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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Immune mechanisms of Concanavalin A model of autoimmune hepatitis显示文摘As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development. | Hai-Xia Wang Man Liu Shun-Yan Weng Jing-Jing Li Chao Xie Hong-Lin He Wen Guan Yun-Sheng Yuan Jin Gao | 2012 | World Journal of Gastroenterology2012，18，2： | 52 |
| 3 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 4 | RNA N^6-methyladenosine modification in cancers: current status and perspectives显示文摘 | Xiaolan Deng Rui Su Hengyou Weng Huilin Huang Zejuan Li Jianjun Chen | 2018 | Cell Research2018，28，5： | 55 |
| 5 | PREVALENCE AND RISK FACTORS OF PERIPHERAL ARTERIAL DISEASE IN DIABETIC PATIENTS OVER 50 YEARS OLD IN CHINA显示文摘Objective To investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD. Methods In total 1 397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China. Results Mean patient age was 63.7±8.2 years and mean duration of diabetes mellitus was 9.39±7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI <0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin Alc, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI. Conclusions PAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors. | Heng Guan Yong-jun Li Zhang-rong XU Guang-wei Li Xiao-hui Guo Zhi-min Liu Da-jin Zou Hui-li Xing Wei Liu Zheng-yan Sheng Hao-ming Tian Da-long Zhu De-min YU Wei-te Zhuang Lu-lu Chen Jian-ping Weng | 2007 | Chinese Medical Sciences Journal2007，22，2： | 41 |
| 6 | Changes in intestinal mucosal immune barrier in rats with endotoxemia显示文摘AIM:To investigate the dysfunction of the immunological barrier of the intestinal mucosa during endotox-emia and to elucidate the potential mechanism of this dysfunction.METHODS:Male Wistar rats were randomly distributed into two groups:control group and lipopolysaccharide(LPS)group.Endotoxemia was induced by a single caudal venous injection of LPS.Animals were sacrifi ced in batches 2,6,12 and 24 h after LPS infusion.The number of microfold(M)-cells,dendritic cells(DCs),CD4+ T cells,CD8+ T cells,regulatory T(Tr)cells and IgA+ B cells in the intestinal mucosa were counted after immunohistochemical staining.Apoptotic lympho-cytes were counted after TUNEL staining.The levels of interleukin(IL)-4,interferon(IFN)-γ and forkhead box P3(Foxp3)in mucosal homogenates were measured by ELISA.The secretory IgA(sIgA)content in the total protein of one milligram of small intestinal mucus was detected using a radioimmunological assay.RESULTS:This research demonstrated that LPS-induced endotoxemia results in small intestinal mucosa injury.The number of M-cells,DCs,CD8+ T cells,and IgA+ B cells were decreased while Tr cell and apoptotic lymphocyte numbers were increased signifi cantly.The number of CD4+ T cells increased in the early stages and then slightly decreased by 24 h.The level of IL-4 significantly increased in the early stages and then reversed by the end of the study period.The level of IFN-γ increased slightly in the early stages and then decreased markedly by the 24 h time point.Level of Foxp3 increased whereas sIgA level decreased.CONCLUSION:Mucosal immune dysfunction forms part of the intestinal barrier injury during endotoxemia.The increased number and function of Tr cells as well as lymphocyte apoptosis result in mucosal immunodefi ciency. | Chong Liu Ang Li Yi-Bing Weng Mei-Li Duan Bao-En Wang Shu-Wen Zhang | 2009 | World Journal of Gastroenterology2009，15，46： | 35 |
| 7 | Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis显示文摘Baicalein, wogonin,和他们的 glycosides 是在药用的植物黄芩 baicalensis Georgi 发现的主要 bioactive 混合物。这些黄酮能在许多癌症房间线导致 apoptosis,但是没在正常房间上有效果。而且,他们为人的健康有许多另外的好处,例如抗氧化剂,抗病毒、肝保护的性质。这里,我们报导二 CYP450 酶, SbCYP82D1.1 和 SbCYP82D2 的隔离和描述,分别地,它在 S. 作为黄酮 6-hydroxylase (F6H ) 和黄酮 8-hydroxylase (F8H ) 工作 ? baicalensis。SbCYP82D1.1 为象 chrysin 和 apigenin 那样的黄酮有宽广底层特性并且在根和 S. 的天线部分为 baicalein 和 scutellarein 的生合成负责 ? baicalensis 分别地。当 SbCYP82D1.1 的表示被击倒时,当时, baicalin 和 baicalein 层次显著地被减少 chrysin glycosides 在毛乎乎的根积累。SbCYP82D2 是有高底层特性的 F8H,接受仅仅象它生产 norwogonin 的底层的 chrysin,尽管次要的 6-hydroxylation 活动能也被检测。种系发生的分析建议 SbCYP82D2 可能经由 neofunctionalization 跟随的基因复制从 SbCYP82D1.1 演变,祖先的 F6H 活动由此部分在导出的 SbCYP82D2 被保留。 | Qing Zhao Meng-Ying Cui Olesya Levsh Dongfeng Yang Jie Liu Jie Li Lionel Hill Lei Yang Yonghong Hu Jing-Ke Weng Xiao-Ya Chen Cathie Martin | 2018 | Molecular Plant2018，11，1： | 30 |
| 8 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 9 | Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice显示文摘Houttuynia cordata polysaccharide(HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg×kg^(–1)×d^(–1). H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP. | CHEN Mei-Yu LI Hong LU Xiao-Xiao LING Li-Jun WENG Hong-Bo SUN Wei CHEN Dao-Feng ZHANG Yun-Yi | 2019 | Chinese Journal of Natural Medicines2019，17，3： | 24 |
| 10 | Recent Progress on Fabrications and Applications of Boron Nitride Nanomaterials:A Review显示文摘Boron nitride(BN) nanostructures with complementary functions to their carbon counterparts are one of the most intriguing nanomaterials.Here we devote a compact review on the syntheses of BN nanomaterials:typical zero-dimensional(OD) fullerenes and nanoparticles,one-dimensional(1D) nanotubes and nanoribbons,two-dimensional(2D) nanosheets as well as three-dimensional(3D) nanoporous BN.Combining low-dimensional quantum confinement and surface effects with unique physical and chemical properties of BN,e.g.excellent electric insulation,wide band gap,and high chemical and thermal stability,BN nanomaterials have drawn particular attention in a variety of potential applications,e.g.luminescence,functional composites,hydrogen accumulators,and advanced insulators,which are also reviewed. | Xiang-Fen Jiang Qunhong Weng Xue-Bin Wang Xia Li Jun Zhang Dmitri Golberg Yoshio Bando | 2015 | Journal of Materials Science & Technology2015，31，6： | 23 |
| 11 | Remission of hyperglycemia following intensive insulin therapy in newly diagnosed type 2 diabetic patients: a long-term follow-up study显示文摘在 2 个糖尿病的病人可以改进的最新诊断的类型的背景早集中的胰岛素治疗房间功能和产量延长了 glycemic 宽恕。这研究被执行评估在 glycemic 宽恕和 p 房间功能之间的关系并且估计长期的 near-normoglycemic 宽恕预兆的变量。84 最新诊断了类型 2 糖尿病的病人的方法与 2 星期的连续下的胰岛素注入(CSII ) 被对待并且在纵上面列在后面。静脉内的葡萄糖忍耐测试(IVGTT ) 被执行,并且血葡萄糖,血红素 A1c (HbA1c ) 和胰岛素在基线被测量,在 CSII 以后并且在 2 年的访问。维持了 glycemic 控制二年的病人被定义为在 2 年的访问前的 relapsed 是谁的宽恕组和那些非宽恕组。结果病人要诊断的持续时间(从病人们开始有糖尿病的症状直到诊断的时间) 在宽恕,组在非宽恕组是比那矮的(1.00 月对 4.38 个月, P=0.040 ) 。尖锐胰岛素反应(空气) 的增加与在干预以后立即测量的空气相比在宽恕组在 2 年以后被维持(413.05 | XU Wen LI Yan-bing DENG Wan-ping HAO Yuan-tao WENG Jian-ping | 2009 | Chinese Medical Journal2009，，21： | 21 |
| 12 | Closed reduction and internal fixation versus total hip arthroplasty for displaced femoral neck fracture显示文摘ObjectiveTo 为代替的大腿骨的颈 fracture.MethodsIn 比较在关上的减小和内部固定和全部的新潮的关节造形术(THA )(CRIF ) 之间的临床的效果这未来的使随机化的研究,与新潮的破裂(花园 III 或 IV ) 在 65 年上面变老的 285 个病人从 2001 年 1 月被包括到 2005 年 12 月。盒子随机被分配到 CRIF 组或 THA 组。有病理学的破裂(骨头肿瘤或新陈代谢的骨头疾病)的病人,大腿骨的头的外科手术前的 avascular 坏死,骨关节炎,风湿性关节炎,半身麻痹,长期的病床休息和影响新潮的功能的复杂并发症是 excluded.ResultsDuring 5年的后续,有的 CRIF 组更高显著地在新潮的关节复杂并发症评价,一般复杂并发症和操作比 THA 组织(38.3%对12.7%, P ;< ; 0.01 ;45.3% 对 21.7% , P < 0.01;33.6% 对 10.2% , P < 0.05 分别地) 。在在二个组之间的死亡没有差别。在与更高级的哈里斯 scores.ConclusionFor 有利地恢复的 THA 组的新潮的关节的手术后的功能在老病人,代替了大腿骨的颈的破裂 THA 能完成复杂并发症和操作的更低的率,以及新潮的联合功能的更好手术后的恢复与 CRIF 相比。 | Cao Liehu Wang Bin Li Ming Song Shaojun Weng Weizong Li Haihang Su Jiacan | 2014 | Chinese Journal of Traumatology2014，17，2： | 21 |
| 13 | New alkylamides from pericarps of Zanthoxylum bungeanum显示文摘二新不饱和的 alkylamides (2E,7E,9E )-N-(2-hydroxy-2-methylpropyl)-6,11-dioxo-2,7,9-dodecatrienamide (1 ) 并且(2E,6E,8E ) 和六已知的混合物(38 ) 的 -N-(2-hydroxy-2-methylpropyl)-10-oxo-2,6,8-decatrienamide (2 ) 从 Zanthoxylum bungeanum 的果皮被孤立。他们的结构根据广泛的分光镜的分析被阐明,包括 MS,红外, 1D 和 2D NMR 实验。 | Shuai Huang Lei Zhao Xian Li Zhou Mei Ying Cui Juan Wang Jie Weng | 2012 | Chinese Chemical Letters2012，23，11： | 21 |
| 14 | Update in version 2021 of CSCO guidelines for colorectal cancer from version 2020显示文摘Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,100 deaths of CRC in China, accounting for 9.87% and 8.01% of all malignancies. The first version of the Chinese Society of Clinical Oncology(CSCO) guidelines was released in April2017, and has been updated annually based on the latest clinical research data and the availability of new drugs(2-4). Here, we present the main updates of the 2021 version compared to 2020 version. | Caixia Dong Yuwei Ding Shanshan Weng Guichao Li Yanqing Huang Hanguang Hu Zhen Zhang Suzhan Zhang Ying Yuan | 2021 | Chinese Journal of Cancer Research2021，33，3： | 19 |
| 15 | Randomized controlled trial: Moxibustion and acupuncture for the treatment of Crohn's disease显示文摘AIM: To evaluate the clinical efficacy and safety of acupuncture and moxibustion for the treatment of active Crohn's disease(CD).METHODS: Ninety-two patients were equally and randomly divided into the treatment group and received herb-partitioned moxibustion combined with acupuncture, and the control group received wheat bran-partitioned moxibustion combined with superficial acupuncture. The patients received three treatment sessions per week for 12 wk and were followed up for 24 wk. The main outcome was evaluated using the CD Activity Index(CDAI) score, and the secondary outcomes were evaluated using laboratory indicators such as hemoglobin(HGB), C-reactive protein(CRP), erythrocyte sedimentation rate, quality-of-life, endoscopic ratings, and intestinal histology scores.RESULTS: The CDAI scores of both the treatment and control groups were significantly reduced after treatment compared with those measured before treatment. However, the degree of improvement in the treatment group was significantly greater than that of the control group. The improvement in symptoms in patients of the treatment group was sustained at follow-up, whereas that of the control group was not. The overall efficacy of the treatment was significantly greater than that of the control. Both groups demonstrated significant improvements in quality-of-life ratings after treatment, but the improvement was significantly greater in the treatment group than in the control group. In addition, the patients in the treatment group showed significantly increased HGB and significantly decreasedCRP levels and histopathological scores at the end of treatment, whereas the control group did not exhibit significant changes.CONCLUSION: Moxibustion with acupuncture provided significant therapeutic benefits in patients with active CD beyond the placebo effect and is therefore an effective and safe treatment for active CD. | Chun-Hui Bao Ji-Meng Zhao Hui-Rong Liu Yuan Lu Yi-Fang Zhu Yin Shi Zhi-Jun Weng Hui Feng Xin Guan Jing Li Wei-Feng Chen Lu-Yi Wu Xiao-Ming Jin Chuan-Zi Dou Huan-Gan Wu | 2014 | World Journal of Gastroenterology2014，20，31： | 19 |
| 16 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 17 | Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo显示文摘The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes.In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs,hydroxyapatite(HA)scaffolds with three different macro-pore sizes of 500–650,750–900 and 1100–1250 mm were prepared via sugar spheres-leaching process,which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size constant.The permeability test showed that the seepage flow of fluid through the porous scaffolds increased with the increase of macro-pore sizes.The cell growth in three scaffolds was not affected by the macro-pore sizes.The in vivo ectopic implantation results indicated that the macro-pore sizes of HA scaffolds with the similar interconnecting structure have impact not only the speed of osteogenesis and angiogenesis but also the space distribution of newly formed bone.The scaffold with macro-pore sizes of 750–900 mm exhibited much faster angiogenesis and osteogenesis,and much more uniformly distribution of new bone than those with othermacro-pore sizes.This work illustrates the importance of a suitable macro-pore sizes in HA scaffolds with the similar interconnecting structure which provides the environment for ectopic osteogenesis and angiogenesis. | Jinyu Li Wei Zhi Taotao Xu Feng Shi Ke Duan JianxinWang Yandong Mu Jie Weng | 2016 | Regenerative Biomaterials2016，3，5： | 16 |
| 18 | Top-dressing nitrogen fertilizer rate contributes to decrease culm physical strength by reducing structural carbohydrate content in japonica rice显示文摘Lodging is an important factor limiting rice yield and quality by bending or breaking stem in japonica rice(Oryza sativa L.) production. The objectives of this study were to determine the mechanism of lodging resistance in japonica rice as affected by carbohydrate components, especially its related arrangement in culm tissue and response to top-dressing nitrogen(N) fertilizer. Field experiments were conducted in Danyang County, Jiangsu Province, China, by using two japonica rice varieties Wuyunjing 23(lodging-resistance variety) and W3668(lodging-susceptible variety) with three top-dressing N fertilizer rates(0, 135 and 270 kg N ha^(–1)) in 2013 and 2014. Lodging related physical parameters, morphological characteristics and stem carbohydrate components were investigated at 30 d after full heading stage. Results showed that with increasing N fertilizer rates, the lodging rate and lodging index increased rapidly primarily due to significant reduction of breaking strength in two japonica rice varieties. Correlation analysis revealed that breaking strength was significantly and positively correlated with bending stress, but negatively correlated with section modulus, except for significant correlation at W3668 in 2014. Higher stem plumpness status and structural carbohydrate contents significantly enhanced stem stiffness, despite of lower non-structural carbohydrate. With higher N fertilizer rate, the culm wall thickness was almost identical, and culm diameter increased slightly. The structural carbohydrates, especially for lignin content in culm, reduced significantly under high N rate. Further histochemical staining analysis revealed that high N treatments decreased the lignin deposition rapidly in the sclerenchyma cells of mechanical tissue, large vascular bundle and small vascular bundle region, which were consistent with reduction of bending stress, especially for W3668 and thus, resulted in poor stem strength and higher lodging index. These results suggested that structural carbohydrate plays a vital role for improving stem strength in japonica rice. N rate decreased lodging resistance primarily due to poor stem stiffness, by reducing structural carbohydrate content and lignin deposition in the secondary cell wall of lower internode culm tissue. | ZHANG Wu-jun WU Long-mei DING Yan-feng WENG Fei WU Xiao-ran LI Gang-hua LIU Zheng-hui TANG She DING Cheng-qiang WANG Shao-hua | 2016 | Journal of Integrative Agriculture2016，15，5： | 14 |
| 19 | Effect of barium sulfate modification on the SO2 tolerance of V2O5/TiO2 catalyst for NH3-SCR reaction显示文摘Sulfur poisoning of V_2O_5/BaSO_4–TiO_2(VBT),V_2O_5/WO_3–TiO_2(VWT) and V_2O_5/BaSO_4–WO_3–TiO_2(VBWT) catalysts was performed in wet air at 350℃ for 3 hr,and activities for the selective catalytic reduction of NO_x with NH_3 were evaluated for 200–500℃.The VBT catalyst showed higher NO_x conversions after sulfur poisoning than the other two catalysts.The introduction of barium sulfate contributed to strong acid sites for the as-received catalyst,and eliminated the redox cycle of active vanadium oxide to some extent,which resulted in a certain loss of activity.Readily decomposable sulfate species formed on VBT-S instead of inactive sulfates on VWT-S.These decomposable sulfates increased the number of strong acid sites significantly.Some sulfate species escaped during catalyst preparation and barium sulfate was reproduced during sulfur poisoning,which protects vanadia from sulfur oxide attachment to a great extent.Consequently,the VBT catalyst exhibited the best resistance to sulfur poisoning. | Tengfei Xu Xiaodong Wu Xuesong Liu Li Cao Qiwei Lin Duan Weng | 2017 | Journal of Environmental Sciences2017，29，7： | 14 |
| 20 | Complete Pathway Elucidation and Heterologous Reconstitution of Rhodiola Salidroside Biosynthesis显示文摘Salidroside 是导出酷氨酸的酉分的自然产品在 Rhodiola 类下面在药用的植物发现了的 bioactive。除了他们在传统的药的反疲劳和反血缺氧角色, Rhodiola 全部的摘录和 salidroside 也作为反心血管的疾病和反癌症代理人显示了药用的性质。在 Rhodiola 植物和 salidroside 的全球需求的产生巨浪驱使某种类靠近到扑灭。这里,我们报导为 Rhodiola rosea 利用第一全面 transcriptomics 和 metabolomics 数据集的 Rhodiola salidroside biosynthetic 小径的完整的说明。不同于包含分开的去碳酸基和 deamination 的以前建议的小径从酷氨酸的酶的步到关键中间的 4-hydroxyphenylacetaldehyde (4-HPAA ) , Rhodiola 包含 pyridoxal 磷酸盐依赖者 4-HPAA synthase ? 那直接把酷氨酸变换成 4-HPAA。我们推进 ? 编码随后的 4-HPAA reductase 的识别基因 ? 并且 tyrosol :UDP 葡萄糖 8-O-glucosyltransferase,分别地在 Rhodiola 完成 salidroside 生合成。我们证明 salidroside 的那 heterologous 生产能通过 Rhodiola salidroside biosynthetic 基因的转基因的表示在酵母 Saccharomyces cerevisiae 以及植物 Nicotiana benthamiana 被完成。这研究为在 heterologous 主人设计 salidroside 的持续生产提供新工具。 | Michael P. Torrens-Spence Tomas Pluskal Fu-Shuang Li Valentina Carballo Jing-Ke Weng | 2018 | Molecular Plant2018，11，1： | 14 |
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