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| 1 | The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants显示文摘到 Arabidopsis 幼苗的螃蟹壳几丁质或 pentamer 几丁质 oligosaccharide 的申请增加了忍耐到咸度在野类型然而并非在 LysM 像受体的 Kinase1 (CERK1/LysM RLK1 ) 的猛烈异种基因,知道在表明外长的几丁质导致的防卫回答起一个关键作用。从真菌 Trichoderma asperelleoides T203 的 endochitinase chit36 和 hexoaminidase excy1 基因显示出的 Arabidopsis 植物 overexpressing 增加了忍耐到咸度,重金属的压力,和 Botrytis cinerea 感染。抵抗的线, overexpressing 在不同层次的真菌的 chitinases,是到 lysm rlk1 异种的 outcrossed。独立同型结合的混血儿失去了抵抗到关於生命、不能生活的压力,尽管有提高的 chitinase 活动。 270 压力相关的基因的表示分析包括反应的氧种类( ROS )和几丁质导致的那些,揭示经常的起来规定(至少双重) 10 ,在 chitinase-overexpressing 的基因排队并且一另外其表情没在怀有变化的 lysm rlk1 大美人异种或混血儿被提高的 76 导致盐的基因。这些调查结果阐明那个导致几丁质的发信号由 LysM RLK1 调停了受体没被限制到关於生命的压力反应而且包含不能生活压力的发信号和罐头被 chitinases 的宫外的表示在植物传送。 | Yariv Brotman Udi Landau Smadar Pnini Jan Lisec Salma Balazadeh Bernd Mueller-Roeber Aviah Zilberstein Lothar Willmitzer Ilan Chet Ada Viterbo | 2012 | Molecular Plant2012，5，5： | 5 |
| 2 | Mapping theArabidopsis Metabolic Landscape by Untargeted Metabolomics at Different Environmental Conditions显示文摘新陈代谢的染色体宽的协会研究(mGWAS ) ,因此,代谢物层次被认为是特点,帮助能解开新陈代谢的网络的基因基础。309 Arabidopsis 就职的一个总数在二个独立环境条件(控制和应力) 下面被种并且使遭到到介绍的 untargeted LC-MS-based metabolomic;获得的吸水的代谢物的层次在 GWAS 被使用。我们为超过 3000 半极的代谢物的 two-condition-based GWAS 导致了 123 高度解决的代谢物的察觉量的特点 loci ?(p 1.0E-08 ) 。有趣地,不同地,从在 Arabidopsis 主要代谢物,趋于被很多小效果的 loci 控制,的自然变化,我们在发现几个学生大效果的 loci 控制第二等的代谢物的变化的小效果的 loci 的一个广阔数字。two-condition-based GWAS 被集成用一个时间功课压力实验与导出网络的代谢物抄本关联跟随。通过这条综合途径,我们选择了在结构的基因和代谢物之间的 70 个关键候选人协会,并且试验性地验证了八个新奇协会,他们中的二个在二环境的出现微分基因规定学习了。我们表明联合有 time-course-derived 网络的基于 metabolomics 的 GWAS 两个都为识别代谢物基因协会在不同不能生活的环境下面执行了的大规模 untargeted 的力量,提供进 Arabidopsis 的新陈代谢的风景的新奇全球卓见。 | Si Wu Takayuki Tohge Alvaro Cuadros-lnostroza Hao Tong Hezi Tenenboim Rik Kooke Michael Meret Joost B. Keurentjes Zoran Nikoloski Alisdair R. Fernie Lothar Willmitzer Yariv Brotman | 2018 | Molecular Plant2018，11，1： | 3 |
| 3 | Analysis of the Interface between Primary and Secondary Metabolism in Catharanthus roseus Cell Cultures Using ^13C-Stable Isotope Feeding and Coupled Mass Spectrometry显示文摘Dear Editor, The tropical plant Madagascar periwinkle Catharanthus roseus (L.) G.Don is a rich source of plant-derived medicinal terpenoid indole alkaloids (TIAs),including the anti-hypertensive ajmalicine,the sedative compound serpentine,and the anticancer drugs vinblastine and vincristine.However,the latter two compounds are produced in C roseus plants only in very low amounts.Elicitors such as hormones (e.g.jasmonates or salicylic acid) activate plant natural defense responses,including increased secondary metabolite production (EI-Sayed and Verpoorte,2007;Lackman et al.,2011).There are two different metabolic pathways for the biosynthesis of terpenoids leading to the formation of the Cs central precursor isopentenyl diphosphate (IPP),namely the classical cytosolic mevalonate pathway and the mevalonate-independent plastidic 2-C-methyI-D-erythritol 4-phosphate (MEP) pathway. | Carla Antonio Natali R. Mustafa Sonia Osorio Takayuki Tohge Patrick Giavalbco Lothar Willmitzer Heiko Rischer Kirsi-Marj Oksman-Caldentey Robert Verpoorte Alisdair R. Fernie | 2013 | Molecular Plant2013，6，2： | 2 |
| 4 | GC–MS libraries for the rapid identification of metabolites in complex biological samples显示文摘 | Nicolas Schauer Dirk Steinhauser Sergej Strelkov Dietmar Schomburg Gordon Allison Thomas Moritz Krister Lundgren Ute Roessner-Tunali Megan G. Forbes Lothar Willmitzer Alisdair R. Fernie Joachim Kopka | 2005 | FEBS Letters2005，，6： | 2 |
| 5 | Improved method for the isolation of RNA from plant tissues 显示文摘 | Logemann J Schell J Willmitzer L | 1987 | Anal Biochem1987，163，： | 1 |
| 6 | Storage of competent cells for Agrobacterium transformation显示文摘 | Hfgen R Willmitzer L | | 0，，： | 1 |
| 7 | Molecular cloning and characterization of novel isoforms of potato ADP-glucose pyrophosphorylase 显示文摘 | Cognata U L Willmitzer L Muller-Rober B | 1995 | Molecular General Genetic1995，246，： | 1 |
| 8 | One of two different ADP-glucose pyrophosphorylase genes from potato responds strongly to elevated levels of sucrose显示文摘 | Bernd Thomas Müller-R?ber Jens Ko?mann L. Curtis Hannah Lothar Willmitzer Uwe Sonnewald | 1990 | MGG Molecular & General Genetics1990，，1： | 1 |
| 9 | Storage of competent cells for Agrobacterium transformation 显示文摘 | Hofen R Willmitzer L 1988 | 1988 | Nucl Acids Res1988，16，： | 1 |
| 10 | Potato hexokinase 2 complements transgenic Arabidopsis plants deficient in hexokinase 1 but does not play a key role in tuber carbohydrate metabolism显示文摘 | Jon Veramendi Alisdair R. Fernie Andrea Leisse Lothar Willmitzer Richard N. Trethewey | 2002 | Plant Molecular Biology2002，，5： | 1 |
| 11 | Transgenic potato tubers accumulate high level of 1- kestose and nystose: Functional identification of a sucrose : sucrose 1-fructosytltransferase of artichoke ( Cynara scolymus) blossom discs 显示文摘 | HELLWEGE E M GRITSCHER D WILLMITZER L | 1997 | Plant Journal1997，12，： | 1 |
| 12 | Storage of competent cells for agrobacterium transformation显示文摘 | Hofen R Willmitzer L | 1988 | Nucleic Acids Research1988，16，： | 1 |
| 13 | The contribution of adenosine 5'-diphosphoglucose pyrophosphorylase to the control of starch synthesis in potato tubers显示文摘 | Sweetlove L J Muller-Roeber B Willmitzer L | 1999 | Planta1999，209，： | 1 |
| 14 | Analysis of the expression of potato uridinediphosphate-glucose pyrophosphorylase and its inhibition by antisense RNA显示文摘 | R. Zrenner L. Willmitzer U. Sonnewald | 1993 | Planta1993，，2： | 1 |
| 15 | Inhibition of the ADPglucose pyrophosphorylase in transgenic potatoes leads to sugarstoring tubers and influences tuber formation and expression of tuber storage protein genes显示文摘 | Muller-Rober B Sonnewald U Willmitzer L | 1992 | EMBO J1992，11，： | 1 |
| 16 | Improved method for the isolation of RNA from plant tissues显示文摘 | Logemann J Schell J Willmitzer L | 1987 | Anal Biochem1987，163，： | 1 |
| 17 | Storage of competent cells for Agrohacterium transformation 显示文摘 | Loathar Willmitzer | 1988 | Nucleic Acids Research1988，16，20： | 1 |
| 18 | Signals involved in wound-induced proteiase inhibitor Ⅱ gene expression in tomato and potato plants显示文摘 | Peita-Cortes H Fisahn J Willmitzer L | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 19 | Inhibition of a starchgranule-bound protein leads to modified starch and repression of cold sweetening显示文摘 | Lorberth R Ritte G Willmitzer L | 1998 | Nature Biotech1998，16，： | 1 |
| 20 | Isolation and characerization of a sucrose carrier cDNA from spinach by functional expression in yeast 显示文摘 | Riesmeier J W Willmitzer L Frommer W B | 1992 | EMBO J1992，11，： | 1 |
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