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| 1 | MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs. | Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho | 2018 | World Journal of Gastroenterology2018，24，27： | 29 |
| 2 | Hepatic adenylate energy charge levels in patients with hepatoma after hepatic artery embolization显示文摘HepaticadenylateenergychargelevelsinpatientswithhepatomaafterhepaticarteryembolizationLILi1,YANLuNan1,CHENXiaoLi1,LUWuShe... | Li, L Yan, LN Chen, XL Lu, WS Xie, XD Wu, YT | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 3 | Taxuchin B,a New Chlorine-Containing Taxoid显示文摘A new taxoid, taxuchin B[1], has been isolated from twigs and needles of Taxus chinensis. It is the first chlorine-containing taxoid reported to | Fang, WS Fang, QC Liang, XT Lu, Y Wu, N Zheng, QT | 1997 | Chinese Chemical Letters1997，8，3： | 2 |
| 4 | Incidenee and factors predictive of acute renal failure in patients with ad- vanced liver cirrhosis显示文摘 | Wu CC Yeung LK Tsai WS | 2010 | Clin Nephrol2010，13，3： | 1 |
| 5 | Dexamethasone induction of keloid regression through effective suppression of VE GF espression and keloid fibroblast proliferation 显示文摘 | Wu Ws Wang FS Yang KD | 2006 | J Invest Dermatol2006，126，6： | 1 |
| 6 | Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation 显示文摘 | Wu WS Wang FS Yang KD | 2006 | J Invest Dermatol2006，126，： | 1 |
| 7 | Mechanical strain modulates age-related changes in the pro-liferation and differentiation of mouse adipose-derived stromal cells显示文摘 | Huang SC Wu TC Yu HC Chen MR Liu CM Chiang WS Lin KM | | 0，，： | 1 |
| 8 | Flashlamp pulsed-dye laser suppressed TGF-beta 1 expression and proliferation in cultured keloid fibroblasts in mediated by MAPK pathway显示文摘 | Kuo YR Wu WS Wang FS | 2007 | Lasers Surg Med2007，39，4： | 1 |
| 9 | Hepatitis B virus X protein blocks filamentous actin bundles by interaction with eukaryotic translation elongation factor 1 alpha l显示文摘 | Lin WS Jiao BY Wu YL | 2012 | J Med Virol2012，84，6： | 1 |
| 10 | Neuromedin B and its receptor induce labor onset and are associated with the RELA (NFKB P65)/IL6 pathway in pregnant mice显示文摘 | Zhang WS Xie QS Wu XH | | 0，，： | 1 |
| 11 | Ferrous ion enhanced lipopeptide antibiotic iturin A production from Bacillus amyloliquefaciens B128显示文摘 | Lin HY Rao YK Wu WS | 2007 | International Journal of Ap- plied Science and Engineering2007，5，2： | 1 |
| 12 | Suppressed TGF-beta1 expression is correlated with up- regulation of matrix metallo proteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment 显示文摘 | Kuo YR Wu WS Jeng SF | 2005 | Lasers Surg Med2005，36，1： | 1 |
| 13 | Activation of ERK and p38 kinase mediated keloid fi- broblast apoptosis after flashlamp pulsed- dye laser treatment 显示文摘 | Kuo YR Wu WS Jeng SF | 2005 | Lasers Surg Med2005，36，3： | 1 |
| 14 | Flashlamp pulsed-dye laser suppressed TGF-betal ex- pression and proliferation in culturedkeloid fibroblasts is mediated by MAPK pathway 显示文摘 | Kuo YR Wu WS Wang FS | 2007 | Lasers Surg Med2007，39，4： | 1 |
| 15 | Evaluation of prognosis for malignant rectal gastrointestinal stromal tumor by clinical parameters and immunohistochemical staining显示文摘 | Changchien CR Wu MC Tasi WS | 2004 | Dis Colon Rectum2004，47，11： | 1 |
| 16 | The effect of click rate on latency and interpeak interval of the brain-stem auditory evoked potentials in children from birth to 6 years 显示文摘 | Jiang ZD Wu YY Zheng WS | 1991 | Electroencephalogr Clin Neurophysiol1991，80，1： | 1 |
| 17 | The signaling mechanism of ROS in tumor pro- gression显示文摘 | Wu WS | 2006 | Cancer Metastasis Rev2006，25，4： | 1 |
| 18 | Synthetic peroxisome proliferator-activated receptor-gamma agonist,rosiglitazone,increases plasma levels of adiponectin in type 2 diabetic patients显示文摘 | Yang WS Jeng CY Wu TJ | 2002 | Diabetes Care2002，25，2： | 1 |
| 19 | The lumbar multifidus muscle in polysegmentally innervated显示文摘 | Wu PB Date ES Kingery WS | 2000 | Electromyography and Clinical Neurophysiology2000，40，： | 1 |
| 20 | The signaling mechanism of ROS in tumor progression 显示文摘 | Wu WS | 2006 | Cancer Metastasis Rev2006，25，4： | 1 |
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