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| 1 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 2 | Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-lc/FASN axis显示文摘Dear Editor,Metformin,a widely prescribed drug for treating typeⅡdiabetes,has shown an important anti-cancer property.1 However,new launched clinical trials did not achieve such desirable results.2 One explanation could be that metformin’s anti-cancer mechan-isms and precise therapeutic targets remain unclear.To identify potential therapeutic targets of metformin in bladder cancer,we screened differential proteins with metformin treatment in T24 cells by high-throughput protein chip. | Jun Deng Mei Peng Sichun Zhou Di Xiao Xin Hu Simeng Xu Jingtao Wu Xiaoping Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 3 | A composite of Ni-Fe-Zn layered double hydroxides/biochar for atrazine removal from aqueous solution显示文摘This study assembled corn stalk-derived biochar(BC)with layered double hydroxide(LDH)through a rapid coprecipitation of biochar and metal(Ni/Fe/Zn)hydroxide precipitates.A BC and LDH composite(BC-LDH)and modified BC-LDH material after heating(BC-LDH-P)were prepared successfully for atrazine adsorptive removal.The physicochemical properties of the synthesized samples were analyzed by X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared(FT-IR),and X-ray photoelectron spectroscopy(XPS).Batch experiments were conducted to study the sorption of atrazine onto BC,BC-LDH,and BC-LDH-P from the aqueous solution.The adsorption of atrazine onto BC-LDH and BC-LDH-P were performed following with the pseudo-second-order kinetic model,and the sorption isotherms agreed well with the Freundlich fitting model.The adsorption amounts of the three materials are arranged in descending order is as follows:BC-LDH-P>BC-LDH>BC(143.15>123.10>95.93 mg g−1,respectively).Due to the high crystallinity of the LDH material and the high binding degree with biochar,Ni/Fe/Zn-LDH biochar composites offer a potential alternative to a carbon-based adsorbent for atrazine removal from aqueous solution. | Yifan Wang Jiaming Kang Simeng Jiang Hui Li Zheyi Ren Qinbo Xu Qun Jiang Wenzhu Liu Ruizhen Li Ying Zhang | 2020 | Biochar2020，2，4： | 2 |
| 4 | Evolution of pore fluid of low porosity and permeability reservoir in Qinnan Sag:a case study of 29-2 structurein Qinhuangdao area显示文摘The southeast depression of Qinnan Sag is a potential oil-gas exploration region in the Bohai Sea area. With the analysis of large quantity of rock thin sections,scanning electron microscope and the physical property data of reservoir,the authors studied the petrological characteristics and the evolution of pore and fluid of sandstone in the deeper strata in 29-2 structure in Qinhuangdao area. The results show that the evolutionary tendency of Paleogene sandstone reservoir porous fluid in research area is changed from alkaline porous fluid to acidic porous fluid,and back to alkaline porous fluid. There are three stages of reservoir porous evolution in Qinhuangdao area,namely sharp decrease in porosity due to mechanical compaction,increase in porosity because of corrosion and dissolution,and remarkable reduction owing to carbonate cementation. | XU Simeng PENG Xiaolei LIU Na LIU Li WANG Qingbin LIU Xiaojian JIN Xiaoyan | 2017 | Global Geology2017，20，2： | 1 |
| 5 | A core epitope targeting antibody of SARS-CoV-2显示文摘Dear Editor,Tremendous efforts have been made globally to develop therapeutics and prophylactics against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)which has caused thousands of millions of infections and deaths worldwide.A series of potent neutralizing antibodies with defined epitopes targeting RBD have been recently identified with different strategies.However,being an RNA virus,the instability of the SARS-CoV-2 genome results in numerous S-protein variants with altered viral phenotypes. | Simeng Zhao Fengjiang Liu Shizhen Qiu Qiaoshuai Lan Yiran Wu Wei Xu Junzi Ke Jie Yang Xiaoyan Liu Kun Wang Hangtian Guo Shuai Xia Fangfang Zhang Jiabei Wang Xiaowen Hu Lu Lu Shibo Jiang Suwen Zhao Lianxin Liu Youhua Xie Xiuna Yang Haopeng Wang Guisheng Zhong | 2023 | Protein & Cell2023，14，1： | 0 |
| 6 | Stacking monolayers at will:A scalable device optimization strategy for two-dimensional semiconductors显示文摘In comparison to monolayer(1L),multilayer(ML)two-dimensional(2D)semiconducting transition metal dichalcogenides(TMDs)exhibit more application potential for electronic and optoelectronic devices due to their improved current carrying capability,higher mobility,and broader spectral response.However,the investigation of devices based on wafer-scale ML-TMDs is still restricted by the synthesis of uniform and high-quality ML films.In this work,we propose a strategy of stacking MoS_(2) monolayers via a vacuum transfer method,by which one could obtain wafer-scale high-quality MoS_(2) films with the desired number of layers at will.The optical characteristics of these stacked ML-MoS_(2) films(>2L)indicate a weak interlayer coupling.The stacked MLMoS_(2) phototransistors show improved optoelectrical performances and a broader spectral response(approximately 300-1,000 nm)than that of 1L-MoS_(2).Additionally,the dual-gate ML-MoS_(2) transistors enable enhanced electrostatic control over the stacked ML-MoS_(2) channel,and the 3L and 4L thicknesses exhibit the optimal device performances according to the turning point of the current on/off ratio and the subthreshold swing. | Xiaojiao Guo Honglei Chen Jihong Bian Fuyou Liao Jingyi Ma Simeng Zhang Xinzhi Zhang Junqiang Zhu Chen Luo Zijian Zhang Lingyi Zong Yin Xia Chuming Sheng Zihan Xu Saifei Gou Xinyu Wang Peng Gong Liwei Liu Xixi Jiang Zhenghua An Chunxiao Cong Zhijun Qiu Xing Wu Peng Zhou Xinyu Chen Ling Tong Wenzhong Bao | 2022 | Nano Research2022，15，7： | 0 |
| 7 | Identification of natural products as novel ligands for the human 5-HT2c receptor显示文摘 | Yao Peng Simeng Zhao Yiran Wu Haijie Cao Yueming Xu Xiaoyan Liu Wenqing Shui Jianjun Cheng Suwen Zhao Ling Shen Jun Ma Ronald J. Quinn Raymond C. Stevens Guisheng Zhong Zhi-Jie Liu | 2018 | Biophysics Reports2018，4，1： | 0 |
| 8 | Temperature/pH dual-responsive reversible morphology evolution of block copolymer microparticles under three-dimensional confinement显示文摘Development of block copolymer(BCP)microparticles with switchable morphology in response to external stimuli is important for exploiting new intelligent materials.In this work,thermo/p H dual-responsive nanoparticles(NPs)were employed as a cosurfactant to modulate the self-assembly morphology of polystyrene-b-poly(2-vinylpyridine)(PS-b-P2VP)microparticles within confined emulsion droplets.The co-surfactant was synthesized by grafting poly(acrylic acid)-b-poly(N-isopropylacrylamide)onto the surface of Fe3O4NP.The introduction of the dual-responsive co-surfactant enabled thermo/p H dual-responsive reversible morphology transition of the PS-b-P2VP microparticles by tailoring the hydrophobicity and interfacial affinity of the cosurfactant.By using this strategy,the thermo-inert PS-b-P2VP self-assembled into pupa-like microparticles at T=10℃ and p H7.5,which could transform into tulip-like microparticles when T was increased to 50℃.When the p H value was increased to 11,the pupa-like particles turned into onion-like microparticles although the PS-b-P2VP was inert to alkali.However,the pupa-like microparticles remained unchanged when both T and p H were simultaneously increased.The PAA-b-PNIPAM-grafted Fe3O4NP surfactants showed obvious advantages over the linear PAA-b-PNIPAM surfactants in modulating the morphology transition,since the linear PAA-b-PNIPAM could not induce the reversible shape transition of microparticles.Our work provides an efficient strategy to achieve reversible shape transformation of BCP microparticles while the internal phase structure is preserved,which may be utilized to switch the structural color properties of BCP microparticles. | Mengmeng Zhang Zaiyan Hou Simeng Liu Guoqiang Han Meirong Tian Jintao Zhu Jiangping Xu | 2023 | Science China Chemistry2023，66，12： | 0 |
| 9 | Rapid inactivation of human respiratory RNA viruses by deep ultraviolet irradiation from light-emitting diodes on a high-temperatureannealed AlN/Sapphire template显示文摘Efficient and eco-friendly disinfection of air-borne human respiratory RNA viruses is pursued in both public environment and portable usage.The AlGaN-based deep ultraviolet(DUV)light-emission diode(LED)has high practical potentials because of its advantages of variable wavelength,rapid sterilization,environmental protection,and miniaturization.Therefore,whether the emission wavelength has effects on the disinfection as well as whether the device is feasible to sterilize various respiratory RNA viruses under portable conditions is crucial.Here,we fabricate AlGaN-based DUV LEDs with different wavelength on high-temperature-annealed(HTA)AlN/Sapphire templates and investigate the inactivation effects for several respiratory RNA viruses.The AlN/AlGaN superlattices are employed between the template and upper n-AlGaN to release the strong compressive stress(SCS),improving the crystal quality and interface roughness.DUV LEDs with the wavelength of 256,265,and 278 nm,corresponding to the light output power of 6.8,9.6,and 12.5 mW,are realized,among which the 256 nm-LED shows the most potent inactivation effect in human respiratory RNA viruses,including SARS-CoV-2,influenza A virus(IAV),and human parainfluenza virus(HPIV),at a similar light power density(LPD)of~0.8 mW/cm2 for 10 s.These results will contribute to the advanced DUV LED application of disinfecting viruses with high potency and broad spectrum in a portable and eco-friendly use. | Ke Jiang Simeng Liang Xiaojuan Sun Jianwei Ben Liang Qu Shanli Zhang Yang Chen Yucheng Zheng Ke Lan Dabing Li Ke Xu | 2023 | Opto-Electronic Advances2023，6，9： | 0 |
| 10 | Effects of hydrological and climatic variables on cyanobacterial blooms in four large shallow lakes fed by the Yangtze River显示文摘Shallow lakes,one of the most widespread water bodies in the world,are easily shifted to a new trophic state due to external interferences.Shifting hydrologic conditions and climate change can cause cyanobacterial harmful algal blooms(CyanoHABs)in shallow lakes,which pose serious threats to ecological integrity and human health.This study analyzed the effects of hydrologic and meteorological variables on cyanobacterial blooms in Yangtze-connected lakes(Lake Dongting and Poyang)and isolated lakes(Lake Chao and Tai).The results show that(i)chlorophyll-a(Chl-a)concentration tends to decrease exponentially with increasing relative lake level fluctuations(RLLF)and precipitation,but to increase linearly with increasing wind speed and air temperature;(ii)Chl-a concentrations in lakes were significantly higher when RLLF<100,precipitation<2.6 mm,wind speed>2.6 ms^(-1),or air temperature>17.8℃;(iii)the Chl-a concentration of Yangtze-isolated lakes was more significantly affected by water level amplitude,precipitation,wind speed and air temperature than the Yangtze-connected lakes;(iv)the RLLF and the ratio of wind speed to mean water depth could be innovative coupling factors to examine variation characteristics of Chl-a in shallow lakes with greater correlation than single factors. | Jian Huang Qiujin Xu Xixi Wang Hao Ji Edward J.Quigley Mohamadali Sharbatmaleki Simeng Li Beidou Xi Biao Sun Caole Li | 2021 | Environmental Science and Ecotechnology2021，，1： | 0 |
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