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| 1 | 照料孙子女的经历对农村老年人生理健康的影响显示文摘本文利用'安徽省老年人生活状况'纵贯数据进行路径分析,研究照料孙子女的经历对农村老年人生理健康的影响,并且讨论了成年子女提供的代际支持在其影响路径中的作用。研究发现,相比于未曾照料过孙子女的农村老年人,提供持续性隔代照料的农村老年人的自陈健康状况和日常生活自理能力更好,而曾经提供过隔代照料的农村老年人也有更好的自陈健康状况。同时,对于提供持续性隔代照料的农村老年人而言,情感支持在照料经历对其自陈健康状况的影响路径中发挥了一定的中介作用,即能否从其成年子女处获得情感支持影响了他们的自陈健康状况。 | 周晶 韩央迪 Weiyu Mao Yura Lee Iris Chi | 2016 | 中国农村经济2016，，7： | 42 |
| 2 | Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis显示文摘Hereditary spherocytosis(HS), the most common cause of congenital hemolytic anemia, is caused by deficiency of the erythrocyte membrane proteins. Five causative genes(ANK1, SPTB, SPTA1, SLC4 A1, and EPB42) have been identified. To date,molecular genetic studies have been performed in different populations, including the American, European, Brazilian, Japanese and Korean populations, whereas only a few studies have been described in the Chinese population. Here, by reanalysis of the exome data, we revealed causative mutations and established a definitive diagnosis of HS in all 38 Chinese families. We found 34 novel mutations and four reported mutations in three known HS-causing genes—17 in ANK1, 17 in SPTB and four in SLC4 A1,suggesting that ANK1 and SPTB are the major genes in Chinese patients with HS. All of the ANK1 or SPTB mutations, scattered throughout the entire genes, are non-recurrent; and most of them are null mutations, which might cause HS via a haploinsufficiency mechanism. De novo mutations in ANK1 or SPTB often occur with an unexpected high frequency(87.5% and64.2%, respectively). Our study updates our knowledge about the genetic profile of HS in Chinese and shows that family-based,especially parent-offspring trio, sequencing analysis can help to increase the diagnostic power and improve diagnostic efficiency. | Rongrong Wang Shuanghao Yang Ming Xu Jia Huang Hongyan Liu Weiyue Gu Xue Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 22 |
| 3 | Brain tumor-targeted drug delivery strategies显示文摘Despite the application of aggressive surgery,radiotherapy and chemotherapy in clinics,brain tumors are still a difficult health challenge due to their fast development and poor prognosis.Brain tumor-targeted drug delivery systems,which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue,are a promising new approach to brain tumor treatments.Since brain tumors exhibit many distinctive characteristics relative to tumors growing in peripheral tissues,potential targets based on continuously changing vascular characteristics and the microenvironment can be utilized to facilitate effective brain tumor-targeted drug delivery.In this review,we briefly describe the physiological characteristics of brain tumors,including blood–brain/brain tumor barriers,the tumor microenvironment,and tumor stem cells.We also review targeted delivery strategies and introduce a systematic targeted drug delivery strategy to overcome the challenges. | Xiaoli Wei Xishan Chen Man Ying Weiyue Lu | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 14 |
| 4 | Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties:preparation, characterization and application in a vaginal drug delivery system显示文摘Lack of mucoadhesive properties is the major drawback to poloxamer 407(F127)-based in situ hydrogels for mucosal administration. The objective of the present study was to construct a novel mucoadhesive and thermosensitive in situ hydrogel drug delivery system based on an aminofunctionalized poloxamer for vaginal administration. First, amino-functionalized poloxamer 407(F127-NH2) was synthesized and characterized with respect to its micellization behavior and interaction with mucin. Then using acetate gossypol(AG) as model drug, AG-loaded F127-NH2-based in situ hydrogels(NFGs) were evaluated with respect to rheology, drug release, ex vivo vaginal mucosal adhesion, in vivo intravaginal retention and local irritation after vaginal administration to healthy female mice. The results show that F127-NH2 is capable of forming a thermosensitive in situ hydrogel with sustained drug release properties. An interaction between positively charged F127-NH2 and negatively charged mucin wasrevealed by changes in the particle size and zeta potential of mucin particles as well as an increase in the complex modulus of NFG caused by mucin. Ex vivo and in vivo fluorescence imaging and quantitative analysis of the amount of AG remaining in mouse vaginal lavage all demonstrated greater intravaginal retention of NFG than that of an unmodified F127-based in situ hydrogel. In conclusion, amino group functionalization confers valuable mucoadhesive properties on poloxamer 407. | Liqian Ci Zhigang Huang Yu Liub Zhepeng Liu Gang Wei Weiyue Lu | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 11 |
| 5 | Improvement of the Surface Pressure Operator in GRAPES and Its Application in Precipitation Forecasting in South China显示文摘在这研究,我们调查了涉及在当前的全球、地区性的吸收和预言系统吸收表面压力的问题,葡萄。吸收表面压力的一个新计划被建议,包括一个新插值计划和使清醒的背景协变性。新计划考虑车站举起和模型地形学之间的差别,并且它特别处理在第一模型水平的下面在举起定位的车站。对比实验用原版和新吸收计划被进行。新插值计划和更新的背景协变性的影响被调查。我们的结果证明新插值计划利用了更多的观察并且改进了集体分析的质量。背景协变性用源于帕里什和 Derber 在 1992 建议的技术的统计被使清醒。当吸收表面压力时,实验证明更新的垂直协变性可以在空气的高水平在分析上有积极影响。如果在高水平的背景地的质量是差的,这影响可能是更重要的。一系列吸收实验被执行测试新计划的有效性。相应模拟实验作为起始的条件用两个计划的分析被进行。结果显示新计划导致在华南的海水平压力和降水的更好的预报,特别预报中等并且大雨。 | HUANG Yanyan XUE Jishan WAN Qilin CHEN Zitong DING Weiyu ZHANG Chengzhong | 2013 | Advances in Atmospheric Sciences2013，30，2： | 10 |
| 6 | Single-Atom Catalysts for Electrochemical Hydrogen Evolution Reaction: Recent Advances and Future Perspectives显示文摘Hydrogen,a renewable and outstanding energy carrier with zero carbon dioxide emission,is regarded as the best alternative to fossil fuels.The most preferred route to large-scale production of hydrogen is by water electrolysis from the intermittent sources(e.g.,wind,solar,hydro,and tidal energy).However,the efficiency of water electrolysis is very much dependent on the activity of electrocatalysts.Thus,designing high-effective,stable,and cheap materials for hydrogen evolution reaction(HER)could have a substantial impact on renewable energy technologies.Recently,single-atom catalysts(SACs)have emerged as a new frontier in catalysis science,because SACs have maximum atom-utilization efficiency and excellent catalytic reaction activity.Various synthesis methods and analytical techniques have been adopted to prepare and characterize these SACs.In this review,we discuss recent progress on SACs synthesis,characterization methods,and their catalytic applications.Particularly,we highlight their unique electrochemical characteristics toward HER.Finally,the current key challenges in SACs for HER are pointed out and some potential directions are proposed as well. | Zonghua Pu Ibrahim Saana Amiinu Ruilin Cheng Pengyan Wang Chengtian Zhang Shichun Mu Weiyue Zhao Fengmei Su Gaixia Zhang Shijun Liao Shuhui Sun | 2020 | Nano-Micro Letters2020，12，2： | 10 |
| 7 | Liposomes and lipid disks traverse the BBB and BBTB as intact forms as revealed by two-step F?rster resonance energy transfer imaging显示文摘The blood–brain barrier(BBB) and the blood–brain tumor barrier(BBTB) prevent drug and nano-drug delivery systems from entering the brain. However, ligand-mediated nano-drug delivery systems have significantly enhanced the therapeutic treatment of glioma. In this study we investigated the mechanism especially the integrity of liposomes and lipid disks while traversing the BBB and BBTB both in vitro and in vivo. Fluorophores(DiO, DiI and DiD) were loaded into liposomes and lipid disks to form F?rster resonance energy transfer(FRET) nano-drug delivery systems. Using brain capillary endothelial cells as a BBB model, we show that liposomes and disks are present in the cytoplasm as their intact forms and traverse the BBB with a ratio of 0.68‰ and 1.67‰, respectively. Using human umbilical vein endothelial cells as BBTB model, liposomes and disks remained intact and traversed the BBTB with a ratio of 2.31‰and 8.32‰ at 3 h. Ex vivo imaging and immunohistochemical results revealed that liposomes and disks could traverse the BBB and BBTB in vivo as intact forms. In conclusion, these observations explain in part the mechanism by which nano-drug delivery systems increase the therapeutic treatment of glioma. | Tongcheng Dai Kuan Jiang Weiyue Lu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 8 |
| 8 | A Preliminary Study on the Use of NCEP Temperature Images and Additive Tectonic Stress from Astro-Tidal-Triggering to Forecast Short-Impending Earthquakes显示文摘Taking the three earthquakes which occurred in Tibet, China during the period of July 12 to August 25, 2004 as an example,the paper analyses the M_S≥6.0 earthquakes that occurred in China and M_S≥7.0 earthquakes that occurred overseas since May of 2003 by combining the image data from the National Center for Environmental Prediction of America(NCEP)with the additive tectonic stress from astro-tidal-triggering (ATSA) and makes the following conclusions: The abnormal temperature image data of NCEP can better reflect the spatial-temporal evolution process of tectonic earthquake activity; The ATSA has an evident triggering effect on the activity of a fault when the terra stress is in critical status; using the NCEP images and the ATSA to forecast short-impending earthquake is a new concept; The three earthquakes occurred during the same phase of the respective ATSA cycle, i.e. that occurred at the time when the ATSA reached the relatively steady end of a peak, rather than at the time when the variation rate was maximal. In addition, the author discovered that the occurrence time of other earthquake cases during 2003~2004 in Tibet was also in the same phase of the above-mentioned cycles, and therefore, further study of this feature is needed with more earthquake cases in other areas over longer periods of time. | Ma Weiyu Zhang Xingcai Dai Xiaofang Xie Fang | 2007 | Earthquake Research in China2007，21，1： | 8 |
| 9 | Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer worldwide.Although many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully clarified.Methods:A total of 165 HCC patients,including 146 males and 19 females,were enrolled.The median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene sequencing.Genomic alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were analyzed.Tumor mutational burden(TMB)was measured by an algorithm developed in-house.The top quartile of HCC was classified as TMB high.Results:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC tissues.TMB values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/Mb.The most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and FGF19.SNV was the most common mutation type and C:G>T:A and guanine transformation were the most common SNVs.Compared to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TERT was independently correlated with tumor invasion of the liver capsule(P=0.001,OR=3.030),and the mutation of CTNNB1 was independently correlated with AFP(<25μmg/L)(P=0.009,OR=3.414).Conclusions:The most frequently mutated genes of HCC patients in China were TP53,TERT,and CTNNB1,which mainly lead to the occurrence and development of HCC by regulating the P53 pathway,Wnt pathway,and telomere repair pathway.There were more patients with microvascular invasion and Edmondson III-IV grade in TP53 mutated patients and more patients with hepatic capsule invasion in TERT mutated patients,while in CTNNB1 mutated patients,there were more patients with Edmondson I-II grade,AFP<25μmg/L,and a non-hepatitis B background.Also,the TMB values were significantly higher in CTNNB1 mutated patients than in wild type patients. | Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi Yunjin Zang Jingyu Cao Liqun Wu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 8 |
| 10 | Dynamics of ecosystem carbon stocks during vegetation restoration on the Loess Plateau of China显示文摘In the last few decades, the Loess Plateau had experienced an extensive vegetation restoration to reduce soil erosion and to improve the degraded ecosystems. However, the dynamics of ecosystem carbon stocks with vegetation restoration in this region are poorly understood. This study examined the changes of carbon stocks in mineral soil(0–100 cm), plant biomass and the ecosystem(plant and soil) following vegetation restoration with different models and ages. Our results indicated that cultivated land returned to native vegetation(natural restoration) or artificial forest increased ecosystem carbon sequestration. Tree plantation sequestered more carbon than natural vegetation succession over decades scale due to the rapid increase in biomass carbon pool. Restoration ages had different effects on the dynamics of biomass and soil carbon stocks. Biomass carbon stocks increased with vegetation restoration age, while the dynamics of soil carbon stocks were affected by sampling depth. Ecosystem carbon stocks consistently increased after tree plantation regardless of the soil depth; but an initial decrease and then increase trend was observed in natural restoration chronosequences with the soil sampling depth of 0–100 cm. Moreover, there was a time lag of about 15–30 years between biomass production and soil carbon sequestration in 0–100 cm, which indicated a long-term effect of vegetation restoration on deeper soil carbon sequestration. | WANG Kaibo DENG Lei REN Zongping SHI Weiyu CHEN Yiping SHANG-GUAN Zhouping | 2016 | Journal of Arid Land2016，8，2： | 7 |
| 11 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 12 | Cloning of Ln Gene Through Combined Approach of Map-based Cloning and Association Study in Soybean显示文摘Increasing yield is one of the most important goals in crop breeding.Soybean(Glycine max L.Merr.),one of the most economically important leguminous seed crops,provides the majority of plant proteins,and more than a quarter of the world's food and animal feed(Graham and Vance,2003). The yield of soybean is finally determined by the number of seeds per unit area,which affected by many characters,such as height,branching number,photosynthesis,seed size,seed number.The number of seeds per pod is taken for one of the critical components that related to yield(You et al.,1995),and it has long been considered in soybean production(Takahashi, | Chao Fang Weiyu Li Guiquan Li Zheng Wang Zhengkui Zhou Yanming Ma Yanting Shen Congcong Li Yunshuai Wu Baoge Zhu Weicai Yang Zhixi Tian | 2013 | Journal of Genetics and Genomics2013，40，2： | 7 |
| 13 | Unsaturated-sulfur-rich MoS2 nanosheets decorated on free-standing SWNT film: Synthesis, characterization and electrocatalytic application显示文摘此处,我们报导一条自底向上的 solvothermal 线路综合为氢进化反应的灵活、高度有效的瞬间 2@SWNT electrocatalyst (她的) 。描述表明包含 sulfurrich 地点的像分支的瞬间 2 nanosheets 在一致地在自立的围单人赛的碳 nanotube (SWNT ) 上驱散的 situ 电影,能暴露更不饱和的硫原子,与活跃地点允许优秀电的接触。展出的灵活催化剂优秀她有低过电位的表演(~ 在 10 妈 / 厘米 2) 和小 Tafel 斜坡(41 mV/dec ) 的 150 mV。为了推进,解释改进表演,本地电子结构被 X 光检查吸收调查近边的结构(XANES ) 分析,证明不饱和的硫原子并且在瞬间 2 和 SWNT 之间的强壮的电子联合的存在。这研究提供一条在原处合成的线路在催化剂微观结构,电子结构,和性质之中创造新多功能的灵活 hybridized 催化剂和有用卓见进关系。 | Daobin Liu Weiyu Xu Qin Liu Qun He Yasir A. Haleem Changda Wang Ting Xiang Chongwen Zou Wangsheng Chu Jun Zhong Zhiqiang Niu Li Song | 2016 | Nano Research2016，9，7： | 7 |
| 14 | Effects of Fatty Acids on Low-Sulfur Diesel Lubricity:Experimental Investigation, DFT Calculation and MD Simulation显示文摘The continuous reduction in sulfur content of fuels would lead to diesel fuel with poor lubricity which could result in engine pump failure. In the present work, fatty acids were adopted as lubricity additives to low-sulfur diesel fuel. It was attempted to correlate the molecular structures of fatty acids, such as carbon chain length, degree of saturation and hydroxylation, to their lubricity enhancement, which was evaluated by the High-Frequency Reciprocating Rig (HFRR) method. The efficiency order was supported by the density functional theory (DFT) calculations and the molecular dynamics (MD) simulations. The lubricity enhancing properties of fatty acids are mainly determined by the cohesive energy of adsorbed films formed on iron surface. The greater the cohesive energy, the more efficiently the fatty acid would enhance the lubricity of low-sulfur diesel fuel. | Luo Hui Fan Weiyu Li Yang Zhao Pinhui Nan Guozhi | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，2： | 6 |
| 15 | Experimental validation of dynamic polarization compensation in ground-satellite quantum key distribution显示文摘Ground-satellite quantum key distribution(QKD)is a feasible way to implement global-scale quantum communication.Herein we propose an approach to dynamically compensate the polarization of the photons when passing through the optical telescope used in ground-satellite QKD.Our results experimentally demonstrate that the fidelity of any polarization state after dynamic compensation can be achieved by more than 99.5%,which fulfills the requirements of ground-satellite QKD. | WANG ChaoZe GUO Hui REN JiGang CAO Yuan PENG ChengZhi LIU WeiYue | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，7： | 6 |
| 16 | LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients显示文摘Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PCR and Western blot were conducted to detect the expression of DDP10-AS1 and DPP10 in lung cancer cell lines and tissues.The effects of DDP10-AS1 on DPP10 expression,cell growth,invasion,apoptosis,and in vivo tumor growth were investigated in lung cancer cells by Western blot,rescue experiments,colony formation,flow cytometry,and xenograft animal experiments.Results:The novel antisense lnc RNA DPP10-AS1 was found to be highly expressed in cancer tissues(P<0.0001),and its upregulation predicted poor prognosis in patients with lung cancer(P=0.0025).Notably,DPP10-AS1 promoted lung cancer cell growth,colony formation,and cell cycle progression,and repressed apoptosis in lung cancer cells by upregulating DPP10 expression.Additionally,DPP10-AS1 facilitated lung tumor growth via upregulation of DPP10 protein in a xenograft mouse model.Importantly,DPP10-AS1 positively regulated DPP10 gene expression,and both were coordinately upregulated in lung cancer tissues.Mechanically,DPP10-AS1 was found to associate with DPP10 m RNA but did not enhance DPP10 m RNA stability.Hypomethylation of DPP10-AS1 and DPP10 contributed to their coordinate upregulation in lung cancer.Conclusions:These findings indicated that the upregulation of the antisense lnc RNA DPP10-AS1 promotes lung cancer malignant processes and facilitates tumorigenesis by epigenetically regulating its cognate sense gene DPP10.DPP10-AS1 may serve as a candidate prognostic biomarker and a potential therapeutic target in lung cancer. | Haihua Tian Jinchang Pan Shuai Fang Chengwei Zhou Hui Tian Jinxian He Weiyu Shen Xiaodan Meng Xiaofeng Jin Zhaohui Gong | 2021 | Cancer Biology & Medicine2021，18，3： | 5 |
| 17 | Spatio-temporal analysis and simulation on shallow rainfall-induced landslides in China using landslide susceptibility dynamics and rainfall I-D thresholds显示文摘An empirical simulation method to simulate the possible position of shallow rainfall-induced landslides in China has been developed.This study shows that such a simulation may be operated in real-time to highlight those areas that are highly prone to rainfall-induced landslides on the basis of the landslide susceptibility index and the rainfall intensity-duration(I-D) thresholds.First,the study on landslide susceptibility in China is introduced.The entire territory has been classified into five categories,among which high-susceptibility regions(Zone 4-'High' and 5-'Very high') account for 4.15%of the total extension of China.Second,rainfall is considered as an external triggering factor that may induce landslide initiation.Real-time satellite-based TMPA3B42 products may provide real rainfall spatial and temporal patterns,which may be used to derive rainfall duration time and intensity.By using a historical record of 60 significant past landslides,the rainfall I-D equation has been calibrated.The rainfall duration time that may trigger a landslide has resulted between 3 hours and 45 hours.The combination of these two aspects can be exploited to simulate the spatiotemporal distribution of rainfall-induced landslide hazards when rainfall events exceed the rainfall I-D thresholds,where the susceptibility category is 'high' or 'very high'.This study shows a useful tool to be part of a systematic landslide simulation methodology,potentially providing useful information for a theoretical basis and practical guide for landslide prediction and mitigation throughout China. | LI WeiYue LIU Chun Marco SCAIONI SUN WeiWei CHEN Yu YAO DongJing CHEN Sheng HONG Yang ZHANG KaiHang CHENG GuoDong | 2017 | Science China Earth Sciences2017，60，4： | 5 |
| 18 | Vulnerability to drought-induced cavitation in shoots of two typical shrubs in the southern Mu Us Sandy Land, China显示文摘Salix psammophila and Caragana korshinskii are two typical shrubs in the southern Mu Us Sandy Land of China which are threatened by increasing water deficits related to climate change and large-scale human activities(e.g. coal mining and oil exploitation). In this study, we assessed their vulnerability to xylem embolism and the related anatomical traits in two-year-old regenerated shoots of these two shrubs to understand how they cope with drought environment. We also evaluated the in situ hydraulic safety margins to hydraulic failure from measurements of annual predawn and midday leaf water potentials. The results showed that S. psammophila stems had a higher water transport capacity than C. korshinskii stems. The stem xylem water potentials at 12%, 50% and 88% loss of conductivity were –1.11, –1.63 and –2.15 MPa in S. psammophila, respectively, and –1.37, –2.64 and –3.91 MPa in C. korshinskii, respectively. This suggested that C. korshinskii was more resistant to cavitation than S. psammophila. Compared with S. psammophila, C. korshinskii had shorter maximum vessel length, lower vessel density, smaller conductive area and higher wood density, which may contribute to its more resistant xylem. The in situ hydraulic safety margins indicated that even during the driest periods, both shrubs lived well above the most critical embolism thresholds, and the hydraulic safety margin was wider in C. korshinskii than in S. psammophila, suggesting that the regenerated shoots of both shrubs could function normally and C. korshinskii had greater hydraulic protection. These results provide the basis for an in-depth understanding of the survival, growth and functional behavior of these two shrubs under harsh and dry desert environments. | LI Yangyang CHEN Weiyue CHEN Jiacun SHI Hui | 2016 | Journal of Arid Land2016，8，1： | 5 |
| 19 | In vivo retention of poloxamer-based in situhydrogels for vaginal application in mouse and rat models显示文摘The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188(GEL1, relative hydrophobic)or 6% poloxamer 188(GEL2, relative hydrophilic), were compared with respect to the rheological properties, in vitro hydrogel erosion and drug release. The vaginal retention capabilities of these hydrogel formulations were further determined in two small animal models, including drug quantitation of vaginal rinsing fluid in mice and isotope tracing with99 m Tc in rats. The two formulations exhibited similar phase transition temperatures ranging from 27 to 32 1C. Increasing the content of poloxamer 188 resulted in higher rheological moduli under body temperature, but slightly accelerated hydrogel erosion and drug release. When compared in vivo, GEL1 was eliminated significantly slower in rat vagina than GEL2,while the vaginal retention of these two hydrogel formulations behaved similarly in mice. In conclusion,increases in the hydrophilic content of formulations led to faster hydrogel erosion, drug release andintravaginal elimination. Rats appear to be a better animal model than mice to evaluate the in situ hydrogel for vaginal application. | Yu Liu Fujin Yang Linglin Feng Long Yang Lingyun Chen Gang Wei Weiyue Lu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 5 |
| 20 | 臭氧总量探测仪(TOU)与臭氧监测仪(OMI)和SBUV/2的交叉定标及其在环境中的应用显示文摘基于臭氧监测仪(OMI)对FY-3A卫星臭氧总量探测仪(TOU)进行交叉定标,交叉定标的结果用于TOU全球臭氧总量的反演。OMI是搭载在美国国家航空和航天局的地球观测系统的Aura卫星上的一个仪器,将其Level 3臭氧总量产品作为辐射传输模式的输入,计算中低纬度太平洋上臭氧总量探测仪像元的辐亮度,通过回归过程计算TOU在轨辐亮度定标系数。结果显示,在轨交叉定标后,TOU反演的臭氧总量产品与OMI仪器基于TOMS-V8算法反演臭氧总量产品相比,相对偏差大约为3%,与地面观测站点测量的臭氧总量相比,相对偏差大约为了5%。TOU、太阳后向散射紫外辐射仪(SBUV/2)以及OMI反演的2010年1月份到2011年2月份期间臭氧总量的变化相当一致。 | 王维和 Law rence E.Flynn 张兴赢 王咏梅 王英鉴 江芳 张艳 黄富祥 李晓静 刘瑞霞 郑照君 WeiYu 刘国扬 | 2013 | 气象科技进展2013，3，4： | 5 |
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