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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Connections Between Insomnia and Cognitive Aging显示文摘Insomnia is a common sleep disorder among older adults,and a risk factor for poor physical and mental health.However,the relationship between insomnia and cognitive health is not well understood.Here,we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia,magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure,and interventional studies that have explored whether the treatment of insomnia can improve cognitive outcomes.There are inconsistent findings regarding impaired performance in objective cognitive tests and reduced grey matter volumes,and limited,emerging,evidence that suggests that insomnia is associated with an increased risk of dementia and reduced white matter integrity.Although the interventional literature is still in its infancy,there is some indication that treatment may have an impact on vigilance.Well-powered studies examining sources of heterogeneity are warranted. | Claire E.Sexton Konstantina Sykara Elissaios Karageorgiou Jenny Zitser Talita Rosa Kristine Yaffe Yue Leng | 2020 | Neuroscience Bulletin2020，36，1： | 13 |
| 3 | Current Alzheimer disease research highlights: evidence for novel risk factors显示文摘Alzheimer disease(AD)is the most common type of dementia characterized by the progressive cognitive and social decline.Clinical drug targets have heavily focused on the amyloid hypothesis,with amyloid beta(Aβ),and tau proteins as key pathophysiologic markers of AD.However,no effective treatment has been developed so far,which prompts researchers to focus on other aspects of AD beyond Aβ,and tau proteins.Additionally,there is a mounting epidemiologic evidence that various environmental factors influence the development of dementia and that dementia etiology is likely heterogenous.In the past decades,new risk factors or potential etiologies have been widely studied.Here,we review several novel epidemiologic and clinical research developments that focus on sleep,hypoxia,diet,gut microbiota,and hearing impairment and their links to AD published in recent years.At the frontiers of AD research,these findings and updates could be worthy of further attention. | Willa D.Brenowitz Yang Xiang Claire T.McEvoy Cui Yang Kristine Yaffe Wei-Dong Le Yue Leng | 2021 | Chinese Medical Journal2021，，18： | 3 |
| 4 | Decreased response of osteoblasts obtained from aged Cohen diabetic sensitive rats to sex steroid hormones and 1,25OH2D3 in culture显示文摘 | Yaffe P Zangen SW | 2006 | Odontology2006，94，1： | 1 |
| 5 | MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells显示文摘 | Obata T Brown GE Yaffe MB | 1994 | Science1994，265，5173： | 1 |
| 6 | Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A显示文摘 | Aramburu J Yaffe M B Lopez-Rodriguez C | 1999 | Science1999，285，5436： | 1 |
| 7 | Promising strategies for the preven- tion of dementia显示文摘 | MIDDLETON L E YAFFE K | 2009 | Arch Neurol2009，66，10： | 1 |
| 8 | The structural ba- sis for 14-3-3 : phosphopeptide binding specificity 显示文摘 | Yaffe M B Rittinger K Volinia S | 1997 | Cell1997，91，7： | 1 |
| 9 | Serum lipoprotein levels, statin use and cognitive function in older women 显示文摘 | YAFFE K BARRETT-CONNOR E L N F | 2002 | Arch Neurol2002，59，3： | 1 |
| 10 | Effective kinetic theory for high temperature gauge theories显示文摘 | Arnold P B Moore G D Yaffe L G | 2003 | Journal of High Energy Physics2003，1，01： | 1 |
| 11 | TAZ:a Beta-catenin-like Molecule that Regulates Mesenchymal Stem Cell Differentiation 显示文摘 | Hong J H Yaffe M B | 2006 | Cell Cycle2006，5，： | 1 |
| 12 | MAP kinase pathways activated by stress: the p38 MAPK pathway显示文摘 | Obata T Brown G E Yaffe M B | 2000 | Crit Cace Med2000，28，4： | 1 |
| 13 | Sex hormones and cognitive function in older men显示文摘 | Yaffe K Lui LY Zmuda J | 2009 | J Am Geriatr Soc2009，50，： | 1 |
| 14 | Diabetes, glucose control, and 9- year cognitive decline among older adults without dementia 显示文摘 | Yaffe K Falvey C Hamilton N er al | 2012 | Arch Neurol2012，69，9： | 1 |
| 15 | Diagnostic accuracy of digital versus film mammography:exploratory analysis of selected popula tion subgroups in DMIST显示文摘 | Pisano ED Hendrick RE Yaffe MJ | 2008 | Radiology2008，246，2： | 1 |
| 16 | A prospective study of physical activity and cognitive decline in elderly women:women who walk显示文摘 | Yaffe K Barnes D Nevitt M | 2001 | Arch Intern Med2001，161，14： | 1 |
| 17 | Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group 显示文摘 | Gregg EW Yaffe K Cauley JA | 2000 | Arch Intern Med2000，160，2： | 1 |
| 18 | How do 14-3-3 proteins work?--Gatekeeper phosphorylation and the molecular anvil hypothesis显示文摘 | Yaffe M B | 2002 | Febs Lett2002，513，： | 1 |
| 19 | MAP kinase pathways activated by stress:the p38 MAPK pathway显示文摘 | Obata T Brown GE Yaffe MB | 2000 | Crit Care Med2000，28，4： | 1 |
| 20 | Molecular signaling in bone re-generation显示文摘 | Bahar H Benayahu D Yaffe A | 2007 | Crit Rev Eukaryot Gene Expr2007，2，： | 1 |
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