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| 1 | Effects of Fatty Acids on Low-Sulfur Diesel Lubricity:Experimental Investigation, DFT Calculation and MD Simulation显示文摘The continuous reduction in sulfur content of fuels would lead to diesel fuel with poor lubricity which could result in engine pump failure. In the present work, fatty acids were adopted as lubricity additives to low-sulfur diesel fuel. It was attempted to correlate the molecular structures of fatty acids, such as carbon chain length, degree of saturation and hydroxylation, to their lubricity enhancement, which was evaluated by the High-Frequency Reciprocating Rig (HFRR) method. The efficiency order was supported by the density functional theory (DFT) calculations and the molecular dynamics (MD) simulations. The lubricity enhancing properties of fatty acids are mainly determined by the cohesive energy of adsorbed films formed on iron surface. The greater the cohesive energy, the more efficiently the fatty acid would enhance the lubricity of low-sulfur diesel fuel. | Luo Hui Fan Weiyu Li Yang Zhao Pinhui Nan Guozhi | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，2： | 6 |
| 2 | Experimental and Molecular Dynamics Simulations for Investigating the Effect of FattyAcid and Its Derivatives on Low Sulfur Diesel Lubricity显示文摘In this work,fatty acid and its derivatives were adopted as lubricity additives for low sulfur diesel.Tribological evaluation obtained from the High-Frequency Reciprocating Rig(HFRR)apparatus showed that the lubricating performance of the additives increased in the following order:stearic acid>glycol monopalmitate>stearyl alcohol>ethyl palmitate>cetyl ethyl ether.The adsorption behavior of the additives on Fe(110)surface and Fe2O3(001)surface was investigated by molecular dynamics(MD)simulations to verify their lubricity performance.The results suggested that adsorption energies of the additives on Fe(110)surface are determined by the van der Waals forces,while adsorptions on Fe2O3(001)surface are significantly attributed to the electrostatic attractive forces.Higher values of adsorption energy of the additives on Fe2O3(001)surface indicate that the additive has more efficient lubricity enhancing properties. | Luo Hui Fan Weiyu Li Yang Zhao Pinhui Nan Guozhi | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，3： | 4 |
| 3 | Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271显示文摘Objective: Cancer metastasis remains the primary cause of cancer-related death worldwide.In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.The purpose of this study was to identify the roles of KCTD12 in cancer metastasis.Methods: The Cancer Genome Atlas(TCGA) datasets were used to evaluate the relationship between KCTD12 and skin cutaneous melanoma(SKCM) prognosis.The effects of endogenous KCTD12 on biological behaviors were examined using the MTT assay.The impacts of KCTD12 on melanoma stemness were explored using spheroid formation assay.KCTD12 knockout A375 cells were generated to confirm the inhibitory effect of KCTD12 on CD271, and a mouse metastatic model was used to determine the impact of KCTD12 on melanoma metastasis in vivo.Results: KCTD12 levels were lower in lung metastatic cells than in paired parental melanoma cells, and low KCTD12 expression indicated a poor prognosis in SKCM.Cancer metastasis-related capacities were higher in lung metastatic cells than in parental melanoma cells.Moreover, KCTD12 knockdown enhanced tumor growth and metastasis both in vitro and in vivo.Mechanistically, the interaction between KCTD12 and CD271 might be responsible for the stemness transformation after KCTD12 knockdown.Conclusions: This study identifies for the first time the role of the interaction between KCTD12 and CD271 in inducing melanoma cell stemness transformation.Moreover, KCTD12 repression enhances melanoma cell growth, adhesion, migration and invasion. | Weiyu Shen Yumei Li Bifei Li Liping Zheng Xiaodong Xie Jingqing Le Yusheng Lu Tao Li Fan Chen Lee Jia | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 4 | Increasing prevalence of antibiotic resistance genes in manured agricultural soils in northern China显示文摘Land application of manure tends to result in the dissemination of antibiotic resistance in the environment.In this study,the influence of long-term manure application on the enrichment of antibiotic resistance genes(ARGs)and mobile genetic elements(MGEs)in agricultural soils was investigated.All the analyzed eight ARGs(tetA,tetW,tetX,sull,sulll,ermF,aac(6')-Ib-cr and blaTEM)and two MGEs(intJJ and Tn916/1545)were detected in both the manured and control soils,with relative abundances ranging from 10^-6 to 10^-2 Compared with the control soil,the relative abundances of ARGs and MGEs in manured soils were enriched 1.0-18.1 fold and 0.6-69.1 fold,respectively.High-throughput sequencing analysis suggested that at the phylum level,the bacteria carrying intll and ermF might be mainly affiliated with Proteobacteria and Bacteroides,respectively.The dominant genera carrying intll and ermF cow\d be Pseudomonas and Bacteroides,independent of manure application.Correlation analysis revealed that ARGs had strong links with soil physicochemical properties(TC,TN,and OM),heavy metals(Cu,Zn and Pb)and MGEs,indicating that the profile and spread of ARGs might be driven by the combined impacts of multiple factors.In contrast,soil pH and C/N exhibited no significant relationships with ARGs.Our findings provide evidence that long-term manure application could enhance the prevalence and stimulate the propagation of antibiotic resistance in agricultural soils. | Nan Wu Weiyu Zhang Shiyu Xie Ming Zeng Haixue Liu Jinghui Yang Xinyuan Liu Fan Yang | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 3 |
| 5 | nvestigation of the theological properties and storage stability of CR/SBS modified asphalt显示文摘 | Ming Liang Xue Xin Weiyu Fan | 2014 | Construction and Building Materials2014，74，： | 1 |
| 6 | EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription显示文摘TSPAN family of protei ns are gen erally con sidered to assemble as multimeric complexes on the plasma membra ne.Our previous work uncovered that TSPAN8 can translocate into the nucleus as a membrane-free form,a process that requires TSPAN8 palmitoylation and association with cholesterol to promote its extraction from the plasma membrane and subsequent binding with 14-3-30 and importin-p.However,what upstream signal(S)regulate(s)the nuclear translocation of TSPAN8,the potential function of TSPAN8 in the n ucleus,and the un derlying molecular mechanisms all remai n unclear.Here,we dem on strate that,epidermal growth factor receptor(EGFR)signaling induces TSPAN8 nuclear translocation by activating the kinase AKTZ which in turn directly phosphorylates TSPAN8 at Ser129,an event essential for its binding with 14-3-30 and importin B1.In the nucleus,phosphorylated TSPAN8 interacts with STAT3 to enhance its chromatin occupancy and therefore regulates transcription of downstream cancer-promoting genes,such as MYC,BCL2,MMP9,etc.The EGFR-AKT-TSPAN8-STAT3 axis was found to be hyperactivated in multiple human cancers,and associated with aggressive phe no type and dismal prog nosis.We further developed a humanized mono clonal antibody hT8Ab4 that specifically recognizes the large extracellular loop of TSPAN8(TSPAN8-LEL),thus being able to block the extract!on of TSPAN8 from the plasma membrane and consequently its nuclear localization.Importantly,both in vitro and in vivo studies demonstrated an antitumor effect of hT8Ab4.Collectively,we discovered an unconventional function of TSPAN8 and dissected the underlying molecular mechanisms,which not only showcase a new layer of biological complexity of traditional membrane proteins,but also shed light on TSPAN8 as a novel therapeutic target for refractory cancers. | Xiaoqing Lu Liwei An Guangjian Fan Lijuan Zang Weiyi Huang Junjian Li Jun Liu Weiyu Ge Yuwei Huang Jingxuan Xu Shaoqian Du Tianhao Zhou Huijing Yin Li Yu Shi Jiao Hongxia Wang | 2022 | Cell Research2022，32，4： | 1 |
| 7 | Effects of different heavy crude oil fractions on the stability of oil-in-water emulsions-isolation of functional fractions from heavy crude oil and study of their properties显示文摘 | Fan Weiyu Song Yuanming Nan Guo | 2004 | Petrol Sci2004，1，3： | 1 |
| 8 | NOL7 facilitates melanoma progression and metastasis显示文摘Dear Editor,Metastasis is the cause of most fatalities in cancer patients and remains the phenomenon poorly understood mechanistically. Deciphering of the regulatory networks underlying the cancer cell metastasis is urgently needed. Nucleolar protein 7 (NOL7) has been reported to function as a tumor suppressor in cervical cancer.1 Our current study reveals a novel tumor-promoting capacity of NOL7 in melanoma. We first detected that NOL7 expression is upregulated in metastatic melanoma as compared with its expression at the primary site through isobaric tag for relative and absolute quantitation proteomic screening, further confirming this finding with the analysis of NOL7 protein and messenger RNA (mRNA) levels (Supplementary Fig. S1). Importantly, NOL7 expression increased with the disease progression from benign nevus to primary melanoma and further to metastatic melanoma (Fig. 1a and Supplementary Fig. S1d). Previous studies have shown that melanoma is commonly associated with the amplification of the chromosome region 6p, particularly 6p21–23, where the NOL7 gene resides, and that this region frequently undergoes heterozygous loss in cervical cancer.2 It might therefore be predicted that NOL7 exhibits a different expression pattern and plays different roles in melanoma and cervical cancer. | Yumei Li Chunlian Zhong Jie Wang Fan Chen Weiyu Shen Bifei Li Ning Zheng Yusheng Lu Vladimir L.Katanaev Lee Jia | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 0 |
| 9 | A highly efficient atomically thin curved Pd Ir bimetallene electrocatalyst显示文摘The multi-metallene with an ultrahigh surface area has great potential in precise tuning of surface heterogeneous d-electronic correlation by surface strain effect for the distinctive surface electronic structure,which is a brand new class of promising 2 D electrocatalyst for sustainable energy device application.However,achieving such an atomically thin multi-metallene still presents a great challenge.Herein,we present a new synthetic method for an atomic-level palladium-iridium(Pd Ir)bimetallene with an average thickness of only~1.0 nm for achieving superior catalysis in the hydrogen evolution reaction(HER)and the formic acid oxidation reaction(FAOR).The curved Pd Ir bimetallene presents a top-ranked high electrochemical active area of 127.5±10.8 m^(2)g Pd+Ir^(-1)in the reported noble alloy materials,and exhibits a very low overpotential,ultrahigh activity and improved stability for HER and FAOR.DFT calculation reveals that the Pd Ir bimetallene herein has a unique lattice tangential strain,which can induce surface distortion while concurrently creating a variety of concave-convex featured micro-active regions formed by variously coordinated Pd sites agglomeration.Such a strong strain effect correlates the abnormal on-site active 4 d^(10)-t_(2g)-orbital Coulomb correlation potential and directly elevates orbital-electronegativity exposure within these active regions,resulting in a preeminent barrier-free energetic path for significant enhancement of FAOR and HER catalytic performance. | Fan Lv Bolong Huang Jianrui Feng Weiyu Zhang Kai Wang Na Li Jinhui Zhou Peng Zhou Wenxiu Yang Yaping Du Dong Su Shaojun Guo | 2021 | National Science Review2021，8，9： | 0 |
| 10 | Intramolecular Charge Transfer-Enhanced BODIPY Photosensitizer in Photoinduced Electron Transfer and Its Application to Photoxidation under Mild Condition显示文摘Photoinduced 电子转移过程是在 photooxidation 的一个关键步骤获得合成化学药品。然而,当在所有的优先级很少在逐步的详细被学习了,电子的驱动力转。此处,我们报导有 intramolecular 上的一个重音的一系列 BODIPY 衍生物控告转移,提高 photoinduced 电子转移过程和 photooxidation 表演的关键步骤。一系列新奇 BODIPY photosensitizers (B-1-B-5 ) 被准备,充电注射组被结合到 2,6-diiodo-styryl-BODIPY 的 B-3 氨基的 diethylamine,和电子在那里转移动力,由于它的更否定的氧化还原作用潜力被提高 1.6 次。这些结果被 DFT/TDDFT 计算也证实。没有纯氧, B-3 能仍然在温和状况下面在 1,4-DHP 的 photoxidative aromatization 展出非凡的表演。在为 28 min 的照耀以后,变换率来到了 98.2% 。 | Ruiqin Wang Ying Geng Lili Zhang Wenting Wu Weiyu Fan Zhongtao Li Lizhuo Wang Liying Zhan Xueyan Wu Mingbo Wu | 2015 | Chinese Journal of Chemistry2015，33，11： | 0 |
| 11 | A boronic acid conjugation integrates antitumor drugs into albumin-binding prodrugs-based nanoparticles with robust efficiency for cancer therapy显示文摘Despite great therapeutic effect of Abraxane®,complex preparation technology and unfavorable pharmacokinetics still restricted the clinical application of albumin-based paclitaxel(PTX)nanoparticles(NPs).Herein,we reported that an albumin-binding prodrug,phenylboronic acid-conjugated PTX(P-PTX),can form the uniform NPs with the diameters around 100 nm with the help of albumin via simple one-step nano-precipitation method.The albumin-based nanomedicines were stabilized by the integration of a single boronic acid with PTX due to the increased affinity based on multiple intermolecular interactions.We found that albumin-based P-PTX NPs exhibited superior colloidal stability over albumin-based PTX NPs through one-step nanoprecipitation approach,achieving longer in vivo circulation time and higher concentration in tumor than those of the marketed Abraxane®.Furthermore,the albumin-based P-PTX NPs with great stability and enhanced intratumoral enrichment,increased the maximum tolerated dose of PTX,remarkably suppressed the growth of breast tumor and lung metastasis,prolonged survival of melanoma tumors-bearing mice.Such a convenient and effective system gains an insight into the impact of phenylboronic acid group on the albumin-based PTX NPs,provides potent strategy for the rational design of albumin-based antitumor nanomedicines. | Weiyue Ban Qiuhua Luo Chengda Yan Xiaoying Fan Guorui Zhu Maosheng Cheng Zhonggui He Mengchi Sun Jin Sun | 2023 | Nano Research2023，16，5： | 0 |
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