|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The influence of water-based drilling fluid on mechanical property of shale and the wellbore stability显示文摘Because of high cost and pollution of oil-based drilling fluid,the water-based drilling fluid is increasingly used now.However,bedding planes and micro-cracks are rich in shale formation.When water-based drilling fluid contacts formation rock,it causes the propagation of crack and invasion of drilling fluid,which decrease shale strength and cause wellbore instability.In this paper,we analyzed influence of water-based drilling fluid on shale strength and failure mode by mechanics experiment.Based on those experimental results,considering the effect of bedding plane and drilling time,we established modeling of wellbore stability for shale formation.The result from this model indicates that in certain azimuth of horizontal well,collapsing pressure increases dramatically due to shale failure along with bedding plane.In drilling operation,those azimuths are supposed to be avoided.This model is applicable for predication of collapsing pressure in shale formation and offers reference for choosing suitable mud weight. | Shu He Lixi Liang Yinjin Zeng Yi Ding Yongxue Lin Xiangjun Liu | 2016 | Petroleum2016，2，1： | 6 |
| 2 | Homogenization treatment of high Nb containing TiAl alloys with as-cast and as-forged microstructures显示文摘包含 TiAl 合金的高 Nb 的微观结构进化上的热处理的效果被学习了。结果显示在当演员组和同样伪造的合金的那 -segregation, 分离和 S 分离能有效地在 T 上面在温度被消除(1350-1400 癯牥吗? | XU Zhengfang XU Xiangjun LIN Junpin ZHANG Yong WANG Yanli LIN Zhi CHEN Guoliang | 2008 | Rare Metals2008，27，2： | 4 |
| 3 | Comparative literature study between investigations in foreign Science Citation Index journals and Chinese core domestic journals in the treatment of low back pain with acupuncture显示文摘OBJECTIVE: To investigate the quality and methods of clinical research literature published in foreign Science Citation Index(SCI) journals studying the treatment of low back pain with acupuncture.To conduct a comparative study with clinical research literature published in Chinese core domestic journals,and to understand the prospects of current research trends of acupuncture clinical studies in Western countries and China.METHODS: Studies on clinical acupuncture treatment of low back pain in English SCI journals and four Chinese core domestic journals dated from 2002 to 2012 were sourced and summarized for this study. Objective analysis and evaluation on the differences in subject and scope of study on low back pain by foreign and Chinese researchers were conducted.RESULTS: Forty-seven English studies and 115 Chinese studies met our inclusion criteria. A keyword search revealed different kinds of low back pain related conditions in English and Chinese studies.The English studies were broad in scope, while the Chinese studies were more focused. There were also differences in the understanding and definition of concepts and study orientation.CONCLUSION: More study should be undertaken to understand the contradictions that acupuncture faces in view of modern research to further advance the field. | Xiangjun Lin Rui Li | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 2 |
| 4 | DNA damage stress induces the dissociation of Smurf1/2 from MDM2 in a slow manner显示文摘The tumor suppressor p53 locates at the key point of cell growth or apoptosis balance, and the expression level of p53 is tightly controlled by ubiquitin ligases including MDM2. Upon DNA damage stresses, p53 was accumulated and activated, leading to cell cycle arrest or apoptosis. We previously showed that Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by interacting with and stabilizing MDM2, and consequently enhancing MDM2-mediated ubiquitylation of p53. However, it is unclear how the Smurf1-MDM2 interaction is regulated in response to DNA damage stress. Here, we show that in response to etoposide treatment Smurf1 dissociates from MDM2, resulting in MDM2 destabilization and p53 accumulation. The negative regulation of Smurf1 on apoptosis is released. Notably, this dissociation is a slow process rather than a rapid response, implicating high expression of Smurf1 might confer the resistance against p53 activation. Consistent with this notion, we observed that Smurf1/2 ligases are highly expressed in colon cancer, esophageal squamous cell carcinoma and pancreatic cancer tissues, suggesting the oncogenic tendency of Smurf1/2. | NIE Jing LIU Lin ZHAO XiaoHang XIE Ping ZHOU PingKun XING GuiChun LIU XiangJun HE FuChu HAN WeiDong ZHANG LingQiang | 2011 | Chinese Science Bulletin2011，56，30： | 2 |
| 5 | Strain rate sensitivity of tensile properties in high Nb containing TiAl alloys显示文摘The effect of strain rate on the yield strength of high Nb containing TiAl alloy was studied. The results show that the strain rate sensitivity varies with the test temperature, and the yield strength is not sensitive to the strain rate at room temperature but sig- nificantly sensitive to the strain rate at high temperature. An increase of the strain rate or a decrease of the temperature results in an obvious change of fracture mode. It is found that the strain rate sensitivity of this alloy varying with temperature is due to the dislo- cation climb generated at high temperature. | Jianfeng Gao Xiangjun Xu Junpin Lin Xiping Song Yanli Wang Guoliang Chen | 2005 | Journal of University of Science and Technology Beijing2005，12，6： | 2 |
| 6 | Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity显示文摘 | Yong‐Ning Xin Yuqi Zhao Zhong‐Hua Lin Xiangjun Jiang Shi‐Ying Xuan Jingfei Huang | 2012 | Proteins2012，，3： | 2 |
| 7 | Strengthened Indian summer monsoon brought more rainfall to the western Tibetan Plateau during the early Holocene显示文摘The Tibetan Plateau(TP)is considered to be the‘‘Third Pole”of the earth because of its huge area(5 million km2),its high elevation(>4000 m average altitude),and the presence of more than 100,000 km2 of glaciers in this northern mid-latitude region.As a result of these factors,the TP influences both short-term regional and large-scale atmospheric circulation and long-term climate change[1].More than ten large rivers originate from the TP and constitute an essential water supply for nearly one sixth of the global population.Hence the TP is often referred to as‘‘the water tower of Asia”[1,2].Variations of summer rainfall over the TP greatly impact inland closed lakes,river discharge,glaciers,plant phenology,and natural hazards[2]. | Xiangjun Liu Xiaojian Zhang Yanluan Lin Liya Jin Fahu Chen | 2019 | Science Bulletin2019，64，20： | 1 |
| 8 | Relationship between rnicrostructures and contents of Ca/P in near-eutectie Al-Si piston alloys 显示文摘 | Qiao Jinguo Liu Xiangfa Lin Xiangjun | 2005 | Mater Lett2005，59，： | 1 |
| 9 | Fabric-substrated capacitive biopotential sensors enhanced by dielectric nanoparticles显示文摘Wearable biopotential sensing devices are essential to long-term and real-time monitoring of human health.Non-contact,capacitive sensing electrodes prevent potential skin iritations,and are thus beneficial for long-term monitoring.Existing capacitive electrodes are either connected to a separate control circuit via external wires or have limited sensing capacitances,which leads to low signal qualities.This study demonstrates a stretchable capacitive sensing device with integrated electrodes and control electronics,with enhanced signal qualities.The electrodes and the control electronics are fabricated on a common fabric substrate for breathability and strain-limiting protection.The stretchable electrodes are based on an island-bridge design with a stretchability as high as-100%,and an area ratio as high as-80%.By using a dielectric calcium copper titanate(CCTO)composite as the adhesive layer,the electrode capacitance can be increased,yielding an enhanced signal-to-noise ratio(SNR)in the acquired biopotentials.This device offers a convenient and comfortable approach for long-term non-contact monitoring of biopotential signals. | Xiangjun Chen Xiaoxiang Gao Akihiro Nomoto Keren Shi Muyang Lin Hongjie Hu Yue Gu Yangzhi Zhu Zhuohong Wu Xue Chen Xinyu Wang Baiyan Qi Sai Zhou Hong Ding Sheng Xu | 2021 | Nano Research2021，14，9： | 1 |
| 10 | Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish显示文摘 | An Xiao Zhanxiang Wang Yingying Hu Yingdan Wu Zhou Luo Zhipeng Yang Yao Zu Wenyuan Li Peng Huang Xiangjun Tong Zuoyan Zhu Shuo Lin Bo Zhang | 2013 | Nucleic Acids Research2013，，14： | 1 |
| 11 | Study on Extraction Process of Sipunculus nudus Polysaccharide and Its Antioxidant Activity显示文摘[Objectives] This study was conducted to optimize the extraction process of Sipunculus nudus polysaccharide. [Methods]S. nudus polysaccharide was extracted by ultrasonic water extraction,with the marine S. nudus as a raw material from Sanya City,Hainan Province,by single factor variable method,to find the optimal extraction conditions including ultrasonic power,solid-liquid ratio,ultrasonic extraction temperature,ultrasonic extraction time,ultrasonic extraction times and lye concentration. The absorbance of the polysaccharide was determined by an ultraviolet spectrophotometer,and polysaccharide yield were calculated. The antioxidant activity of scavenging hydroxyl and DPPH radicals was measured at different concentrations. [Results]The optimal extraction conditions for S. nudus polysaccharide were as follows: solid-liquid ratio at 1∶11 mg/ml,extraction temperature at 60 ℃,three times of ultrasonic extraction,ultrasonic power of 960 W,extraction time of 1. 5 h,and lye concentration of 5%,under which the polysaccharide yield was 3. 21%. The scavenging rates of hydroxyl radical and DPPH radical were 12. 58% at the concentration of 0. 20 mg/ml. Moreover,the scavenging rates increased significantly with the increase of concentration. [Conclusions] This method is a new trial with satisfactory results. | wen chen xiangjun wang dongxu shao lirong li yuzhi huang hongyuan sun lingyan li yong lin | 2018 | Agricultural Biotechnology2018，7，2： | 1 |
| 12 | ω_o phase precipitation in annealed high Nb containing TiAl alloys显示文摘The ordered ω phases in high Nb containing Ti Al(Nb-Ti Al) alloys have been garnering increasing attention in the recent years. However, the investigations on the Nb dependence on the ωoprecipitation are scarce. In this study, the effect of Nb content on the ωoprecipitation in high Nb(6–10 at%) containing Ti Al alloys after long-time annealing at 850 1C has been studied. The results show that small ordered ω particles in the retained βophase cannot be discerned under scanning electron microscope(SEM) but can be observed using transmission electron microscopy(TEM). Although the Nb segregation can be eliminated after the homogenization heat treatment, the ωophase precipitated in all the alloys studied after annealing at 850 1C. TEM examination reveals that the orientation relationship between the ωoand α2phases can be derived as: [0001]ωo//[1120]α2;(1120)ωo//(0001)α2, which indicates that the ωophase is directly transformed from the parent α2phase. Small γ particles are also observed within the ωoareas. The α2-ωot γ decomposition process is expected during annealing. It is concluded that ωophase is an equilibrium phase in high Nb-Ti Al alloys at 850 1C. | Lin Song Cong Peng Xiangjun Xu Li You Yanli Wang Junpin Lin | 2015 | Progress in Natural Science:Materials International2015，25，2： | 1 |
| 13 | The Exploration of Trimeresurus Divided to Multiple Genera Based on Molecular Systematics显示文摘According to the contradictions about classification on Trimeresurus between ' China's Fauna' and international database,the rationality about Trimeresurus divided to multiple genera based on molecular systematics was discussed. The genetic distance was calculated by sequencing 12S gene of the original Trimeresurus snakes,including 80 individuals of 33 species; and the molecular phylogenetic tree was established by taking Hypnale hypnale as the outgroup. The results showed that the topological structures of ME tree and ML tree were basically consistent,and all of the species in the molecular trees were divided into 8 branches;and the difference of T. albolabris between Hainan and other locations is not obvious. The viewpoint that original Trimeresurus genera subdivided into 8 genera was more rational,and new authoritative reference books are expected to be published in China. | Xiangjun WANG Wen CHEN Yu DU Jieman LIN Chixian LIN Wenjing CHEN | 2018 | Agricultural Biotechnology2018，7，1： | 0 |
| 14 | The Study on Taxonomic Status of Trimeresurus stejnegeri chenbihuii Based on Scale Counting Method显示文摘[Objectives] This study was conducted to further investigate the taxonomic status of Hainan population of Trimeresurus stejnegeri from the morphological point of view.[Methods]The difference coefficients between different populations were compared using the 75% law,and the relationship between scales and latitudes was analyzed.[Results] The scales(abdominal and subcaudal) of 325 Trimeresurus individuals were counted according to China Animal Fauna,including156 T.stejnegeri individuals.Some difference coefficients between the Hainan population and others were greater than 1.28,and there was no correlation between the number of scales and latitude.It conforms to subclassification criteria.[Conclusions]The view about the subspecies status of T.stejnegeri chenbihuii should be supported. | Xiangjun WANG Wen CHEN Haili TANG Yu DU Chixian LIN Wenjin CHEN | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 15 | A binary logistic regression model for discriminating real protein-protein interface显示文摘The selection and study of descriptive variables of protein-protein complex interface is a major question that many biologists come across when the research of protein-protein recognition is concerned. Several variables have been proposed to understand the structural or energetic features of complex interfaces. Here a systematic study of some of these 'traditional' variables, as well as a few new ones, is introduced. With the values of these variables extracted from 42 PDB samples with real or false complex interfaces, a binary logistic regression analysis is performed, which results in an effective empirical model for the evaluation of binding probabilities of protein-protein interfaces. The model is validated with 12 samples, and satisfactory results are obtained for both the training and validation sets. Meanwhile, three potential dimeric interfaces of staphylokinase have been investigated and one with the best suitability to our model is proposed. | LIN Wei, SUN Ping and LIU Xiangjun(Bioinformatics Laboratory, School of Medicine, Tsinghua University, Beijing 100084, China) | 2003 | Progress in Natural Science:Materials International2003，13，6： | 0 |
| 16 | Ultrasonic Microwave Assisted Extraction of Polysaccharides from Sipunculus nudus显示文摘[Objectives] This study was conducted to optimize experimental conditions for extraction of polysaccharides from Sipunculus nudus.[Methods]With the Sipunculus nudus from Sanya as the experimental material,S.nudus polysaccharide was extracted by ultrasonic microwave assisted method,during which univariate factors including solid-liquid ratio,time,temperature,ultrasonic power,microwave power were investigated,to select optimal extracting conditions,which were also demonstrated and optimized by variance and response surface analysis.The optimized conditions were adopted to carry out a test,in which the absorbance of S.nudus polysaccharide was measured with an ultraviolet and visible spectrophotometer,followed by the calculation of the extracting amount of polysaccharide,and precision test and recovery test were also carried out to verify the experimental method.[Results]The standard solutions were determined at the maximum absorption wavelength of 486 nm,and the regression equation was A = 0.2677 C + 0.001 8,R^2= 0.999 8.Solid-liquid ratio,time,temperature,ultrasonic power and microwave power were investigated by univariate analysis and then optimized by response surface method as follows: solid-liquid ratio at 1:20( g/ml),time of 35 min,temperature at 50 ℃,ultrasonic power at 420 W and microwave power at 300 W,under which the measured extracting amount of S.nudus polysaccharide was1.37 mg/g.The RSD was 0.985% in precision experiment.In the repeatability test,the extracting amounts of polysaccharide were 1.41,1.43 and 1.38 mg/g for three parallel tests,respectively,with a RSD of 1.140%.The recovery test obtained following results: for group a( added with glucose standard) : the recovery of S.nudus polysaccharide was in the range of 100.3%-101.4%,RSD = 0.03%; and for group b( not added with glucose standard) : the recovery of S.nudus polysaccharide was in the range of 99.7%-100.3%,RSD = 0.02%.[Conclusions]The research method is stable and reliable.This study provides data basis and reference for follow-up study on S.nudus. | Wen CHEN Xiangjun WANG Yujie WANG Shunqi ZHANG Xu LIN Chenjia JIAO Congcong ZHANG | 2018 | Agricultural Biotechnology2018，7，6： | 0 |
| 17 | Past, present and future of the carbon cycle显示文摘The recent Ninth International Carbon Dioxide Conference(ICDC9)held in Beijing highlighted the importance and urgency of global carbon management,research challenges,and recent eforts made by Chinese scientists in this area.Emissions from fossil fuel use for energy and land use increase atmospheric carbon dioxide(CO2)levels,but carbon sinks in the ocean and on land are currently absorbing half of fossil fuel emissions.However,neither it is clear how | Zhenghui Xie Ning Zeng Huijun Wang Zheng Lin Xiangjun Tian Binghao Jia | 2014 | National Science Review2014，1，1： | 0 |
| 18 | Atmospheric correction of HJ-1 A/B CCD over land: Land surface reflectance calculation for geographical information product显示文摘这份报纸建议了一个方法从 HJ-1A/B 电荷耦合器件数据检索陆地表面反射。喷雾器光深度(AOD ) ,影响电荷耦合器件的大气的修正的最重要的因素根本想象乐队,被建议由稠密的黑暗的途径从电荷耦合器件形象检索植被(DDV ) 方法。一张查找表格为许多太阳传感器几何学和喷雾器装载以象 AOD 的功能的发射度,路径发光和大气的球形的反照率被建立。大气的修正然后作为 priori 数据集与查找表格和 MODIS 表面反射产量(MOD09 ) 被完成。基于检索 AOD 和大气的修正系数的查找表格,陆地表面反射根据大气的放射的转移方程为 HJ-1A/B 数据被检索。一些在原处,为在华东和 MODIS 陆地表面反射产品 MOD09 的山东省的 Yanzhou 的测量数据被用来 preliminarily 验证建议方法。结果证明建议方法能有效地移开大气的贡献,和检索陆地表面反射的全面精确性能实质地被改进。 | FU Qiaoyan MIN Xiangjun SUN Lin MA Shengfang | 2014 | Journal of Geographical Sciences2014，24，6： | 0 |
| 19 | Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture显示文摘Although widely applied in treating hematopoietic malignancies,transplantation of hematopoietic stem/progenitor cells(HSPCs)is impeded by HSPC shortage.Whether circulating HSPCs(cHSPCs)in steady-state blood could be used as an alternative source remains largely elusive.Here we develop a three-dimensional culture system(3DCS)including arginine,glycine,aspartate,and a series of factors.Fourteen-day culture of peripheral blood mononuclear cells(PBMNCs)in 3DCS led to 125-and 70-fold increase of the frequency and number of CD34+cells.Further,3DCS-expanded cHSPCs exhibited the similar reconstitution rate com-pared to CD34+HSPCs in bone marrow.Mechanistically,3DCS fabricated an immunomodulatory niche,secreting cytokines as TNF to support cHSPC survival and proliferation.Finally,3DCS could also promote the expansion of cHSPCs in patients who failed in HSPC mobilization.Our 3DCS successfully expands rare cHSPCs,providing an alternative source for the HSPC therapy,particularly for the patients/donors who have failed in HSPC mobilization. | Yulin Xu Xiangjun Zeng Mingming Zhang Binsheng Wang Xin Guo Wei Shan Shuyang Cai Qian Luo Honghu Li Xia Li Xue Li Hao Zhang Limengmeng Wang Yu Lin Lizhen Liu Yanwei Li Meng Zhang Xiaohong Yu Pengxu Qian He Huang | 2022 | Protein & Cell2022，13，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员