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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Kinematics of pectoral fin propulsion in cymatogaster aggregate显示文摘 | WEBB P W | 1973 | Journal of Experimental Biology1973，59，： | 1 |
| 3 | The nondimensionalization of equations describing fluidization with application to the correlation of jet penetration height显示文摘 | Blake T R Webb H Sunderland P B | 1990 | Chemical Engineering Science1990，45，2： | 1 |
| 4 | Student learning with concept mapping of care plans in community-based education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 5 | Hierarchical Vector Basis Function of Arbitrary Order for Triangular and Tetrahedral Finite Elements显示文摘 | Webb J P | 1999 | IEEE Trans Antennas Propagat1999，47，： | 1 |
| 6 | Prediction of radiative transfer in aluminum-recycling furnace 显示文摘 | SOLOVJOV V P WEBB B M | 2005 | Journal of the Institute of Energy2005，78，1： | 1 |
| 7 | Edge elements and what they can do for you显示文摘 | Webb J P | 1993 | IEEE Trans on Magnetics1993，29，2： | 1 |
| 8 | An efficient method for modeling radiative transfer in muhicomponent gas mixtures with soot显示文摘 | Solovjov V P Webb B W | 2001 | Journal of Heat Transfer2001，123，： | 1 |
| 9 | Active protein transport through plastid tubules: Velocity quantified by fluorescence correlation spectroscopy 显示文摘 | Kohler R H Schwille P Webb W W | 2000 | J Cell Sci2000，113，22： | 1 |
| 10 | 查看详情显示文摘 | Critchlow G W Webb P W Tremlett C J | | 0，，： | 1 |
| 11 | Mechanisms of Implementation Intention Effects: The Role of Goal Intentions, Self-Efficacy and Ac- cessibility of Plan Components显示文摘 | Webb T Sheeran P | 2008 | British Journal of Social Psychology2008，47，3： | 1 |
| 12 | In vitro absorption of amino acids by the smallintestine of sheep显示文摘 | Phillips W A Webb K E Fontenot J P | 1976 | Journal of Animal Science1976，42，： | 1 |
| 13 | , 40 Gbit/s all-optical XOR gate based on hybrid-integrated Mach-Zehnder interferometer 显示文摘 | R P Webb | 2003 | Electronics Letters2003，39，： | 1 |
| 14 | Long-term evaluation of phosphorus and zinc interactions in corn 显示文摘 | Mallarino A P Webb J R | 1995 | Journal of Production Agriculture1995，8，1： | 1 |
| 15 | Differential ligand activation of estrogen receptors Eralpha and Erbeta at AP1 sites 显示文摘 | Peach K Webb P George G | 1997 | Science1997，277，： | 1 |
| 16 | Anaphylaxis:a review of601 cases显示文摘 | Webb LM Lieberman P | 2006 | Ann Allergy Asthma Immunol2006，97，： | 1 |
| 17 | Grazing impacts on the susceptibility of rangelands to wind erosion: The effects of stocking rate, stocking strategy and land condition显示文摘 | AUBAULT H WEBB N P STRONG C L | 2015 | Aeolian Research2015，17，： | 1 |
| 18 | Differentiallig and activation of estrogen receptors ERαand Erβat API sites 显示文摘 | Paech K Webb P Kuiper GG | 1997 | Science1997，277，： | 1 |
| 19 | Global changes during the last 3 million years: climatic controls and biotic responses显示文摘 | Webb Iii T Bartlein P J | 1992 | Annual Review of Ecology and Systematies1992，23，1： | 1 |
| 20 | Meat quality of designated South African indigenous goat and sheep breeds 显示文摘 | Tshabalala P A Strydom P E Webb E C | 2003 | Meat Science2003，65，： | 1 |
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