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| 1 | Xinfeng capsule improves pulmonary function in ankylosing spondylitis patients via NF-κB-iNOS-NO signaling pathway显示文摘OBJECTIVE: To study changes in the nuclear factor-κB p65(NF-κB p65)-inducible nitric oxide synthase(i NOS)-nitric oxide(NO) signaling pathway and the effects of Xinfeng capsules(XFC) in patients with ankylosing spondylitis(AS)METHODS: One hundred twenty patients with AS were randomly divided into an XFC group and a Salazopyrin group. Sixty health subjects were included as a normal control group. In the two treatment groups, pulmonary functional parameters,forced vital capacity(FVC), forced expiratory volume in 1 second(FEV1), maximal voluntary ventilation(MVV), peak expiratory flow(PEF), forced expiratory flow at 25% of forced vital capacity(FEF25),forced expiratory flow at 50% of forced vital capacity(FEF50), and forced expiratory flow at 75% of forced vital capacity(FEF75) were determined. Enzyme linked immunosorbent assays were used for detection of the serum oxidative stress indexes,NF-κB p65, i NOS, NO, reactive oxygen species(ROS), reactive nitrogen species(RNS), malondialdehyde(MDA), superoxide dismutase(SOD), catalase(CAT), total antioxidative capacity(TAOC) and interleukin-4(IL-4), IL-10, IL-1β, and tumor necrosis factor-α(TNF-α) contents. Westergren's method was used for determination of erythrocyte sedimentation rate(ESR). High-sensitivity C-reactive protein(Hs-CRP) was detected with a 7060 full-automatic biochemical analyzer(Hitachi, Japan).RESULTS: The clinical therapeutic effect in the XFC group was significantly superior to that in the Salazopyrin group(P<0.01). Compared with the normal control group, FEV1, MVV, PEF, FEF50, FEF75, SOD, CAT,TAOC, IL-4, IL-10 were significantly lower, and NF-κB p65, i NOS, NO, ROS, RNS, MDA, IL-1β, TNF-α, ESR,and Hs-CRP significantly higher in patients with AS(P<0.01 or P<0.05). Compared with before treatment, FEV1, MVV, PEF, FEF50, FEF75, SOD, CAT, TAOC,IL-4, and IL-10 were significantly increased, and NF-κB p65, i NOS, NO, ROS, RNS, MDA, IL-1β, TNF-α,ESR, CRP, visual analog scales(VAS), Bath ankylosing spondylitis disease active index, Bath ankylosing spondylitis functional index, and Bath ankylosing spondylitis global index significantly decreased in the two treatment groups after treatment(P<0.01 or P<0.05), with significant differences between the XFC and Salazopyrin groups(P<0.01 or P<0.05). Spearman correlation analysis indicated that FEV1, MVV, PEF, FEF50, and FEF75 were positively correlated with SOD, CAT, TAOC, IL-4, and IL-10, and were negatively correlated with NF-κB p65, i NOS,NO, ROS, RNS, MDA, IL-1β, TNF-α, ESR, and CRP.CONCLUSION: Patients with AS have local pathologic changes in the spinal cord and other joints.They also have decreased pulmonary function,which is negatively correlated with the NF-κB-i NOS-NO signaling pathway, oxidative indexes, and inflammatory factors. XFC improves rigidity and pain in spinal joints and other symptoms, laboratory indexes, and pulmonary function. The mechanism is possibly related to inhibition of the NF-κB-i NOS-NO signaling pathway. | Jian Liu Yajun Qi Li Zheng Yunxiang Cao Lei Wan Wenfang Ye Li Fang | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 24 |
| 2 | Study on BaTiO_3 films prepared by AC power microarc oxidation显示文摘BaTiO3 films were prepared by microarc oxidation (MAO) with an in-house built alternating current (AC) power supply in Ba(OH)2 solution in this study. The surface morphology, combinability with the substrate and phase composition of the films were investigated by XRD, SEM and TEM. The BaTiO3 films were annealed at a temperature range of 900 to 1200℃ and phase compositions were tested thereafter. The results showed that the BaTiO3 films were mainly composed of the primitive hexagonal phase with relatively small amount of tetragonal and amorphous phases. Moreover, the amount of amorphous phase decreased with the time of annealing. The transformation of BaTiO3 from hexagonal structure to tetragonal stucture became obvious until the annealing temperature reached 1200℃. The film consisted mainly of BaTiO3 tetragonal structure with ferroelectric property. The influence of annealing on surface morphology and mechanism of phase transformation of the films were also discussed. | HUANG WenBo, LI WenFang & HAN Bing College of Material Science and Engineering, South China University of Technology, Guangzhou 510640, China | 2009 | Science China(Technological Sciences)2009，52，8： | 11 |
| 3 | Investigation of the Ce-Mn conversion coating on 6063 aluminium alloy显示文摘In this paper,the sustainable Ce-Mn chemical conversion coating was fabricated on 6063 aluminium alloy by means of Ce(NO3)3 and KMnO4 as the inhibitors and NaF as the accelerator.The morphologies,composition and valence state of the coating were analyzed by scanning electron microscopy(SEM),energy dispersive spectrometry(EDS) and X-ray photoelectron spectroscopy(XPS),respectively.The results indicated that the Ce-Mn conversion coating was formed.The anticorrosion of the coating was evaluated in 3.5 wt.% NaCl aqueous solution at room temperature by using polarization curve and electrochemical impedance spectroscopy(EIS).It indicated that the treated surface presented better anticorrosion behavior in chloride media than on the original material surface.The corrosion resistance of Ce-Mn conversion coating was about equal to the trivalent chromium conversion coating. | ZHANG JunJun LI WenFang DU Jun HAN Dong ZHENG XiaoPing | 2010 | Chinese Science Bulletin2010，55，29： | 9 |
| 4 | Microstructure evolution of rare earth Pr modified alumina-silicate short fiber-reinforced Al-Si metal matrix composites显示文摘Al-Si metal matrix composites (MMCs) reinforced with 20 vol.% alumina-silicate shot fibers (Al2O3-SiO2(sf)) were fabricated by an infiltration squeeze method. Pure Pr metal was added into these composites. The effect of Pr addition on the microstructure evolution of Al-Si MMCs was investigated by SEM,TEM,and EDS. Pr addition is favorable to make uniform microstructures with the modified eutectic Si crystal. PrAlSi phase with high contents of Pr and Si is observed on the interface between the fiber and the matrix. The addition of Pr promotes interface SiO2 reduction,and SiO2 comes from the crystallization of Al2O3-SiO2 short fibers. | Peng Jihua Li Wenfang Huang Fangliang Tian Jun Liu Gang Du Jun | 2009 | Rare Metals2009，28，2： | 6 |
| 5 | Viral MIPα homologous with human MIP-1α acts on HIV co-receptor CCR5显示文摘The function and usage of vMIPα encoded by K6 gene of herpesvirus 8 (HHV8) which has homology with human macrophage protein (MIP) have not been clearly known. In the present note the K6 gene of HHV8 was cloned and transfected into NIH3T3 cells and E. coli cells. Conditional media from the 3T3-transfected cells and K6 product vMIPa from E. coli. Cells were used to perform the experiments of ligand-receptor binding and cellular adhesion with peripheral blood macrophages. The conditional media and the purified vMIPa from E. coli could compete to bind to CCR5 located on macrophages from peripheral blood with I125-hMIP-1α chemokine of human. Cellular adhesion showed that the conditional media from transfected cells and the purified vMIPa did not induce the adhesion of macrophages from peripheral blood to ICAM-1. In conclusion, vMIPα encoded by K6 gene of HHV8 can bind to CCR5 of peripheral blood macrophage cells and does not induce their adhesion. This suggests that vMIPa enclosed CCR5, also known as HIV | Hanxiao Sun Lixia Feng Yicheng Li Wenfang He | 2001 | Chinese Science Bulletin2001，46，15： | 6 |
| 6 | PpERF3 positively regulates ABA biosynthesis by activating PpNCED2/3 transcription during fruit ripening in peach显示文摘The plant hormone ethylene regulates ripening in climacteric fruits.The phytohormone abscisic acid(ABA)affects ethylene biosynthesis,but whether ethylene influences ABA biosynthesis is unknown.To explore this possibility,we investigated the interactions between the ABA biosynthesis genes PpNCED2/3 and the ethylene response transcription factor PpERF3 in peach fruit.The ABA content increased during fruit maturation and reached a peak at stage S4 III.The increase was greatly inhibited by the ethylene inhibitor 1-MCP,which also suppressed PpERF3 expression.PpERF3 shared a similar expression profile with PpNCED2/3,encoding a rate-limiting enzyme involved in ABA biosynthesis,during fruit ripening.A yeast one-hybrid assay suggested that the nuclear-localized PpERF3 might bind to the promoters of PpNCED2/3.PpERF3 increased the expression of PpNCED2/3 as shown by dual-luciferase reporters,promoter-GUS assays and transient expression analyses in peach fruit.Collectively,these results suggest that ethylene promotes ABA biosynthesis through PpERF3’s regulation of the expression of ABA biosynthesis genes PpNCED2/3. | Xiaobei Wang Wenfang Zeng Yifeng Ding Yan Wang Liang Niu Jia-Long Yao Lei Pan Zhenhua Lu Guochao Cui Guohuai Li Zhiqiang Wang | 2019 | Horticulture Research2019，6，1： | 5 |
| 7 | Effect of transverse static magnetic field on radial microstructure of hypereutectic aluminum alloy during directional solidification显示文摘The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directional solidification,focusing on the formation of freckle.Our experimental and numerical simulation results indicate that the TEMC circulation at sample scale under transverse static magnetic field leads to the enrichment of solute Al on one side of the sample.The TEMC and the solute enrichment degree increase with the increase of magnetic field when the magnetic field increases to 0.5 T.The enrichment degree of solute elements under magnetic field is affected by temperature gradient and growth rate.The non-uniform distribution of solute Al in the radial direction of the sample results in the non-uniform distribution of primary dendrite arm spacing(PDAS).Moreover,the applied magnetic field can lead to freckle formation and its number increases with the increase of magnetic field.The change of freckle is consistent with the anisotropy TEMC caused by the anisotropy of primary dendrite or primary dendrite network under magnetic field.Finally,the mechanism of synergism effect of the anisotropy TEMC,the distribution of solute Al and the PDAS on freckle formation and evolution is studied during directional solidification under magnetic field. | Shaodong Hu Long Hou Kang Wang Zhongmiao Liao Wen Zhu Aihua Yi Wenfang Li Yves Fautrelle Xi Li | 2021 | Journal of Materials Science & Technology2021，，17： | 4 |
| 8 | MRI结合数字化钼靶诊断乳腺癌的临床研究(英文)显示文摘目的将在乳癌的察觉和诊断比较数字早期胸部肿瘤Ⅹ射线测定法和 MRI 的有效性并且象二的联合一样估计这些形式的价值。有外科和病理的 57 个病人证明了胸损害的方法(恶意, n = 32;良性, n = 46 ) 经历了数字早期胸部肿瘤Ⅹ射线测定法和 MRI,脉搏序列包括了 T 1 WI, T 2 WI,弥漫的加权的成像(DWI ) ,和在外科前的动态提高对比的 MRI。这二种形式的结果,所有损害根据 BI-RADS 分类被分类进 5 个组,并且成像调查结果被相关到组织病理学说。每种形式的敏感以及二的联合是计算的。这 78 乳房损害的结果,敏感为数字早期胸部肿瘤Ⅹ射线测定法是 78.13%%(25/32 ) 并且 93.75%(30/32 ) 为 MRI (P >
0.05 ) 。特性是 73.91%%(34/46 ) 并且 89.13%(41/46 ) 因此(P <
0.05 ) ,他们俩出现了统计差别。当这二种形式在联合被使用,敏感和特性分别地是 98.63% 和 97.16% 。在有 MRI 的联合的结论数字早期胸部肿瘤Ⅹ射线测定法在乳癌,敏感和特性的诊断是有用的当时,被提高与单个形式的相比。 | Fang Ye Mengsu Zeng Fuhua Yan Wei Feng Meiling Zhou Renchen Li Wenfang Chen | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 3 |
| 9 | Robust hydrogen production from HCOOH over amino-modified KIT-6-confined Pd Ir alloy nanoparticles显示文摘Formic acid (FA), which can be produced via CO_(2) reduction and biomass conversion, has received extensive interest as a convenient and safe hydrogen carrier due to its wide range of sources, renewable, high hydrogen content (4.4 wt%), and convenient storage/transportation. Designing highly efficient catalysts is the main challenge to realize the hydrogen production from FA. In this work, well-dispersed and electron-rich PdIr alloy nanoparticles with a size of 1.8 nm are confined in amino-modified 3D mesoporous silica KIT-6 and applied as a highly efficient catalyst for robust hydrogen production from FA at ambient temperature. Small PdIr alloy nanoparticles confined by amino-modified KIT-6 (PdIr/KIT-6-NH_(2)) lead to better catalytic activity compared to that of Pd/KIT-6-NH_(2) and PdIr confined by bare KIT-6, achieving a high turnover frequency (TOF) value of 3533 h-1 at ambient temperature (303 K), 100% H_(2) selectivity and conversion toward the dehydrogenation of FA, which is comparable to the best heterogeneous catalysts ever reported. The high catalytic activity of PdIr/KIT-6-NH_(2) can be attributed to the synergistic effect between Pd and Ir, strong interaction between PdIr and KIT-6-NH_(2), as well as the amino-groups of KIT-6-NH_(2) which can act as a proton scavenger to promote the breaking of O-H bond of formic acid. | Wenfang Peng Shiwen Liu Xiugang Li Gang Feng Jianhui Xia Zhang-Hui Lu | 2022 | Chinese Chemical Letters2022，33，3： | 3 |
| 10 | Discussion on grain refining mechanism of AM30 alloy inoculated by MgCO_(3)显示文摘AM30 was inoculated by MgCO_(3) powder with different holding time.The influence of MgO decomposed by MgCO_(3)on the grain refinement effect was mainly discussed in the present study.Three sets of comparative samples were prepared.They were AM30 alloy inoculated by MgO and pure Mg inoculated by MgO and MgCO_(3).The possible nucleating particles were observed and analyzed by EPMA and SEM.AM30 alloy could be effectively refined by either MgCO_(3)or MgO inoculation.Grain refining efficiency and fading effect of MgO inoculation were better than those of MgCO_(3) inoculation.However,pure Mg could not be refined by these two inoculants.Al is an indispensable element to determine the grain refinement of Mg alloys inoculated by either MgCO_(3)or MgO.MgO should not be the effective substrates forα-Mg phase.A novel grain refining mechanism of MgCO_(3) inoculation on AM30 alloy was proposed by combining experimental results with theoretical calculation,i.e.,MgAl_(2)O_(4) should be the potent nuclei ofα-Mg grain for the AM30 alloy in addition to Al_(4)C_(3). | Jun Du Zejiang Yao Shuai Han Wenfang Li | 2017 | Journal of Magnesium and Alloys2017，5，2： | 3 |
| 11 | Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays显示文摘Androgen receptor(AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the conformational changes in AR that may affect the recruitment of coactivators and downstream response of AR signaling pathway.Therefore, AR ligands have great potential to treat these diseases. In this study, we searched for novel AR ligands by performing a docking-based virtual screening(VS) on the basis of the crystal structure of the AR ligand binding domain(LBD) in complex with its agonist. A total of 58 structurally diverse compounds were selected and subjected to LBD affinity assay, with five of them(HBP1-3, HBP1-17, HBP1-38, HBP1-51, and HBP1-58) exhibiting strong binding to AR-LBD. The IC50 values of HBP1-51 and HBP1-58 are 3.96 m M and 4.92 m M, respectively, which are even lower than that of enzalutamide(Enz, IC50= 13.87 m M), a marketed second-generation AR antagonist. Further bioactivity assays suggest that HBP1-51 is an AR agonist, whereas HBP1-58 is an AR antagonist. In addition, molecular dynamics(MD) simulations and principal components analysis(PCA) were carried out to reveal the binding principle of the newlyidentified AR ligands toward AR. Our modeling results indicate that the conformational changes of helix 12 induced by the bindings of antagonist and agonist are visibly different. In summary,the current study provides a highly efficient way to discover novel AR ligands, which could serve as the starting point for development of new therapeutics for AR-related diseases. | Wenfang Zhou Mojie Duan Weitao Fu Jinping Pang Qin Tang Huiyong Sun Lei Xu Shan Chang Dan Li Tingjun Hou | 2018 | Genomics, Proteomics & Bioinformatics2018，16，6： | 3 |
| 12 | EVOLUTION OF THE MICROCRACKS IN WHISKER TOUGHENING CERAMIC MATRIX COMPOSITES显示文摘The modified equivalent inclusion theory by the authors and the internalvariable theory are employed to investigate the evolution of the microcracks in whiskertoughening ceramics and the influence of the microcracks on the mechanical propertiesof the material. The effect of residual thermostrain, whisker content and aspect ratio isconsidered. The modulus, initial nonlinear load, strength and nonlinear constitutiverelation are calculated and some important conclusions are given. | Li Wenfang, South China University of Technology, Guangzhou 510641, R. R. ChinaDu Shanyi, Harbin Institute of Technology, Harbin 150001 | 1995 | Acta Mechanica Solida Sinica1995，8，1： | 2 |
| 13 | Effect of Sr on Grain Refinement of Mg–3%Al Alloy Containing Trace Fe by Carbon-Inoculation显示文摘Magnesium(Mg)–3% aluminum(Al)(in weight) alloy was modified by carbon(C) inoculation combining with strontium(Sr).The effects of trace 0.1% iron(Fe) addition and operating sequence of carboninoculation and Fe addition on the grain size of Mg–3%Al alloy were studied.The results reveal that the Sr addition could effectively suppress grain-coarsening resulted from the inclusion of Fe in the carboninoculated Mg–Al alloy.Sr addition could contribute to the formation of the duplex-phase particles that Al–C-rich phases coated on Al–Fe or Al–C–Fe-rich phases,regardless of the Fe addition sequence.These duplex-phase particles should be the potent substrates for α-Mg grains.Consequently,Sr addition could effectively subsidize the inhibiting effect of Fe on grain refinement and the active nuclei were maintained.In other words,Sr plays a counter role in the poisoning effect of Fe on the microstructure of Mg–3%Al alloy. | Jun Du Yutong Shi Mingchuan Zhou Wenfang Li | 2016 | Journal of Materials Science & Technology2016，32，12： | 2 |
| 14 | Effects of trace ytterbium addition on microstructure,mechanical and thermal properties of hypoeutectic Al-5Ni alloy显示文摘Over the past decade,the cast aluminum alloys with excellent mechanical and conductivity properties have emerged as potential materials for thermal management.However,the traditional Al-Si based alloys are difficult to make significant breakthrough in conductivity performance.The hypoeutectic Al-5Ni alloy also possesses sound castability and is expected to be applied in thermal management applications.In this study,the effects of ytterbium(Yb element) at 0-0.5 wt% on the microstructures as well as the electrical/thermal conductivity and mechanical properties of the Al-5Ni alloy were systematically investigated.The experimental results indicate that the addition of Yb at a relatively low amount not only reduces the secondary dendrite arm spacing of the α-Al grains,but also modifies the morphology and distribution of eutectic boundary phase.Moreover,it is found that the dosage of Yb at 0.3 wt% in the Al-5Ni alloy can simultaneously improve the yield strength,ultimate tensile strength and electrical/thermal conductivity.The strengthening and toughening of the Al-5Ni alloy are mainly attributed to the decrease of secondary dendrite arm spacing and the improvement of eutectic phases.The transmission electron microscopy/selected area electron diffraction(TEM/SAED) analysis indicates that the ytterbium in Al-5Ni alloy will form Al_(3)Yb phase,which mainly agglomerates in the Al_(3)Ni phase region.This phase is helpful to decrease the solubility of impurity elements(e.g.,Fe and Si) in the α-Al matrix,which is beneficial to electrical/thermal conductivity.The value of this study lays foundation for manufacturing Al-Ni alloys with high thermal conductivity and acceptable mechanical properties. | Kang Wang Shaodong Hu Yanglin Zhong Shuoxun Jin Zirong Zhou Zhiyu Wang Jiongcai Chen Bingbing Wan Wenfang Li | 2022 | Journal of Rare Earths2022，40，8： | 2 |
| 15 | WHIRLY1 recruits the histone deacetylase HDA15 repressing leaf senescence and flowering in Arabidopsis显示文摘Leaf senescence is controlled by a complex regulatory network in which robustness is ensured by the activity of transcription factors and epigenetic regulators.However,how these coordinate the process of leaf senescence remains poorly understood.We found that WHIRLY1 interacts with Histone Deacetylase(HDA)15,a Reduced Potassium Dependence3(RPD3)/HDA1-type HDA,by using green fluorescent protein-nanotrap-mass spectrum assays.The development-dependent interaction between WHIRLY1 and HDA15 was further confirmed by bimolecular fluorescence complementation assays and co-immunoprecipitation assays in Arabidopsis.Multi-omics genome-wide transcriptome and H3K9 acetylome enrichment analysis showed that HDA15 delays leaf senescence and flowering by repressing the expression of the positive regulators of leaf senescence and flowering,such as LOX2 and LARP1 C,and reducing H3K9 ac levels at these loci;WHIRLY1 and HDA15 co-target to the region near the transcription start site of a subset of nutrient recycling-related genes(e.g.,Glutathione S-transferases 10,non-coding RNA,and photosystem II protein D1 synthesizer attenuator PDIL1-2),as well as WRKY53 and ELF4,and co-repress their expression by removing H3K9 acetylation.Our study revealed a key transcription regulatory node of nutrient recycling and senescence-associated genes involved in leaf senescence and flowering via the recruitment of HDA15 by the single-stranded DNA/RNA-binding protein WHIRLY1. | Dongmei Huang Wei Lan Weibo Ma Rulin Huang Wenfang Lin Mengsi Li Chia-Yang Chen Keqiang Wu Ying Miao | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 16 | Research and Prospect of Mulberry (Morus alba L.)显示文摘Mulberry(Morus alba L.)is not only rich in nutrients,but also has medicinal value.As a drug and food,it is widely planted all over the country,with considerable yield and economic value.In recent years,it has attracted many scholars and been widely reported,and in-depth research has already been conducted.Through reviewing the literatures on mulberry,this paper summarized the chemical composition,pharmacological effects and quality evaluation of mulberry,providing some reference for the further development and utilization of mulberry. | Zhenhua SUN Li LI Wenfang MA | 2019 | Agricultural Biotechnology2019，8，4： | 2 |
| 17 | Ductile damage measurement and necking analysis of metal sheets based on digital image correlation and direct current potential drop methods显示文摘 | ZHANG Saijun XIA Qinxiang LI Wenfang | 2014 | International Journal of Damage Mechanics2014，23，8： | 1 |
| 18 | 显示文摘 | Li Wenfang Han Bing Du Jun | 2006 | Trans Nonferrous Met Soc China2006，16，： | 1 |
| 19 | Molten salt of lithium bis(fluorosulfonyl)imide (LiFSI)-potassium bis(fluorosulfonyl)imide (KFSI) as electrolyte for the natural graphite/LiFePO 4 lithium-ion cell显示文摘 | Fei Xu Chengyong Liu Wenfang Feng Jin Nie Hong Li Xuejie Huang Zhibin Zhou | 2014 | Electrochimica Acta2014，，： | 1 |
| 20 | Recent advance in the researchof flavonoids as anticancer agents 显示文摘 | LI Yanling FANG Hao XU Wenfang | 2007 | Mini Reviews in MedicinalChemistry2007，7，7： | 1 |
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