|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients显示文摘BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening test.However, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still unknown.AIM To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC patients.METHODS A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-Meier univariate analysis.RESULTSIn Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.CONCLUSION MSEPT9 analysis may add valuable information to current tumor staging. Serum m SEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. | Xue Yang Zhi-Jie Xu Xi Chen Shuang-Shuang Zeng Long Qian Jie Wei Mei Peng Xiang Wang Wan-Li Liu Hong-Ying Ma Zhi-Cheng Gong Yuan-Liang Yan | 2019 | World Journal of Gastroenterology2019，25，17： | 16 |
| 2 | Two new diarylheptanoids from the pericarps of Juglans regia L.显示文摘二新周期的 diarylheptanoids juglanin A (1 ) 和 juglanin B (2 ) 从 Juglans regia L 的果皮被孤立。他们的结构被各种各样的分光镜的方法包括 2D NMR 技术阐明(舒适, HMQC, HMBC, NOESY ) 并且 HR-ESIMS。 | Jun Xi Liu Duo Long Di Xin Yi Huang Chen Li | 2007 | Chinese Chemical Letters2007，18，8： | 14 |
| 3 | Seasonal and inter-annual variations in carbon fluxes and evapotranspiration over cotton field under drip irrigation with plastic mulch in an arid region of Northwest China显示文摘Xinjiang is the largest semi-arid and arid region in China, and drip irrigation under plastic mulch is widely used in this water-limited area. Quantifying carbon and water fluxes as well as investigating their environmental drivers over cotton fields is critical for understanding regional carbon and water budgets in Xinjiang, the largest cotton production basin of China. In this study, an eddy covariance(EC) technique was used to measure the carbon and water fluxes of cotton field under drip irrigation with plastic mulch in the growing seasons of 2009, 2010, 2012 and 2013 at Wulanwusu Agrometeorological Experiment Station, a representative oasis cropland in northern Xinjiang. The diurnal patterns of gross primary production(GPP), net ecosystem exchange(NEE) and evapotranspiration(ET) showed obviously sinusoidal variations from June to September, while the diurnal ecosystem respiration(Res) was stable between daytime and nighttime. The daytime hourly GPP and ET displayed asymptotic relationships with net solar radiation(Rnet), while showed concave patterns with raising vapor pressure deficit(VPD) and air temperature(Ta). The increases in hourly GPP and ET towards the maximum occurred over half ranges of VPD and Ta. The seasonal variations of GPP, NEE and ET were close to the cotton phenology, which almost reached the peak value in July. The cumulative GPP averaged 816.2±55.0 g C/m2 in the growing season(from April to October), and more than half of GPP was partitioned into NEE(mean value of –478.6±41.4 g C/m2). The mean seasonal ET was 501.3±13.9 mm, and the mean water use efficiency(WUE) was 1.0±0.1(mg C/g H2O)/d. The agro-ecosystem behaved as a carbon sink from squaring to harvest period, while it acted as a carbon source before the squaring time as well as after the harvest time. | Jie BAI Jin WANG Xi CHEN Ge Ping LUO Hao SHI Long Hui LI Jun Li LI | 2015 | Journal of Arid Land2015，7，2： | 12 |
| 4 | Comparative investigation on high-speed grinding of TiCp/Ti–6Al–4V particulate reinforced titanium matrix composites with single-layer electroplated and brazed CBN wheels显示文摘In order to develop the high-efficiency and precision machining technique of Ti Cp/Ti–6Al–4V particulate reinforced titanium matrix composites(PTMCs), high-speed grinding experiments were conducted using the single-layer electroplated cubic boron nitride(CBN) wheel and brazed CBN wheel, respectively. The comparative grinding performance was studied in terms of grinding force, grinding temperature, grinding-induced surface features and defects. The results display that the grinding forces and grinding temperature obtained with the brazed CBN wheel are always lower than those with the electroplated CBN wheel. Though the voids and microcracks are the dominant grinding-induced surface defects, the brazed CBN wheel produces less surface defects compared to the electroplated wheel according to the statistical analysis results. The maximum materials removal rate with the brazed CBN wheel is much higher than that with the electroplated one. All above indicate that the single-layer brazed CBN super-abrasive wheel is more suitable for high-speed grinding of PTMCs than the electroplated counterpart. | Li Zheng Ding Wenfeng Shen Long Xi Xinxin Fu Yucan | 2016 | Chinese Journal of Aeronautics2016，29，5： | 11 |
| 5 | Super-resolution dipole orientation mapping via polarization demodulation显示文摘Fluorescence polarization microscopy(FPM)aims to detect the dipole orientation of fluorophores and to resolve structural information for labeled organelles via wide-field or confocal microscopy.Conventional FPM often suffers from the presence of a large number of molecules within the diffraction-limited volume,with averaged fluorescence polarization collected from a group of dipoles with different orientations.Here,we apply sparse deconvolution and least-squares estimation to fluorescence polarization modulation data and demonstrate a super-resolution dipole orientation mapping(SDOM)method that resolves the effective dipole orientation from a much smaller number of fluorescent molecules within a sub-diffraction focal area.We further apply this method to resolve structural details in both fixed and live cells.For the first time,we show that different borders of a dendritic spine neck exhibit a heterogeneous distribution of dipole orientation.Furthermore,we illustrate that the dipole is always perpendicular to the direction of actin filaments in mammalian kidney cells and radially distributed in the hourglass structure of the septin protein under specific labelling.The accuracy of the dipole orientation can be further mapped using the orientation uniform factor,which shows the superiority of SDOM compared with its wide-field counterpart as the number of molecules is decreased within the smaller focal area.Using the inherent feature of the orientation dipole,the SDOM technique,with its fast imaging speed(at sub-second scale),can be applied to a broad range of fluorescently labeled biological systems to simultaneously resolve the valuable dipole orientation information with super-resolution imaging. | Karl Zhanghao Long Chen Xu-San Yang Miao-Yan Wang Zhen-Li Jing Hong-Bin Han Michael Q Zhang Dayong Jin Jun-Tao Gao Peng Xi | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 6 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 7 | Study of Static Adsorption Capacity of ACF for Xenon at 201 K显示文摘The static adsorption performances of a series of active carbon fiber(ACF)for xenon at 201 K were measured with a model ASAP2010M specific surface area and aperture distribution instrument by changing the working gas of instrument from N 2 to Xenon. Compared with grain active carbon(GAC): (1) the adsorption performance of Viscose based ACF(VACF) adsorbents is better than that of GAC; (2) owing to the difference of aperture distribution, the adsorption performance of ACF with different radicales is different under the same experiment conditions though the specific surface area is similar; (3) there is no definite relationship between adsorption performance and specific surface area; (4) the VACF A2 is the superior xenon adsorbent at the experimental temperature. | WANG Ya long ** , ZHANG Hai tao, WANG Xu hui, ZHANG Li xing, CHEN Li yun, XIE Jin chuan (Northwest Institute of Nuclear Technology, Xian 710024, P. R. China) | 2002 | Chemical Research in Chinese Universities2002，18，2： | 9 |
| 8 | Astaxanthin promotes M2 macrophages and attenuates cardiac remodeling after myocardial infarction by suppression inflammation in rats显示文摘Background:Cardiac remodeling after acute myocardial infarction(AMI)is an important process.The present study aimed to assess the protective effects of astaxanthin(ASX)on cardiac remodeling after AMI.Methods:The study was conducted between April and September 2018.To create a rat AMI model,rats were anesthetized,and the left anterior descending coronary artery was ligated.The rats in the ASX group received 10 mg·kg-1·day-1 ASX by gavage for 28 days.On the 1st day after AMI,but before ASX administration,six rats from each group were sacrificed to evaluate changes in the heart function and peripheral blood(PB)levels of inflammatory factors.On the 7th day after AMI,eight rats from each group were sacrificed to evaluate the PB levels of inflammatory factors and the M2 macrophage count using both immunofluorescence(IF)and flow cytometry(FC).The remaining rats were observed for 28 days.Cardiac function was examined using echocardiography.The inflammatory factors,namely,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and IL-10,were assessed using enzyme-linked immunosorbent assay.The heart weight/body weight(BW),and lung weight(LW)/BW ratios were calculated,and myocardial fibrosis in the form of collagen volume fraction was measured using Masson trichrome staining.Hematoxylin and eosin(H&E)staining was used to determine the myocardial infarct size(MIS),and TdT-mediated dUTP nick-end labeling staining was used to analyze the myocardial apoptosis index.The levels of apoptosis-related protein,type I/III collagen,transforming growth factorβ1(TGF-β1),metalloproteinase 9(MMP9),and caspase 3 were assessed by Western blotting.Unpaired t-test,one-way analysis of variance,and non-parametric Mann-Whitney test were used to analyze the data.Results:On day 1,cardiac function was worse in the ASX group than in the sham group(left ventricular end-systolic diameter[LVIDs]:0.72±0.08 vs.0.22±0.06 cm,t=-11.38;left ventricular end-diastolic diameter[LVIDd]:0.89±0.09 vs.0.48±0.05 cm,t=-9.42;end-systolic volume[ESV]:0.80[0.62,0.94]vs.0.04[0.03,0.05]mL,Z=-2.89;end-diastolic volume[EDV]:1.39[1.03,1.49]vs.0.28[0.22,0.32]mL,Z=-2.88;ejection fraction[EF]:0.40±0.04 vs.0.86±0.05,t=10.00;left ventricular fractional shortening[FS]rate:0.19[0.18,0.20]%FS vs.0.51[0.44,0.58]%FS,Z=-2.88,all P<0.01;n=6).The levels of inflammatory factors significantly increased(TNF-α:197.60[133.89,237.94]vs.50.48[47.2157.10]pg/mL,Z=-2.88;IL-1β:175.23[160.74,215.09]vs.17.78[16.83,19.56]pg/mL,Z=-2.88;IL-10:67.64[58.90,71.46]vs.12.33[11.64,13.98]pg/mL,Z=-2.88,all P<0.01;n=6).On day 7,the levels of TNF-αand IL-1βwere markedly lower in the ASX group than in the AMI group(TNF-α:71.70[68.60,76.00]vs.118.07[106.92,169.08]pg/mL,F=42.64;IL-1β:59.90[50.83,73.78]vs.151.60[108.4,198.36]pg/mL,F=44.35,all P<0.01,n=8).Conversely,IL-10 levels significantly increased(141.84[118.98,158.36]vs.52.96[42.68,74.52]pg/mL,F=126.67,P<0.01,n=8).The M2 macrophage count significantly increased(2891.42±211.29 vs.1583.38±162.22,F=274.35,P<0.01 by immunofluorescence test;0.96±0.18 vs.0.36±0.05,F=46.24,P<0.05 by flowcytometry test).On day 28,cardiac function was better in the ASX group than in the AMI group(LVIDs:0.50[0.41,0.56]vs.0.64[0.56,0.74]cm,Z=-3.60;LVIDd:0.70[0.60,0.76]vs.0.80[0.740.88]cm,Z=-2.96;ESV:0.24[0.18,0.45]vs.0.58[0.44,0.89]mL,Z=-3.62;EDV:0.76[0.44,1.04]vs.1.25[0.82,1.46]mL,Z=-2.54;EF:0.60±0.08 vs.0.50±0.12,F=160.48;%FS:0.29[0.24,0.31]vs.0.20[0.17,0.21],Z=-4.43,all P<0.01;n=16).The MIS and LW/BW ratio were markedly lower in the ASX group than in the AMI group(myocardial infarct size:32.50±1.37 vs.50.90±1.73,t=23.63,P<0.01,n=8;LW/BW:1.81±0.15 vs.2.17±0.37,t=3.66,P=0.01,n=16).The CVF was significantly lower in the ASX group than in the AMI group:12.88±2.53 vs.28.92±3.31,t=10.89,P<0.01,n=8.The expression of caspase 3,TGF-β1,MMP9,and type I/III collagen was lower in the ASX group than in the AMI group(caspase 3:0.38±0.06 vs.0.66±0.04,t=8.28;TGF-β1:0.37±0.04 vs.0.62±0.07,t=6.39;MMP9:0.20±0.06 vs.0.40±0.06,t=4.62;type I collagen:0.42±0.09 vs.0.74±0.07,t=5.73;type III collagen:0.13±0.02 vs.0.74±0.07,t=4.32,all P<0.01;n=4).Conclusions:ASX treatment after AMI may promote M2 macrophages and effectively attenuate cardiac remodeling by inhibiting inflammation and reducing myocardial fibrosis. | Xia Pan Kai Zhang Cheng Shen Xi Wang Long Wang Ya-Yi Huang | 2020 | Chinese Medical Journal2020，，15： | 8 |
| 9 | Genetic Analysis of Two Weak Dormancy Mutants Derived from Strong Seed Dormancy Wild Type Rice N22 (Oryza sativa)显示文摘Two weak dormancy mutants,designated Q4359 and Q4646,were obtained from the rice cultivar N22 after treatment with 400 Gy 60Co gamma-radiation.Compared to the N22 cultivar,the dormancy of the mutant seeds was more readily broken when exposed to a period of room temperature storage.The mutants also showed a reduced level of sensitivity to abscisic acid compared to the N22 cultivar,although Q4359 was more insensitive than Q4646.A genetic analysis indicated that in both mutants,the reduced dormancy trait was caused by a single recessive allele of a nuclear gene,but that the mutated locus was different in each case.The results of quantitative trait locus(QTL)mapping,based on the F2 population from Q4359 x Nanjing35,suggested that Q4359 lacks the QTL qSdn-1 and carries a novel allele at QTL qSdn-9, while a similar analysis of the Q4646 x Nanjing35 F2 population suggested that Q4646 lacks QTL qSdn-5, both qSdn-1 and qSdn-5 are major effect seed dormancy QTL in N22.Therefore,these two mutants were helpful to understand the mechanism of seed dormancy in N22. | Bingyue Lu KunXie Chunyan Yang Long Zhang Tao Wu Xi Liu Ling Jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，5： | 7 |
| 10 | Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model显示文摘Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction(MI). Increasing evidence indicates that neuregulin-1(NRG-1) improves cardiac function following heart failure. Since its impact on cardiac function and neural remodeling post-MI is poorly understood, we aimed to investigate the role of NRG-1 in autonomic nervous system remodeling post-MI. Forty-five Sprague-Dawley rats were equally randomized into three groups: sham(with the left anterior descending coronary artery exposed but without ligation), MI(left anterior descending coronary artery ligation), and MI plus NRG-1(left anterior descending coronary artery ligation followed by intraperitoneal injection of NRG-1(10 μg/kg, once daily for 7 days)). At 4 weeks after MI, echocardiography was used to detect the rat cardiac function by measuring the left ventricular end-systolic inner diameter, left ventricular diastolic diameter, left ventricular end-systolic volume, left ventricular end-diastolic volume, left ventricular ejection fraction, and left ventricular fractional shortening. m RNA and protein expression levels of tyrosine hydroxylase, growth associated protein-43(neuronal specific protein), nerve growth factor, choline acetyltransferase(vagus nerve marker), and vesicular acetylcholine transporter(cardiac vagal nerve fiber marker) in ischemic myocardia were detected by real-time PCR and western blot assay to assess autonomous nervous remodeling. After MI, the rat cardiac function deteriorated significantly, and it was significantly improved after NRG-1 injection. Compared with the MI group, m RNA and protein levels of tyrosine hydroxylase and growth associated protein-43, as well as choline acetyltransferase m RNA level significantly decreased in the MI plus NRG-1 group, while m RNA and protein levels of nerve growth factor and vesicular acetylcholine transporters, as well as choline acetyltransferase protein level slightly decreased. Our results indicate that NRG-1 can improve cardiac function and regulate sympathetic and vagus nerve remodeling post-MI, thus reaching a new balance of the autonomic nervous system to protect the heart from injury. | Xin Lai Liang Zhong Hai-xia Fu Song Dang Xin Wang Ning Zhang Gao-ke Feng Zi-qiang Liu Xi Wang Long Wang | 2017 | Neural Regeneration Research2017，12，11： | 7 |
| 11 | MmNet:Identifying Mikania micrantha Kunth in the wild via a deep Convolutional Neural Network显示文摘Mikania micrantha Kunth is an invasive alien weed and known as a plant killer around the world.Accurately and rapidly identifying M.micrantha in the wild is important for monitoring its growth status,as this helps management officials to take the necessary steps to devise a comprehensive strategy to control the invasive weed in the identified area.However,this approach still mainly depends on satellite remote sensing and manual inspection.The cost is high and the accuracy rate and efficiency are low.We acquired color images of the monitoring area in the wild environment using an Unmanned Aerial Vehicle(UAV)and proposed a novel network-MmNet-based on a deep Convolutional Neural Network(CNN)to identify M.micrantha in the images.The network consists of AlexNet Local Response Normalization(LRN),along with the GoogLeNet and continuous convolution of VGG inception models.After training and testing,the identification of 400 testing samples by MmNet is very good,with accuracy of 94.50%and time cost of 10.369 s.Moreover,in quantitative comparative analysis,the proposed MmNet not only has high accuracy and efficiency but also simple construction and outstanding repeatability.Compared with recently popular CNNs,MmNet is more suitable for the identification of M.micrantha in the wild.However,to meet the challenge of wild environments,more M.micrantha images need to be acquired for MmNet training.In addition,the classification labels need to be sorted in more detail.Altogether,this research provides some theoretical and scientific basis for the development of intelligent monitoring and early warning systems for M.micrantha and other invasive species. | QIAO Xi LI Yan-zhou SU Guang-yuan TIAN Hong-kun ZHANG Shuo SUN Zhong-yu YANG Long WAN Fang-hao QIAN Wan-qiang | 2020 | Journal of Integrative Agriculture2020，19，5： | 7 |
| 12 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 13 | Functionalized graphene oxide based on p-phenylenediamine as spacers and nitrogen dopants for high performance supercapacitors显示文摘p-Phenylenediamine(PPD)functionalized graphene oxide(GO)materials(PPDG)were prepared through a one-step solvothermal process and their application as supercapacitors(SCs)were studied.The PPD is not only as the spacers to prevent aggregating and restacking of the graphene sheets in the preparing process but also as nitrogen sources to obtain the nitrogen-doped graphene.The structures of PPDG were characterized by Fourier transformed infrared spectroscopy(FT-IR),X-ray diffraction spectroscopy(XRD),Raman spectroscopy and X-ray photoelectron spectroscopy(XPS)and the results show that the nitrogen-doped graphene was achieved with nitrogen content as high as 10.85 at.%.The field emission scanning electron microscopy(FE-SEM)and high resolution transmission electron microscopy(HR-TEM)have confirmed that the morphologies of PPDG were loose layered with less aggregation,indicating that PPD molecules,as spacers,effectively prevent the graphene sheets from restacking during the solvothermal reaction.The special loose textures make PPDG materials exhibit excellent electrochemical performance for symmetric SCs with superior specific capacitance(313 F/g at 0.1 A/g),rate capability and cycling stability.The present synthesis method is convenient and may have potential applications as ultrahigh performance SCs. | Yanhong Lu Yi Huang Fan Zhang Long Zhang Xi Yang Tengfei Zhang Kai Leng Mingjie Zhang Yongsheng Chen | 2014 | Chinese Science Bulletin2014，59，16： | 5 |
| 14 | CYCLIC AMP-DEPENDENT PROTEIN KINASE CONTRIBUTES TO THE EXCITATORY RESPONSE TO NOREPINEPHRINE IN CHRONICALLY COMPRESSED RAT DORSAL ROOT GANGLION NEURONS显示文摘Chronic compression of the dorsal root ganglion (DRG) in the rat, which closely mimics intervertbral foraminal stenosis in humans, produces mechanical and thermal hyperalgesia as shown by behavioral signs. The present study was undertaken to further investigate the catecholarnine sensitivity and its underlying intracellular mechanism in sensory neurons with a new model of chronic DRG compression. Extracellular recordings of | Hui XU~1, San-Jue HU~1, Kai-Ping Long~2, Hong-Jun YANG~2 ~1Institute of Neuroscience, ~2Department of Physics, The Fourth Military Medical University, Xi’an, 710032 | 2001 | 神经解剖学杂志2001，17，B07： | 5 |
| 15 | Computational methods in super-resolution microscopy显示文摘超分辨显微成像技术已广泛应用于多个领域。其中,计算方法的优化和提升,对超分辨显微系统成像质量优化至关重要。本文综述了目前主流超分辨显微技术采用的计算方法,包括反卷积显微技术、基于偏振的超分辨显微技术、结构光照明显微技术、图像扫描显微技术、超分辨光学涨落显微成像技术、单分子定位显微技术、贝叶斯分析超分辨显微技术、受激辐射损耗显微技术和移位显微技术。新计算方法的发展将有助于提升超分辨显微的成像效果,使其具备更好的分辨率、更高的精度和更快的图像处理速度。 | Zhi-ping ZENG Hao XIE Long CHEN Karl ZHANGHAO Kun ZHAO Xu-san YANG Peng XI | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，9： | 4 |
| 16 | Quality metrics and outcomes among critically ill patients in China:results of the national clinical quality control indicators for critical care medicine survey 2015-2019显示文摘Background:It is crucial to improve the quality of care provided to ICU patient,therefore a national survey of the medical quality of intensive care units(ICUs)was conducted to analyze adherence to quality metrics and outcomes among critically ill patients in China from 2015 to 2019.Methods:This was an ICU-level study based on a 15-indicator online survey conducted in China.Considering that ICU care quality may vary between secondary and tertiary hospitals,direct standardization was adopted to compare the rates of ICU quality indicators among provinces/regions.Multivariate analysis was performed to identify potential factors for in-hospital mortality and factors related to ventilator-associated pneumonia(VAP),catheter-related bloodstream infections(CRBSIs),and catheter-associated urinary tract infections(CAUTIs).Results:From the survey,the proportions of structural indicators were 1.83%for the number of ICU inpatients relative to the total number of inpatients,1.44%for ICU bed occupancy relative to the total inpatient bed occupancy,and 51.08%for inpatients with Acute Physiology and Chronic Health Evaluation II scores≥15.The proportions of procedural indicators were 74.37%and 76.60%for 3-hour and 6-hour surviving sepsis campaign bundle compliance,respectively,62.93%for microbiology detection,58.24%for deep vein thrombosis prophylaxis,1.49%for unplanned endotracheal extubations,1.99%for extubated inpatients reintubated within 48 hours,6.38%for unplanned transfer to the ICU,and 1.20%for 48-hour ICU readmission.The proportions of outcome indicators were 1.28‰for VAP,3.06‰for CRBSI,3.65‰for CAUTI,and 10.19%for in-hospital mortality.Although the indicators varied greatly across provinces and regions,the treatment level of ICUs in China has been stable and improved based on various quality control indicators in the past 5 years.The overall mortality rate has dropped from 10.19%to approximately 8%.Conclusions:The quality indicators of medical care in China’s ICUs are heterogeneous,which is reflected in geographic disparities and grades of hospitals.This study is of great significance for improving the homogeneity of ICUs in China. | Xi Rui Fen Dong Xudong Ma Longxiang Su Guangliang Shan Yanhong Guo Yun Long Dawei Liu Xiang Zhou | 2022 | Chinese Medical Journal2022，，9： | 4 |
| 17 | Autophagy and the nutritional signaling pathway显示文摘During their growth and development, animals adapt to tremendous changes in order to survive. These include responses to both environmental and physiological changes and autophagy is one of most important adaptive and regulatory mechanisms. Autophagy is defined as an autolytic process to clear damaged cellular organelles and recycle the nutrients via lysosomic degradation. The process of autophagy responds to special conditions such as nutrient withdrawal. Once autophagy is induced,phagophores form and then elongate and curve to form autophagosomes. Autophagosomes then engulf cargo,fuse with endosomes, and finally fuse with lysosomes for maturation. During the initiation process, the ATG1/ULK1(unc-51-like kinase 1) and VPS34(which encodes a class III phosphatidylinositol(Ptd Ins) 3-kinase) complexes are critical in recruitment and assembly of other complexes required for autophagy. The process of autophagy is regulated by autophagy related genes(ATGs). Amino acid and energy starvation mediate autophagy by activating m TORC1(mammalian target of rapamycin) and AMPactivated protein kinase(AMPK). AMPK is the energy status sensor, the core nutrient signaling component and the metabolic kinase of cells. This review mainly focuses on the mechanism of autophagy regulated by nutrient signaling especially for the two important complexes,ULK1 and VPS34. | Long HE Shabnam ESLAMFAM Xi MA Defa LI | 2016 | Frontiers of Agricultural Science and Engineering2016，3，3： | 4 |
| 18 | Defective T wave combined with incomplete right bundle branch block: a new electrocardiographic index for diagnosing atrial septal defect显示文摘 | WANG Mu-xuan WU Gui-fu GU Jing-li LI Li LU Kun YANG Da CHEN Long ZHANG Xi LUO Fu-tian Andrew D. Michaels MA Hong | 2012 | Chinese Medical Journal2012，，6： | 4 |
| 19 | Effect of transverse static magnetic field on radial microstructure of hypereutectic aluminum alloy during directional solidification显示文摘The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directional solidification,focusing on the formation of freckle.Our experimental and numerical simulation results indicate that the TEMC circulation at sample scale under transverse static magnetic field leads to the enrichment of solute Al on one side of the sample.The TEMC and the solute enrichment degree increase with the increase of magnetic field when the magnetic field increases to 0.5 T.The enrichment degree of solute elements under magnetic field is affected by temperature gradient and growth rate.The non-uniform distribution of solute Al in the radial direction of the sample results in the non-uniform distribution of primary dendrite arm spacing(PDAS).Moreover,the applied magnetic field can lead to freckle formation and its number increases with the increase of magnetic field.The change of freckle is consistent with the anisotropy TEMC caused by the anisotropy of primary dendrite or primary dendrite network under magnetic field.Finally,the mechanism of synergism effect of the anisotropy TEMC,the distribution of solute Al and the PDAS on freckle formation and evolution is studied during directional solidification under magnetic field. | Shaodong Hu Long Hou Kang Wang Zhongmiao Liao Wen Zhu Aihua Yi Wenfang Li Yves Fautrelle Xi Li | 2021 | Journal of Materials Science & Technology2021，，17： | 4 |
| 20 | Electrochemical property of LiFePO4/C composite cathode with different carbon sources显示文摘To improve the performance of battery cathode materials that consist of carbonaceous organic material,carbon coatings on lithium iron phosphate (LiFePO_4/C)materials were synthesized by different carbon sources.LiFePO_4/C was synthesized by a combination method of sol-gel and gas-phase diffused permeation. LiFeO_4/C materials were prepared by coating different carbon contents. High-performance composite materials were prepared by combining carbon with element doped by two modified methods. The elements of Fe and C came from Fe3+and sucrose, glucose, citric acid. Thermogravimetrydifferential thermal analysis (TG-DTA), X-ray diffractometer (XRD), scanning electron microscope (SEM),cycle voltammetry (CV), and charge-discharge test were used to characterize and test the surface morphology,structure, and electrochemical performance. The results show that LiFePO_4/C synthesized with sucrose has higher specific discharge capacity than the other materials. The specific discharge capacity of this material is 84.27 mAh·g^(-1). The capacity retention could attain 94%of the initial discharge capacity after 30 cycles, showing good electrochemical performance. | Xin Li Yu Zhi Jiang Xi Kun Li Hai Xia Jiang Jun Long Liu Jun Feng Shi Bin Lin Xin Guan | 2018 | Rare Metals2018，37，9： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员