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| 1 | Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients显示文摘Objective: The purposes of this study were to identify risk factors for cervical lymph node metastasis and to examine the association between BRAF^(V600E) status and clinical features in papillary thyroid microcarcinoma(PTMC).Methods: A total of 1,587 patients with PTMC, treated in Tianjin Medical University Cancer Institute and Hospital from January2011 to March 2013, underwent retrospective analysis. We reviewed and analyzed factors including clinical results, pathology records, ultrasound results, and BRAF^(V600E) status.Results: Multivariate logistic regression analyses demonstrated that gender(male) [odds ratio(OR) = 1.845, P = 0.000], age(< 45 years)(OR = 1.606, P = 0.000), tumor size(> 6 mm)(OR = 2.137, P = 0.000), bilateralism(OR = 2.011, P = 0.000) and extrathyroidal extension(OR = 1.555, P = 0.001) served as independent predictors of central lymph node metastasis(CLNM).Moreover, CLNM(OR = 29.354, P = 0.000) served as an independent predictor of lateral lymph node metastasis(LLNM). Among patients with a solitary primary tumor, those with tumor location in the lower third of the thyroid lobe or the isthmus were more likely to experience CLNM(P < 0.05). Univariate analyses indicated that CLNM, LLNM, extrathyroidal extension, and multifocality were not significantly associated with BRAF^(V600E) mutation.Conclusions: The present study suggested that prophylactic neck dissection of the central compartment should be considered in patients with PTMC, particularly in men with tumor size greater than 6 mm, age less than 45 years, extrathyroidal extension, and tumor bilaterality. Among patients with PTMC, BRAF^(V600E) mutation is not significantly associated with prognostic factors. For a better understanding of surgical management of PTMC and the risk factors, we recommend multicenter research and long-term follow-up. | Xiangqian Zheng Chen Peng Ming Gao Jingtai Zhi Xiukun Hou Jingzhu Zhao Xi Wei Jiadong Chi Dapeng Li Biyun Qian | 2019 | Cancer Biology & Medicine2019，16，1： | 54 |
| 2 | Evolution and Coarsening of Carbides in 2.25Cr-1Mo Steel Weld Metal During High Temperature Tempering显示文摘Transformation and coarsening of carbides in 2.25Cr-1Mo steel weld metal during tempering at 700 ℃ for different time intervals ranging from 1 to 150 h were examined by transmission electron microscopy and scanning electron microscopy. M3C carbides were observed in the as-welded specimens and when tempered, the precipitates were mainly composed of M3C, M7C3, and M23C6 carbides. A sequence for corresponding carbide transformation during tempering with initial precipitation of M3C and the subsequent precipitation of M7C3 and M23C6 was proposed. The precipitation of M7C3 with higher chromium content was the main factor contributing to the decrease in coarsening rate of precipitates after prolonged tempering. The decrease in hardness of the tempered specimens agreed well with the prediction of the weakening of precipitation strengthening owing to the coarsening of carbides. | TAO Peng ZHANG Chi YANG Zhi-gang Takeda Hiroyuki | 2010 | Journal of Iron and Steel Research(International)2010，17，5： | 22 |
| 3 | Effects of urbanization on heavy metal accumulation in surface soils, Beijing显示文摘Urbanization processes affect the accumulation of heavy metals in urban soils. Effects of urbanization on heavy metal accumulation in soils were studied using Beijing as an example. It has been suggested that the ecological function of vegetation covers shifting from natural to agricultural settings and then to urban greenbelts could increase the zinc(Zn) concentrations of soils successively. The Zn concentration of urban soils was significantly correlated to the percentage of the impervious land surface at the500 m × 500 m spatial scale. For urban parks, the age or years since the development accounted for 80% of the variances of cadmium(Cd) and Zn in soils. The population density,however, did not affect the heavy metal distributions in urban soils. To conclude, the urban age turned out to be a notable factor in quantifying heavy metal accumulation in urban soils. | Meie Wang Rui Liu Weiping Chen Chi Peng Bernd Markert | 2018 | Journal of Environmental Sciences2018，30，2： | 14 |
| 4 | Problems in wavelet analysis of hydrologic series and some suggestions on improvement显示文摘使用小浪理论和方法调查象降水和流量那样的水疗院逻辑过程是一个热领域。然而,切断,在研究的方面通常被忽略:小浪功能和为时期, find 结果上的一个水疗院逻辑时间系列的长度的效果,和在为小浪分析的异例和原来的时间系列之间的选择的察觉的噪音的骚乱的可被考虑的状况的效果。在这篇论文,这些问题充分被讨论。来自 Lanzhou 降水车站的降水数据为案例研究被拿。结果显示在水疗院逻辑系列的小浪分析,降噪方法应该被用来消除噪音的影响。MexHat 小浪函数满足可被考虑的条件,它保证水疗院逻辑进程的周期的性质能被为分解使用 MexHat 小浪很好代表。在分析被给以前,应该被丢弃的水疗院逻辑系列的影响范围。异例系列应该被用来加亮水疗院逻辑系列的实际波动,这也被建议。 | WANG Hongrui YE Letian LIU Changming YANG Chi LIU Peng | 2007 | Progress in Natural Science:Materials International2007，17，1： | 13 |
| 5 | Mixed Reality-based Interactive Technology for Aircraft Cabin Assembly显示文摘Due to the narrowness of space and the complexity of structure, the assembly of aircraft cabin has become one of the major bottlenecks in the whole manufacturing process. To solve the problem, at the beginning of aircraft design, the different stages of the lifecycle of aircraft must be thought about, which include the trial manufacture, assembly, maintenance, recycling and destruction of the product. Recently, thanks to the development of the virtual reality and augmented reality, some low-cost and fast solutions are found for the product assembly. This paper presents a mixed reality-based interactive technology for the aircraft cabin assembly, which can enhance the efficiency of the assemblage in a virtual environment in terms of vision, information and operation. In the mixed reality-based assembly environment, the physical scene can be obtained by a camera and then generated by a computer. The virtual parts, the features of visual assembly, the navigation information, the physical parts and the physical assembly environment will be mixed and presented in the same assembly scene. The mixed or the augmented information will provide some assembling information as a detailed assembly instruction in the mixed reality-based assembly environment. Constraint proxy and its match rules help to reconstruct and visualize the restriction relationship among different parts, and to avoid the complex calculation of constraint's match. Finally, a desktop prototype system of virtual assembly has been built to assist the assembly verification and training with the virtual hand. | LI Shiqi PENG Tao WANG Junfeng XU Chi | 2009 | Chinese Journal of Mechanical Engineering2009，22，3： | 11 |
| 6 | Review on fate of chlorine during thermal processing of solid wastes显示文摘Chlorine(Cl) is extensively present in solid wastes, causing significant problems during the thermal conversion of waste to energy or fuels, by combustion, gasification or pyrolysis.This paper introduces the analytical methods for determining the Cl content in solid materials and presents the concentrations of Cl in various types of wastes, as reported in literature. Then, it provides a comprehensive analysis on the Cl emission behavior and Cl species formed during the thermal processing of the inorganic and organic Cl sources. The challenges resulted from the reactions between the formed Cl species and the ferrous metals, the heavy metals and the organic matters are summarized and discussed, e.g., high temperature corrosion, heavy metal evaporation and dioxin formation. The quality degradation of products(oil, char and syngas) by Cl is analyzed. Finally, the available controlling methods of Cl emission, including pre-treatment(water washing, sorting,microwave irradiation and stepwise pyrolysis) and in-furnace(absorbents, co-treatment and catalysts) methods are assessed. | Peng Lu Qunxing Huang A.C.(Thanos) Bourtsalas Nickolas J.Themelis Yong Chi Jianhua Yan | 2019 | Journal of Environmental Sciences2019，31，4： | 11 |
| 7 | Magnetohydrodynamics (MHD) numerical simulations on the interaction of the solar wind with the magnetosphere: A review显示文摘The magnetosphere is the outermost layer of the geospace, and the interaction of the solar wind with the magnetosphere is the key element of the space weather cause-and-effect chain process from the Sun to Earth, which is one of the most challenging scientific problems in the geospace weather study. The nonlinearity, multiple component, and time-dependent nature of the geospace make it very difficult to describe the physical process in geospace using traditional analytic analysis approach. Numerical simulations, a new research tool developed in recent decades, have a deep impact on the theory and application of the geospace. MHD simulations started at the end of the 1970s, and the initial study was limited to two-dimensional (2D) cases. Due to the intrinsic three-dimensional (3D) characteristics of the geospace, 3D MHD simulations emerged in the 1980s, in an attempt to model the large-scale structures and fundamental physical processes in the magnetosphere. They started to combine with the space exploration missions in the 1990s and make comparisons with observations. Physics-based space weather forecast models started to be developed in the 21st century. Currently only a few space-power countries such as USA and Japan have developed 3D magnetospheric MHD models. With the rapid advance of space science in China, we have developed a new global MHD model, namely PPMLR-MHD, which has high order spatial accuracy and low numerical dissipation. In this review, we will briefly introduce the global 3D MHD modeling, especially the PPMLR-MHD code, and summarize our recent work based on the PPMLR-MHD model, with an emphasis on the interaction of interplanetary shocks with the magnetosphere, large-scale current systems, reconnection voltage and transpolar potential drop, and Kelvin-Helmholtz (K-H) instability at the magnetopause. | WANG Chi GUO XiaoCheng PENG Zhong TANG BinBin SUN TianRan LI WenYa HU YouQiu | 2013 | Science China Earth Sciences2013，56，7： | 10 |
| 8 | Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients:A Randomized Controlled 48-Week Trial显示文摘Objective:To evaluate the effects of a 48-week course of adefovir dipivoxil(ADV)plus Chinese medicine(CM)therapy,namely Tiaogan Jianpi Hexue(调肝健脾和血)and Tiaogan Jiedu Huashi(调肝解毒化湿)fomulae,in hepatitis B e antigen(HBeAg)-positive Chinese patients.Methods:A total of 605 HBeAg-positive Chinese CHB patients were screened and 590 eligible participants were randomly assigned to 2 groups in 1:1 ratio including experimental group(EG,received ADV plus CM)and control group(CG,received ADV plus CM-placebo)for 48 weeks.The major study outcomes were the rates of HBeAg and HBV-DNA loss on week 12,24,36,48,respectively.Secondary endpoints including liver functions(enzymes and bilirubin readings)were evaluated every 4 weeks at the beginning of week 24,36,and 48.Routine blood,urine,and stool analyses in addition to electrocardiogram and abdominal B scan were monitored as safety evaluations.Adverse events(AEs)were documented.Results:The combination therapy demonstrated superior HBeAg loss at 48 weeks,without additional AEs.The full analysis population was 560 and 280 in each group.In the EG,population achieved HBeAg loss on week 12,24,36,and 48 were 25(8.90%),34(12.14%),52(18.57%),and 83(29.64%),respectively;the equivalent numbers in the CG were 20(7.14%),41(14.64%),54(19.29%),and 50(17.86%),respectively.There was a statistically significant difference between two groups on week 48(P<0.01).No additional AEs were found in EG.Subgroup analysis suggested different outcomes among treatment patterns.Conclusion:Combination of CM and ADV therapy demonstrated superior HBeAg clearance compared with ADV monotherapy.The finding indicates that this combination therapy may provide an improved therapeutic effect and safety profile(ChiCTR-TRC-11001263). | LI Xiao-ke ZHANG Ming-xiang SHAO Feng-zhen ZHOU Da-qiao XUE Jing-dong LIU Tie-jun CHI Xiao-ling LU Bing-jiu WANG Xian-bo LI Qin LI Jun MAO De-wen YANG Hua-sheng YANG Hong-zhi ZHAO Wen-xia LI Yong ZHANG Guo-liang ZHAO Yi-ming ZOU Jian-dong LIU Meng-yang ZHANG Ke-ke YANG Xian-zhao GAN Da-nan LI Ying ZHANG Peng LI Zhi-guo LI Shuo YE Yong-an | 2020 | Chinese Journal of Integrative Medicine2020，26，5： | 9 |
| 9 | Catalytic oxidation of benzene over nanostructured porous Co_3O_4-CeO_2 composite catalysts显示文摘Mesostructured Co3O4-CeO2 composite was found to be an effective catalytic material for the complete oxidation of benzene. The Co3O4-CeO2 catalysts with different Co/Ce ratios (mol/mol) were prepared via the nanocasting method and the mesostructure was replicated from two-dimensional (2D) hexagonal SBA-15 and three-dimensional (3D) cubic KIT-6 silicas, respectively. All the obtained Co3O4-CeO2 catalysts exhibited the similar symmetry with the parent silicas and well ordered mesostructures. The Co3O4- CeO2 catalysts with 2D mesostructure showed lower catalytic activities than the corresponding 3D materials. The Co3O4-CeO2 catalyst nanocasted from KIT-6 and with the Co/Ce ratio of 16/1 possessed the best catalytic benzene oxidation activity due to larger quantities of surface hydroxyl groups and surface oxygenated species. The mesostructured Co3O4-CeO2 material thus shows great potential as a promising eco-environmental catalyst for benzene effective elimination. | Chunyan Ma Zhen Mu Chi He Peng Li Jinjun Li Zhengping Hao | 2011 | Journal of Environmental Sciences2011，23，12： | 9 |
| 10 | How does Helicobacter pylori cause gastric cancer through connexins: An opinion review显示文摘Helicobacter pylori (H. pylori) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases. Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis. Investigations into H. pylori infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies. Therefore, in this review, the potential mechanisms of H. pylori-induced gastric cancer through connexins are summarized in detail. | Huan Li Can-Xia Xu Ren-Jie Gong Jing-Shu Chi Peng Liu Xiao-Ming Liu | 2019 | World Journal of Gastroenterology2019，25，35： | 9 |
| 11 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 12 | A plasmonic route for the integrated wireless communication of subdiffraction-limited signals显示文摘Perfect lenses,superlenses and time-reversal mirrors can support and spatially separate evanescent waves,which is the basis for detecting subwavelength information in the far field.However,the inherent limitations of these methods have prevented the development of systems to dynamically distinguish subdiffraction-limited signals.Utilizing the physical merits of spoof surface plasmon polaritons(SPPs),we demonstrate that subdiffraction-limited signals can be transmitted on planar integrated SPP channels with low loss,low channel interference,and high gain and can be radiated with a very low environmental sensitivity.Furthermore,we show how deep subdiffraction-limited signals that are spatially coupled can be distinguished after line-of-sight wireless transmission.For a visualized demonstration,we realize the high-quality wireless communication of two movies on subwavelength channels over the line of sight in real time using our plasmonic scheme,showing significant advantages over the conventional methods. | Hao Chi Zhang Le Peng Zhang Pei Hang He Jie Xu Cheng Qian Francisco J.Garcia-Vidal Tie Jun Cui | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 13 | Partitioning properties of rare earth ores in China显示文摘The properties of rare earth partitioning in Chinese industrial rare earth ores were analyzed. Rare earth ores canbe divided into the single-mineral type ore with bastnaesite, the multi-mineral type ore with bastnaesite and monazite, andthe weathering crust type. Both the Bayan Obo rare earth ore and the Zhushan rare earth ore are a kind of mixed ore, con-sisting of bastnaesite and monazite. Their rare earth partitionings are strongly enriched in light rare earths, where CeO2 is50% and the light rare earth partitioning is totally over 95%. The Mianning rare earth ore as well as the Weishan rare earthis a kind of rare earth ore only having bastnaesite. Their rare earth partitionings are also strongly enriched in light rare earths,in which CeO2 is 47% and the light rare earth partitioning is totally over 94%. For the weathering crust type rare earth ore,there are the Longnan rare earth ore, the Xunwu rare earth ore, and the middle yttrium and rich europium ore. In the Long-nan rare earth ore, which is strongly enriched in heavy rare earths, Y2O3 is 64.83%, and the heavy and light rare earthpartitionings are 89.40% and 10.53%, respectively. In the Xunwu rare earth ore, which is strongly enriched in light rareearths, CeO2 is 47.16%, and the light rare earth partitioning is totally 93.25%. Y and Eu are enriched in the middle yttriumand rich europium ore. Its middle rare earth partitioning is totally over 10%, and Eu2O3 and Y2O3 are over 0.5% and 20%,respectively, which are mainly industrial resources of the middle and the heavy rare earths. | CHI Ru 'an LI Zhongjun PENG Cui ZHU Guocai XU Shengming | 2005 | Rare Metals2005，24，3： | 8 |
| 14 | Multi-reservoir joint operating rule in inter-basin water transfer-supply project显示文摘The joint operation of inter-basin water transfer-supply(IBWTS)project can be more complex when there is joint water demand in multi-reservoir system and multi-importing reservoirs simultaneously transferring water from exporting reservoir.In this study,a joint operating rule is proposed for the purpose of solving such complex operation problem.This rule is composed of a set of sub-rules,including hedging rule curves of virtual aggregation reservoir(i.e.equivalent reservoir)and other individual reservoirs,water-transfer rule curves of each individual reservoir,as well as some of important assisted rules.These assisted rules refer to allocation models for water transfer-supply.In the proposed rule,an equivalent reservoir is established to determine under what condition the water supply should be reduced and specify the total supplied water for joint water demand(i.e.aggregation method).Allocation models are developed to distribute the total transferred water into each importing reservoir and determine the water releases for joint water demand by each member reservoir of the aggregation system(i.e.decomposition method).And these models are integrated with a set of influence factors such as hydrologic characteristics,reservoir storage or vacant storage,regulating ability,water-supply pressure,and so on.The aggregation of multi-reservoirs and the disaggregation of water quantities are taken into a whole consideration to reduce the complexity in reallocation of water target storage or water release.Finally,the proposed rule is applied to the North-line IBWTS Project in Liaoning Province,China.The results indicate that the proposed rule can take full advantage of hydrologic compensation in basins and capacity compensation in reservoirs.Thus it can improve the utilization efficiency of water resources in system. | PENG AnBang PENG Yong ZHOU HuiCheng ZHANG Chi | 2015 | Science China(Technological Sciences)2015，58，1： | 8 |
| 15 | Comparison of safety and efficacy between fondaparinux and nadroparin in non-ST elevation acute coronary syndromes显示文摘心病学(ACC/AHA/ESC ) 指南的心病学 / 美国人心协会 / 欧洲人社会的背景美国学院与非圣举起在病人为使用给了 fondaparinux 一个班建议经历侵略或保守的策略的急性冠的症候群(NSTE 交流) 。Nadroparin 是在中国在 NSTE 交流使用的普通抗凝剂之一。因此,这研究在这未来的、使随机化的、开标签、单个的中心研究在病人把在 fondaparinux 和 nadroparin 之间的安全和功效与 NSTE-ACS.Methods 作比较,有NSTE交流的 300 个病人的一个总数被使随机化收到任何一个 fondaparinux (组 F , n=150 , 2.5 mg/d )或 nadroparin (组 N , n=150 , 0.1 ml/10 kgq12 h )为 4 天的一个平均数。主要安全端点是专业或在不与冠的动脉有关的 9 天的次要的流血的发生绕过 grafting (CABG ) 。主要功效端点在 9 天包括了死亡,心肌的梗塞,或周期性的局部缺血。所有病人经历了一个 180 天的 follow-up.Results 基线特征很好在二个组之间被匹配。有一不重要在在组 F 的主要安全端点的 28 相对风险减小与组 N 相比(4.7 对 6.7, HR 0.72, 95 CI0.42-1.65, P=0.38 ) 。主要功效端点在组 F 是 8.0 并且 10.0 在组 N (HR, 0.82, 95 CI0.54-1.71, P=0.49 ) 。在 9 天的安全和功效端点合成( 10.0 对 16.0 , HR 0.61 , 95 CI0.31-1.10 , P=0.10 ), 30 天( 14.0 对 17.9 , HR 0.72 , 95 C/0.47-1.16 , P=0.21 ),或 180 天( 18.7 对 27.3 , HR0.65 , 95 CI0.38-1.11 , P=0.11 )证明向在组 F.Conclusion Fondaparinux 的更低的价值的一个不重要的趋势在与 nadroparin 相比在短期、长期的后续期间流血和 ischaemic 事件与NSTE交流在病人导致了不重要的风险减小。 | YAN Hong-bing SONG Li LIU Ran ZHAO Han-jun WANG Shao-pin CHI Yun-peng ZHENG Bin LI Wen-zheng LIU Chen ZHOU Peng | 2011 | Chinese Medical Journal2011，，6： | 7 |
| 16 | Generative API usage code recommendation with parameter concretization显示文摘Many programming languages and development frameworks have extensive libraries(e.g., JDK and Android libraries) that ease the task of software engineering if used effectively. With numerous library classes and sometimes intricate API(application programming interface) usage constraints, programmers often have difficulty remembering the library APIs and/or using them correctly. This study addresses this problem by developing an engine called DeepAPIRec, which automatically recommends the API usage code.Compared to the existing proposals, our approach distinguishes itself in two ways. First, it is based on a tree-based long short-term memory(LSTM) neural network inspired by recent developments in the machinelearning community. A tree-based LSTM neural network allows us to model and reason about variable-length,preceding and succeeding code contexts, and to make precise predictions. Second, we apply data-flow analysis to generate concrete parameters for the API usage code, which not only allows us to generate complete code recommendations but also improves the accuracy of the learning results according to the tree-based LSTM neural network. Our approach has been implemented for supporting Java programs. Our experimental studies on the JDK library show that at statement-level recommendations, DeepAPIRec can achieve a top-1 accuracy of about 37% and a top-5 accuracy of about 64%, which are significantly better than the existing approaches. Our user study further confirms that DeepAPIRec can help developers to complete a segment of code faster and more accurately as compared to IntelliJ IDEA. | Chi CHEN Xin PENG Jun SUN Zhenchang XING Xin WANG Yifan ZHAO Hairui ZHANG Wenyun ZHAO | 2019 | Science China(Information Sciences)2019，62，9： | 7 |
| 17 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 18 | Common-anode LED on a Si substrate for beyond 15 Gbit/s underwater visible light communication显示文摘Visible light communication based on light-emitting diodes(LEDs) has become a promising candidate by providing high data rates, low latency, and secure communication for underwater environments. In this paper,a self-designed common-anode GaN-based five-primary-color LED(RGBYC LED) on a Si substrate is proposed and fabricated. The design of a common anode is used to mitigate the saturation effect for a low-frequency component. Additionally, compared with commercially available LEDs that suffer from nonlinearity distortion,applying the designed LED can provide much better and broader linearity according to the measurement results.Therefore, the modulation depth and system performance can be further improved to implement a high-speed underwater visible light communication(UVLC) system. There is no nonlinearity compensation algorithm applied due to the good linearity of the proposed LED;thus, the offline digital signal processing is simplified. We experimentally demonstrate 14.81 Gbit/s 64 quadrature amplitude modulation(QAM)-discrete multitone(DMT)and 15.17 Gbit/s bit-loading-DMT transmissions through a 1.2-m-long underwater channel based on the proposed RGBYC LED with an intrasymbol frequency-domain averaging channel estimation and zero-forcing equalization.As far as we know, this is the highest data rate for an LED-based UVLC system. | YINGJUN ZHOU XIN ZHU FANGCHEN HU JIANYANG SHI FUMIN WANG PENG ZOU JUNLIN LIU FENGYI JIANG NAN CHI | 2019 | Photonics Research2019，7，9： | 7 |
| 19 | Mass balance-based regression modeling of Cd and Zn accumulation in urban soils of Beijing显示文摘Accumulation of heavy metals in urban soil can pose adverse impacts on public health and terrestrial ecosystems. We developed a mass balance-based regression model to simulate the heavy metal accumulation in urban soils as a function of time and to explore connections between metal concentration and urbanization processes. Concentrations of Cd and Zn in 68 residential soil samples in the urban area of Beijing were used. The background concentrations, the loss rates and the input fluxes of Cd and Zn in urban soils of Beijing during the last three decades were estimated using a regression of the time series of accumulations of the metals. Based on the regression estimates, we simulated the general trends of Cd and Zn accumulation in the soils from 1978 to 2078. The concentrations of Cd and Zn in urban soil generally increased with the population growth, vehicle use and coal consumption. The mean concentrations of Cd and Zn in urban soil of Beijing would increase by 3 fold over the next 70 years for the current development scenario. The mass balance-based regression approach, which is able to reconstruct the history data of urban soil pollution, provides fundamental information for urban planning and environmental management. | Chi Peng Meie Wang Weiping Chen Andrew C.Chang John C.Crittenden | 2017 | Journal of Environmental Sciences2017，29，3： | 6 |
| 20 | A Lunar-based Soft X-ray Imager(LSXI)for the Earth's magnetosphere显示文摘We propose to use the Moon as a platform to obtain a global view of Earth's magnetosphere by a Lunar-based Soft X-ray Imager(LSXI).LSXI is a wide field-of-view Soft X-ray telescope,which can obtain X-ray images of Earth's magnetosphere based on the solar wind charge exchange(SWCX)X-ray emission.Global perspective is crucial to understand the overall interaction of the solar wind with magnetosphere.LSXI is capable of continuously monitoring the evolution of geospace conditions under the impact of the solar wind by simultaneous observation of the bow shock,magnetosheath,magnetopause and cusps for the first time.This proposal is answering the call for the Chinese Lunar Exploration Program Phase IV. | Yihong GUO Chi WANG Fei WEI Tianran SUN Xizheng YU Songwu PENG Graziella BRANDUARDI-RAYMONT Steven SEMBAY | 2021 | Science China Earth Sciences2021，64，7： | 5 |
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