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| 1 | 欧洲肿瘤内科协会对宫颈癌的诊断、治疗和随访所制定的临床实践指南显示文摘2010年底,在意大利米兰召开了欧洲肿瘤年会。会上推出了常见妇科肿瘤的诊治指南。这些指南与国际妇产科联盟(FIGO)、美国国立综合癌症网(NCCN)等的指南有一些差异,但细腻周全,有其特点和重要参考价值。现邀请北京协和医院杨华博士翻译,《国际妇产科学杂志》主编郎景和教授审校,依宫颈癌、子宫内膜癌、卵巢上皮癌、非卵巢上皮癌顺序陆续发表,以飨读者。指南均发表于欧洲肿瘤协会(European Society forMedical Oncology,ESMO)主办的肿瘤年刊 Annals of Oncology,2010,21(Suppl 5)。 | Haie-Meder C Morice P Castiglione M On Behalf of the ESMO Guidelines Working Group 杨华 郎景和 | 2011 | 国际妇产科学杂志2011，38，1： | 21 |
| 2 | 欧洲肿瘤内科协会对非上皮性卵巢癌的诊断、治疗和随访所制定的临床实践指南显示文摘非上皮性卵巢癌是一类少见的卵巢癌,因此,其诊断较难建立。然而,通过仔细观察各种肿瘤的标记物[尤其是人绒毛膜促性腺激素β亚单位(β-hCG)、α-甲胎蛋白(α-AFP)和乳酸脱氢酶(LDH)]、临床体征(如妊娠期体征, | Reed N Millan D Verheijen R Castiglione M On behalf of the ESMO Guidelines Working Group 杨华(译) 郎景和(审校) | 2011 | 国际妇产科学杂志2011，38，4： | 13 |
| 3 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 4 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 5 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 6 | Characterization of proteolipid protein-peptide-specific CD_4^+ T cell of experimental allergic encephalomyelitis in Biozzi AB/H mice | Yong Peng and Chih pin Liu Department of Neurology, The Third Affiliated Hospital, Hunan Medical University , Changsha 410013, China (Peng Y) Division of Immunology, Beckman Research Institute, City of Hope National M edical Center, Duarte, CA 9 | 2002 | Chinese Medical Journal2002，，4： | 3 |
| 7 | p53 Expression in hepatocellular carcinoma in a population in Singapore with endemic hepatitis B virus infections 显示文摘 | M The C Raju | 1995 | J Clin Pathol1995，48，： | 1 |
| 8 | Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion显示文摘 | Coll the PPAR ino M Aragno M Ma oxidative stress -gamma agonists in stro and the cola R et a7 | 2006 | Eur J Pharmacol2006，530，： | 1 |
| 9 | ERCP core curriculum显示文摘 | Chutkan R K Ahmad A S Cohen J Cruz-Correa M R Desilets D J Dominitz J A ERCP Core Curriculum prepared by the ASGE Training Committee | 2006 | Gastrointest Endosc2006，63，： | 1 |
| 10 | Management of hepatocellular carcinoma: an update显示文摘 | Bruix J Sherman M American Association for the Study of Liver Diseases | 2011 | Hepatology2011，53，： | 1 |
| 11 | Rosiglitazone improves glycemic control without adversely affecting cardiac function in type 2 diabetes显示文摘 | Dole J for the Rosiglitazone Study Group | 1999 | Diabetologia1999，42，1： | 1 |
| 12 | The t(15; 17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus显示文摘 | DE THE H CHOMIENNE C LANOTFE M DEGOS L DEJEAN A | 1990 | Nature1990，347，6293： | 1 |
| 13 | Risk factors for isolated biliary atresia, National Birth Defects Prevention Study, 1997-2002显示文摘 | THE N S HONEIN M A CATON A R | 2007 | Am J Med Genet A2007，143，19： | 1 |
| 14 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 15 | 显示文摘 | Seth M L Raychaudhuri S P Investigations on the relationship of new brinjal mosaic virus and its vector Aphis gossypii Glov | 1977 | Acta Botanica Indica1977，5，2： | 1 |
| 16 | The Gene Ontology Consortium显示文摘 | Ball CA Blake JA Gene ontology: tool for the unification of biology | 2000 | Nat Genet2000，25，： | 1 |
| 17 | The long protective rust layer formed on weathering steel by atmospheric corrosion during a quarter of a century 显示文摘 | Jing Gui Deuine T term growth of the M | 1994 | Corros Sci1994，34，4： | 1 |
| 18 | Prostate cancer involving survival and implications for A- JCC staging modification显示文摘 | DASH A SANDA MG YU M the bladder neck:recurrence-free | 2002 | American Joint Committee on Cancer J Urol2002，60，2： | 1 |
| 19 | Evi- dence report: the medical treatment of ocular myas- thenia (an evidence - based review) :report of the Quality Standards Subcommittee of the American A- cademy of Neurology 显示文摘 | Benatar M Kaminski HJ:Quality Standards Subcom- mittee of the American Academy of Neurology | 2007 | Neurology2007，68，： | 1 |
| 20 | Testing and interpreting measures of ovarian reserve: a commit- tee opinion 显示文摘 | Practice Committee of the American Society for Reproductive M | 2015 | Fertil Steril2015，103，3： | 1 |
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