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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | The nondimensionalization of equations describing fluidization with application to the correlation of jet penetration height显示文摘 | Blake T R Webb H Sunderland P B | 1990 | Chemical Engineering Science1990，45，2： | 1 |
| 3 | Active protein transport through plastid tubules: Velocity quantified by fluorescence correlation spectroscopy 显示文摘 | Kohler R H Schwille P Webb W W | 2000 | J Cell Sci2000，113，22： | 1 |
| 4 | , 40 Gbit/s all-optical XOR gate based on hybrid-integrated Mach-Zehnder interferometer 显示文摘 | R P Webb | 2003 | Electronics Letters2003，39，： | 1 |
| 5 | Long-term evaluation of phosphorus and zinc interactions in corn 显示文摘 | Mallarino A P Webb J R | 1995 | Journal of Production Agriculture1995，8，1： | 1 |
| 6 | Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators 显示文摘 | An J Ribeiro R C Webb P | 1999 | Proc Natl Acad Sci USA1999，96，15： | 1 |
| 7 | Frequency and initiation of debris flows in Grand Canyon, Arizona 显示文摘 | Griffiths P G Webb R H Melis T S | 2004 | Journal of Geophysical Research2004，，109： | 1 |
| 8 | The United States Re- nal Data System' s 1991 annual data report : an introduction 显示文摘 | HELD P J PORT F K WEBB R L | 1991 | Am J Kidney Dis1991，18，52： | 1 |
| 9 | Determination of the deposition order of overlapping latent fingerprints and inks using secondary ion mass spectrometry显示文摘 | Bright N J Webb R P Bleay S | 2012 | Anal Chem2012，84，9： | 1 |
| 10 | Performance and testing of thermal interface materials 显示文摘 | J P Gwinn R L Webb | 2003 | Microelectron2003，34，3： | 1 |
| 11 | Condensation of steam with and without the presence of non-condensable gases in a vertical tube 显示文摘 | AlShammari S B Webb D R Heggs P | 2004 | Desalination2004，169，2： | 1 |
| 12 | Performance and testing of thermal in- terface materials 显示文摘 | Gwinn J P Webb R L | 2003 | Microelectronics Journal2003，34，3： | 1 |
| 13 | Me-thionine-ontaining peptides can be used as nine sources for protein accretion in culttured methicr C 12 and MAC-T cells 显示文摘 | Pan Y Bender P K Akers R M Webb K E | 1996 | Journal of Nutrition1996，126，10： | 1 |
| 14 | Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors显示文摘 | HADDAD R LIPSON K E WEBB C P | 2001 | Anticancer Res2001，21，6： | 1 |
| 15 | Effects of immunization with somatostatin on growth and arterio-venous differences of metabolites across muscle tissue of growing lambs 显示文摘 | Webb M M S McDowell G H Gooden J M Hoskinson R M Wynn P C | 1986 | Prod Nutr Soc Aust1986，11，： | 1 |
| 16 | Wettability of natural superhydrophobic surfaces 显示文摘 | WEBB H K CRAWFORD R J IVANOVA E P | 2014 | Adv Colloid Interface Sci2014，210，8： | 1 |
| 17 | All optical loop mirror switch employing an asymmetric amplifier/attenuator combination 显示文摘 | ONEILL A W WEBB R P | 1990 | Electron Lett1990，26，24： | 1 |
| 18 | Sediment yield and runoff frequency of small drainage basins in the Mojave Desert, USA 显示文摘 | GRIFFITHS P G HEREFORD R WEBB R H | 2006 | Geomorphology2006，74，1234： | 1 |
| 19 | Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3 F1 mice显示文摘 | Mittelstaedt R A Mei N Webb P J | | 0，，1： | 1 |
| 20 | Meta-analysis of genome-wide association dataidentifies four new susceptibility loci for colorectalcancer 显示文摘 | HOULSTON R S WEBB E BRODERICK P | 2008 | Nature Genetics2008，40，12： | 1 |
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