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| 1 | Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers显示文摘NR4A2 is a transcription factor belonging to the steroid orphan nuclear receptor superfamily.It was originally considered to be essential in the generation and maintenance of dopaminergic neurons,and associated with neurological disorders such as Parkinson's disease.Recently,NR4A2 has been found to play a critical role in some inflammatory diseases and cancer.NR4A2 can be efficiently trans-activated by some proinflammatory cytokines,such as tumor necrosis factor-α,interleukin-1β,and vascular endothelial growth factor(VEGF).The nuclear factor-κB signaling pathway serves as a principal regulator of inducible NR4A expression in immune cells.NR4A2 can trans-activate Foxp3,a hallmark specifically expressed in regulatory T(Treg) cells,and plays a critical role in the differentiation,maintenance,and function of Treg cells.NR4A2 in T lymphocytes is pivotal for Treg cell induction and suppression of aberrant induction of Th1 under physiological and pathological conditions.High density of Foxp3 + Treg cells is significantly associated with gastrointestinal inflammation,tumor immune escape,and disease progression.NR4A2 is produced at high levels in CD133 + colorectal carcinoma(CRC) cells and significantly upregulated by cyclooxygenase-2-derived prostaglandin E 2 in a cyclic adenosine monophosphate(cAMP)/protein kinase A(PKA)-dependent manner in CRC cells.The cAMP/PKA signaling pathway is the common pathway of NR4A2-related inflammation and cancer.NR4A2 trans-activates osteopontin,a direct target of the Wnt/β-catenin pathway associated with CRC invasion,metastasis,and poor prognosis.Knockdown of endogenous NR4A2 expression attenuates VEGF-induced endothelial cell proliferation,migration and in vivo angiogenesis.Taken together,NR4A2 emerges as an important nuclear factor linking gastrointestinal inflammation and cancer,especially CRC,and should serve as a candidate therapeutic target for inflammation-related gastrointestinal cancer. | Yi-Fang Han Guang-Wen Cao | 2012 | World Journal of Gastroenterology2012，18，47： | 7 |
| 2 | 他汀类药物与结直肠癌相关性的Meta分析显示文摘目的探讨他汀类药物与结直肠癌间的关系,为结直肠癌的预防提供循证医学依据。方法系统检索中国知网(CNKI)、万方数据知识服务平台(Wanfang data)、PubMed和Cochrane Library数据库中从2000年1月至2020年1月所有他汀类药物与结直肠癌研究的文献,按照纳入排除标准选择文献,并用纽卡斯尔-渥太华量表和Jadad评分进行评价。采用Revman 5.0和Stata 12.1软件进行Meta分析。结果共纳入31篇文献,162万受试者参与。病例对照研究(RR=0.93,95%CI:0.88~0.98)、队列研究(RR=0.75,95%CI:0.63~0.88)和随机对照试验研究(RR=0.79,95%CI:0.65~0.97)均显示他汀类药物对结直肠癌具有一定保护作用;服用他汀类药物<5年(RR=0.86,95%CI:0.76~0.96)、日均服用剂量≥34 mg(RR=0.81,95%CI:0.66~0.98)和服用脂溶性他汀类药物(RR=0.86,95%CI:0.74~0.99)会降低结直肠癌发生风险。结论他汀类药物对结直肠癌有一定的预防作用。 | 戚家豪 魏俊妮 张振君 东靓 张丽 董丽 毛盈颖 雷立健 胡晓琴 白文启 | 2021 | 中华流行病学杂志2021，42，2： | 6 |
| 3 | Chemopreventive drugs:Mechanisms via inhibition of cancer stem cells in colorectal cancer显示文摘Recent epidemiological studies,basic research and clinical trials on colorectal cancer(CRC)prevention have helped identify candidates for effective chemopreventive drugs.However,because of the conflicting results of clinical trials or side effects,the effective use of chemopreventive drugs has not been generalized,except for patients with a high-risk for developing hereditary CRC.Advances in genetic and molecular technologies have highlighted the greater complexity of carcinogenesis,especially the heterogeneity of tumors.We need to target cells and processes that are critical to carcinogenesis for chemoprevention and treatment of advanced cancer.Recent research has shown that intestinal stem cells may serve an important role in tumor initiation and formation of cancer stem cells.Moreover,studies have shown that the tumor microenvironment may play additional roles in dedifferentiation,to enable tumor cells to take on stem cell features and promote the formation of tumorigenic stem cells.Therefore,early tumorigenic changes of stem cells and signals for dedifferentiation may be good targets for chemoprevention.In this review,I focus on cancer stem cells in colorectal carcinogenesis and the effect of major chemopreventive drugs on stem cell-related pathways. | Tae Il Kim | 2014 | World Journal of Gastroenterology2014，20，14： | 2 |
| 4 | 他汀类药物在结直肠癌预防中作用的研究进展显示文摘他汀类药物为3-羟基-3-甲基戊二酰辅酶A(HMG-Co A)还原酶抑制剂,通常用于治疗高脂血症,预防心血管事件的发生。最近一些研究表明他汀类药物还可降低结直肠癌发生风险,但对其化学预防作用仍存在争议。本文通过总结国内外相关研究,对他汀类药物对结直肠癌和结直肠腺瘤的预防作用及其作用机制作一概述。 | 钱为芬 徐萍萍 韩真 | 2018 | 胃肠病学2018，23，4： | 2 |
| 5 | 关于他汀类药物对结直肠癌预防作用的系统评价显示文摘目的探讨他汀类药物对结直肠癌发生率的影响。方法广泛收集2009年12月31日前国内外公开发表的相关文献,采用相对危险度(relative risk RR)作为统计学指标对入选文献进行综合分析。结果筛选出符合纳入和排除标准的文献共21篇,其中病例对照研究9篇,队列研究6篇,随机对照研究6篇,采用随机效应模型合并RR值为0.90,95%CI为0.80~1.01,P=0.07。结论使用常规剂量的他汀类药物对结直肠癌发生率无影响。 | 陈仕才 宋新明 陈志辉 李明哲 | 2010 | 结直肠肛门外科2010，16，5： | 0 |
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