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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | Grading system modification and management of blunt aortic injury显示文摘 | Kaavya N Reddy Tim Matatov Linda D Doucet Maureen Heldmann Cynthia X Zhao Wayne W Zhang | 2013 | Chinese Medical Journal2013，，3： | 2 |
| 4 | Characterization of spermidine hydroxycinnamoyl transferases from eggplant (Solanum melongena L.) and its wild relative Solanum richardii Dunal显示文摘Eggplant produces a variety of hydroxycinnamic acid amides(HCAAs)that have an important role in plant development and adaptation to environmental changes.In this study,we identified and characterized a spermidine hydroxycinnamoyl transferase(SHT)from eggplant(Solanum melongena)and its wild relative S.richardii,designated as SmSHT and SrSHT,respectively.SmSHT was abundant in flowers and fruits,whereas the level of SrSHT was remarkably low in all tissues.Heat-shock/drought treatment stimulated the expression of SmSHT in both leaves and fruits,indicating its involvement in plant stress response.Both SHT polypeptides had extremely high identity with just five amino-acid substitutions.Recombinant SmSHT catalyzed the synthesis of mono-,bi-and tri-acylated polyamines.Using caffeoyl-CoA as the acyl donor,SmSHT preferred spermidine as the acyl acceptor.When spermidine was the acyl acceptor,the donor preference order for SmSHT was caffeoyl-CoA>feruloyl-CoA>ρ-coumaroyl-CoA.SrSHT exhibited the same substrate specificity as SmSHT,yet exhibited significantly higher catalytic activity than SmSHT.For example,under caffeoyl-CoA and spermidine,Kcat of SrSHT was 37.3%higher than SmSHT.Molecular modeling suggests that five amino-acid substitutions in SrSHT result in four alterations in their predicted 3D structures.In particular,the conserved Lys402 adjacent to the DFGWG motif,and Cys200 in the crossover loop in SmSHT were replaced by Glu and Ser in SrSHT.These substitutions may contribute to the enhanced activity in SrSHT.Our study provides a platform to generate HCAA rich fruits for eggplant and other solanaceous crops. | Hui Peng Tianbao Yang Bruce D Whitaker Frances Trouth Lingfei Shangguan Wen Dong Wayne M Jurick | 2016 | Horticulture Research2016，3，1： | 2 |
| 5 | Oil and gas in reservoirs with subnormal pressure显示文摘 | Prake A D Wayne C | 1977 | AAPG Bulletin1977，61，12： | 1 |
| 6 | Leader-Member Exchange, Differentiation, and Psychological Contract Fulfillment: A Multilevel Examination 显示文摘 | HENDERSON D J WAYNE S J SHORE L M | 2008 | Journal of Applied Psychology2008，93，6： | 1 |
| 7 | 显示文摘 | Jason C Wayne D Mader J T | 1988 | J Bone Joint Surg (Am)1988，70，： | 1 |
| 8 | Radiation-induced epigenetic DNA methylation modification of radiation-response pathways显示文摘 | Deborah A Antwih Kristina M Gabbara Wayne D Lancaster Douglas M Ruden Steven P Zielske | 2013 | Epigenetics2013，，8： | 1 |
| 9 | Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 yeas 显示文摘 | BILIMORIA K Y BENTREM D J WAYNE J D | 2009 | Ann Surg2009，249，1： | 1 |
| 10 | An overview of NSPCG:A nonsymmetric preconditioned conjugate gradient package显示文摘 | THOMAS C OPPE WAYNE D | | 0，，53： | 1 |
| 11 | A practical scientific app roach to riparian vegetation rehabilitation in Australia显示文摘 | Ashley A W Wayne D E | 2003 | Journal of Environmental Management2003，68，4： | 1 |
| 12 | A clinical test of stepping and change of direction to identify multiple falling older adults 显示文摘 | Wayne D Temple VA | 2002 | Arch Phys Med Rehabi12002，83，11： | 1 |
| 13 | Reconfiguration of electric distribution networks for resistive line losses reduction显示文摘 | Shirmohammadi D Wayne H | 1989 | IEEE Trans on Power Delivery1989，4，2： | 1 |
| 14 | The prensent status of QSAR in toxicology显示文摘 | T Wayne Schultz Mark T D Cronin | 2003 | Journal of Molecular Structure:THEOCHEM2003，622，12： | 1 |
| 15 | Total force fitness for the 21st Century,a new paradigm显示文摘 | Wayne J Patricia D Francis G | | 0，，08： | 1 |
| 16 | A comparison of theeffect of diet extrusion or screw-press pelleting on the digesti-bility of grain protein products when fed to rainbow troutj显示文摘 | Brett G D Wayne H D David E | 2011 | Aquaculture2011，312，： | 1 |
| 17 | Service Ori- entation of a Retailer' s Business Strategy : Dimensions, Antecedents and Performance Outcomes 显示文摘 | Homburg Christian Wayne D Hoyer Martin Fassnacht | 2002 | Journal of Marketing2002，66，4： | 1 |
| 18 | Serum Uric Acid and Risk of Coronary Heart Disease显示文摘 | Joseph T Moriarity Aaron R Folsom Carlos Iribarren F.Javier Nieto Wayne D Rosamond | 2000 | Annals of Epidemiology2000，，3： | 1 |
| 19 | Dynamic adsorption of radon by activated carbon 显示文摘 | WAYNE C G UNDERHILL D W | 2005 | Health Physics2005，88，4： | 1 |
| 20 | Geographic Mobility and Student Achievement in an Urban Setting显示文摘 | Ingersoll Gary Scamman James Eckerling Wayne D | 1989 | Educational Evaluation and Policy Analysis1989，，2： | 1 |
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