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| 1 | Construction,Characterization,and Chromosomal Mapping of a Fosmid Library of the White-Cheeked Gibbon (Nomascus leucogenys)显示文摘Gibbons have experienced extensive karyotype rearrangements during evolution and represent an ideal model for studying the underlying molecular mechanism of evolutionary chromosomal rearrangements. It is anticipated that the cloning and sequence characterization of evolutionary chromosomal breakpoints will provide vital insights into the molecular force that has driven such a radical karyotype reshuffle in gibbons. We constructed and characterized a high-quality fosmid li-brary of the white-cheeked gibbon (Nomascus leucogenys) containing 192,000 non-redundant clones with an average insert size of 38 kb and 2.5-fold genome coverage. By end sequencing of 100 randomly selected fosmid clones,we generated 196 se-quence tags for the library. These end-sequenced fosmid clones were then mapped onto the chromosomes of the white-cheeked gibbon by fluorescence in situ hy-bridization,and no spurious chimeric clone was detected. BLAST search against the human genome showed a good correlation between the number of hit clones and the number of chromosomes,an indication of unbiased chromosomal distribu-tion of the fosmid library. The chromosomal distribution of the mapped clones is also consistent with the BLAST search result against human and white-cheeked gibbon genomes. The fosmid library and the mapped clones will serve as a valu-able resource for further studying gibbons' chromosomal rearrangements and the underlying molecular mechanism as well as for comparative genomic study in the lesser apes. | Liping Chen Jianping Ye Yan Liu Jinghuan Wang Weiting Su Fengtang Yang Wenhui Nie | 2007 | Genomics, Proteomics & Bioinformatics2007，5，3： | 5 |
| 2 | A multi-responsive luminescent sensor towards Fe_(3+) and acetone based on a Cd-containing metal–organic framework显示文摘A Cd-containing metal–organic framework(Cd L), formula as {[Cd_3(L)_2(H_2O)_6] 1.5DMF}, has been synthesized under solvothermal condition by the reaction of 4,40,400-(methylsilanetriyl)tribenzoic acid(H_3L) and Cd^(2+)ion. Single-crystal X-ray diffraction reveals that Cd L displays a three-dimensional framework with 2-fold interpenetration and DMF molecules locate in the void space of the channels. A topological analysis of the framework indicates Cd L is a 3,4-connected pto net. The photoluminescence properties of Cd L are systematically studied in detail. Impressively, Cd L shows excellent detection performance towards Fe^(3+)ion and acetone in the sensing experiments, which undoubtedly demonstrates the great potential of Cd Lasa highly selective multi-responsive luminescent sensor for the detection of organic solvents and metal ions. | Ting Wang Qing-Hui Liu Ying Gao Xiu-Yun Yang Weiting Yang Song Dang Zhong-Ming Sun | 2016 | Chinese Chemical Letters2016，27，4： | 5 |
| 3 | Auto-compensation of velocity-height ratio for Chang’E-2 satellite CCD stereo camera显示文摘The TDI-CCD imaging method using auto-compensation of velocity-height ratio (VHR) was applied to Chang’E-2 satellite CCD stereo camera.Factors that influence the image quality of the camera were discussed,among which the mismatch error in VHR was found to be the main cause.An auto-compensation scheme for VHR was developed.The validity and effectiveness were proved by the on-orbit high quality images. | XUE Bin ZHAO BaoChang YANG JianFeng GAO Weit QIAO WeiDong MA XiaoLong ZHANG Bo LIU JiaHang ZHAO Wei JING Juan Juan | 2011 | Science China(Technological Sciences)2011，54，9： | 4 |
| 4 | Simultaneously optimizing pore morphology and enhancing mechanical properties of Al-Si alloy composite foams by graphene nanosheets显示文摘The integrity and regularity of pore morphology play an important role in determining the mechanical properties of the metallic foam materials.The conventional methods on refining pore morphology are mainly focused on the optimization of fabrication techniques,however,they are usually inconvenient and complicated.Recently,incorporating nano reinforcement is considered to be a suitable way to fabricate metallic composite foams accompanied by optimized pore morphology and enhanced mechanical properties.In this work,through a facile and rapid powder metallurgy foaming method,the aluminum-silicon(Al-Si)alloy composite foams reinforced by graphene nanosheets(GNSs)are successfully fabricated.The microstructure analyses reveal that,for the Al-Si alloy foams incorporating the GNSs(GNSs/Al-Si composite foams),the pore size is transformed to be smaller,the pore size distributions become more homogeneous and the pore shape is also refined to a regular and roundish state.Meanwhile,the shape of Si precipitates is found transforming from an irregular long strip(length of~20μm,width of~5μm)to a fine particle state(diameter of~5μm).Moreover,the compressive testing results show that,the 0.4wt%GNSs/Al-Si composite foams own the optimal compression stress of 11.7±0.5 MPa,plateau stress of 10.0±1.0 MPa and energy absorption capacity of 6.8±0.7 MJ/m^(3),which have improvement of 58.1%,53.8%and 51.1%in comparison with the Al-Si alloy foams counterpart,respectively.The present findings may pave a new way for developing new generation of metallic composite foams that with stable microstructure and excellent mechanical performance. | Weiting Li Xudong Yang Kunming Yang Chunnian He Junwei Sha Chunsheng Shi Yunhui Mei Jiajun Li Naiqin Zhao | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 5 | Metal-Organic Framework-based Wood Aerogel for Effective Removal of Micro/Nano Plastics显示文摘The large amount of microplastic pollution in the aquatic environment has been regarded as a major challenge facing the world. Although some traditional water treatment processes can effectively remove microplastics in the millimeter range, research is still needed to solve the problem of removing smaller microplastics. Here, we made a durable zinc metal-organic framework-based composite material ZIF-8@Aerogel by in situ growing ZIF-8 on wood aerogel fibers, which can successfully remove microplastics in simulated water and seawater. The removal efficiencies on micro/nano plastics including poly(1,1-difluoroethylene)(60-110 nm) and polystyrene(90-140 nm) reached 91.4% and 85.8%, respectively. This work is expected to provide a new and efficient way to remove small-sized microplastic particles in the environment. | YOU Dongyu ZHAO Yujuan YANG Weiting PAN Qinhe LI Jiyang | 2022 | Chemical Research in Chinese Universities2022，38，1： | 2 |
| 6 | Synthesis, Structures, and Properties of Uranyl Hybrids Constructed by a Variety of Mono- and Polycarboxylic Acids显示文摘 | YANG Weiting DANG Song WANG Hao | 2013 | Inorganic Chemistry2013，52，12： | 1 |
| 7 | An innovative model for the transient response of a spherical thin-shell transducer and an experimental confirmation显示文摘 | Lin Fa Xin Zhou YuXiao Fa YanDong Zhang JinPeng Mou Meng Liang MaoMao Wang Qi Zhang PengFei Ding WeiTing Feng Hong Yang MeiShan Zhao | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 1 |
| 8 | Vapor phase growth of two-dimensional PdSe2 nanosheets for high-photoresponsivity near-infrared photodetectors显示文摘Palladium diselenide(PdSe2),a stable layered material with pentagonal structure,has attracted extensive interest due to its excellent electrical and optoelectronic performance.Here,we report a reliable process to synthesize PdSe2 via chemical vapor deposition(CVD)method.Through systematic regulation of temperature in the growth process,we can tune the thickness,size,nucleation density and morphology of PdSe2 nanosheets.Field-effect transistors based on PdSe2 nanosheets exhibit n-type behavior and present a high electron mobility of 105 cm^2·V^−1·s^−1.The electrical property of the devices after 6 months keeping in the air show little change,implying outstanding air-stability of PdSe2.In addition,PdSe2 near-infrared photodetector shows a photoresponsivity of 660 A·W^−1 under 914 nm laser.These performances are better than those of most CVD-grown 2D materials,making ultrathin PdSe2 a highly qualified candidate material for next-generation optoelectronic applications. | Weiting Xu Jiayang Jiang Huifang Ma Zhengwei Zhang Jia Li Bei Zhao Ruixia Wu Xiangdong Yang Hongmei Zhang Bailing Li Weining Shu Zucheng Zhang Bo Li Yuan Liu Lei Liao Xidong Duan | 2020 | Nano Research2020，13，8： | 1 |
| 9 | Preparation of silver nanoparticles of en- hanced antibacterial effect with Benzalko- nium Bromide 显示文摘 | Yang Weite Li Hui Chen Wuyong ct al | 2011 | Journal of Optoelec- tronics and Advanced Materials2011，13，6： | 1 |
| 10 | Lanthanide Metal–Organic Frameworks Showing Luminescence in the Visible and Near‐Infrared Regions with Potential for Acetone Sensing显示文摘 | Song Dang Xue Min Weiting Yang Fei‐Yan Yi Hongpeng You Zhong‐Ming Sun | 2013 | Chem Eur J2013，，50： | 1 |
| 11 | Toughening Effects through Optimizing Cell Structure and Deformation Behaviors of Al–Mg Foams显示文摘As widely used protective materials,the application of Al foams is still limited by their low intrinsic mechanical properties caused by the brittleness of struts.The introduction of Mg is recently demonstrated effective to improve the mechanical performance of Al foams;however,the mechanism of Mg modification is still not clear.In this work,Al-Mg foams are developed through a powder metallurgy process with excellent compression performance and high energy absorption capacity.The effects of Mg modification on the cell structure,toughness,and deformation behavior are investigated systematically.As a result,the small cell size of~1.8 mm and the high sphericity of 0.92 are achieved with 5% of Mg addition,delivering high compression stress of 8.5±0.43 MPa and energy absorption capacity of 6.9±0.36 MJ/m^(3),simultaneously.The synergistic mechanism for the improved mechanical performance is also demonstrated to be the combination of stress transfer and plastic deformation behavior of cells.The results provide a new strategy to develop high-performance foam materials by improving toughness and further promote the practical application. | Hao Yu Xudong Yang Weiting Li Xudong Rong Siyuan Guo Lishi Ma Lizhuang Yang Junwei Sha Naiqin Zhao | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，12： | 1 |
| 12 | Heterometallic zinc uranium oxyfluorides incorporating imidazole ligands显示文摘Two heterometallic uranium oxyfluorides with hybrid networks were hydrothermally synthesized by incorporating two imidazoles, 1-(biphenyl-4-yl)-1H-imidazole(bpi) and 1,4-di(1H-imidazol-1-yl)benzene(dib), formulated as Zn(bpi)2(UO2)2(H2O)F6(1) and Zn(dib)(UO2)F4 0.5H2O(2). Compound 1consists of chains of edge-sharing UO2F5 and UO2F4(H2O) pentagonal bipyramids, which are linked by Zn(bpi)2moieties to form the sheet structure with decorated bpi. While in compound 2, sheets of edgesharing dimers of UO2F5 pentagonal bipyramids and Zn F3N2 polyhedra are linked by dib, creating a pillared three-dimensional framework. The two compounds represent the few examples of heterometallic uranium oxyfluorides incorporating organic ligands. The syntheses, structure as well as the IR spectra, UV–vis spectra and luminescent properties of the bimetallic uranium oxyfluorides are studied. | Xiao-Xiao Liu Yuan Wang Wan-Guo Tian Weiting Yang Zhong-Ming Sun | 2015 | Chinese Chemical Letters2015，26，6： | 1 |
| 13 | A new method to determine the reliability comparability for products, components, and systems in reliability testing显示文摘 | CHIEN Weiting Kary YANG Siyuan Frank | 2007 | IEEE Transaction on Reliability2007，56，1： | 1 |
| 14 | Layered and three-dimensional uranyl–organic assemblies with 4,4′-oxidiphthalic acid显示文摘Hydrothermal reactions of uranyl nitrate and 4,4'-oxidiphthalic acid(H_4L) resulted in the formation of three new uranyl-organic framework materials,namely(NH_4)_2[(UO_2)_3(L)_2]·5H_2O(1),(NEt_4)[(UO_2)_3(H_2O)(L)(HL)](2) and(UO_2)_7(H_2O)_2(phen)_4(L)_2(HL)_2(3)(NEt_4 = tetraethylammonium,phen = 1,10-phenanthroline).These three structures all comprise common uranyl pentagonal bipyramids.In 1,UO_7polyhedra are linked by hexadentate ligands to form a 3D framework with 1D channels,in which are located NH_4^+ ions and water molecules.While in 2,the organic ligands adopt pentadentate and hexadentate coordination modes,ligating UO_7 units to create a layered structure with channels filled by NEt_4^+ ions.For 3,uranyl square bipyramids are also accommodated together with pentagonal bipyramids,which are linked by tetradentate carboxylate ligands to produce the layered assembly.Phen molecules also coordinate to the uranyl centers to build up the structure.Luminescent studies indicate that 2 and 3 exhibit the characteristic uranyl emission. | Dai Wu Ying Gao Wan-Guo Tian Yun-Hui Li Weiting Yang Zhong-Ming Sun | 2016 | Chinese Chemical Letters2016，27，3： | 1 |
| 15 | Preparation of antibacterial sheepskin with silver nanoparticles,potential use as a mattress for pressure ulcer prevention 显示文摘 | Yang Weite Wang Xuan Gong Ying | 2012 | Journal of the American Leather Chemists Association2012，107，： | 1 |
| 16 | Decorating Covalent Organic Frameworks with High-density Chelate Groups for Uranium Extraction显示文摘The extraction of uranium from aqueous solution is highly desirable for sustaining the increasing demand for environmental safety and nuclear fuel.Herein,we report a strategy using a two-step covalent modification for the synthesis of covalent organic frameworks(COFs)with high-density amidoxime chelate groups at periphery.The introduction of dense amidoxime groups plays a pivotal role in uranium adsorption.The resulting COF exhibits strong affinity with the distribution coefficient of 5.2×104 mL/g and a high adsorption capacity of 319.9 mg/g.The strategy could be expanded to identify and remove different contaminants by introducing special functional groups. | QIN Xudong TANG Xiaohui MA Yu XU Hong XU Qing YANG Weiting GU Cheng | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 17 | Comparative transcriptome analysis of the climacteric of apple fruit uncovers the involvement of transcription factors affecting ethylene biosynthesis显示文摘Apple(Malus domestica)fruit generally undergoes a climacteric.During its ripening process,there is a peak in ethylene release and its firmness simultaneously decreases.Although more in-depth research into the mechanism of climacteric-type fruit ripening is being carried out,some aspects remain unclear.In this study,we compared the transcriptomes of 0-Pre and 15-Post(pre-and post-climacteric fruit),and 15-Post and 15-MCP[fruit treated with 1-MCP(1-methylcyclopropene)].Various transcription factors,such as MADS-box,ERF,NAC,Dof and SHF were identified among the DEGs(differential gene expressions).Furthermore,these transcription factors were selected for further validation analysis by qRT-PCR.Moreover,yeast one hybrid(Y1H),β-glucuronidase(GUS)transactivation assay and dual-luciferase reporter assay showed that MdAGL30,MdAGL104,MdERF008,MdNAC71,MdDof1.2,MdHSFB2a and MdHSFB3 bound to MdACS1 promoter and directly regulated its transcription,thereby regulating ethylene biosynthesis in apple fruit.Our results provide useful information and new insights for research on apple fruit ripening. | Tong Li Xiao Zhang Yun Wei Yaxiu Xu Weiting Liu Hongjian Li Guangxin Yang Aide Wang Xiaoxue Wang | 2023 | Horticultural Plant Journal2023，9，4： | 0 |
| 18 | Face-directed Strategy for the Construction of Polyoxovanadate-based Metal-Organic Tetrahedra显示文摘Polyoxometalate-based metal-organic polyhedra(MOPs)were of particular concern because of the various exquisite building blocks and the suitable constructional characteristics.To further understand the design and particularity of polyoxovanadate-based MOPs,(NH_(2)Me)_(8){[V_(6)O_(6)(OCH_(3))_(9)(C_(6)H_(5)PO_(3))]_(4)·(BPT)_(4)}·2DMF(HNU-74)and(NH_(2)Me)12{[V_(6)O_(6)(OCH_(3))_(9)(C_(6)H_(5)PO_(3))]4·(HBCBAIP)_(4)}(SO_(4))_(2)·MeOH·DMF(HNU-75)were constructed by a face-directed synthesis strategy.Both structures were assembled with four secondary building units as vertexes and four organic ligands served as faces.Different from HNU-74,HNU-75 showed a carboxyl group free during the coordination process,resulting in the pore channels being blocked and the free carboxyl group linking outwards,paving the way for the formation of the 3D structure.Due to the pore channels of HNU-74,the adsorption of I2 was studied and the adsorption capacity was 148 mg/g. | CHEN Huiping GONG Yaru CHU Qiangqiang PANG Xiao HUANG Xiaojing TIAN Xudong YANG Weiting PAN Qinhe SU Zhongmin WANG Xinlong | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 19 | Application Study of Greenhouse Environment Monitoring System Based on ZigBee Technology显示文摘Against the demand of intelligent greenhouse construction of facility agriculture,greenhouse environment monitoring system is developed.The system contains three-layer architecture: sensor network layer at the bottom,data transmission convergence layer in the middle and monitoring application layer on the top,which is different from design idea of the existing system architecture.The bottom layer uses ZigBee wireless communication technology to construct wireless sensor network,and node type contains coordinator,router and acquisition terminal.Acquisition terminal is distributed in each greenhouse to collect data and play the role of wireless transmission,and router plays the function of data forwarding as the bridge of acquisition terminal and coordinator.Middle layer is composed of monitoring software developed by Lab VIEW software of NI Company and coordinator,which is used to gather data from the bottom layer.The top layer is comprehensive monitoring platform developed by Java language,which is used to gather greenhouse data of all plantation bases in one region,thereby providing comprehensive information service for government,enterprise and farmer.Greenhouse environment monitoring system realizes data collection and sharing of greenhouse environment information(air temperature,air humidity,light intensity and carbon dioxide concentration).Via test verification,the system's operation is stable,with certain application value. | Weiting ZHANG Hongye YANG Wentao FENG Rui WANG | 2017 | Asian Agricultural Research2017，9，2： | 0 |
| 20 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
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