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| 1 | Identification of mecciRNAs and their roles in the mitochondrial entry of proteins显示文摘Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus. | Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan | 2020 | Science China(Life Sciences)2020，63，10： | 15 |
| 2 | Foraging strategies in the greater horseshoe bat(Rhinolophus ferrumequinum)on Lepidoptera in summer显示文摘The diet of the bat Rhinolophus ferrumequinum was studied at the Zhi’an Village of Ji’an City in China, from June to August 2004. The bats were trained in a laboratory (volume: 9×4×4 m3). Foraging strategies of the bat were ob- served at night and prey remains were collected and identi- fied. The results showed that the diet consisted mainly of Lepidoptera in summer, including 11 families, more than 30 species of moths, such as Noctuidae (36.6% by number), Sphingidae (24.1%), Geometridae (13.4%) and Limacodidae (9.5%). The length of culled wings ranged from 10―40 mm (97.7%). Pearson correlation analysis showed that the bat R. ferrumequinum foraged their prey selectively, but not op- portunistically. From field studies, two ways were observed in which the bats retrieved their prey including aerial hawk- ing during peak active period of the insects and flycatching during the insects’ non-peak activity period. The bats never gleaned prey from the ground, though they appeared to be well able to detect fluttering moths on the ground. | JIN Longru FENG Jiang SUN Keping LIU Ying WU Lei LI Zhenxin ZHANG Xichen | 2005 | Chinese Science Bulletin2005，50，14： | 5 |
| 3 | Experimental study of single-row chevron-jet impingement heat transfer on concave surfaces with different curvatures显示文摘To address the curvature effect on single-row chevron-nozzle jet impingement heat transfer on concave surface,a series of experiments are conducted in the present investigation.Four concave surfaces including one semi-cylindrical concave surface and three parabolic concave surfaces with different width-to-depth ratios are tested under three typical Reynolds numbers(Re=5000,10000 and 15000)and several dimensionless nozzle-to-surface distances ranging from 1 to 8.The results show that the concave curvature has a clear impact on chevron-nozzle jet impingement heat transfer,tightly dependent on jet Reynolds number and impinging distance.In general,the semicylindrical concave surface produces the highest longitudinally-averaged Nusselt number at the leading line of concave surface.Under a low jet Reynolds number,the parabolic concave surface with a highly curved curvature produces higher longitudinally-averaged Nusselt number at the leading line and more uniform longitudinally-averaged Nusselt number distribution along the curvilinear direction.However,the longitudinally-averaged Nusselt number at the leading line of concave surface is the lowest for the highly curved surface under a high jet Reynolds number and large impinging distance.In comparison with the round-nozzle,chevron nozzle plays a more significant role on improving jet impingement heat transfer at small impinging distances. | Yuanwei LYU Jingzhou ZHANG Xichen LIU Yong SHAN | 2019 | Chinese Journal of Aeronautics2019，32，10： | 3 |
| 4 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 5 | Biomass-based aligned carbon networks with double-layer construction for tunable electromagnetic shielding with ultra-low reflectivity显示文摘Nowadays,carbon frameworks derived from natural biomaterials have attracted extensive attention for electromagnetic interference(EMI)shielding due to their renewability and affordability.However,it is critical and challenging to achieve effective regulation of shielding effectiveness(SE)as well as weaken the strong EM reflection of highly conductive biomass-based carbon materials.Herein,commercial cotton pads with oriented structure were selected as carbonaceous precursor to fabricate aligned carbon networks by pyrolysis,and the EMI SE of the samples with increased temperature of 800-1000℃ can be accurately controlled in the effective range of~21.7-29.1,~27.7-37.1 and~32.7-43.3 d B with high reflection coefficient of>0.8 by changing the cross-angle between the electric-field direction of incident EM waves and the fiber-orientation direction due to the occurrence of opposite internal electric field.Moreover,the further construction of Salisbury absorber-liked double-layer structure could result in an ultralow reflection coefficient of only~0.06 but enhanced SE variation range up to~38.7-49.3 d B during the adjustment of cross-angle,possibly due to the destructive interference of EM waves in the double-layer carbon networks.This work would provide a simple and effective way for constructing high-performance biomass carbon materials with adjustable EMI shielding and ultra-low reflectivity. | Jiali Chen Da Yi Xichen Jia Guoqing Wang Zhouping Sun Lihua Zhang Yinfeng Liu Bin Shen Wenge Zheng | 2022 | Journal of Materials Science & Technology2022，，8： | 2 |
| 6 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 7 | Prevalence and molecular characterization of Pentatrichomonas hominis in Siberian tigers(Panthera tigris altaica)in northeast China显示文摘INTRODUCTION Pentatrichomonas hominis,an anaerobic flagellated protozoan that inhabits the large intestines of mammals and belongs to the Trichomonadidae family(Wenrich 1944;Kim et al.2010;Li et al.2014b,2016,2018a,2020;Maritz et al.2014;Zhang et al.2019),is mainly transmitted through the fecal-oral route.It was originally presumed to be a commensal protozoan(Tolbert et al.2012)but was found to cause gastrointestinal symptoms. | Hongbo ZHANG Nan ZHANG Pengtao GONG Shuqin CHENG Xiaocen WANG Xin LI Zhijun HOU Chang LIU Tianqi BI Bobo WANG Yidan CHENG Jianhua LI Xichen ZHANG | 2022 | Integrative Zoology2022，17，4： | 1 |
| 8 | A Robust and Fast Non-local Means Algorithm for Image Denoising显示文摘 | Liu Yanli Wang Jin Chen Xichen | | 0，，04： | 1 |
| 9 | A recombinant pseudorabies virus expressing TgSAG1 protects against challenge with the virulent Toxoplasma gondii RH strain and pseudorabies in BALB/c mice显示文摘 | Quan Liu Shengyan Gao Li Jiang Limin Shang Jingtao Men Ze Wang Yujia Zhai Zhiping Xia Rongliang Hu Xichen Zhang Xing-Quan Zhu | 2008 | Microbes and Infection2008，，12： | 1 |
| 10 | Brief report: An epidemiologic Survey of the prevalence of sleep disorder among children to years old in Beijing, China显示文摘 | Xichen Liu Yuyan Ma Yizhuo Wang | 2005 | Pediatrics2005，115，： | 1 |
| 11 | Photophysical and photochemical processes of riboflavin (vitamin B2) by means of the transient absorption spectra in aqueous solution显示文摘 | Changyuan Lu Zhenhui Han Guanshu Liu Xichen Cai Yuling Chen Side Yao | 2001 | Science in China Series B: Chemistry2001，，1： | 1 |
| 12 | Protective immunity induced by a DNA vaccine encoding Eimeria tenella rhomboid against homologous challenge显示文摘 | Yingli Liu Jun Zheng Jianhua Li Pengtao Gong Xichen Zhang | 2013 | Parasitology Research2013，，1： | 1 |
| 13 | Investigation of positive bias temperature instability for monolayer polycrystalline MoS2 field-effect transistors显示文摘In recent years,molybdenum disulfide(Mo S2)has exhibited remarkable electrical,mechanical and optical properties because of its ultrathin body thickness,flexibility and direct bandgap for photo response[1]. | GuanHua Yang Jia Wei Wang JieBin Niu XiChen Chuai CongYan Lu Di Geng NianDuan Lu Ling Li Ming Liu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，1： | 0 |
| 14 | Delayed Antarctic melt season reduces albedo feedback显示文摘Antarctica’s response to climate change varies greatly both spatially and temporally.Surface melting impacts mass balance and also lowers surface albedo.We use a 43-year record(from 1978 to 2020)of Antarctic snow melt seasons from space-borne microwave radiometers with a machine-learning algorithm to show that both the onset and the end of the melt season are being delayed.Granger-causality analysis shows that melt end is delayed due to increased heat flux from the ocean to the atmosphere at minimum sea-ice extent from warming oceans.Melt onset is Granger-caused primarily by the turbulent heat flux from ocean to atmosphere that is in turn driven by sea-ice variability.Delayed snowmelt season leads to a net decrease in the absorption of solar irradiance,as a delayed summer means that higher albedo occurs after the period of maximum solar radiation,which changes Antarctica’s radiation balance more than sea-ice cover. | Lei Liang Huadong Guo Shuang Liang Xichen Li John C.Moore Xinwu Li Xiao Cheng Wenjin Wu Yan Liu Annette Rinke Gensuo Jia Feifei Pan Chen Gong | 2023 | National Science Review2023，10，9： | 0 |
| 15 | Immunol detection of cathepsin L from Fasciola hepatica infection in sheep by monoclonal antibody-based colloidal gold test strip assay显示文摘Fascioliasis is caused by the zoonotic parasite Fasciola hepatica,Fasciola gigantica and their intermediate forms.The distribution of fascioliasis is worldwide and the main type of infection by Fasciola sp.in sheep in China is F.hepatica.The epidemic areas in China are mainly in Hubei,Anhui,Yunnan,and Xinjiang[1],which causes huge economic in the animal husbandry industry each year[2].Sheep infected with F.hepatica show symptoms of malnutrition,and acute infection can lead to death in lambs[3]. | Shaoxiong Liu Nan Zhang Qinlei Yu Jianhua Li Xiaocen Wang Xin Li Xu Zhang Shuqin Cheng Taotao Yue Hongbo Zhang Pengtao Gong Xichen Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 16 | Empirical study on directionalmillimeter-wave propagation in vehicle-to-infrastructure communications between road and roadside显示文摘With the increased demand for unmanned driving technology and big-data transmission between vehicles,millimeter-wave(mmWave)technology,due to its characteristics of large bandwidth and low latency,is considered to be the key technology in future vehicular communication systems.Different from traditional cellular communication,the vehicular communication environment has the characteristics of long distance and high moving speed.However,the existing communication channel tests mostly select low-speed and small-range communication scenarios for testing.The test results are insufficient to provide good data support for the existing vehicular communication research;therefore,in this paper,we carry out a large number of channel measurements in mmWave vehicle-toinfrastructure(V2I)long-distance communication scenarios in the 41 GHz band.We study the received signal strength(RSS)in detail and find that the vibration features of RSS can be best modeled by the modified two-path model considering road roughness.Based on the obtained RSS,a novel close-in(CI)model considering the effect of the transmitter(TX)and receiver(RX)antenna heights(CI-TRH model)is developed.As for the channel characteristics,the distribution of the root-mean-square(RMS)delay spread is analyzed.We also extend the twosection exponential power delay profile(PDP)model to a more general form so that the distance-dependent features of the mmWave channel can be better modeled.Furthermore,the variation in both RMS delay spread and PDP shape parameters with TX-RX distance is analyzed.Analysis results show that TX and RX antenna heights have an effect on large-scale fading.Our modified two-path model,CI-TRH model,and two-section exponential PDP model are proved to be effective. | Xichen LIU Lin YANG Daizhong YU | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，4： | 0 |
| 17 | Analysis of the record-breaking August 2021 rainfall over the Greenland Ice Sheet显示文摘Rainfall was witnessed for the first time at the highest area of the Greenland Ice Sheet on 14 August,2021.The thermodynamic mechanisms supporting the rainfall are revealed by ERA5 reanalysis,in-situ and satellite data.We find that a strong southward intrusion of the polar vortex favored the maintenance of a deep cyclone over Baffin Island and an amplification of anticyclonic circulation over the southeastern ice sheet,which pumped warm and moist air toward Greenland from anomalously warm waters south of Greenland.Across a wide swath of the ice sheet,atmospheric uplift maintained above-melting and rainfall conditions via condensation and enhanced downward infrared irradiance.Without the low-level liquid clouds,the spatial extent and duration of the rainfall would have been smaller.Over the ice sheet topographic summit,the air temperature from the ground to 250 hPa level was~2℃higher than the previous record set on 12 July,2012.Such events may occur more frequently with the decreased temperature contrast between the Arctic and the mid-latitude regions that drives highly amplified jet streams.Thus,this extreme event serves as a harbinger of a more likely wet surface condition across all elevations of the ice sheet. | DOU Tingfeng XIE Zuowei Jason E.BOX YANG Qing YANG Yifan TENG Shiwen XU Gaojie LIU Chao LI Xichen Derek HOUTZ GONG Xun DU Zhiheng DING Minghu YU Yongqiang XIAO Cunde | 2023 | Advances in Polar Science2023，34，3： | 0 |
| 18 | Evaluation of temporal compositing algorithms for annual land cover classification using Landsat time series data显示文摘In this paper, four widely used temporal compositing algorithms, i.e.median, maximum NDVI, medoid, and weighted scoring-basedalgorithms, were evaluated for annual land cover classification usingmonthly Landsat time series data. Four study areas located in California,Texas, Kansas, and Minnesota, USA were selected for image compositingand land cover classification. Results indicated that images compositedusing weighted scoring-based algorithms have the best spatial fidelitycompared to other three algorithms. In addition, the weighted scoringbasedalgorithms have superior classification accuracy, followed bymedian, maximum NDVI, and medoid in descending order. However, themedian algorithm has a significant advantage in computational efficiencywhich was ~70 times that of weighted scoring-based algorithms, andwith overall classification accuracy just slightly lower (~0.13% onaverage) than weighted scoring-based algorithms. Therefore, werecommended the weighted scoring-based compositing algorithms forsmall area land cover mapping, and median compositing algorithm forthe land cover mapping of large area considering the balance betweencomputational complexity and classification accuracy. The findings of thisstudy provide insights into the performance difference between variouscompositing algorithms, and have potential uses for the selection ofpixel-based image compositing technique adopted for land covermapping based on Landsat time series data. | Xichen Meng Shuai Xie Lin Sun Liangyun Liu Yilong Han | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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