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| 1 | Early neurosurgical intervention of spinal cord contusion: an analysis of 30 cases显示文摘背景有针的绳索殴打的脊柱受伤的发生在发达国家高并且现在在中国正在成长。而且,针的绳索损害主要在有长寿期待的年轻人发生。很多病人因此是为他们的生活的其余部分的轮椅界限。因此,针的绳索损害引起了世界范围的大担心。尽管有大努力,从针的绳索损害的恢复仍然保持不能令人满意。基于针的绳索殴打的病理,早 neurosurgical 干预的一个想法在这研究被提出了。有“完全”的针的绳索损害的 30 个病人全部或象美国脊柱受伤协会(亚洲) A 分类的方法 A 被学习。受伤椎骨(e) ,脊椎的列的内部固定,和为硬膜上的解压缩的双边的 laminectomy 的矫形治疗被 neurosurgical 管理直接跟随,包括恢复脑髓的液体流动和针的绳索的清创术的蛛网状的粘附的分离有伴随物 intramedullary 解压缩的坏死的织物。康复在操作以后开始了 17 天。最后的结果在 3 月康复以后被评估。皮尔森 chi 平方分析被用于统计分析。所有病人恢复了的结果走的某能力。最少的恢复病人能在稳定忍受膝关节的重量与 wheeled 重量支持和帮助走(12 个盒子, 40%) 。13 个病人(43%) 能与一双丁字拐走,一根棍子或没有任何支持。在损害以后预定操作是重要的。一扇最佳的操作时间窗户在损害以后在 4-14 天被识别。康复跟随的针的绳索殴打的结论早 neurosurgical 干预能显著地改进病人的运动。它是为针的绳索殴打的一条治疗学的途径的一个新想法并且被证明了很成功。 | ZHU Hui FENG Ya-ping Young Wise YOU Si-wei SHEN Xue-feng LIU Yan-sheng JU Gong | 2008 | Chinese Medical Journal2008，，24： | 30 |
| 2 | 嗅鞘细胞促使脊髓挫裂伤后神经再生和功能恢复的研究显示文摘目的 :研究嗅鞘细胞在脊髓挫裂损伤后不同时期植入能否帮助轴突再生、穿过瘢痕和神经功能恢复。方法 :用 NYU打击器制造 Log Evans Hooded大鼠的脊髓挫裂损伤模型 ,在伤后即刻和二周后植入嗅鞘细胞 ,采用 BBB方法做行为学观察三个月 ,经运动皮层注入神经示踪剂 (BDA)后行组织化学研究。结果 :部分大鼠嗅鞘细胞植入后比对照组的神经功能恢复好 ,组织学发现这些神经功能恢复好 (BBB分数 >10 )的大鼠 ,再生神经轴突能穿过损伤瘢痕区到达损伤下段。结论 :嗅鞘细胞在脊髓挫裂损伤后即刻和二周后植入均能帮助轴突再生、穿过瘢痕和神经功能恢复。 | 黄红云 刘凯 黄文成 刘宗惠 Wise Young | 2001 | 海军总医院学报2001，14，2： | 30 |
| 3 | Emergency bedside ultrasound for the diagnosis of pediatric intussusception: a retrospective review显示文摘BACKGROUND: Ultrasound diagnosis of pediatric intussusception is feasible with limited operator training. The authors report the test characteristics of bedside ultrasound(BUS) for the diagnosis of pediatric intussusception at a single institution.METHODS: Inclusion criteria were: 1) patients of 0–18 years old were seen in the pediatric emergency department(ED) with a clinical presentation suspicious for intussusception; 2) BUS was performed to identify intussusception and bedside impression documented in the medical record; 3) a 'formal' diagnostic study(such as computed tomography, ultrasound, or barium enema) was performed by the radiology department after BUS was completed. Electronic medical record and ED BUS archive were screened for potentially eligible ED visits between January 1st 2009 to October 3rd 2012. These records were then reviewed to identify patients for inclusion in the study. All emergency physicians who performed the BUS had undergone a minimum of 1-hour didactic training on the use of BUS to diagnose pediatric intussusception.RESULTS: A total of 1 631 charts were reviewed, with 49 meeting inclusion criteria. Five of those were later excluded for incomplete documentation or lack of saved BUS images. The prevalence of intussusception was 23%. The mean age of the subjects was 31 months. BUS was 100% sensitive(95%CI 66%–100%) and 94% specifi c(95%CI 79%–99%) for detection of pediatric intussusception compared to radiology study results. Positive and negative likelihood ratios were 16.5(95%CI 4.30%–63.21%) and 0(95%CI 0–0) respectively.CONCLUSIONS: BUS is an accurate means of diagnosing acute intussusception in pediatric patients. Further study might be indicated to confi rm such benefi ts. | Samuel H. F. Lam Adam Wise Christopher Yenter | 2014 | World Journal of Emergency Medicine2014，5，4： | 10 |
| 4 | Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines显示文摘AIM: To study the effect of a number of chemotherapeutic drugs on five human intrahepatic cholangiocarcinoma (CCA) cell lines. The expressions of genes that have been proposed to influence the resistance of chemotherapeutic drugs including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), glutathione-S-transferase P1 (GSTP1), multidrug resistance protein (MDR1) and multidrug resistance-associated proteins (MRPs) were also determined.METHODS: Five human CCA cell lines (KKU-100, KKU M055, KKU-M156, KKU-M214 and KKU-OCA17) weretreated with various chemotherapeutic drugs and growth inhibition was determined by 3-(4,5-dimethylthiazol-2-yl)5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. Semi-quantitative levels of gene expression were determined by a reverse transcriptase polymerase chain reaction (RT-PCR). Results of IC50 values and the ratios of gene expression were analyzed by linear regression to predict their relationship. RESULTS: Among five CCA cell lines, KKU-M055 was the most sensitive cell line towards all chemotherapeutic drugs investigated, particularly taxane derivatives with IC50 values of 0.02-3 nmol/L, whereas KKU-100 was apparently the least sensitive cell line. When compared to other chemotherapeutic agents, doxorubicin and pirarubicin showed the lowest IC50 values (<5 μmol/L) in all five CCA cell lines. Results from RT-PCR showed that TS, MRP1, MRP3 and GSTP1 were highly expressed in these five CCA cell lines while DPD and MRP2 were only moderately expressed. It should be noted that MDR1 expression was detected only in KKU-OCA17 cell lines. A strong correlation was only found between the level of MRP3 expression and the IC50 values of etoposide, doxorubicin and pirarubicin (r = 0.86-0.98, ,P<0.05). CONCLUSION: Sensitivity to chemotherapeutic agents is not associated with the histological type of CCA. Choosing of the appropriate chemotherapeutic regimen for the treatment of CCA requires knowledge of drug sensitivity. MRP3 was correlated with resistance of CCA cell lines to etoposide, doxorubicin and pirarubicin, whereas other chemotherapeutic drugs showed no association. The roleof this multidrug resistance-associated protein, MRP3, in chemotherapeutic resistance in CCA patients needs to be further investigated. | Nisana Tepsiri Liengchai Chaturat Banchob Sripa Wises Namwat Sopit Wongkham Vajarabhongsa Bhudhisawasdi Wichittra Tassaneeyakul | 2005 | World Journal of Gastroenterology2005，11，18： | 10 |
| 5 | Involvement of cholangiocyte proliferation in biliary fibrosis显示文摘Cholangiocytes are the epithelial cells that line the biliary tree.In the adult liver,they are a mitotically dormant cell population,unless ductular reaction is triggered by injury.The ability of cholangiocytes to proliferate is important in many different human pathological liver conditions that target this cell type,which are termed cholangiopathies(i.e.primary biliary cirrhosis,primary sclerosing cholangitis and biliary atresia).In our article,we provide background information on the morphological and functional heterogeneity of cholangiocytes,summarize what is currently known about their proliferative processes,and briefly describe the diseases that target these cells.In addition,we address recent findings that suggest cholangiocyte involvement in epithelial-to-mesenchymal transformation and liver fibrosis,and propose directions for future studies. | Sally Priester Candace Wise Shannon S Glaser | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 10 |
| 6 | 中国西南地区儿童土源性线虫感染及影响因素调查显示文摘目的了解中国西南贫困地区儿童土源性线虫感染情况和主要影响因素,为制定土源性线虫病防治措施提供依据。方法采用改良加藤厚涂片法对受检儿童粪便进行病原学检查,其中部分儿童进行透明胶纸肛拭法检查蛲虫卵。采用问卷调查和Probit估计多元统计方法,分析儿童服药驱虫、个体特征、饮食卫生习惯和家庭特征等16个相关因素对土源性线虫感染的影响。结果共粪检1 707名儿童,土源性线虫感染率为22.2%,其中蛔虫、钩虫、鞭虫感染率分别为16.9%、3.8%和6.6%,且以蛔虫感染率和感染度为最高;蛲虫检查495名,感染率为5.1%。Probit估计多元统计显示,兄弟姐妹数量、母亲受教育程度、饮用生水、饲养畜禽等4个因素差异均有统计学意义(P均<0.05)。其中,母亲受教育程度能降低土源性线虫感染率,边际效应为-0.074;兄弟姐妹数量、饮用生水和饲养畜禽均能提高土源性线虫感染率,边际效应分别为0.028、-0.112和0.080。结论我国西南贫困地区儿童土源性线虫感染率仍然较高,且以蛔虫感染为主;改变儿童饮用生水的不良卫生习惯、家庭饲养畜禽习惯和针对其母亲开展寄生虫病防治知识的健康教育,对儿童土源性线虫病的预防和控制具有重要意义。 | 王晓兵 王国飞 张林秀 罗仁福 田洪春 唐丽娜 王聚君 Alexis Medina Paul Wise Scott Rozelle | 2012 | 中国血吸虫病防治杂志2012，24，3： | 10 |
| 7 | Cochrane回顾性研究指出对心力衰竭患者电话随访能有效减少死亡显示文摘一项Cochrane系统回顾报道:如果能够得到密切的个案管理(通常是指由专业护士进行的电话随访或家庭访问),慢性心力衰竭患者在出院后1年内死亡的可能性更低,出院后6个月内再次入院的可能性也更低。 | Jacqui Wise 刘定华(译) 杜昕(校) | 2012 | 英国医学杂志中文版2012，15，6： | 7 |
| 8 | 中国干旱、洪水、地震灾害监测空间采样设计显示文摘研究了空间采样设计对监测估值精度的影响,样本集用于监测和估计中国4个样区的干旱、洪水、地震综合活动水平.空间相关信息从中国干旱、洪水、地震综合区划图上提取.揭示了采样策略(采样方式、采样密度)和估值精度之间的最优关系,并论证了正或负的空间相关性和采样策略在监测网络设计中起关键作用,方法和结果可以为我国将来建立综合自然灾害监测网设计和减灾卫星系统参数选择所参考. | 王劲峰 Haining Robert Wise Steve | 1999 | 自然科学进展(国家重点实验室通讯)1999，9，4： | 6 |
| 9 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 10 | Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines显示文摘AIM:To investigate the growth inhibitory mechanism of four caged xanthones from Garcinia hanburyi in cholangiocarcinoma(CCA) KKU-100 and KKU-M156 cells.METHODS:Four caged xanthones,selected on the basis of their anticancer potency and chemical structure diversities(i.e.isomorellin,isomorellinol,forbesione and gambogic acid) were used in this study.Growth inhibition of these caged xanthones was determined using the sulforhodamine B assay.Induction of apoptosis was assessed by observing cell morphology,ethidium bromide and acridine orange staining and DNA fragmentation assay.Levels of apoptotic-related gene and protein expressions were determined by a real-time reverse transcriptase polymerase chain reaction and Western blotting analysis,respectively.RESULTS:The compounds were found to inhibit growth of both cell lines in a dose-dependent manner and also showed selective cytotoxicity against the cancer cells when compared with normal peripheral blood mononuclear cells.Growth suppression by these compounds was due to apoptosis,as evidenced by the cell morphological changes,chromatin condensation,nuclear fragmentation,and DNA ladder formation.At the molecular level,these compounds induced down-regulation of Bcl-2 and survivin proteins with up-regulation of Bax and apoptosisinducing factor proteins,leading to the activation of caspase-9 and-3 and DNA fragmentation.The functional group variations did not appear to affect the anticancer activity with regard to the two CCA cell lines;however,at a mechanistic level,isomorellinol exhibited the highest potency in increasing the Bax/Bcl-2 protein expression ratio(120 and 41.4 for KKU-100 and KKU-M156,respectively) and in decreasing survivin protein expression(0.01 fold as compared to control cells in both cell lines).Other activities at the molecular level indicate that functional groups on the prenyl side chain may be important.CONCLUSION:Our findings for the first time demonstrate that four caged xanthones induce apoptosis in CCA cells which is mediated through a mitochondriadependent signaling pathway. | Chariya Hahnvajanawong Wongwarut Boonyanugomol Tapanawan Nasomyon Watcharin Loilome Nisana Namwat Natthinee Anantachoke Wichittra Tassaneeyakul Banchob Sripa Wises Namwat Vichai Reutrakul | 2010 | World Journal of Gastroenterology2010，16，18： | 5 |
| 11 | High efficiency, high power 808nm laser array and stacked arrays optimized for elevated temperature operation显示文摘Operation of 808-nm laser diode pumping at elevated temperature is crucial to many applications. Reliable operation at high power is limited by high thermal load and low catastrophic optical mirror damage (COMD) threshold at elevated temperature range. We demonstrated high efficiency and high power operation at elevated temperature with high COMD power. These results were achieved through device design optimization such as growth conditions, doping profile, and materials composition of the quantum-well and other layers. Electrical-to-optical efficiency as high as 62% was obtained through lowered threshold current, lowered series resistance and increased slope efficiency. The performance of single broad-area laser diodes scales to that of high power single bars on water-cooled copper micro-channel heatsinks or conductively-cooled CS heatsinks. No reduction in bar performance or significant spectral broadening is seen when these micro-channel coolers are assembled into 6-bar and 18-bar CW stacks for the highest power levels. | Crump P A Crum T R DeVito M Farmer J Grimshaw M Huang Z Igl S A Macomber S Thiagarajan P Wise D | 2004 | 光机电信息2004，21，6： | 4 |
| 12 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 13 | NICE推荐慢性阻塞性肺疾病患者的肺康复计划显示文摘英国国家健康与临床优选研究所(NICE)鼓励处于慢性阻塞性肺疾病(COPD)稳定期和因呼吸问题运动受限的患者参与肺康复计划。NICE在最新版质量标准里建议急性加重COPD病情的患者应在出院后的4周内开始肺康复计划,好处一是降低短期再入院的风险,二是提高COPD患者短期运动能力和个人生活质量。 | Jacqui Wise 李丹麑 | 2016 | 英国医学杂志中文版2016，0，6： | 3 |
| 14 | Morphological and biochemical changes in Escherichia coli after exposure to ciprofloxacin 显示文摘 | Diver J M Wise R | 1986 | J Antimicrob Chemother1986，18，： | 3 |
| 15 | 研究发现外科减重手术后体重下降持续4年以上显示文摘一项发表在PLoS Med上的研究(Douglas I,2015)结果显示,外科减重手术相关的显著体重下降可以持续至少4年。这项来自英国的关于外科减重手术远期影响的最大综合研究的结果显示,外科减重手术可降低2型糖尿病、高血压、心绞痛、心肌梗死和阻塞性睡眠呼吸暂停综合征的发生风险。 | Jacqui Wise 余洁 许岭翎 | 2016 | 中华外科杂志2016，54，11： | 2 |
| 16 | 脐血单核细胞移植治疗慢性完全性脊髓损伤Ⅱ期临床试验的安全性和疗效评估显示文摘目的评估人类白细胞抗原(HLA≥4:6)配型的脐血单核细胞(UCBMC)移植治疗慢性完全性脊髓损伤(SCI)的安全性、可行性、有效性以及最佳细胞剂量和联合使用甲基强的松龙(MP)、碳酸锂对细胞移植的作用。方法选取联勤保障部队第九二〇医院神经外科自2011年2月至2014年1月收治的20例SCI患者,按照随机数字表法分为5组(A、B、C、D、E组),每组4例受试者。在患者损伤上下缘脊神经背根入处的4个点(上下各2点)注射UCBMC,A、B、C组分别为每点各注射4、8和16μL(100000 UCBMC/μL,640万细胞)到SCI部位的上方和下方脊神经背根入处,D组为16μL细胞注射加30 mg/kg MP静脉注射,E组为16μL细胞注射加MP和口服碳酸锂(750 mg/d),一个疗程6周。受试者进行3~6个月的强化步行训练,以美国脊髓损伤协会(ASIA)为主要评分指标,脊髓损伤步行指数(WISCI)和脊髓独立量表(SCIM)为次要评分指标。结果20例受试者的SCI平面分别位于C3~T11,平均受伤7年。治疗前,16例(80%)患者行走<10 m,18例(90%)患者自理生活需要协助。治疗后41~87周,受试者ASIA运动评分无明显变化,而WISCI和SCIM评分明显提高。15例(75%)患者可在辅助下步行10 m,12例(60%)患者恢复膀胱和肠道控制,5例(25%)患者由完全性SCI变为不完全性SCI;所有患者无神经功能丢失。结论UCBMC移植和步行训练能提高慢性完全性SCI患者的WISCI和SCIM评分,但对运动评分没有改善,因此推测UCMBC移植能促进轴突的生长,从而激活中枢模式发生器,改善运动、排尿和排便等功能,而且联合使用MP和碳酸锂对细胞移植治疗无明显作用。 | 封亚平 Wise Young 朱辉 封雨 邓洵鼎 谢佳芯 张社敏 方芳 石静 陈永和 郑爽 | 2020 | 中华神经创伤外科电子杂志2020，6，4： | 2 |
| 17 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 18 | Femtosecond ytterbium fiber laser with photonic crystal fiber for dispersion control显示文摘 | Lim H Ilday F O Wise F W | 2002 | Optics Express2002，10，25： | 2 |
| 19 | 跨学科视域下的体育与政治研究——Alan Bairner教授学术访谈录显示文摘通过学术访谈的形式,英国拉夫堡大学Alan Bairner教授深入讨论了体育与政治研究领域的基本特质、理论方法运用以及各种挑战等问题。他认为,体育与政治研究具有跨学科的属性,而他自己是从事该领域研究的'社会(科)学家';在开展体育与政治研究的过程中,需要批判性地综合运用社会理论与质性研究范式,以生动呈现并深入解释人们日常生活中与体育相关的政治议题;当前,该领域的研究和其他体育社会科学一样,不得不面临新自由主义和精英主义的高等教育环境、学科发展中的'双重边缘化'、体育研究者自身知识结构限制等学科内外部多重挑战。最后,他还评析了中国体育发展及其亟待研究的相关议题,并希望我国体育社会科学工作者为推动学科知识的积累做贡献。 | 田恩庆 姜凯笑 Nicholas Wise | 2021 | 成都体育学院学报2021，47，4： | 2 |
| 20 | Concealed fault analysis based on the CT projection matrix显示文摘This paper proposes the concept of projection curves based on the theory of CT image reconstruction to probe the internal structure of the working panel prior to formal mining of the working panel.As well as reducing costs,this method provides safe and efficient excavation of the working panel.According to the results of the numerical model and the actual working panel,the new method has been proven to be accurate in detecting the location of the fault that extends into the face.Concealed faults of the internal working panel,as well as the start and end points of the fault,can be detected by this method.Engineering practice has proven that the method is highly reliable,has a highly decisive impact on faults for coal mining,and can be used to guide the safe mining of the working panel. | Yang Zhen Yao Wenli Ma Liuzhu Wise Lucas | 2016 | International Journal of Mining Science and Technology2016，26，2： | 2 |
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