlates with the pathological response of patients with esophageal cancer undergoing preoperative chemoradiation therapy显示文摘 | Yamamoto M Tsujinake T Shiozaki H | 1999 | Oncology1999，56，4： | 1 |
| 7 | J Power Sources显示文摘 | Matsuoka O Hiwara A Omi T Toriida M Hayashi T Tanaka C Saito Y Ishida T Tan H Ono S S Yamamoto S | 2002 | 108:1282002，108，： | 1 |
| 8 | Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency显示文摘 | MIYABAYASHI T TEO JL YAMAMOTO M | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 9 | Application of met- amorphosis assay to a native Japanese amphbian species, Rata rugosa, for assessing effects of thyroid system affect- ing chemicals 显示文摘 | Oka T Miyahara M Yamamoto J | 2009 | Ecotoxicology and Environment Safety2009，72，5： | 1 |
| 10 | Highly effective synthesis of ethanol by CO2 hydrogenation on well balanced multi-functional FT-type composite catalysis显示文摘 | Inui T Yamamoto T Inoue M | 1999 | Appl Catal A1999，186，12： | 1 |
| 11 | Synthesis of monodisperse platinum nanoparticles supported on carbon gel microspheres显示文摘 | YAMAMOTO T YOSHIMURA Y TOBA M | 2006 | Journal of Non-Crystalline Solids2006，352，2627： | 1 |
| 12 | Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid - responsive element 显示文摘 | Yamamoto T Nakahata Y Tanaka M | 2005 | J Biol Chem2005，280，42： | 1 |
| 13 | Barriers and facilitators in relation to starting insulin therapy in type 2 diabetes显示文摘 | Okazaki K Goto M Yamamoto T | 1999 | Diabetes1999，48，： | 1 |
| 14 | Left thoracoabdominal approach versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia: a randomised controlled trial 显示文摘 | Sasako M Sano T Yamamoto S | 2006 | Lancet Oncol2006，7，： | 1 |
| 15 | Improving withstand vol- tage by roughening the surface of an insulating spacer used in vacuum显示文摘 | Yamamoto O Takuma T Fukuda M | 2003 | IEEE Transactions on Dielectrics and Electrical Insulation2003，10，4： | 1 |
| 16 | Effect of shrinking microbubble on gas hydrate formation显示文摘 | Takahashi M T K Yamamoto Y | 2003 | The Journal of Physical Chemistry B2003，107，： | 1 |
| 17 | 查看详情显示文摘 | Yamamoto M Kumasaka T Ishikawa T | | 0，，： | 1 |
| 18 | Gastric cancer surgery:morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy--Japan Clinical Oncology Group study 9501显示文摘 | Sano T Sasako M Yamamoto S | | 0，，14： | 1 |
| 19 | Enhancement of surface-damage resistance by removing a subsurface damage in fused silica显示文摘 | Kamimura T Akamatsu S Yamamoto M | 2004 | Proceedings of SPIE2004，5273，： | 1 |
| 20 | Lambda-shaped anastomosis with intravascular stenting method for safe and effective lymphaticovenular anastomosis 显示文摘 | Yamamoto T Narushima M Kikuehi K | 2011 | Plast Reconstr Surg2011，127，5： | 1 |
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