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| 1 | Nab-paclitaxel(abraxane)-based chemotherapy to treat elderly patients with advanced non-small-cell lung cancer:a single center,randomized and open-label clinical trial显示文摘Background:The purpose of this study is to evaluate the clinical efficacy and safety of abraxane-based chemotherapy with/without nedaplatin in elderly patients with non-small-cell lung cancer(NSCLC).Materials and methods:From October 2009 to January 2013,48 elderly patients(>65 years) with NSCLC were investigated in this clinical trial.The patients were randomized and equally allocated into arms A and AP:(A) abraxane(130 mg/m^2,days 1,8);(B) abraxane + nedaplatin(20 mg/m^2 days 1-3,q3w).The parameters of objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),overall survival(OS) and side effects were evaluated between two arms.Results:Over 80%of the patients completed four cycles of chemotherapy.The total ORR was 21.3%,DCR was 55.3%,PFS 4.5 months and OS 12.6 months.No significant difference was found between arms A and AP in terms of ORR(16.7%vs.26.1%,P=0.665) or DCR(55.3%vs.56.5%,P=0.871).The median PFS in arm A was 3.3 months[25-75%confidence interval(CI):3.1-7.2]and 5.5 months(25-75%CI:3.2-7.0) in arm AP with no statistical significance(P=0.640).The median OS in arm A was 12.6 months(25-75%CI:5.7-26.2) and 15.1 months(25-75%CI:6.4-35.3) in arm AP with no statistical significance(P=0.770).The side effects were mainly grade 1-2.The incidence of grade 3-4 toxicities was 29.1%in arm A and 62.5%in arm AP with a statistical significance(P=0.020).Conclusions:Compared with combined therapy,abraxane alone chemotherapy was beneficial for elderly NSCLC patients with better tolerability and less adverse events,whereas did not significantly differ in terms of ORR,DCR,PFS or OS. | Hanrui Chen Xuewu Huang Shutang Wang Xinting Zheng Jietao Lin Peng Li Lizhu Lin | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 2 | Studies on Reducing Nitrogen Excretion: Ⅰ. Net Energy Requirement of Finishing Pigs Maximizing Performance and Carcass Quality Fed Low Crude Protein Diets Supplemented with Crystalline Amino Acids显示文摘Two experiments were conducted to investigate the effects of net energy (NE) level on the performance and carcass traits of finishing pigs fed low crude protein (CP) diets supplemented with crystalline amino acids (CAA). A total of 216 (Exp.1) and 360 (Exp.2) barrows (Yorkshire×Landrace×Duroc) were allotted to one of six treatments (n=6). The experimental diets were based on corn and soybean meal, and consisted of a highCP diet that contained approximately 16% CP and 2.50 Mcal/kg of NE as well as five lowCP diets in which the CP level of the diet was reduced by approximately four percentage units but was supplemented with crystalline lysine, methionine, threonine, and tryptophan. The low CP diets provided 2.64, 2.58, 2.50, 2.42, or 2.36 Mcal/kg in Exp.1 as well as 2.45, 2.40, 2.35, 2.30, or 2.25 Mcal/kg in Exp.2. In Exp.1, a linear (P=0.03) increase in weight gain was observed with decreasing NE level while the ratio of gain to feed was unaffected (P>0.05) by NE level. There was a linear increase (P=0.01) in the percentage of fatfree lean and a linear decrease (P=0.03) in the percentage of total fat with decreasing NE levels. In Exp.2, a significant quadratic (P=0.03) effect of NE level was observed for weight gain. The ratio of gain to feed demonstrated a significant (P<0.01) quadratic effect with pigs fed 2.35 and 2.40 Mcal/kg of NE. Pigs fed the diet containing 2.40 Mcal/kg of NE had the lowest percentage of total fat (36.95%) and the highest percentage of fatfree lean (49.36%). The overall results of these experiments indicate that feeding either a surplus or a deficiency of NE is detrimental to both pig performance and carcass composition when low CP diets supplemented with CAA are fed. Our results indicate that when the CP content of the diet is reduced by four percentage units and the diet is properly supplemented with CAA, maximum performance and carcass quality will be obtained if the diet provides approximately 2.42 Mcal/kg of NE. | Hongyu Chen Xuewu Yi Guijie Zhang Ning Lu Licui Chu P. A. Thacker Shiyan Qiao | 2011 | Journal of Animal Science and Biotechnology2011，2，2： | 9 |
| 3 | Catalase-imprinted Fe3O4/Fe@fibrous SiO2/polydopamine nanoparticles: An integrated nanoplatform of magnetic targeting, magnetic resonance imaging, and dual-mode cancer therapy显示文摘在关于为 nanomaterials 的准备的房间死亡和方法的分子的机制的研究的最近的进展做各种各样的治疗学的途径的集成,指向,并且成像模式进单个 nanoscale 建筑群为未来 nanotherapeutics 的发展的一个新趋势。因此,新奇椭圆体的合成 nanoplatform 磁性的 Fe 3 O 4/Fe nanorod 核心(~ 120 nm ) 由印的过氧化氢酶(猫) 包了含纤维的 SiO 2/ polydopamine (有厚度 70 nm 的 F-SiO 2/PDA) 壳在这个工作被准备。在 vitro,实验证明 Fe 3 O 4/Fe@F-SiO2/PDA nanoparticles 能有选择地由分子的印技术在肿瘤房间禁止猫的 bioactivity。作为结果, H 2 在肿瘤房间的 O 2 水平戏剧性地被提高。同时, Fe 3 O 4/Fe 核心释放了 Fe 离子催化 H 2 O 2 到/ | Jinxing Chen Shan Lei Kun Zeng Mozhen Wang Anila Asif Xuewu Ge | 2017 | Nano Research2017，10，7： | 4 |
| 4 | Autonomous navigation method and technology implementation of high-precision solar spectral velocity measurement显示文摘The velocity information of spacecraft can be directly obtained by the autonomous navigation method based on astronomical spectral velocity measurement. It provides complete direct velocity measurement information for the traditional navigation methods represented by astronomical angle measurement and astronomical ranging, which is of great significance for spacecraft high precision autonomous navigation. This paper comprehensively introduces the principle and navigation method of astronomical spectral velocity measurement, as well as the technical realization of the solar atomic frequency discriminator for autonomous navigation(SAFDAN) based on atomic frequency discrimination velocity measurement. The new SAFDAN is the first instrument to measure the Doppler velocity of spacecraft relative to the Sun. Carried by the CHASE mission, the in-orbit experiment of the SAFDAN is realized, and the in-orbit velocity measurement accuracy reaches 1.93 m/s, which effectively verifies the feasibility of the astronomical spectral velocity measurement method and technology. | Wei Zhang Yong Yang Wei You JinZhou Zheng Hui Ye KaiJun Ji Xiao Chen Xin Lin QingLong Huang XueWu Cheng Wei Zhang FaQuan Li | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 3 |
| 5 | Visual dual chemodynamic/photothermal therapeutic nanoplatform based on superoxide dismutase plus Prussian blue显示文摘Enzyme-based anticancer therapy is more attractive for the less side effect than conventional chemotherapy.However,the poor stability and low membrane permeability of enzymes during the intracellular delivery are constraints for its practical applications.In this work,we synthesized novel near-infrared (NIR)-responsive core-shell-structured Prussian blue@fibrous SiO2 (PBFS) nanoparticles as the carrier of superoxide dismutase (SOD) and a glutathione (GSH)-activated Fenton reagent (DiFe).The PBFS nanoparticles are further modified with aGSH-responsive cationic polymer (poly(2-(acryloyloxy)-N,N-dimethyl-N-(4-(((2-((2-(((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)oxy)ethyl)disulfaneyl)ethoxy)carbonyl)amino)benzyl)ethan-1-aminium,PSS) containing disulfide bonds and fluorophores.After SOD and DiFe are loaded on the PBFS-PSS nanoparticles,dual chemodynamic/photothermal therapeutic nanoparticulate systems (PBFS-PSS/DiFe/SOD) are obtained.In vitro experiments show that PBFS-PSS/DiFe/SOD nanoparticles have good biocompatibility and can be tracked under fluorescence microscope during the intracellular delivery process in MCF-7 tumor cells due to the GSH-activated release of fluorophores.They also exhibit high efficiency in NIR photothermal conversion and GSH-activated Fenton reaction in tumor cells,thus achieving high-efficient killing effect of tumor cells based on the combination of photothermal and chemodynamic therapeutic performance (PTT and CDT).This work offers a novel pathway to construct a visual multifunctional nanomedicine platform for future cancer therapy. | Shan Lei Jinxing Chen Kun Zeng Mozhen Wang Xuewu Ge | 2019 | Nano Research2019，12，5： | 2 |
| 6 | The Effects of Different Post-Heat Treatments on Rolling Contact Fatigue Behaviors of Direct Laser Cladding Inconel 625 Coatings显示文摘In this paper,the microstructures and rolling contact fatigue behaviors of laser cladding Inconel 625 coatings with or without post-heat treatments were analyzed.The results revealed that the fatigue resistance of the laser cladding coating after any post-heat treatment was worse than that of the as-deposited coating.First,through the finite element analysis,the distribution of stress along the thickness direction of the coating was obtained,and it was concluded that the bonding interface between the coating and the matrix had little effect on the fatigue properties of the coating.Then X-ray diffraction(XRD),scanning electron microscopy(SEM)and energy dispersive spectrometry(EDS)were used to analyze the microstructure and failure morphology.The results revealed that the subsurface failure morphology of the coatings showed a consistent correlation with rolling fatigue property after different heat treatments.The TCP phase and carbides have been shown in the laser cladding coating.The coating after stress relieved annealing exhibited chain-shaped granular carbides on the grain boundaries which could accelerate crack propagation.The aging heat treatment made small amounts of Laves phase dissolved in the coating,while the dispersed phase was precipitated which could result in the formation of pores.And the solution treatment made large amounts of Laves phase dissolved,while the rod-shape brittle phases were generated which was easy to fracture and contribute to crack initiation and spalling. | Qiaoxin Zhang Rui Chen Ding Jin Chen Zhou Xuewu Li | 2021 | Journal of Renewable Materials2021，9，1： | 1 |
| 7 | Activity-trip chaining behavior of urban low-income populations in Nanjing, China: A structural equations analysis显示文摘 | Zhaoming Chu Hui Chen Lin Cheng Xuewu Chen Senlai Zhu | 2014 | Discrete Dynamics in Nature and Society2014，，： | 1 |
| 8 | Moving cancer diagnostics from bench to bedside显示文摘 | Xuewu Zhang Lin Li Dong Wei Yeeleng Yap Feng Chen | 2007 | Trends in Biotechnology2007，，4： | 1 |
| 9 | Downregulation of hsa_circ_0002198 inhibits keloid fibroblast activities in vitro by reducing NLRP3 inflammasome activity显示文摘The levels of hsa circular RNA_0002198(hsa_circ_0002198)have been found to be significantly upregulated in keloid dermal fibroblasts.However,the functional role of hsa_circ_0002198 in keloid fibroblasts and the underlying molecular mechanism for its effects have not been reported.In this study,the levels of hsa_circ_0002198 and nucleotide-binding and oligomerization domain,leucine rich repeat and pyrin domain containing 3(NLRP3)expression in keloid scar tissues and adjacent normal skin tissues were determined by quantitative real-time PCR and western blotting,respectively.In vitro models of keloid tissue were created by culturing primary keloid fibroblasts obtained from patients.A series of functional experiments,including CCK-8 assays,Transwell assays,and ELISA assays were performed to analyze the functional role of hsa_circ_0002198/NLRP3.Our data showed that hsa_circ_0002198 and NLRP3 were upregulated in keloid scar tissues when compared with adjacent normal tissues.Knockdown of hsa_circ_0002198 expression significantly suppressed cell proliferation,migration,and invasion,and those effects could be partially reversed by forced NLRP3 overexpression in keloid fibroblasts.At the molecular level,knockdown of hsa_circ_0002198 downregulated the levels of Col I,α-SMA,and NLRP3 proteins,as well as the levels of TGF-β,IL-1ß,and IL-33,but upregulated caspase 3 expression in keloid fibroblasts.All those effects were partially reversed after NLRP3 overexpression.In conclusion,our results suggest hsa_circ_0002198 as a potential target for treating keloid lesions. | LEI FU JINGWEN JIANG XUEWU CHEN FENGTING ZHU HUI ZHANG | 2022 | BIOCELL2022，46，5： | 1 |
| 10 | Kinetic models for heterotrophic growth of Chlamydomonas reinhardtii in batch and fedbatch cultures显示文摘 | Zhang Xuewu Chen Feng Johns M R | 1999 | Process Biochemistry1999，35，34： | 1 |
| 11 | Mercury emissions from natural surfaces highly impacted by human activities in Guangzhou province, South China显示文摘 | Xuewu Fu Xinbin Feng Hui Zhang Ben Yu Laiguo Chen | 2012 | Atmospheric Environment2012，，： | 1 |
| 12 | Effect of Hydro- thermal Conditions on the Synthesis of Siliceous MCM-48 in Mixed Cationic-Anionic Surfactants Systems 显示文摘 | Chen Fengxi Yan Xuewu Li Quanzhi | 1998 | Stud SurfSci Catal1998，117，： | 1 |
| 13 | Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING显示文摘 | Xu Zhang Heping Shi Jiaxi Wu Xuewu Zhang Lijun Sun Chuo Chen Zhijian J. Chen | 2013 | Molecular Cell2013，，2： | 1 |
| 14 | Gamma radiation-induced grafting of a cationic monomer onto chitosan as a flocculant显示文摘 | Wang Jianping Chen Yongzhen Ge Xuewu | 2007 | Chemosphere2007，66，： | 1 |
| 15 | An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity显示文摘Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC. | Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 16 | Stress and noises of steel box girders in Sutong Bridge显示文摘Sutong Bridge is a cable-stayed bridge with a main span of 1 088 m. 370 high-precision stress monitoring measured data show that in the process of hoisting the steel box girders,the stress of the main girders is in the fluctuant and complex state and many meteorological factors,such as sunshine radiation,temperature and wind,have important influence on the change of stress of the steel box girders. According to the real-time weather data,the stress data after the process of wavelet denoising from representative measuring points in different weather conditions is picked to establish the stress response brought by meteorological factors with Layered Separation method,thereby basically eliminating the influence of meteorological factors on the stress of main girders,so that accurate and reliable stress data can be got for steel box girders adjustment and cable-tensioned construction control. | Xue Tao Chen Zhijian Dong Xuewu | 2008 | Engineering Sciences2008，6，4： | 0 |
| 17 | Microstructures and electrochemical behaviors of casting magnesium alloys with enhanced compression strengths and decomposition rates显示文摘New-type magnesium alloy with prominent solubility and mechanical property lays foundation for preparing fracturing part in petroleum extraction.Herein,Mg-xZn-Zr-SiC alloy is prepared with casting strategy.Electrochemical and compression tests are conducted to assess the feasibility as decomposable material.Morphology,composition,phase and distribution are characterized to investigate decomposition mechanism.Results indicate that floccule,substrate component and reticulate secondary phase are formed on as-prepared surface.Sample also acts out enhanced compression strength to maintain pressure and guarantee stability in dissolution process.Furthermore,as decomposition time and zinc content increase,couple corrosion intensifies,resulting in gradually enhanced decomposition rate.Rapid sample decomposition is mainly due to basal anode dissolution,micro particle exfoliation and poor decomposition resistance of corroding product.Such work shows profound significance in preparing new-type accessible alloy to ensure rapid dissolution of fracturing part and guarantee stable compression strength in oil-gas reservoir exploitation. | Xuewu Li Qingyuan Yu Xi Chen Qiaoxin Zhang | 2023 | Journal of Magnesium and Alloys2023，11，4： | 0 |
| 18 | Constructing irreducible integrable modules for extended baby TKK algebra显示文摘In this paper, we give explicit realizations for the irreducible integrable modules, which were clas- sified in Chang and Tan [Pacific J Math, 2011, 252: 293-312], of the extended baby TKK algebra. Moreover, conditions for these modules to be unitary are determined. | CHANG XueWu CHEN FuLin TAN ShaoBin | 2012 | Science China Mathematics2012，55，12： | 0 |
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