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| 1 | Association of Fusobacterium nucleatum with immunity andmolecular alterations in colorectal cancer显示文摘The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures, and host immunity. Fusobacterium species are part of the human oral and intestinal microbiota. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum(F. nucleatum) in colorectal carcinoma tissue. Using 511 colorectal carcinomas from Japanese patients, we assessed the presence of F. nucleatum. Our results showed that the frequency of F. nucleatum positivity in the Japanese colorectal cancer was 8.6%(44/511), which was lower than that in United States cohort studies(13%). Similar to the United States studies, F. nucleatum positivityin Japanese colorectal cancers was significantly associated with microsatellite instability(MSI)-high status. Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets(i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. Concerning the association between the gut microbiome and immunity, F. nucleatum has been shown to expand myeloid-derived immune cells, which inhibit T-cell proliferation and induce T-cell apoptosis in colorectal cancer. This finding indicates that F. nucleatum possesses immunosuppressive activities by inhibiting human T-cell responses. Certain micro RNAs are induced during the macrophage inflammatory response and have the ability to regulate host-cell responses to pathogens. Micro RNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity through the inhibition of the antigen-presenting capacities of dendritic cells and T-cell proliferation in colorectal cancer cells. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment. Further investigation is needed to clarify the association of Fusobacterium with T-cells and micro RNA expressions in colorectal cancer. | Katsuhiko Nosho Yasutaka Sukawa Yasushi Adachi Miki Ito Kei Mitsuhashi Hiroyoshi Kurihara Shinichi Kanno Itaru Yamamoto Keisuke Ishigami Hisayoshi Igarashi Reo Maruyama Kohzoh Imai Hiroyuki Yamamoto Yasuhisa Shinomura | 2016 | World Journal of Gastroenterology2016，22，2： | 44 |
| 2 | Braking Performance of a Biomimetic Squid-Like Underwater Robot显示文摘 | Md. Mahbubar Rahman Sinpei Sugimori Hiroshi Miki Risa Yamamoto Yugo Sanada Yasuyuki Toda | 2013 | Journal of Bionic Engineering2013，10，3： | 13 |
| 3 | MicroRNA-31 expression in colorectal serrated pathway progression显示文摘MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers(CRC).We have recently observed that microRNA-31(miR-31)expression is associated with BRAF mutation and prognosis in CRC.Moreover,high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps(HPs).These results suggest that miR-31 may contribute to the progression of serrated lesions.At a follow-up colonoscopy,we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features.Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component.Higher miR-31 expression was observed in the carcinoma component(57-fold increase)and the HP component(8-fold increase)compared with the paired normal mucosa,suggesting that miR-31 may be one of the key molecules in serrated pathway progression. | Hironori Aoki Katsuhiko Nosho Hisayoshi Igarashi Miki Ito Kei Mitsuhashi Takafumi Naito Eiichiro Yamamoto Tokuma Tanuma Masafumi Nomura Hiroyuki Maguchi Toshiya Shinohara Hiromu Suzuki Hiroyuki Yamamoto Yasuhisa Shinomura | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 4 | Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection显示文摘 | N. Hiki Y. Yamamoto T. Fukunaga T. Yamaguchi S. Nunobe M. Tokunaga A. Miki S. Ohyama Y. Seto | 2008 | Surgical Endoscopy2008，，7： | 3 |
| 5 | Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection显示文摘 | N. Hiki Y. Yamamoto T. Fukunaga T. Yamaguchi S. Nunobe M. Tokunaga A. Miki S. Ohyama Y. Seto | 2008 | Surgical Endoscopy2008，，7： | 3 |
| 6 | Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis显示文摘Esophagectomy with extended lymphadenectomy and gastric conduit reconstruction is a radical procedure for the treatment of esophageal cancer that is associated with a high morbidity rate.Gastric conduit necrosis is a fatal complication that occurs in 2%of patients.Conventionally,two-stage salvage surgery consisting of removal of the necrotic gastric conduit followed by reconstruction has been performed;however,this procedure has a high morbidity rate.We describe a61-year-old man who underwent minimally invasive esophagectomy complicated by slowly progressive gastric conduit necrosis associated with complete neck drainage and a stable overall condition.There was a 2 cm gap in the anastomosis.Because there was no evidence of residual gastric conduit necrosis,a removable,covered self-expanding metal stent(SEMS)was inserted to bridge the anastomosis.The stent was fixed to the patient's ear with silk thread through the lasso on its proximal end to prevent migration.Eight weeks after insertion,the stent was removed easily without any associated complications.The anastomotic defect was completely bridged with granulation tissue,showing progressive epithelialization without leakage or stenosis.The patient was discharged home in good general health.This is the first report of the successful conservative management of esophago-gastric conduit anastomosis disruption with SEMS placement. | Taro Oshikiri Yoshinobu Yamamoto Ikuya Miki Masahiro Tsuda Tetsu Nakamura Yasuhiro Fujino Masahiro Tominaga Yoshihiro Kakeji | 2015 | World Journal of Gastroenterology2015，21，28： | 2 |
| 7 | Nucleotide sequence of a cDNA for 1-aminocyclopropane-l-carboxylate synthase from melon fruits 显示文摘 | Miki T Yamamoto M Nakagaw H | 1995 | Plant Physiol1995，107，： | 1 |
| 8 | Nucleotide sequence of a cDNA for 1-aminocyclopropane-1-carboxylate synthase from melon fruits 显示文摘 | Miki T Yamamoto M Nakagawa H | 1995 | Plant Physiology1995，107，1： | 1 |
| 9 | Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer’s Disease in the Japanese Population显示文摘 | Kouzin Kamino Keiko Nagasaka Masaki Imagawa Hideki Yamamoto Hiroshi Yoneda Akira Ueki Shin Kitamura Kazuhiko Namekata Tetsuro Miki Shigeo Ohta | 2000 | Biochemical and Biophysical Research Communications2000，，1： | 1 |
| 10 | Malignant phyllodes tumor of the prostate显示文摘 | Yamamoto S Ito T Miki M | 2000 | Int J Urol2000，7，10： | 1 |
| 11 | Short communication changes inreelin expression in the mouse olfactory bulb after chemical lesion to the olfactory epithelium显示文摘 | Ayako OY Yamamoto T Miki A | 2005 | Eur J Neurosci2005，21，7： | 1 |
| 12 | Diagnosis of moyamoya disease using 3-T MRI and MRA: Value of cisternal moyamoya vessels显示文摘 | Sawada T Yamamoto A Miki Y | 2012 | Neuroradiology2012，54，10： | 1 |
| 13 | Upfront transection and subsequent ligation of the dorsal vein complex during laparoscopic radical prostatectomy显示文摘 | Sasaki H Miki J Kimura T Yamamoto Y Koike Y Miki K | 2010 | Int J Urol2010，17，： | 1 |
| 14 | Malignant phyllodes tumor of the prostate显示文摘 | Yamamoto S Ito T Miki M | 2000 | Int J Urol2000，7，： | 1 |
| 15 | Oxidation of dibenzothiophenes in an organic biphasic system and its application to oxidative desulfurization of light oil显示文摘 | YAZU K YAMAMOTO Y FURUYA T MIKI K UKEGAWA K | 2001 | Energy Fuels2001，15，6： | 1 |
| 16 | Malignant phyllodes tumor of the prostate显示文摘 | Yamamoto S Ito T Miki M | 2000 | Int J Urol2000，7，10： | 1 |
| 17 | Improving Efficiency of Application- level Multicast with Network Support显示文摘 | Takeshi Sano Taku Noguchi Miki Yamamoto | 2003 | Networked Group Communication2003，1322，： | 1 |
| 18 | Sequence determination and genetic content of an 8.9-kb restriction fragment in the short unique region and the internal inverted repeat of Marek’s disease virus type 1 DNA显示文摘 | Masashi Sakaguchi Toyohiko Urakawa Yumiko Hirayama Noriko Miki Michitaka Yamamoto Dr. Kanji Hirai | 1992 | Virus Genes1992，，4： | 1 |
| 19 | A comparison of magnifying and nonmagnifying colonoscopy for diagnosis of colorectal polyps: A prospective study显示文摘 | Kazuo Konishi Kazuhiro Kaneko Toshinori Kurahashi Taikan Yamamoto Miki Kushima Akira Kanda Hisao Tajiri Keiji Mitamura | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
| 20 | Influences of TCP Congestion Control Mechanisms to Multi-Fractal Nature of Generated Traffic显示文摘 | DOI HIROKI MATSUDA TAKAHIRO YAMAMOTO MIKI | 2003 | Conference Record/IEEE Global Telecommunications Conference2003，8，： | 1 |
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