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| 1 | Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis显示文摘AIM: To evaluate the phagocytic activity and neutrophil oxidative burst in liver cirrhosis.METHODS: In 45 patients with advanced postalcoholic liver cirrhosis (aged 45±14 years) and in 25 healthy volunteers (aged 38±5 years), the percentage of phagocytizing cells after in vitro incubation with E. coli (Phagotest Kit), phagocytic activity (mean intensity of fluorescence, MIF) and the percentage of neutrophil oxidative burst (Bursttest Kit), and the level of free oxygen radical production (MIF of Rodamine 123)were analyzed by flow cytometry. The levels of soluble sICAM-1, sVCAM-1, sP-selectin, sE-selectin, sL-selectin,and TNF-α were determined in blood serum.RESULTS: The percentage of E. coli phagocytizing neutrophils in liver cirrhosis patients was comparable to that in healthy subjects. MIF of neutrophil - ingested E. coli was higher in patients with liver cirrhosis. The oxidative burst in E. coli phagocytizing neutrophils generated less amount of active oxygen compounds in liver cirrhosis patients (MIF of R123:24.7±7.1 and 29.7±6.6 in healthy,P<0.01). Phorbol myristate acetate (PMA) - stimulated neutrophilsproduced less reactive oxidants in liver cirrhosis patients than in healthy subjects (MIF of R123: 42.7±14.6 vs 50.2±13.3, P<0.01). A negative correlation was observed between oxidative burst MIF of PMA-stimulated neutrophils and ALT and AST levels (r -0.35, P<0.05;r-0.4, P<0.03). sVCAM-1, sICAM-1, sE-selectin concentrations correlated negatively with the oxygen free radical production (MIF of R123) in neutrophils after PMA stimulation in liver cirrhosis patients (r-0.45, P<0.05;r-0.41, P<0.05; r-0.39, P<0.05, respectively).CONCLUSION: Neutrophil metabolic activity diminishes together with the intensification of liver failure. The metabolic potential of phagocytizing neutrophils is significantly lower in liver cirrhosis patients, which can be one of the causes of immune mechanism damage. The evaluation of oxygen metabolism of E. coli-stimulated neutrophils reveals that the amount of released oxygen metabolites is smaller in liver cirrhosis patients than in healthy subjects. | Anatol Panasiuk Jolanta Wysocka Elzbieta Maciorkowska Bozena Panasiuk Danuta Prokopowicz Janusz Zak Karol Radomski | 2005 | World Journal of Gastroenterology2005，11，48： | 4 |
| 2 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 3 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of o- verweight and obese patients 显示文摘 | Wysocka E Cofla S Cymerys M | 2008 | Physiol Pharmacol2008，59，6： | 1 |
| 4 | Analysis of Serum Adiponectin, Resistin and Leptin Levels in Children and Adolescents with Autoimmune Thyroid Disorders显示文摘 | Artur Bossowski Beata Sawicka Mieczys?aw Szalecki Alicja Koput Jolanta Wysocka Beata ?elazowska-Rutkowska | 2010 | Journal of Pediatric Endocrinology and Metabolism2010，，4： | 1 |
| 5 | Naive andmemory Tcells in hypertrophied adenoids in children according to age显示文摘 | Wysocka J Hassmann E Lipska A | 2003 | Int J Pediatric Otorhinolaryngol2003，67，： | 1 |
| 6 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，59，： | 1 |
| 7 | Role of IL 12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL 10 and nitricoxide显示文摘 | Gazzinelli RT Hayashi S Wysocka M | | 0，，05： | 1 |
| 8 | Expression Bcl2 protein of lymphocytes T and B in hypertrophied adenoid in children with otitis media with effusion 显示文摘 | Elazowska R_utkowska B Wysocka J | 2006 | Otolaryngol Pol2006，60，5： | 1 |
| 9 | A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling 显示文摘 | Wysocka J Swigut T Xiao H | 2006 | Nature2006，442，7098： | 1 |
| 10 | Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii显示文摘 | Gazzinelli R T Wysocka M Hayashi S | 1994 | The Journal of Immunology1994，153，6： | 1 |
| 11 | Flt3 ligand treatment reverses endotoxin tolerance-related immunoparalysis显示文摘 | Wysocka M Montaner LJ Karp CL | | 0，，11： | 1 |
| 12 | Expression of adhesion molecule CD28 on subpopulation s of lymphocytes in hypertrophied adenoids in children with otitis media with effusion 显示文摘 | Ratomski K Zelazowska-Rutkowska B Wysocka J | 2006 | Otolaryngol Pol2006，60，6： | 1 |
| 13 | Cardiovascular risk associated with abnormal metabolism of plasma lipoproteins in patients with diabetes mellitus 显示文摘 | Burchardt P Zawada A Wysocka WB | 2012 | Kardiol Pol2012，70，6： | 1 |
| 14 | Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion显示文摘 | Zelazowska-Rutkowska Beata Ilendo Elzbieta Skotnicka Bozena Wysocka Jolanta Kasprzycka Edwina | 2012 | Folia Histochemica et Cytobiologica2012，，4： | 1 |
| 15 | CD80 and CD86 coreceptors expression on lymphocytes B in hypertrophied adenoids in children with otitis media with effusion 显示文摘 | Ratomski K Zelazowska-Rutkowska B Wysocka J | 2010 | Otolaryngol Pol2010，64，2： | 1 |
| 16 | Characteristics of acid phosphatase from Russian sturgeon (Acipenser guelder:taedtii )spermatozoa显示文摘 | Sarosiek B Wysocka J Wysocki P | 2006 | J Appl Ichthyol2006，22，1： | 1 |
| 17 | 显示文摘 | Kreczko S Lipska A Wysocka J | 2000 | PolMerkuriusz Lek2000，8，48： | 1 |
| 18 | Investigation of serum cytokine levels and cytokine production in whole blood cultures of paranoid schizophrenic patients显示文摘 | Kaminska T Wysocka A Marmurowska- Michalowska H | 2001 | Arch Immunol Ther Exp2001，49，6： | 1 |
| 19 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients 显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，596，： | 1 |
| 20 | E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases 显示文摘 | Tyagi S Chabes AL Wysocka J | 2007 | Mol Cell2007，27，1： | 1 |
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