共被期刊论文引用了5次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 多节段背根节慢性压迫大鼠的机械触刺激和冷刺激诱发痛行为显示文摘目的:脊椎间盘突出、椎间孔狭窄、脊髓损伤以及肿瘤造成的背根节(dorsal root ganglion,DRG)及其邻近神经根的机械性压迫可能是引起腰背痛与坐骨神经痛的重要原因。临床上多节段神经根性痛比单一神经根性痛更常见,患者表现出多节段神经根压迫和多节段椎间孔狭窄。为此,本实验观察了多节段DRG慢性压迫大鼠的痛行为。方法:实验在本室创建的大鼠背根节慢性压迫(chronic compression of DRG,CCD)模型基础上采用单侧L3-5多节段DRG慢性压迫模型,应用vonFrey细丝和丙酮分别检测机械触刺激诱发痛阈值和冷刺激诱发痛反应级别及反应百分数。结果:多节段DRG慢性压迫大鼠表现明显双侧机械触刺激诱发痛和冷刺激诱发痛行为,伴随明显延迟的对侧机械触刺激和冷刺激诱发痛的镜像痛行为。组织学观察显示多节段DRG慢性压迫同侧DRG内部及其神经根有明显炎症反应。结论:机械性压迫和炎症共同作用神经根和DRG导致多节段DRG慢性压迫大鼠明显的机械触刺激诱发痛和冷刺激诱发痛行为。 | 陈兴伟 张许杰 谢雅彬 张天蔚 王涛 解柔刚 游思维 徐晖 胡三觉 | 2009 | 中国疼痛医学杂志2009，15，6： | 5 |
| 2 | 混沌和周期的交感神经刺激对大鼠受损背根节神经元放电的影响显示文摘目的研究受损背根节(DRG)神经元对不同时间序列的交感神经刺激反应.方法采用单纤维记录神经元自发放电的方法,在DRG慢性压迫模型上,电刺激腰交感神经干,比较受损DRG神经元对周期和混沌的交感神经刺激的反应.结果慢性压迫DRG中存在交感-感觉耦联现象.受损DRG神经元对交感神经刺激的反应随刺激频率(在5~20Hz范围内)的增加而增大(p<0.01).将刺激平均频率和刺激强度相同而刺激时间序列不同的交感神经刺激引起受损DRG神经元的反应进行比较发现,混沌的交感神经刺激引起的反应比周期的交感神经刺激引起的反应大(P<0.01).结论除刺激频率外,交感神经刺激的时间序列是影响受损DRG神经元反应的重要因素,混沌刺激引起的效应比周期刺激效应强,突触前神经元的混沌放电比周期放电可引起更大的突触后效应,神经元的混沌放电可能是神经传递信息的一种有效形式. | 杨红军 胡三觉 | 2003 | 第一军医大学学报2003，23，11： | 2 |
| 3 | The sensitivity of neurons with non-periodic activity to sympathetic stimulation in rat injured dorsal root ganglion显示文摘Objective The relationship between firing pattern and sensitivity of neurons was studied in chronically compressed dorsal root ganglion (DRG) neurons and the Hindmarsh-Rose (HR) neuronal model. Methods Spontaneous activities from single fibers of chronically compressed DRG neurons in rats were recorded, and divided into periodic and non-periodic firing patterns. The sensitivity of the two kinds of firing pattern neuron to sympathetic stimulation (SS) was compared. Result It was found that 27.3% of periodic firing neurons and 93.2% of non-periodic firing neurons responded to SS respectively (periodic vs non-periodic, P<0.01). The responses to SS with different stimulation time were greater non-periodic firing neurons than periodic firing neurons (P<0.01). The non-periodic firing neurons obviously responded to SS. After the firing pattern of these neurons transformed to periodic firing pattern, their responses to SS disappeared or decreased obviously. The HR neuronal model exhibited a significantly greater response to perturbation in non-periodic (chaotic) firing pattern than in periodic firing pattern. Conclusion The non-periodic firing neurons with deterministic chaos are more sensitive to external stimuli than the periodic firing neurons. | Hong-Jun YANG San-Jue HU Pu-Lin GONG Jian-Hong DUAN | 2006 | Neuroscience Bulletin2006，22，1： | 1 |
| 4 | Influence of sympathetic stumulating time series on activity of chronically compressed dorsal root ganglion neurons in rat显示文摘Objective: To study responses of injured DRG neurons to sympathetic stimulation with different temporal stimulating pattern. Methods: In chronically compressed DRG model, the spontaneous activity of single fiber from the injured DRG neuron was recorded, lumbar sympathetic trunk was electrical stimulated, and the responses of DRG neurons caused by chaotic and periodic sympathetic stimulation were compared. Results: It was found that the response of DRG increased gradually as the sympathetic stimulating frequency increased from 5 Hz to 20 Hz(P<0.01). The chaotic stimulation evoked much greater response than periodic stimulation did, even though the stimulating frequence was similar(P<0.01). Conclusion: Besides the stimulating frequency, the temporal stimulating pattern is one of important factor that effect response of DRG neuron to sympathetic stimulation. The chaotic activity of neurons might be one of effective way to transmit neural information. | 杨红军 胡三觉 | 2003 | Journal of Medical Colleges of PLA(China)2003，18，2： | 0 |
| 5 | 阈下膜电位振荡介导受损DRG神经元的交感敏化现象显示文摘目的 :在背根节 (dorsalrootganglion ,DRG)慢性压迫这一神经病理性痛模型研究交感敏化的膜机制 .方法 :采用离体细胞内记录 ,在受损DRG神经元观察去甲肾上腺素(norepinephrine,NE)对其膜电位的影响 .结果 :NE在受损(4 0 /45 )及正常 (1 5 /2 2 )DRG神经元均可以诱发膜电位的去极化过程 .NE诱发的膜电位去极化有浓度依赖性且可被酚妥拉明阻断 .仅有部分受损DRG神经元可在NE诱发的膜电位去极化基础上出现阈下膜电位振荡 (subthresholdmembranepotentialoscillation ,SMPO)并随后出现重复放电 .当应用TTX选择性地消除SMPO后 ,虽然NE诱发的膜电位去极化仍然存在 ,但神经元的重复放电不再产生 .结论 :触发及增大SMPO是NE诱发受损DRG神经元兴奋效应产生的一个关键因素 . | 邢俊玲 胡三觉 | 2004 | 第四军医大学学报2004，25，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员