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| 1 | Rice Functional Genomics Research: Past Decade and Future显示文摘瑞斯(Oryza sativa ) 是为世界范围的超过 35 亿个人的主要主食食物庄稼。在米饭理解复杂农学的特点的规章的机制为全球食物安全是批评的。瑞斯也是为单子叶植物的 genomics 研究的模型植物。由于功能的 genomic 技术的快速的发展,控制重要农学的特点的超过 2000 基因被克隆,并且他们的分子的生物机制也是部分描绘了。这里,我们简短在米饭考察进展功能的 genomics 研究在过去的 10 年期间包括功能的 genomics 平台的一篇摘要,基因 ? 并且调整重要农学的特点的分子的规章的网络,并且 ? 为基因鉴定的最新发达的工具。在功能的 genomics 研究做的这些成就将极大地便于发展 ? 绿超级米饭。我们也讨论未来挑战和米饭的前景功能的 genomics 研究。 | Yan Li Jinghua Xiaot Lingling Chen Xuehui Huang Zhukuan Cheng Bin Han Qifa Zhang Changyin Wu | 2018 | Molecular Plant2018，11，3： | 14 |
| 2 | Mapping Toll-Like Receptor Signaling Pathway Genes of Zhikong Scallop(Chlamys farreri) with FISH显示文摘Toll-like receptor(TLR) signaling pathway plays a pivotal role in the innate immune system. Studies on TLR signaling pathway genes in Zhikong scallop(Chlamys farreri) have mainly focused on sequence analysis and expression profiling, no research has been carried out on their localization. The chromosomal position of TLR signaling pathway genes can be valuable for assemblying scallop genome and analysizing gene regulatory networks. In the present study, five key TLR signaling pathway genes(Cf TLR, Cf Myd88, Cf TRAF6, Cf NFκB, and Cf IκB) containing bacterial artificial chromosomes(BACs) were isolated and physically mapped through fluorescence in situ hybridization on five non-homologous chromosome pairs, showing a similar distribution to another five model species. The isolation and mapping of these key immune genes of C. farreri will aid to the research on innate immunity, assignment of interested genes to chromosomes, and integration of physical, linkage and cytogenetic maps of this species. | ZHAO Bosong ZHAO Liang LIAO Huan CHENG Jie LIAN Shanshan LI Xuan HUANG Xiaoting BAO Zhenmin | 2015 | Journal of Ocean University of China2015，14，6： | 3 |
| 3 | Effects of Ca(OH)_2 assisted aluminum sulfate coagulation on the removal of humic acid and the formation potentials of tri-halomethanes and haloacetic acids in chlorination显示文摘The effects of addition of calcium hydroxide on aluminum sulphate(or alum) coagulation for removal of natural organic matter(NOM) and its subsequent effect on the formation potentials of two major types of regulated disinfection byproducts(DBPs),haloacetic acids(HAAs) and trihalomethanes(THMs),have been examined.The results revealed several noteworthy phenomena.At the optimal coagulation pH(i.e.6),the coagulation behavior of NOM water solutions versus alum dose,showed large variation and a consequent great change in the formation potentials of the DBPs at certain coagulant doses.However,with addition of a relatively small amount of Ca(OH) 2,although the zeta potential of coagulated flocs remained almost the same,NOM removal became more consistent with alum dose.Importantly,also the detrimental effect of charge reversal on NOM removal at the low coagulant dose disappeared.This resulted in a steady decrease in the formation potentials of DBPs as a function of the coagulant dose.Moreover,the addition of Ca(OH) 2 broadened the pH range of alum coagulation and promoted further reduction of the formation potentials of the DBPs.The enhancement effects of Ca(OH) 2 assisted alum coagulation are especially pronounced at pH 7 and 8.Finally,synchronous fluorescence spectra showed that the reduction in DBPs formation potential by Ca(OH) 2-assisted alum coagulation was connected to an enhanced removal of small hydrophobic and hydrophilic HA molecules.Ca(OH) 2-assistance of alum coagulation appeared to increase substantially the removal of the hydrophilic HA fraction responsible for HAAs formation,prompting further reduction of HAA formation potentials. | Jinming Duan Xiaoting Cao Cheng Chen Dongrui Shi Genmao Li Dennis Mulcahy | 2012 | Journal of Environmental Sciences2012，24，9： | 3 |
| 4 | Auditory characteristics of noise-exposed memberscrossing age-related groups显示文摘Objective: To report audiological characteristics in a group of noise-exposed crew members on board ships.Methods and materials: Clinical and audiological measurements including pure-tone thresholds, acoustic immittance results and tinnitus questionnaires were collected from both the ship crew members(study subjects) and their land based colleagues(controls).Results: 1) Noise exposed crew members showed not only high frequency, but also low frequency hearing loss; 2) Hearing impairment increased with age, with 65.5% of crew members younger than 50 years showing normal hearing while only 14.9% of those older than 50 years had normal hearing; 3)hearing loss gradually increased with the extension of on board career time; and 4) Most study subjects reported high pitch tinnitus, significantly more than the control group although not significantly different among different age groups.Conclusion: Noise induced hearing impairment from working on board ships shows specific frequency and age characteristics. Understanding these characteristics is important for advancing relevant studies and for effective prevention of noise-induced hearing loss in ship crew members. | Liu Chenqing Ding Daxiong Zhu Yuhua Wang Hongyang Cheng Xiaoting Zhao Zhenhua Cao Juyang Zhai Suoqiang Yu Ning | 2018 | Journal of Otology2018，13，2： | 3 |
| 5 | Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial–mesenchymal transition显示文摘 | Bin Zhang Yan Yang Xiaoting Shi Wanyu Liao Min Chen Alfred Sze-Lok Cheng Hongli Yan Cheng Fang Shu Zhang Guifang Xu Shanshan Shen Shuling Huang Guangxia Chen Ying Lv Tingsheng Ling Xiaoqi Zhang Lei Wang Yuzheng Zhuge Xiaoping Zou | 2014 | Cancer Letters2014，，： | 2 |
| 6 | Fluctuations in the tidal limit of the Yangtze River estuary in the last decade显示文摘The tidal limit is the key interface indicating whether water levels will be affected by tidal waves, which is of great significance to navigation safety and regional flood control. Due to limitations in research methods, recent changes in the Yangtze River tidal limit, caused by sea level rise and large-scale engineering projects, urgently need to be studied. In this study,spectrum analysis was undertaken on measured water level data from downstream Yangtze River hydrological stations from2007 to 2016. The bounds of the tidal limit were identified through comparisons between the spectra and red noise curves, and the fluctuation range and characteristics were summarized. The results showed that:(1) During the extremely dry period, when the flow rate at Jiujiang station was about 8440 m3 s-1, the tidal limit was near Jiujiang; whereas during the flood season, when the flow rate at Jiujiang station was about 66700 m3 s-1, the tidal limit was between Zongyang Sluice and Chikou station.(2)From the upper to lower reach, the effect of the Jiujiang flow rate on the tidal limit weakens, while the effect of the Nanjing tidal range increases. The tidal limit fluctuates under similar flow rates and tidal ranges, and the fluctuation range increases with increasing flow rate and decreasing tidal range.(3) With the continued influence of rising sea levels and construction in river basin estuaries, the tidal limit may move further upstream. | Shengyu SHI Heqin CHENG Xiaona XUAN Fangxi HU Xiaoting YUAN Yuehua JIANG Quanping ZHOU | 2018 | Science China Earth Sciences2018，61，8： | 2 |
| 7 | A putative transglycosylase encoded by SC04132 influences morphological differentiation and actinorhodin production in Streptomyces coelicolor显示文摘这里,我们报导那 tgdA,编码通常认为的 transglycosylase 的新奇基因,在 Streptomyces coelicolor 影响词法区别和蓝颜料的复合 actinorhodin 的收益。tgdA 0 异种显示稀少的天线 hyphae 和经常缺乏 chromosomal DNA 的不规则的孢子链。提高的 actinorhodin 生产在异种与 actII-orf4 的 overexpression 与一致。tgdA 表示时间地并且发展地被调整。在 Streptomyces avermilitis 和 Streptomyces lividans 的 tgdA orthologs 也影响区别。 | Pengfei Xie Ana Zeng Xiaoting Lv Qiuxiang Cheng Zhongjun Qin | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 1 |
| 8 | The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital conductive hearing loss due to stapes ankylosis显示文摘Conductive hearing loss is the impairment in the mechanical transduction of sound wave through the external ear and the middle ear.Although most cases are sporadic due to acquired causes such as infections(otitis media and otitis externa),cerumen obstruction,and injuries,congenital structural defects are uncommon for significant etiologies to recognize.Stapes ankylosis is characterized by conductive hearing loss.It may be difficult to differentiate from otosclerosis,the most common cause of progressive conductive hearing loss,by audiologic evaluation,when the diagnosis is delayed.Skeletal anomalies may be subtle,such that the syndrome may not be recognized(Brown et al.,2002). | Yilai Shu Lijun Wang Xiaoting Cheng Chayada Tangshewinsirikul Weili Shi Yasheng Yuan Zhiqiang Yan Huawei Li Jun Shen Bing Chen Weiguo Zou | 2019 | Journal of Genetics and Genomics2019，46，9： | 1 |
| 9 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 10 | SnoRNP is essential for thermospermine-mediated development in Arabidopsis thaliana显示文摘Polyamines have been discovered for hundreds of years and once considered as a class of phytohormones.Polyamines play critical roles in a range of developmental processes.However,the molecular mechanisms of polyamine signaling pathways remain poorly understood.Here,we measured the contents of main types of polyamines,and found that endogenous level of thermospermine(T-Spm)in Arabidopsis thaliana is comparable to those of classic phytohormones and is significantly lower than those of putrescine(Put),spermidine(Spd),and spermine(Spm).We further found a nodule-like structure around the junction area connecting the shoot and root of the T-Spm biosynthetic mutant acl5 and obtained more than 50 suppressors of acl5 nodule structure(san)through suppressor screening.An in-depth study of two san suppressors revealed that NAP57 and NOP56,core components of box H/ACA and C/D snoRNPs,were essential for T-Spm-mediated nodule-like structure formation and plant height.Furthermore,analyses of rRNA modifications showed that the overall levels of pseudouridylation and 2′-O-methylation were compromised in san1 and san2 respectively.Taken together,these results establish a strong genetic relationship between rRNA modification and T-Spm-mediated growth and development,which was previously undiscovered in all organisms. | Xilong Li Zongyun Yan Meiling Zhang Jiayin Wang Peiyong Xin Shujing Cheng Liquan Kou Xiaoting Zhang Songlin Wu Jinfang Chu Chengqi Yi Keqiong Ye Bing Wang Jiayang Li | 2023 | Science China(Life Sciences)2023，66，1： | 0 |
| 11 | Development of Alternative to Animal Testing on Cosmetics by Middle-out Strategy显示文摘 | Shujun Cheng Yu Chen Yihui Ke Xiaoting Qu Yao Qin Jiating Xu | 2016 | China Detergent & Cosmetics2016，1，4： | 0 |
| 12 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 13 | 中国桑科植物物种多样性格局及其主导因子显示文摘理解物种多样性大尺度格局及其驱动机制是生态学的核心议题之一。以往研究已提出了多种解释物种多样性格局的假说,其中包括水热动态假说、热带生态位保守假说、Janzen假说以及包含能量、水分、季节性和生境异质性的综合假说,但各假说对不同类别(如不同生活型、不同分布区大小的物种)植物物种多样性格局的相对贡献仍存在争议,这阻碍了我们理解驱动物种多样性格局形成的一般规律。本研究以桑科植物为对象,评估了以上假说对不同类别桑科植物物种多样性格局的相对影响。我们收集整理了中国164种桑科植物的物种分布图(空间分辨率50 km×50 km)及其生活型(即灌木、小乔木和大乔木)。在此基础上,估算了整个科、不同生活型以及不同分布区大小物种(广域种和狭域种)的物种多样性格局,分析了环境变量对物种多样性格局的影响,比较了不同假说对各类别桑科植物物种多样性格局的相对解释率。不同类别桑科植物的物种多样性格局高度一致,四川省、广州省和海南省的物种多样性较高,形成了该科物种多样性热点。气候季节性是桑科物种多样性格局的主导因素。在所有假说中,包含能量、水分、季节性和生境异质性的综合假说对不同生活型和不同分布区大小物种的多样性格局具有最高的解释率。需要指出的是,对除狭域种外的其他所有物种组的物种多样性格局来说,这些模型均具有较高的共享解释率,但较低的独立解释率(<5%)。这些结果说明,与其他物种组相比,狭域种物种多样性格局及其形成机制可能是不同的。本研究为保护桑科植物、特别是狭域桑科植物提供了理论依据。 | Hua-Feng Wang Xiaoting Xu Xia-Lan Cheng Yunpeng Liu Ao Luo Tong Lyu Wen-Long Wang Mir Muhammad Nizamani Zhiheng Wang | 2022 | Journal of Plant Ecology2022，15，6： | 0 |
| 14 | Atypical manifestations of acute coronary syndrome—throat discomfort:a multi-center observational study显示文摘To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifested primarily as throat discomfort,we conducted a multicentric and retrospective study in the cardiology and otorhinolaryngology departments.Records of patients with primary complaint of throat discomfort,absence of chest pain at onset,and an ultimate diagnosis of acute coronary syndrome,as well as patients with pharyngitis(as controls)were collected from May 2015 to April 2016.The patients’main manifestations were compared.Logistic regression results showed that chest tightness,dyspnea,perspiring,and exertional throat symptoms were significantly associated with acute coronary syndrome,with odds ratios of 8.3(95%CI 2.2–31.5),10.9(95%CI 1.8–66.9),25.4(95%CI 3.6–179.9),and 81.2(95%CI 13.0–506.7).A total of 25(56.82%)out of 44 acute coronary syndrome patients,who were first admitted to the otorhinolaryngology department,were misdiagnosed,with a 12%(3/25)mortality rate.Throat discomfort can be the principal manifestation of acute coronary syndrome.Such patients exhibit high misdiagnosis and mortality rates.Exertional throat symptoms,chest tightness,perspiring,and dyspnea were important indicators of acute coronary syndrome in patients whose main complaint was throat discomfort.The awareness of this condition will result in prompt diagnosis and reduce morbidity and mortality. | Yanqing Fang Xiaoting Cheng Wenhui Peng Xueying Chen Chunping Tang Qiusheng Huang Sihai Wu Yibo Huang Fanglu Chi Matthew RNaunheim Huawei Li Bing Chen Yilai Shu | 2022 | Frontiers of Medicine2022，16，4： | 0 |
| 15 | Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study显示文摘Exposures to copper have become a health concern.We aim to explore the broad clinical effects of blood copper concentrations.A total of 376,346 Caucasian subjects were enrolled.We performed a Mendelian randomization and phenome-wide association study(MR-PheWAS)to evaluate the causal association between copper and a wide range of outcomes in UK Biobank,and we constructed a protein-protein interaction network.We found association between blood copper concentrations and five diseases in the overall population and nine diseases in male.MR analysis implicated a causal role of blood copper in five diseases(overall population),including prostate cancer(OR=0.87,95%CI 0.77-0.98),malignant and unknown neoplasms of the brain and nervous system(OR=0.58,95%CI 0.38-0.89),and hypertension(OR=0.94,95%CI 0.90-0.98),essential hypertension(OR=0.94,95%CI 0.90-0.98)and cancer of brain and nervous system(OR=0.63,95%CI 0.41-0.98).For male,except for dysphagia being newly associated with blood copper(OR=1.39,95%CI 1.18-1.63),other MR results were consistent with the overall population.In addition,the PPI network showed possible relationship between blood copper and four outcomes,namely brain cancer,prostate cancer,hypertension,and dysphagia.Blood copper may have causal association with prostate cancer,malignant and unknown neoplasms of the brain and nervous system,hypertension,and dysphagia.Considering that copper is modifiable,exploring whether regulation of copper levels can be used to optimize health outcomes might have public health importance. | Xiuming Feng Wenjun Yang Lulu Huang Hong Cheng Xiaoting Ge Gaohui Zan Yanli Tan Lili Xiao Chaoqun Liu Xing Chen Zengnan Mo Longman Li Xiaobo Yang | 2022 | Phenomics2022，2，4： | 0 |
| 16 | Identification of the receptor of oncolytic virus M1 as a therapeutic predictor for multiple solid tumors显示文摘Over the last decade,oncolytic virus(OV)therapy has shown its promising potential in tumor treatment.The fact that not every patient can benefit from it highlights the importance for defining biomarkers that help predict patients’responses.As particular self-amplifying biotherapeutics,the anti-tumor effects of OVs are highly dependent on the host factors for viral infection and replication.By using weighted gene co-expression network analysis(WGCNA),we found matrix remodeling associated 8(MXRA8)is positively correlated with the oncolysis induced by oncolytic virus M1(OVM). | Deli Song Xudong Jia Xincheng Liu Linyi Hu Kaiying Lin Tong Xiao Yangyang Qiao Jiayu Zhang Jia Dan Chunwa Wong Cheng Hu Ke Sai Shoufang Gong Max Sander Runling Shen Xiaoyu Chen Xiaoting Xiao Jiehong Chen Yanming Zhang Cailv Wei Xiao Xiao Jiankai Liang Qinfen Zhang Jun Hu Wenbo Zhu Guangmei Yan Yuan Lin Jing Cai | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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