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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 4 | The role of microstructure of nickel–aluminium–bronze alloy on its cavitation corrosion behavior in natural seawater显示文摘 | A Al-Hashem W Riad | 2002 | Materials Characterization2002，，1： | 2 |
| 5 | Renin inhibition improves cardiac function and remodeling after myocardial infarction inde- pendent of blood pressure 显示文摘 | Westemmnn D Riad A Lettau O | 2008 | Hypertension2008，52，6： | 1 |
| 6 | Finite Element Model of Smart Beams with Distributed'Piezoelectric Actuators显示文摘 | Bendary I M Elshafei M A Riad A M | 2010 | Journal of Intelligent Material Systems and Structures2010，，3： | 1 |
| 7 | Anti-inflammatory effects of atorvastatin improved left ventricular function in experimental diabetic cardiomyopathy显示文摘 | Van Linthout S Riad A Dhayat N | 2007 | Diabetologia2007，50，9： | 1 |
| 8 | Aggressive fibromatosis of the head and neck显示文摘 | Abdelkader M Riad M Williams A | 2001 | J Laryngol Otol2001，115，10： | 1 |
| 9 | Toll -like receptor-4 modu- lates survival by induction of left ventricular remodeling after myo- cardial infarction in mice 显示文摘 | Riad A Jager S Sobirey M | 2008 | J Immunol2008，180，10： | 1 |
| 10 | Pretreatment with statin at- tenuates the cardiotoxicity of Doxorubiein in mice显示文摘 | Riad A Bien S Westermann D | 2009 | Cancer Res2009，69，2： | 1 |
| 11 | Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure 显示文摘 | HENTSCHEL T YIN N RIAD A | 2007 | Anesthesiology2007，106，1： | 1 |
| 12 | Cavitation corrosion behavoior of cast nickel-aluminum bronze in seawater显示文摘 | Hashem A Caceres P G Riad W T | 1995 | Corrosion1995，51，5： | 1 |
| 13 | Up-regulation of PPAR gamma in myocardial infarction 显示文摘 | FLIEGNER D WESTERMANN D RIAD A | 2008 | Eur J Heart Fail2008，10，1： | 1 |
| 14 | Up-regulation of PPARγ in myocardial infarction显示文摘 | Fliegner D Westermann D Riad A | 2008 | Eur J Heart Fail2008，10，1： | 1 |
| 15 | Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy显示文摘 | Van Linthout S Spillmann F Riad A | 2008 | Circulation2008，117，： | 1 |
| 16 | Inhalation of the phosphodies-terase-3 inhibitor milrinone attenuates pulmonary hypertension ina rat model of congestive heart failure显示文摘 | Hentschel T Yin N Riad A | 2007 | Anesthesiology2007，106，1： | 1 |
| 17 | Chronic inhibition of p38MAPK improves cardiac and endothelial function in experimental diabetes mellitus显示文摘 | Riad A Unger D Du J | 2007 | Eur J Pharmacol2007，554，1： | 1 |
| 18 | Numerical modeling of groundwater resource management options in the East Oweinat area, SW Egypt 显示文摘 | EBRAHEEM A M GARAMOON H K RIAD S | 2003 | Environmental Geology2003，4，1： | 1 |
| 19 | Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy显示文摘 | Riad A Dhayat N | 2007 | Diabetologia2007，50，9： | 1 |
| 20 | Reduced MMP- 2 activity contributes to cardiac fibrosis in experimental dia- betic cardiomyopathy 显示文摘 | Van Linthout S Seeland U Riad A | 2008 | Basic Res Cardiol2008，103，4： | 1 |
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