|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat显示文摘Wallerian degeneration (WD) remains an important research topic. Many genes are differentially expressed during the process of WD, but the precise mechanisms responsible for these differentiations are not completely understood. In this study, we used microarrays to analyze the expression changes of the distal nerve stump at 0, 1, 4, 7, 14, 21 and 28 days after sciatic nerve injury in rats. The data revealed 6 076 differentially-expressed genes, with 23 types of expression, specifically enriched in genes associated with nerve development and axonogenesis, cytokine biosynthesis, cell differentiation, cytokine/chemokine production, neuron differentiation, cytokinesis, phosphorylation and axon regeneration. Kyoto Encyclopedia of Genes and Genomes pathway analysis gave findings related mainly to the MAPK signaling pathway, the Jak-STAT signaling pathway, the cell cycle, cytokine-cytokine receptor interaction, the p53 signaling pathway and the Wnt signaling pathway. Some key factors were NGF, MAG, CNTF, CTNNA2, p53, JAK2, PLCB1, STAT3, BDNF, PRKC, collagen II, FGF, THBS4, TNC and c-Src, which were further validated by real-time quantitative PCR, Western blot, and immunohistochemistry. Our findings contribute to a better understanding of the functional analysis of differentially-expressed genes in WD and may shed light on the molecular mechanisms of nerve degeneration and regeneration. | Dengbing Yao Meiyuan Li Dingding Shen Fei Ding Shibi Lu Qing Zhao Xiaosong Gu | 2013 | Neuroscience Bulletin2013，29，3： | 18 |
| 2 | Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells显示文摘Resveratrol,a natural compound extracted from the skins of grapes,berries,or other fruits,has been shown to have anti-tumor effects against multiple myeloma(MM)via promoting apoptosis and inhibiting cell viability.In addition to apoptosis,autophagy also plays a significant role in anti-tumor effects.However,whether autophagy is involved in anti-MM activity of resveratrol remains unclear.In this study,human MM cell lines U266,RPMI-8226,and NCI-H929 were treated with resveratrol.Cell Counting Kit-8 assay and colony formation assay were used to measure cell viability.Western blot analysis was used to detect apoptosis-and autophagy-associated proteins.3-Methyladenine(3-MA)was applied to inhibit autophagy.Results showed that resveratrol inhibited cell viability and colony formation via promoting apoptosis and autophagy in MM cell lines U266,RPMI-8226,and NCI-H929.Resveratrol promoted apoptosis-related proteins,Caspase-3 activating poly-ADP-ribose polymerase and Caspase-3 cleavage,and decreased the protein level of Survivin in a dose-dependent manner.Additionally,resveratrol upregulated the levels of LC3 and Beclin1 in a dose-dependent way,indicating that autophagy might be implicated in anti-MM effect of resveratrol.Furthermore,3-MA relieved the cytotoxicity of resveratrol by blocking the autophagic flux.Resveratrol increased the phosphorylation of adenosine monophosphate(AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin(mTOR)and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner,leading to autophagy.Therefore,our results suggest that resveratrol exerts anti-MM effects through apoptosis and autophagy,which can be used as a new therapeutic strategy for MM in clinic. | Ruye Ma Dandan Yu Yu Peng Hongfei Yi Yingcong Wang Taofang Cheng Bingqing Shi Guang Yang Weiming Lai Xiaosong Wu Ye Lu Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 7 |
| 3 | Gene expression profiling of the rat sciatic nerve in early Wallerian degeneration after injury显示文摘Wallerian degeneration is an important area of research in modern neuroscience.A large number of genes are differentially regulated in the various stages of Wallerian degeneration,especially during the early response.In this study,we analyzed gene expression in early Wallerian degeneration of the distal nerve stump at 0,0.5,1,6,12 and 24 hours after rat sciatic nerve injury using gene chip microarrays.We screened for differentially-expressed genes and gene expression patterns.We examined the data for Gene Ontology,and explored the Kyoto Encyclopedia of Genes and Genomes Pathway.This allowed us to identify key regulatory factors and recurrent network motifs.We identified 1 546 differentially-expressed genes and 21 distinct patterns of gene expression in early Wallerian degeneration,and an enrichment of genes associated with the immune response,acute inflammation,apoptosis,cell adhesion,ion transport and the extracellular matrix.Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed components involved in the Jak-STAT,ErbB,transforming growth factor-β,T cell receptor and calcium signaling pathways.Key factors included interleukin-6,interleukin-1,integrin,c-sarcoma,carcinoembryonic antigen-related cell adhesion molecules,chemokine(C-C motif) ligand,matrix metalloproteinase,BH3 interacting domain death agonist,baculoviral IAP repeat-containing 3 and Rac.The data were validated with real-time quantitative PCR.This study provides a global view of gene expression profiles in early Wallerian degeneration of the rat sciatic nerve.Our findings provide insight into the molecular mechanisms underlying early Wallerian degeneration,and the regulation of nerve degeneration and regeneration. | Dengbing Yao Meiyuan Li Dingding Shen Fei Ding Shibi Lu Qin Zhao Xiaosong Gu | 2012 | Neural Regeneration Research2012，7，17： | 5 |
| 4 | Eigen microstates and their evolutions in complex systems显示文摘Emergence refers to the existence or formation of collective behaviors in complex systems.Here,we develop a theoretical framework based on the eigen microstate theory to analyze the emerging phenomena and dynamic evolution of complex system.In this framework,the statistical ensemble composed of M microstates of a complex system with N agents is defined by the normalized N×M matrix A,whose columns represent microstates and order of row is consist with the time.The ensemble matrix A can be decomposed as■,where r=min(N,M),eigenvalueσIbehaves as the probability amplitude of the eigen microstate U_I so that■and U_I evolves following V_I.In a disorder complex system,there is no dominant eigenvalue and eigen microstate.When a probability amplitudeσIbecomes finite in the thermodynamic limit,there is a condensation of the eigen microstate UIin analogy to the Bose–Einstein condensation of Bose gases.This indicates the emergence of U_I and a phase transition in complex system.Our framework has been applied successfully to equilibrium threedimensional Ising model,climate system and stock markets.We anticipate that our eigen microstate method can be used to study non-equilibrium complex systems with unknown orderparameters,such as phase transitions of collective motion and tipping points in climate systems and ecosystems. | Yu Sun Gaoke Hu Yongwen Zhang Bo Lu Zhenghui Lu Jingfang Fan Xiaoteng Li Qimin Deng Xiaosong Chen | 2021 | Communications in Theoretical Physics2021，73，6： | 5 |
| 5 | 深地震反射剖面揭露青藏高原陆-陆碰撞与地壳生长的深部过程显示文摘印度板块与亚洲板块的碰撞使喜马拉雅-青藏高原隆升,地壳增厚和生长扩展。探测青藏高原深部结构,揭露两个大陆如何碰撞,碰撞如何使大陆变形的过程,是全球关切的科学奥秘。深地震反射剖面探测是打开这个科学奥秘的最有效途径之一。20多年来,运用这项高技术探测到青藏高原巨厚地壳的精细结构,攻克了难以得到下地壳和Moho清晰结构的技术瓶颈,揭露了陆陆碰撞过程。本文在探测研究成果基础上,从青藏高原南北东西对比,再到高原腹地,系统地综述了青藏高原之下印度板块与亚洲板块碰撞俯冲的深部行为。印度地壳在高原南缘俯冲在喜马拉雅造山带之下,亚洲板块的阿拉善地块岩石圈在北缘向祁连山下俯冲,祁连山地壳向外扩展,塔里木地块与高原西缘的西昆仑发生面对面的碰撞,在高原东缘发现龙日坝断裂而不是龙门山断裂是扬子板块的西缘边界,高原腹地Moho薄而平坦,岩石圈伸展垮塌。多条深反射剖面揭露了在雅鲁藏布江缝合带下印度板块与亚洲板块碰撞的行为,印度地壳不仅沿雅鲁藏布江缝合带存在由西向东的俯冲角度变化,而且其向北行进到拉萨地体内部的位置也不同。在缝合带中部,显示印度地壳上地壳与下地壳拆离,上地壳向北仰冲,下地壳向北俯冲,并在俯冲过程发生物质的回返与构造叠置,使印度地壳减薄,喜马拉雅地壳加厚。俯冲印度地壳前缘与亚洲地壳碰撞后沉入地幔,处于亚洲板块前缘的冈底斯岩基与特提斯喜马拉雅近于直立碰撞,冈底斯下地壳呈部分熔融状态,近乎透明的弱反射和局部出现的亮点反射,以及近于平的Moho都反映出亚洲板块南缘的伸展构造环境。 | GAO Rui ZHOU Hui GUO Xiaoyu LU Zhanwu LI Wenhui WANG Haiyan LI Hongqiang XIONG Xiaosong HUANG Xingfu XU Xiao | 2021 | 地学前缘2021，28，5： | 4 |
| 6 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 7 | DCZ0801,a novel compound,induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma显示文摘Multiple myeloma(MM)is a refractory malignant hematological malignancy,and many therapeutic strategies have been developed to cure patients with MM.DCZ0801 is a compound that consists of oxophenamide and pterostilbene.The role of these compounds in hematological cancers such as MM has yet to be studied.In this study,we explored the potential mechanism of DCZ0801 action,its anti-tumor activity both in vitro and in vivo on MM.This study was carried out via cell cycle proliferation assay,apoptotic analysis,western blot analysis,and examination of xenotransplantation model of tumors.The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways,inducing S-phase arrest of the cell cycle related to downregulation of CDK2,cyclin-A2,and CDC25A protein expression.The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice.Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM. | Ting Zhang Bo Li Qilin Feng Zhijian Xu Cheng Huang Huiqun Wu Zhangbo Chen Liangning Hu Lu Gao Peng Liu Guang Yang Hui Zhang Kang Lu Tingye Li Yi Tao Xiaosong Wu Jumei Shi Weiliang Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 3 |
| 8 | Myeloma cells resistance to NK cell lysis mainly involves an HLA class I-dependent mechanism显示文摘房间具有升起的生来的杀手(NK ) 的反多重的骨髓瘤(公里) 潜力对最近的年的兴趣。然而,到骨髓瘤房间的 NK 房间 cytotoxicity 的分子的机制仍然保持不清楚。在现在的学习,我们调查了人的白血球的 theexpressions 在耐心的骨髓瘤房间的抗原(HLA ) 一级和 HLA-G,并且决定了他们的关联住院病人肿瘤房间危险性到 NK 房间 cytotoxicity。我们的结果给那个病人看了骨髓瘤房间(n = 12 ) 对 NK-92 房间细胞溶解相对抵抗,与骨髓瘤房间线相比(n = 7, P < 0.01 ) 。基因表示介绍和流动 cytometry 分析证明 HLA 一级的 mRNA 和蛋白质是在 12 个耐心的骨髓瘤房间的 highlyexpressed。有趣地,没有或低 HLA-G 表面表示被检测,尽管多重 HLA-Gtranscripts 在这些骨髓瘤房间被检测。NK 房间功能试金证明由酸治疗的下面调整的 HLA 一级 expressionon 病人房间显著地增加了公里房间的危险性到调停 NK 的细胞溶解。而且,我们发现在骨髓瘤上用抗体堵住膜界限 HLA 一级而非 HLA-G 显著地取样 increasedtheir 危险性到调停 NK 的杀死。这些结果证明到 NK 的耐心的公里房间的抵抗 lysismainly 包含一个 HLA 班我依赖的机制,建议那 HLA 一级可以涉及保护公里房间调停 fromNK 在 vivo 攻击并且贡献他们的有免疫力的逃跑。 | Minjie Gao Lu Gao Guang Yang Yi Tao Jun Hou Hongwei Xu Xiaojing Hu Ying Han Qianqiao Zhang Xiaosong Wu Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 3 |
| 9 | Internal structures and high-velocity frictional properties of Longmenshan fault zone at Shenxigou activated during the 2008 Wenchuan earthquake显示文摘This paper reports internal structures of a wide fault zone at Shenxigou,Dujiangyan,Sichuan province,China,and high-velocity frictional properties of the fault gouge collected near the coseismic slip zone during the 2008 Wenchuan earthquake.Vertical offset and horizontal displacement at the trench site were 2.8 m(NW side up)and 4.8 m(right-lateral),respectively.The fault zone formed in Triassic sandstone,siltstone,and shale about 500 m away from the Yingxiu-Beichuan fault,a major fault in the Longmenshan fault system.A trench survey across the coseismic fault,and observations of outcrops and drill cores down to a depth of 57 m revealed that the fault zone consists of fault gouge and fault breccia of about0.5 and 250–300 m in widths,respectively,and that the fault strikes N62°E and dips 68° to NW.Quaternary conglomerates were recovered beneath the fault in the drilling,so that the fault moved at least 55 m along the coseismic slip zone,experiencing about 18 events of similar sizes.The fault core is composed of grayish gouge(GG) and blackish gouge(BG) with very complex slip-zone structures.BG contains low-crystalline graphite of about 30 %.High-velocity friction experiments were conducted at normal stresses of 0.6–2.1 MPa and slip rates of 0.1–2.1 m/s.Both GG and BG exhibit dramatic slip weakening at constant high slip rates that can be described as an exponential decay from peak friction coefficient lpto steadystate friction coefficient lssover a slip-weakening distance Dc.Deformation of GG and BG is characterized by overlapped slip-zone structures and development of sharp slickenside surfaces,respectively.Comparison of our data with those reported for other outcrops indicates that the high-velocity frictional properties of the Longmenshan fault zones are quite uniform and the high-velocity weakening must have promoted dynamic rupture propagation during the Wenchuan earthquake. | Yu Wang Shengli Ma Toshihiko Shimamoto Lu Yao Jianye Chen Xiaosong Yang Honglin He Jiaxiang Dang Linfeng Hou Tetsuhiro Togo | 2014 | Earthquake Science2014，27，5： | 3 |
| 10 | Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in Jurkat T-leukemia cells显示文摘在现在的学习,我们在 Jurkat T 白血病房间调查了在 proteasome 禁止者 carfilzomib (CFZ ) 和 histone deacetylaseinhibitor vorinostat 之间的相互作用。到 CFZ 与的最低限度地致命的集中的细胞的 Coexposure 很, vorinostat 的 lowconcentration 导致了 synergistic antiproliferative 效果并且在 Jurkat T-leukemiacells 提高了 apoptosis ,与严厉地增加的反应的氧种( ROS )伴随了,在 mitochondrial membranepotential ( MMP )的惹人注目的减少,细胞色素 c 的增加的版本, caspase-9 和-3,和 PARP.The 的劈开的提高的激活联合了 Jurkat 细胞的处理与 ROS 预先对待而且, NAC 也在 apoptotic 房间导致了显著减小,显示为由联合处理的 increasedROS 产生的一个关键角色。另外,联合了逮捕的处理在 G 2-M 的房间周期阶段。这些结果暗示 CFZ 在 Jurkat T 白血病房间与 vorinostat synergistically 交往了,哪个有 vorinostat 的 carfilzomib 的联合可以在对待 T 房间代表新奇策略的 raisedthe 可能性白血病。 | Minjie Gao Lu Gao Yi Tao Jun Hou Guang Yang Xiaosong Wu Hongwei Xu Van S. Tompkins Ying Han Huiqun Wu Fenghuang Zhan Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 3 |
| 11 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 12 | Salivary microbiota may predict the presence of esophageal squamous cell carcinoma显示文摘The aim is to explore the predictive value of salivary bacteria for the presence of esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, and allocated to screening and verification cohorts, respectively. In the screening phase, after saliva DNA was extracted, 16S rRNA V4 regions of salivary bacteria were amplified by polymerase chain reaction (PCR) with high-throughput sequencing. Highly expressed target bacteria were screened by Operational Taxonomic Units clustering, species annotation and microbial diversity assessment. In the verification phase, the expression levels of target bacteria identified in the screening phase were verified by absolute quantitative PCR (Q-PCR). Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of target salivary bacteria. LEfSe analysis revealed higher proportions of Fusobacterium, Streptococcus and Porphyromonas, and Q-PCR assay showed significantly higher numbers of Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in patients with ESCC, when compared with healthy controls (all P < 0.05). The areas under the ROC curves for Streptococcus salivarius, Fusobacterium nucleatum, Porphyromonas gingivalis and the combination of the three bacteria for predicting patients with ESCC were 69%, 56.5%, 61.8% and 76.4%, respectively. The sensitivities corresponding to cutoff value were 69.3%, 22.7%, 35.2% and 86.4%, respectively, and the matched specificity were 78.4%, 96.1%, 90.2% and 58.8%, respectively. These highly expressed Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in the saliva, alone or in combination, indicate their predictive value for ESCC. | Junmin Wei Ruifeng Li Yanxian Lu Fan Meng Bohong Xian Xiaorong Lai Xiayi Lin Yu Deng Dongyang Yang Huabin Zhang Liangfang Li Xiaosong Ben Guibin Qiao Wanwei Liu Zijun Li | 2022 | Genes & Diseases2022，9，4： | 2 |
| 13 | Reaction rates in blanket assemblies of a fusion-fission hybrid reactor显示文摘To validate neutronics calculation for the blanket design of fusion-fission hybrid reactor,experiments for measuring reaction rates inside two simulating assemblies are performed.Two benchmark assemblies were developed for the neutronics experiments.A D-T fusion neutron source is placed at the center of the setup.One of them consists of three layers of depleted uranium shells and two layers of polyethylene shells,and these shells are arranged alternatively.The ^(238)U capture reaction rates are measured using depleted uranium foils and an HPGe gamma spectrometer.The fission reaction rates are measured using a fission chamber coated with depleted uranium.The other assembly consists of depleted uranium and LiH shells.The tritium production rates are measured using the lithium glass scintillation detector which is placed in the LiH region of the assembly.The measured reaction rates are compared with the calculated ones predicted using MCNP code,and C/E values are obtained. | LIU Rong ZHU Tonghua YAN Xiaosong WANG Xinhua LU Xinxin JIANG Li WANG Mei WEN Zhongwei HAN Zijie LIN Jufan YANGYiwei | 2012 | Nuclear Science and Techniques2012，23，4： | 2 |
| 14 | Photonic engineering of superbroadband near-infrared emission in nanoglass composites containing hybrid metal and dielectric nanocrystals显示文摘Photonic media containing hybrid noble metal-dielectric nanocrystals(NCs)represent a wonderland of nanophotonics,with a myriad of uncharted optical functions yet to be explored.Capitalizing on the unique phase separation and spontaneous formation of Au-metal NCs in a gallosilicate glass,we fabricated Ni^2+-doped transparent nanoglass composites(GCs)containing Au-metal/γ-Ga2O3-dielectric NCs.Compared with GCs free of Au-metal NCs,the super broadband near-infrared emission of Ni^2+with a full width at half-maximum over280 nm is enhanced twice in the Au-metal/γ-Ga2O3 dual-phase GCs.A comparison is given as to the spontaneous emission(SPE)properties of Ni^2+in the dual-phase GCs when pumped resonantly and off-resonantly with the localized surface plasmon resonance band of the Au-metal NCs.The important role of the Au-metal NCs in the SPE enhancement is revealed by theoretical simulation based on the finite-element method.Combining the photonic engineering effect of hybrid Au-metal/γ-Ga2O3 NCs and the sensitization effect of Yb^3+on Ni^2+,a record-high enhancement factor of over 10 of the Ni^2+NIR emission is achieved,and optical gain is demonstrated in the GCs at the fiber communication wavelength. | ZHIGANG GAO HAIBO ZHU BOCHAO SUN YINGKE JI XIAOSONG LU HAO TIAN JING REN SHU GUO JIANZHONG ZHANG JUN YANG XIANGENG MENG KATSUHISA TANAKA | 2020 | Photonics Research2020，8，5： | 2 |
| 15 | Implementation of the moving particle semi-implicit method on GPU显示文摘The Moving Particle Semi-implicit (MPS) method performs well in simulating violent free surface flow and hence becomes popular in the area of fluid flow simulation. However, the implementations of searching neighbouring particles and solving the large sparse matrix equations (Poisson-type equation) are very time-consuming. In order to utilize the tremendous power of parallel computation of Graphics Processing Units (GPU), this study has developed a GPU-based MPS model employing the Compute Unified Device Architecture (CUDA) on NVIDIA GTX 280. The efficient neighbourhood particle searching is done through an indirect method and the Poisson-type pressure equation is solved by the Bi-Conjugate Gradient (BiCG) method. Four different optimization levels for the present general parallel GPU-based MPS model are demonstrated. In addition, the elaborate optimization of GPU code is also discussed. A benchmark problem of dam-breaking flow is simulated using both codes of the present GPU-based MPS and the original CPU-based MPS. The comparisons between them show that the GPU-based MPS model outperforms 26 times the traditional CPU model. | ZHU XiaoSong CHENG Liang LU Lin TENG Bin | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 2 |
| 16 | Antitumor effect of dobutamine on multiple myeloma via mitogen-activated protein kinase pathway in vitro显示文摘多重骨髓瘤(公里) 是最恶意的癌症之一并且被房间, monoclonal 免疫球蛋白的分泌物和 osteolytic 损害,和它的发生在中年、老的病人正在增加的血浆被骨头髓的渗入描绘[1 ] 。作为公里房间异构并且药抵抗、起始的公里通常进行到 relapsed/refractory 阶段。尽管象镇静药, bortezomib,和 lenalidomide 那样的存在治疗能延长公里病人的幸存,公里是是仍然考虑了医不好。因此,建立新有效治疗对待 relapsed/refractory 公里是必要的。 | Bingqian Xie Zhijian Xu Guang Yang Gege Chen Bo Li Liangning Hu Wenqin Xiao Xi Sun Minjie Gao Lu Gao Xiaosong Wu Yi Tao Weiliang Zhu Jumei Shi | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 1 |
| 17 | Numerical simulation of radiant floor cooling system:The effects of thermal resistance of pipe and water velocity on the performance显示文摘 | Jin Xing Zhang Xiaosong Lu Yajun | 2010 | Building and Environment2010，45，11： | 1 |
| 18 | Independent humidity control air conditioning systems combined liquid desiccant with radiant cooling显示文摘 | Lu Shikui Zhang Xiaosong | | 0，，： | 1 |
| 19 | A study on the friction and wear behavior of polytetrafluoroethylene filled with potassium titanate whiskers显示文摘 | Xin Feng Xiaosong Diao Yijun Shi Huaiyuan Wang Shenghua Sun Xiaohua Lu | 2006 | Wear2006，，11： | 1 |
| 20 | Monte Carlo modeling of optical coherence tomography imaging through turbid media 显示文摘 | Lu Qiang Gan Xiaosong Gu Min | 2004 | Applied Optics2004，43，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员