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| 1 | Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion显示文摘AIM: To investigate and compare the efficacy of two machine-learning technologies with deep-learning(DL) and support vector machine(SVM) for the detection of branch retinal vein occlusion(BRVO) using ultrawide-field fundus images. METHODS: This study included 237 images from 236 patients with BRVO with a mean±standard deviation of age 66.3±10.6 y and 229 images from 176 non-BRVO healthy subjects with a mean age of 64.9±9.4 y. Training was conducted using a deep convolutional neural network using ultrawide-field fundus images to construct the DL model. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and area under the curve(AUC) were calculated to compare the diagnostic abilities of the DL and SVM models. RESULTS: For the DL model, the sensitivity, specificity, PPV, NPV and AUC for diagnosing BRVO was 94.0%(95%CI: 93.8%-98.8%), 97.0%(95%CI: 89.7%-96.4%), 96.5%(95%CI: 94.3%-98.7%), 93.2%(95%CI: 90.5%-96.0%) and 0.976(95%CI: 0.960-0.993), respectively. In contrast, for the SVM model, these values were 80.5%(95%CI: 77.8%-87.9%), 84.3%(95%CI: 75.8%-86.1%), 83.5%(95%CI: 78.4%-88.6%), 75.2%(95%CI: 72.1%-78.3%) and 0.857(95%CI: 0.811-0.903), respectively. The DL model outperformed the SVM model in all the aforementioned parameters(P<0.001). CONCLUSION: These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy. The proposed combination may be used for automatically diagnosing BRVO in patients residing in remote areas lacking access to an ophthalmic medical center. | Daisuke Nagasato Hitoshi Tabuchi Hideharu Ohsugi Hiroki Masumoto Hiroki Enno Naofumi Ishitobi Tomoaki Sonobe Masahiro Kameoka Masanori Niki Yoshinori Mitamura | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 16 |
| 2 | Derivatization in Liquid Chromatography/Mass Spectrometric Analysis of Neurosteroids显示文摘Liquid chromatography/mass spectrometry (LC/MS) is now considered to be the most promising analytical method for the determination of biological substances, especially nonvolatile or highly polar substances However, some compounds do not show enough sensitivity in LC/MS and soft ionization methods commonly used in LC/MS, such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), sometimes do not give satisfactory structural information This report presents an overview of the derivatization methods in the LC/MS analysis of neurosteroids or neuroactive neurosteroids, which are synthesized and accumulated in the nervous system The derivatization of pregnenolone 3 sulfate, one of these steroids, with 4 ( N,N dimethylaminosulfonyl) 7 hydrazino 2,1,3 benzoxadiazole gave a satisfactory sensitivity during the quantitative analysis using LC/ESI MS The obtained results are much lower than those previously obtained using gas chromatography/mass spectrometry or radioimmunoassay On the other hand, the derivatization to acetate was useful for the treatment of labile catechol estrogens in rat brains and gave enough structural information in LC/APCI MS, which confirmed the existence of catechol estrogens in mammalian | Kuniko MITAMURA, Kazutake SHIMADA (Faculty of Pharmaceutical Sciences, Kanazawa University 13 1, Takara machi, Kanazawa 920 0934, Japan) | 2001 | 色谱2001，19，6： | 5 |
| 3 | Changes in choroidal thickness in healthy pediatric individuals: a longitudinal study显示文摘● AIM: To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness.● METHODS: This study included 64 eyes of 34 healthy Japanese children with a mean age(±SD) of 4.4(±0.4)y(range, 3.6-5.8 y) at baseline. Swept-source optical coherence tomography(SS-OCT) was used to record images of the retina and choroid at the baseline and after a mean followup period of about 1.5 y. The 3 D raster scan protocol was used to construct the choroidal thickness map. Mean choroidal thickness was calculated for each of the nine sectors of the Early Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial length, body height, and weight were also measured. Changes in measurements were defined as the baseline values subtracted from the values at the final visit. A generalized estimating equation was used to eliminate the effect of within-subject intereye correlations.● RESULTS: The mean central choroidal thickness was significantly reduced during the follow-up period(baseline, 301.8±8.6 μm; final visit, 286.6±8.0 μm, P<0.001). The decrease in the choroidal thickness was greatest in the central sector, followed by the sectors of the inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 to 6 mm, respectively. The changes in the choroidal thickness in the central, inner ring, and outer ring sectors were significantly and negatively correlated with the age, baseline body height, baseline body weight, and elongation of the axial length.● CONCLUSION: These results indicate that the choroidal thickness among preschool-aged Japanese children decreased significantly during the follow-up period. The choroidal thinning is significantly associated with the elongation of axial length. These characteristics should be considered in the evaluation of choroidal thickness in younger children with retinochoroidal disorders. | Eiko Ohsugi Yoshinori Mitamura Kayo Shinomiya Masanori Niki Hiroki Sano Toshihiko Nagasawa Yukiko Shimizu Daisuke Nagasato Hitoshi Tabuchi | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 2 |
| 4 | 根据日本乡村绝经后妇女腰椎骨密度的随访研究制定骨质疏松的护理卫生方针(英文)显示文摘为了检测妇女绝经后发生骨量减少的相关指标进而倡导依据生活方式的特点对绝经后妇女骨质疏松的发生采取相应的预防和护理方针,我们对日本乡村的绝经后妇女(末次月经后六个月或更长时间算起)进行了为期4a的随访。我们运用双能X线骨密度仪(DXA)对腰椎骨密度(BMD)进行检测并对各种变量,包括年龄、绝经时的年龄、骨折史、日常摄奶量以及吸烟习惯进行多元分析,结果表明这些因素对于腰椎骨密度(BMD)的恢复是不相关联的。在这些变量中,骨折史被证明对于相关人群是最具危险性的,这些对象有高比例的骨量减少(6.6%),其次是不规律的摄奶(13.6%)和吸烟(9.3%)。在护理中使用的作用于足跟骨的检测骨密度的设备被证实与作用于腰椎的DXA设备可以相互替代。依据这些结果,针对居住在日本乡村的绝经后妇女制订了相应的预防骨质疏松的方针。这些卫生指导方针依据特定区域的生活方式而制定并可适用于其他的人群和区域。在本文中,作者列出了不同的有助于预防绝经后妇女出现骨质疏松的方法并进行了调查。 | 梶田悦子 Iki M Nishino H Mitamura S | 2006 | 内蒙古医学院学报2006，28，5： | 2 |
| 5 | Erythrocyte Na+, K+-ATPase activity in patients with congestive heart failure 显示文摘 | Baba A Yoshikawa T Mitamura H | 1999 | Int J Cardiol1999，69，2： | 2 |
| 6 | Hepatocyte growth factor levels in the vitreous of patients with proliferative vitreoretinopathy显示文摘 | Takeuchi S Matsuda A | 2000 | Am J Ophthalmol2000，，： | 1 |
| 7 | Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative diabetic retinopathy显示文摘 | Mitamura Y Takeuchi S Matsuda A | 2000 | Br J Ophthalmol2000，84，： | 1 |
| 8 | Are surveys on trust trust-worthy? 显示文摘 | Miller A Mitamura T | 2003 | Social Psychology Quarterly2003，66，1： | 1 |
| 9 | Effects of lentinan on coloreetal carcinogenesis in mice with ulcerative colitis显示文摘 | Mitamura T Sakamoto S Suzuki S | 2000 | Oncol Rep2000，7，3： | 1 |
| 10 | Ingestion of difructose anhydride III partially restores calcium absorption impaired by vitamin D and estrogen, deficiency in rats 显示文摘 | Rieko Mitamura Hiroshi Hara | 2006 | European Journal of Nutrition2006，45，： | 1 |
| 11 | Effect of additives on the microstructure of ferrite sintered body and its characteristic evaluation 显示文摘 | SUZUKI Y BI/(N P JU D Y MITAMURA T KOBAYASHI H | 2001 | J Jpn Soc Powder Powder Metallurgy2001，48，： | 1 |
| 12 | Effect of cell plating density and extracellular matrix protein on cell growth of epithelial rests of Malassez in vitro 显示文摘 | Nishimura M Abiko Y Mitamura J | 1999 | Med Electron Microsc1999，32，2： | 1 |
| 13 | Application of a magnetic fluid seal to rotary blood pumps显示文摘 | Mitamura Y Arioka S Sakota D | 2008 | Journal of Physics:Condensed Matter2008，20，20： | 1 |
| 14 | Pattern of expres- sion of beta-defensins in oral squamous cell car cinoma 显示文摘 | Abiko Y Mitamura J Nishimura M | 1999 | Cancer Lett1999，，： | 1 |
| 15 | Thermal diary: connecting temperature history to indoor comfort显示文摘 | Chun C Kwok A Mitamura T | 2008 | Building and Environment2008，43，5： | 1 |
| 16 | Application of overlay reinforcement method on steel deck utilizing engineering cementitious composites- Mihara Bridge 显示文摘 | Mitamura H Sakata N Shakushiro K Suda K Hiraishi T | 2005 | Bridge and Foundation Engineering2005，39，8： | 1 |
| 17 | Clean development mechanism project s and portfolio risks显示文摘 | Ryuji Mat suhashi Sei Fujisawa Wataru Mitamura | 2004 | Energy Policy2004，，29： | 1 |
| 18 | Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome显示文摘 | MIYAZAKI T MITAMURA H MIYOSHI S | 1996 | Am Coll Cardiol1996，27，： | 1 |
| 19 | 显示文摘 | Yuhta T Kikuta Y Mitamura Y | 1994 | J Biomed Mater Res1994，28，2： | 1 |
| 20 | A strategy for supraclavicular lymph node dissection using recurrent laryngeal nerve lymph node status in thoracic esophageal squamous cell carcinoma显示文摘 | Taniyama Y Nakamura T Mitamura A | 2013 | Ann Thorac Surg2013，95，： | 1 |
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