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| 1 | Expression of the B7 - related molecule B7 - H1 by glioma cells: a potential mechanism of immune paralysis显示文摘Human glioblastoma is a highly lethal tumor that is known for its immune inhibitory capabilities.B7-homologue l(B7-H 1),a recently identified homologue of B7.1/2(CD80/86),has been described to exert costimulatoryand immune regulatory functions.We investigated the expression and the functional activity of B7-H 1 in humanglioma cells in vitro and in vivo.Although lacking B7.1/2(CD80/86),all 12 glioma cel1 1ines constitutivelyexpressed B7-H1 mRNA and protein.Exposure to IFN-gamma strongly enhanced B7-H 1 expression.Im- | Wintterle S Schreiner B Mitsdoerffer M Schneider D Chen Meyermann R Weller M Wiendl H | 2003 | 中国神经肿瘤杂志2003，1，4： | 37 |
| 2 | A functional role of HLA- G expression in human gliomas:an alternative strategy of immune escape 显示文摘 | Wiendl H Mitsdoerffer M Hofmeister V | 2002 | J Immunol2002，168，9： | 1 |
| 3 | A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape显示文摘 | Wiendl H Mitsdoerffer M Hofmeister V | 2002 | J Immunol2002，168，9： | 1 |
| 4 | The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast trans- plantation and gene therapy显示文摘 | Wiendl H Mitsdoerffer M Hofmeister V | 2003 | Brain2003，126，： | 1 |
| 5 | Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies显示文摘 | Wiendl H Kieseier BC | 2003 | Expert Opin Investig Drugs2003，12，4： | 1 |
| 6 | The non-classical MHC molecule HLAG protects human muscle cells from immune-mediated lysis:implications for myoblast transplantation and gene therapy显示文摘 | Wiendl H Mitsdoerffer M Hofmeister V Wischhusen J Weiss E H Dichgans J | 2003 | Brain2003，126，： | 1 |
| 7 | Express and protect your- self: the potential role of HLA-G on muscle ceils and in inflamma- tory myopathies 显示文摘 | Wiendl H Mitsdoerffer M Waller M | 2003 | Hum Immunol2003，64，11： | 1 |
| 8 | A Functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape显示文摘 | Wiendl H Mitsdoerffer M Hofmeister V | 2002 | J Immunol2002，165，： | 1 |
| 9 | GIuR3 antibodies: preva- lence in focal epilepsy but no specificity for Rasmussen's en- cephalitis显示文摘 | Wiendl H Bien CG Bernasconi P | 2001 | Neurology2001，57，8： | 1 |
| 10 | CADASIL: underdiagnosed in psychiatric patients?显示文摘 | Leyhe T Wiendl H Buchkremer G | 2005 | Acta Psychiatr Scand2005，111，5： | 1 |
| 11 | Myelin oligodendrocyte glycoprotein(MOG35 55)induced experimental autoimmune encephalomyelitis(EAE)in C57BL/6 mice显示文摘 | Bittner S Afzali AM Wiendl H | 2014 | J Vis Exp2014，15，51： | 1 |
| 12 | CD8+ T cells and neuronal damage:direct and collateral mechanisms of cytotoxicity and impaired electrical excitability显示文摘 | Melzer N Meuth SG Wiendl H | | 0，，01： | 1 |
| 13 | The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis显示文摘Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010. | Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth | 2019 | Neural Regeneration Research2019，14，11： | 1 |
| 14 | Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis : implications for CNS immunity 显示文摘 | Wiendl H Feger U Mittelbronn M | 2005 | Brain2005，128，11： | 1 |
| 15 | Multiple sclerosis:potential therapeutic options and update of ongoing studies显示文摘 | Wiendl H Lehmann HC Hohlfeld R | 2004 | Nervenarzt2004，75，6： | 1 |
| 16 | A functional role of HLA-G expression in human gliomas:an alternative strategy of immune escape显示文摘 | Wiendl H Mitsdoerffer M Hofmeister V | 2002 | J Immunol2002，168，： | 1 |
| 17 | P-release from DOP by phosphatase activity in comparison to P excretion by zooplankton. Studies in hardwater lakes of different trophic level显示文摘 | Birte Hantke Pia Fleischer Inken Domany Matthias Koch Petra Ple? Manfred Wiendl Arnulf Melzer | 1996 | Hydrobiologia1996，，2： | 1 |
| 18 | Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies显示文摘 | Wiendl H Kieseier BC | 2003 | Expert Opin Investig Drugs2003，12，4： | 1 |
| 19 | Fulfilling the dream: tolerogenic dendritic cells to treat multiple sclerosis 显示文摘 | Gross CC Jonuleit H Wiendl H | 2012 | Eur J Immunol2012，42，3： | 1 |
| 20 | A functional role of HLA-G expression in human gliomas: An alternative strategy of immune escape 显示文摘 | Wiendl H Mitsdoerffer M Hofmeister V | 2002 | J Immunol2002，168，9： | 1 |
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