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| 1 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 2 | Overfitting Reduction of Pose Estimation for Deep Learning Visual Odometry显示文摘Error or drift is frequently produced in pose estimation based on geometric'feature detection and tracking'monocular visual odometry(VO)when the speed of camera movement exceeds 1.5 m/s.While,in most VO methods based on deep learning,weight factors are in the form of fixed values,which are easy to lead to overfitting.A new measurement system,for monocular visual odometry,named Deep Learning Visual Odometry(DLVO),is proposed based on neural network.In this system,Convolutional Neural Network(CNN)is used to extract feature and perform feature matching.Moreover,Recurrent Neural Network(RNN)is used for sequence modeling to estimate camera’s 6-dof poses.Instead of fixed weight values of CNN,Bayesian distribution of weight factors are introduced in order to effectively solve the problem of network overfitting.The 18,726 frame images in KITTI dataset are used for training network.This system can increase the generalization ability of network model in prediction process.Compared with original Recurrent Convolutional Neural Network(RCNN),our method can reduce the loss of test model by 5.33%.And it’s an effective method in improving the robustness of translation and rotation information than traditional VO methods. | Xiaohan Yang Xiaojuan Li Yong Guan Jiadong Song Rui Wang | 2020 | China Communications2020，17，6： | 4 |
| 3 | Targeted therapeutics and novel signaling pathways in nonalcohol-associated fatty liver/steatohepatitis(NAFL/NASH)显示文摘Non-alcohol-associated fatty liver/steatohepatitis(NAFL/NASH)has become the leading cause of liver disease worldwide.NASH,an advanced form of NAFL,can be progressive and more susceptible to developing cirrhosis and hepatocellular carcinoma.Currently,lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the development of fibrosis.While there are stll limited appropriate drugs specifically to treat NAFL/NASH,growing progress is being seen in elucidating the pathogenesis and identifying therapeutic targets.In this review,we discussed recent developments in etiology and prospective therapeutic targets,as well as pharmacological candidates in pre/clinical trials and patents,with a focus on diabetes,hepatic lipid metabolism,inflammation,and fibrosis.Importantly,growing evidence elucidates that the disruption of the gut-liver axis and microbederived metabolites drive the pathogenesis of NAFL/NASH.Extracellular vesicles(EVs)act as a signaling mediator,resulting in lipid accumulation,macrophage and hepatic stellate cell activation,further promoting inflammation and liver fibrosis progression during the development of NAFL/NASH.Targeting gut microbiota or EVs may serve as new strategies for the treatment of NAFL/NASH.Finally,other mechanisms,such as cell therapy and genetic approaches,also have enormous therapeutic potential.Incorporating drugs with different mechanisms and personalized medicine may improve the efficacy to better benefit patients with NAFL/NASH. | Xiaohan Xu Kyle L.Poulsen Ljuan Wu Shan Liu Tatsunori Miyata Qiaoling Song Qingda Wei Chenyang Zhao Chunhua Lin Jinbo Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 4 | A rapid real-time recombinase polymerase amplification assay for diagnosis of acute hepatopancreatic necrosis disease in shrimp显示文摘Acute hepatopancreatic necrosis disease(AHPND)is an emerging disease in the shrimp farming industry with a high mortality rate that causes serious economic losses in Asia,Africa,and America[1].AHPND is also known as early mortality syndrome because of its early onset of the disease at 5-30 days of shrimp postlarvae stocking and a high mortality rate up to 100%.Symptoms of AHPND include lighter hepatopancreas,atrophy,jejunal empty stomach,softened carapace,and loss of vitality.AHPND is caused by infection of special strains of Vibrio parahaemolyticus(referred to VPAHPND in this study)containing the 69-kb pVA1 plasmid with the binary toxic Photorhabdus insect-related genes PirA and PirB(referred to PirAB in this study)[2].In January 2016,the World Organization for Animal Health(OIE)added AHPND to the OIE List of Aquatic Animal Diseases.Rapid,sensitive,and reliable diagnosis assays for AHPND are demanded by the shrimp farming industry to prevent the disease and reduce economic loss. | Haiyi Yu Xiaohan Yang Juan Zhang Haitao Yang Panpan Zhao Hui Shen Ge Jiang Jing Ji Jingquan Dong Song Gao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 2 |
| 5 | LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis显示文摘Cardiac fibrosis is one of the crucial pathological factors in the heart,and various cardiac conditions associated with excessive fibrosis can eventually lead to heart failure.However,the exact molecular mechanism of cardiac fibrosis remains unclear.In the present study,we show that a novel lnc RNA that we named cardiac fibrosis-associated regulator(CFAR)is a profibrotic factor in the heart.CFAR was upregulated in cardiac fibrosis and its knockdown attenuated the expression of fibrotic marker genes and the proliferation of cardiac fibroblasts,thereby ameliorating cardiac fibrosis.Moreover,CFAR acted as a ce RNA sponge for mi R-449a-5p and derepressed the expression of LOXL3,which we experimentally established as a target gene of mi R-449a-5p.In contrast to CFAR,mi R-449a-5p was found to be significantly downregulated in cardiac fibrosis,and artificial knockdown of mi R-449a-5p exacerbated fibrogenesis,whereas overexpression of mi R-449a-5p impeded fibrogenesis.Furthermore,we found that LOXL3 mimicked the fibrotic factor TGF-β1 to promote cardiac fibrosis by activating m TOR.Collectively,our study established CFAR as a new profibrotic factor acting through a novel mi R-449a-5p/LOXL3/m TOR axis in the heart and therefore might be considered as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases. | Mingyu Zhang Bowen Zhang Xiaohan Wang Jiahang Song Ming Tong Zheng Dong Jiaonan Xu Meng Liu Yuan Jiang Ning Wang Ying Wang Zhimin Du Yanyan Liu Rong Zhang Chaoqian Xu | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 6 | Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation显示文摘Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative defence.Here,we reveal a previously unidentified function of G6PD.It,even the natural G6PD deficiency-associated mutant without the activity to maintain the normal oxPPP,can antagonize the stresses by supporting the reductive glutamine metabolism and AMPK activation,independently of the NADPH generation by the oxPPP. | Benfu Zhong Dewei Jiang Yang Hong Lifang Li Li Qiu Ronghui Yang Xiaohan Jin Yawen Song Ceshi Chen Binghui Li | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 7 | Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via α-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate显示文摘有代替 S 的 4-methylbenzenesulfonothioate 的 glycine 的 Ni (II ) 建筑群的不对称的 -sulfenylation 被报导。由于温和、简单的反应条件,这不对称的反应与各种各样的功能的组兼容。 | Jia Li Xiaohan Song Shengbin Zhou Jiang Wang Hong Liu | 2017 | Chinese Journal of Chemistry2017，35，9： | 1 |
| 8 | Over 50,000 Metagenomically Assembled Draft Genomes for the Human Oral Microbiome Reveal New Taxa显示文摘The oral cavity of each person is home to hundreds of bacterial species.While taxa for oral diseases have been studied using culture-based characterization as well as amplicon sequencing,metagenomic and genomic information remains scarce compared to the fecal microbiome.Here,using metagenomic shotgun data for 3346 oral metagenomic samples together with 808 published samples,we obtain 56,213 metagenome-assembled genomes(MAGs),and more than 64%of the 3589 species-level genome bins(SGBs)contain no publicly available genomes.The resulting genome collection is representative of samples around the world and contains many genomes from candidate phyla radiation(CPR)that lack monoculture.Also,it enables the discovery of new taxa such as a genus Candidatus Bgiplasma within the family Acholeplasmataceae.Large-scale metagenomic data from massive samples also allow the assembly of strains from important oral taxa such as Porphyromonas and Neisseria.The oral microbes encode genes that could potentially metabolize drugs.Apart from these findings,a strongly male-enriched Campylobacter species was identified.Oral samples would be more user-friendly collected than fecal samples and have the potential for disease diagnosis.Thus,these data lay down a genomic framework for future inquiries of the human oral microbiome. | Jie Zhu Liu Tian Peishan Chen Mo Han Liju Song Xin Tong Xiaohuan Sun Fangming Yang Zhipeng Lin Xing Liu Chuan Liu Xiaohan Wang Yuxiang Lin Kaiye Cai Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Liang Xiao Tao Zhang Huijue Jia Zhuye Jie | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 1 |
| 9 | A chloride efflux transporter,BIG RICE GRAIN 1,is involved in mediating grain size and salt tolerance in rice显示文摘Grain size is determined by the size and number of cells in the grain.The regulation of grain size is crucial for improving crop yield;however,the genes and molecular mechanisms that control grain size remain elusive.Here,we report that a member of the detoxification efflux carrier/Multidrug and Toxic Compound Extrusion(DTX/MATE)family transporters,BIG RICE GRAIN 1(BIRG1),negatively influences grain size in rice(Oryza sativa L.).BIRG1 is highly expressed in reproductive organs and roots.In birg1 grain,the outer parenchyma layer cells of spikelet hulls are larger than in wild-type(WT)grains,but the cell number is unaltered.When expressed in Xenopus laevis oocytes,BIRG1 exhibits chloride efflux activity.Consistent with this role of BIRG1,the birg1 mutant shows reduced tolerance to salt stress at a toxic chloride level.Moreover,grains from birg1 plants contain a higher level of chloride than those of WT plants when grown under normal paddy field conditions,and the roots of birg1 accumulate more chloride than those of WT under saline conditions.Collectively,the data suggest that BIRG1 in rice functions as a chloride efflux transporter that is involved in mediating grain size and salt tolerance by controlling chloride homeostasis. | Zhijie Ren Fenglin Bai Jingwen Xu Li Wang Xiaohan Wang Qian Zhang Changxin Feng Qi Niu Liying Zhang Jiali Song Fang Bao Liangyu Liu Yikun He Ligeng Ma Wang Tian Congcong Hou Legong Li | 2021 | Journal of Integrative Plant Biology2021，63，12： | 1 |
| 10 | Rapid and label-free classification of pathogens based on light scattering,reduced power spectral features and support vector machine显示文摘The rapid identification of pathogens is crucial in controlling the food quality and safety.The proposed system for the rapid and label-free identification of pathogens is based on the principle of laser scattering from the bacterial microbes.The clinical prototype consists of three parts:the laser beam,photodetectors,and the data acquisition system.The bacterial testing sample was mixed with 10 mL distilled water and placed inside the machine chamber.When the bacterial microbes pass by the laser beam,the scattering of light occurs due to variation in size,shape,and morphology.Due to this reason,different types of pathogens show their unique light scattering patterns.The photo-detectors were arranged at the surroundings of the sample at different angles to collect the scattered light.The photodetectors convert the scattered light intensity into a voltage waveform.The waveform features were acquired by using the power spectral characteristics,and the dimensionality of extracted features was reduced by applying minimal-redundancy-maximal-relevance criterion(mRMR).A support vector machine(SVM)classifier was developed by training the selected power spectral features for the classification of three different bacterial microbes.The resulting average identification accuracies of E.faecalis,E.coli and S.aureus were 99%,87%,and 94%,respectively.The ove rall experimental results yield a higher accuracy of 93.6%,indicating that the proposed device has the potential for label-free identification of pathogens with simplicity,rapidity,and cost-effectiveness. | Mubashir Hussain Zhen Chen Mu Lv Jingyi Xu Xiaohan Dong Jingzhou Zhao Song Li Yan Deng Nongyue He Zhiyang Li Bin Liu | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 11 | Low genetic diversity in the endangered marine alga Silvetia siliquosa(Ochrophyta:Fucaceae)and the implication to conservation显示文摘Although signifi cant research eff orts have been targeted toward conservation and management of endangered terrestrial fl ora and fauna,attempts have been limited to conserve threatened seaweeds.Silvetia siliquosa is an ecologically and commercially vital brown alga that is uniquely distributed in the Yellow-Bohai Sea and along the southwest coast of Korea.A massive decline in its distribution range and biomass from the mid-1990s onward indicates that this species has become endangered.In the present study,we used nuclear internal transcribed spacer and concatenated mitochondrial cytochrome oxidase I subunit+intergenic spacer to estimate the genetic diversity,population connectivity,and degree of genetic diff erentiation of S.siliquosa in China and Korea.The molecular results exhibited strikingly low levels of haplotype/ribotype and nucleotide diversity in S.siliquosa populations,with only three mitochondrial haplotypes and nuclear ribotypes detected in 136 and 143 specimens,respectively.The analysis of molecular variance revealed 85%-95%of genetic variance among populations.Population diff erentiation coeffi cient(F_(ST))and gene fl ow(N_(m))suggested that two populations(JIN and GWA)along the southern coast of Korea are highly divergent from the others,with weak genetic exchange.No signifi cant genetic diff erentiation was observed among populations either in China or along the geographically proximate west coast of Korea.Thus,four independent management units were designated for sustainable management:the LII and RUS populations in China,the YEO and CHA populations along the west coast of Korea,and each of the GWA and JIN populations along the south coast of Korea.We suggest that artifi cial cultivation and transplantation of S.siliquosa are the eff ective approaches for restoration and conservation. | Yanshuo LIANG Jie ZHANG Xiaohan SONG Han-Gil CHOI Xu GAO Delin DUAN Zi-min HU | 2022 | Journal of Oceanology and Limnology2022，40，1： | 0 |
| 12 | Fracture features of brittle coal under uniaxial and cyclic compression loads显示文摘Under the efects of complex geological and stress environments,burst hazards continue to be a major challenge for underground space utilization and deep resources exploration as its occurrence can lead to personnel causalities,equipment damage and structural collapse.Considering the stress path experienced by in-situ coal body,cyclic loading appears in quite various forms for instance shearer cutting,overlying strata breakage,hydro-fracturing and blasting,during tunnel,mining and underground space utilizing process.The stability of the underground coal body subject to periodic loading/unloading stress is extremely important for maintain the function of designed engineering structure for waste storage,safe mining,roadway development,gas recovery,carbon sequestration and so on.The mechanical properties of hard rock subject to cyclic fatigue loads has been intensively investigated by many researchers as the rock burst induced by supercritical loads has long been a safety risk and engineering problems for civil and tunneling engineering under deep overburden.More recently,the mechanical properties of coal samples under cyclic fatigue loads is investigated from the aspect of hysteresis,energy dissipation and irreversible damage as the burst hazards of brittle coal is rising in many countries.However,the crack propagation and fracture pattern of brittle coal need more research to understand the micro mechanism of burst incubation subject to cyclic fatigue loads as brittle coal can store more elastic strain energy and rapidly release the energy when its ultimate strength once reached.This research studied the internal crack status corresponding to diferent cyclic fatigue loading stage of brittle coal samples.The AE monitoring was applied during the uniaxial and cyclic loading process of brittle coal samples to record the crack intensity of samples at diferent loading stages.The damage evolution curve corresponding to loading status was then determined.The fracture pattern of coal samples determined by micro-CT scan was observed and discussed.It has been found by this paper that brittle coal of uniaxial compression tests demonstrated sudden failure caused by major splitting fracture while that of cyclic fatigue tests experienced progressive failure with mixture fracture network. | Shikang Song Ting Ren Linming Dou Jian Sun Xiaohan Yang Lihai Tan | 2023 | International Journal of Coal Science & Technology2023，10，1： | 0 |
| 13 | Study of Priority Recommendation Method Based on Cognitive Diagnosis Model显示文摘In the context of personalized learning,the recommendation method aims to provide appropriate exercises for each student.And individualized knowledge status may give more effective recommendation.In this study,a priority recommendation method based on cognitive diagnosis model is proposed,and cosine similarity algorithm is applied to improve the accuracy and interpretability of recommendation.Then the performance of the methods was compared under cognitive diagnosis models.The experimental results show that the method proposed achieves more accurate results and better performance. | Suojuan Zhang Jiao Liu Song Huang Jinyu Song Xiaohan Yu Xianglin Liao | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 14 | Recalling the Past of My Husband显示文摘Song Xiaohan is the widow of the patriotic general He Jifeng, who served in the War of Resistance Against Japan, He Jifeng was once a brigade commander of the 110th Brigade in the 29th Corps under the Kuomintang. In September 1935, he was transferred to Beiping (the old name of Beijing], and was put in charge of defending Wanping County Seat, Fengtai Township, the Pinghan Railway and Lugouqiao areas. On July 7th, 1937, when the Lugouqiao Incident happened he took his place in front of the troups to direct the battle, and issued an order to fight back the Japanese invaders. The commanders and soldiers of the 29th Corps shot the first bullet in the War of Resistance Against Japan.Song Xiaohan met General He Jifeng after the Lugouqiao Incident, and accompanied him through the disturbances of a half century. He Jifeng died in 1980. Now 80 years old Song Xiaohan lives in Beijing and spends her remaining years quietly. She recalled her old days as follows. | SONG XIAOHAN LINDA LEE | 1995 | Women of China1995，，11： | 0 |
| 15 | Green rapid synthesis of Cu_(2)O/Ag heterojunctions exerting synergistic antibiosis显示文摘Semiconductor-noble metal composite has become a research focus due to its superior performance compared with its respective component.Although various methods have been developed to synthesize semiconductor-noble metal heterostructures,most of them are relatively complex multistep and use toxic reactants of high cost and risk.In this work,a series of Cu_(2)O/Ag heterojunctions were quickly prepared in one step via simple microwave-assisted green route.XRD,SEM,TEM,EDS,XPS,etc.were used to characterize obtained products,and the results indicate a Cu_(2)O/Ag metal-semiconductor heterojunction in micro-nano size was fabricated successfully.In addition,antibacterial behavior of Cu_(2)O/Ag heterojunctions against E.coli and S.aureus were investigated.Owing to the synergistic effect of Cu_(2)O and Ag,the heterojunction exhibits much better antibacterial performance than the pristine Cu_(2)O does.This work provides new insights into the green design and fabrication of surface-modified Cu_(2)O hybrid multifunctional materials for antibacterial applications. | Feiyue Hu Bo Song Xiaohan Wang Shen Bao Siyang Shang Shupei Lv Bingbing Fan Rui Zhang Jingguo Li | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 16 | Effect of cOVID-19 lockdown on the characterization and mixing state of carbonaceous particles in the urban atmosphere of Liaocheng, the North China Plain显示文摘To investigate the effect of covID-19 control measures on aerosol chemistry,the chemical compositions,mixing states,and formation mechanisms of carbonaceous particles in the urban atmosphere of Liao-cheng in the North China Plain(NCP)were compared before and during the pandemic using a single particle aerosol mass spectrometry(SPAMS).The results showed that the concentrations of five air pollutants including PM2.5,PM1o,SO2,NO2,and cO decreased by 41.2%-71.5%during the pandemic compared to those before the pandemic,whereas O3 increased by 1.3 times during the pandemic because of the depressed titration of O3 and more favorable meteorological conditions.The count and percentage contribution of carbonaceous particles in the total detected particles were lower during the pandemic than those before the pandemic.The carbonaceous particles were dominated by elemental and organic carbon(ECOC,35.9%),followed by elemental carbon-aged(EC-aged,19.6%)and organic carbon-fresh(OC-fresh,13.5%)before the pandemic,while EC-aged(25.3%),ECOC(17.9%),and secondary ions-rich(SEC,17.8%)became the predominant species during the pandemic.The carbonaceous particle sizes during the pandemic showed a broader distribution than that before the pandemic,due to the condensation and coagulation of carbonaceous particles in the aging processes.The relative aerosol acidity(Rra)was smaller before the pandemic than that during the pandemic,indicating the more acidic particle aerosol during the pandemic closely related to the secondary species and relative humidity(RH).More than 95.0%and 86.0%of carbonaceous particles in the whole period were internally mixed with nitrate and sulfate,implying that most of the carbonaceous particles were associated with secondary oxidation during their formation processes.The diurnal variations of oxalate particles and correlation analyses suggested that oxalate particles before the pandemic were derived from aqueous oxidation driven by RH and liquid water content(LwC),while oxalate particles during the pandemic were originated from O3-dominatedphotochemical oxidation. | Min Chen Jingjing Meng Yuanyuan Li Yachen Wang Tonglin Huang Zheng Li Xiaohan Song Can Wu Zhanfang Hou | 2023 | Particuology2023，，7： | 0 |
| 17 | Multifunctional catalytic activity of Cu 3 N(001)surface:A first-principles study显示文摘Multifunctional catalysts that exhibit high catalytic performance for the hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and oxygen reduction reaction(ORR)in a single material hold great promise for broad-spectrum applications,including overall water splitting,fuel cells,and metal-air batteries.In this first-principles study,Cu_(3) N is computationally demonstrated as a multifunctional electrocatalyst for the HER,OER,and ORR owing to the unique coordination of N and Cu atoms on the(001)surface.Cu_(3) N exhibits better HER catalytic activity than noble Pt-based catalysts.Furthermore,its OER and ORR catalytic activity is comparable to that of commercialized unifunctional catalysts,and its 4e-pathway selectivity is high during the ORR.The catalytic performance of the ORR is significantly improved by the introduction of vacancy defects.The integration of highly efficient HER,OER,and ORR catalytic performance in earth-abundant Cu_(3) N not only opens an avenue for developing cost-efficient omnipotent catalysts but also facilitates advances in clean and renewable energy. | Junru Wang Zhichao Liu Zhenhong Dai Xiaohan Song Xiaobiao Liu | 2023 | ChemPhysMater2023，2，3： | 0 |
| 18 | Application of Virtual Fitting Technology and Impac on the Clothing Market显示文摘 | FU Yihan XU Weiwei LIU Lu SONG Xiaohan XU Zengbo | 2017 | International English Education Research2017，，2： | 0 |
| 19 | Bioinspired Scalable Total Synthesis of Opioids显示文摘As one of the largest and most representative families of natural medicines harvested from plants,the mass production of opioids legitimately occupies large,worldwide farmland cultivation of opium poppies,causing severe regulation limitations and supply uncertainty.Due to their complex structures,the chemical synthesis of opioids has been criticized as infeasible for large-scale production in view of lengthy synthetic steps and overall low efficiency. | Xiaohan Zhou Wenfei Li Ruijie Zhou Xiaoqing Wu Yuan Huang Wenlong Hou Chunxin Li Yifan Zhang Wei Nie Yu Wang Hao Song Xiao-Yu Liu Zhibing Zheng Fei Xie Song Li Wu Zhong Yong Qin | 2021 | CCS Chemistry2021，3，9： | 0 |
| 20 | Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization显示文摘Due to their broad functional plasticity,myeloid cells contribute to both liver injury and recovery during acetaminophen overdose-induced acute liver injury(APAP-ALI).A comprehensive understanding of cellular diversity and intercellular crosstalk is essential to elucidate the mechanisms and to develop therapeutic strategies for APAP-ALI treatment.Here,we identified the function of IFN-I in the myeloid compartment during APAP-ALI.Utilizing single-cell RNA sequencing,we characterized the cellular atlas and dynamic progression of liver CD11b+cells post APAP-ALI in WT and STAT2 T403A mice,which was further validated by immunofluorescence staining,bulk RNA-seq,and functional experiments in vitro and in vivo.We identified IFN-I-dependent transcriptional programs in a three-way communication pathway that involved IFN-I synthesis in intermediate restorative macrophages,leading to CSF-1 production in aging neutrophils that ultimately enabled Trem2+restorative macrophage maturation,contributing to efficient liver repair.Overall,we uncovered the heterogeneity of hepatic myeloid cells in APAP-ALI at single-cell resolution and the therapeutic potential of IFN-I in the treatment of APAP-ALI. | Qiaoling Song Shyamasree Datta Xue Liang Xiaohan Xu Paul Pavicic Xiaonan Zhang Yuanyuan Zhao Shan Liu Jun Zhao Yuting Xu Jing Xu Lihong Wu Zhihua Wu Minghui Zhang Zhan Zhao Chunhua Lin Yuxin Wang Peng Han Peng Jiang Yating Qin Wei Li Yingying Zhang Yonglun Luo Ganes Sen George R.Stark Chenyang Zhao Thomas Hamilton Jinbo Yang | 2023 | Cellular & Molecular Immunology2023，20，2： | 0 |
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