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| 1 | Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters显示文摘维生素 D 层次包括繁殖混乱被连接了到各种各样的健康结果。这研究的目的是探索在浆液维生素 D 水平(25-hydroxy-vitamin D,或 25OHD ) 和精液和神经质的参数之间的协会。这是包括了从一般人口为精子发生的学习招募的 170 个健康的人的代表性的研究。完成的将军和繁殖健康问询表,和捐赠的血和精液取样的人。主要措施是神经质的(全部、免费的睾丸激素,性荷尔蒙绑定血球素, estradiol ,刺激滤泡的荷尔蒙和 luteinizing 荷尔蒙)并且精液参数,调整( n=147 )好久,身体团索引( BMI ),季节,白酒吸入并且吸烟,在与维生素 D 层次的范畴的关系,决定了 priori 。学习人口的吝啬的年龄是 29.0 ± 8.5 年和吝啬的 BMI 是 24.3 ± 3.2 kg m −2 。吝啬的 25OHD 是 34.1 ± 15.06 ng ml −1 。BMI 与 25OHD 显示出一个否定协会。精子集中,进步活动性,精子形态学,和全部的日益增多地能动的精子数的精子在有 ‘ 的人是更低的; 25OHD ≥ 50 ng ml −1' 什么时候与有 ‘ 的人相比; 20 ng ml −1≤25OHD<50 ng ml −1' 。全部的精子计数和全部的进步能动精子计数在有 ‘ 的人是更低的; 25OHD < 20 ng ml −1' 什么时候与有 ‘ 的人相比; 20 ng ml −1≤25OHD<50 ng ml −1' 。各种各样的神经质的参数的调整工具没在 25OHD 的不同范畴显示出统计差别。在结论,在高度和底层的浆液维生素 D 层次能否定地与精液参数被联系。 | Ahmad O Hammoud A Wayne Meikle C Matthew Peterson Joseph Stanford Mark Gibson Douglas T Carrell | 2012 | Asian Journal of Andrology2012，14，6： | 19 |
| 2 | 超重与男性生殖能力研究进展:睡眠呼吸暂停,一个新领域显示文摘肥胖会对男性生殖产生负面影响,主要是因为肥胖与低睾酮水平和促性腺激素改变有关。男性肥胖已经被发现与男性生育力下降有关,但由于影响的性质和程度不同,肥胖与精子参数相关性的数据存在争议。一些新研究领域的出现,如遗传多态性和睡眠呼吸暂停,将有助于解释研究结果的差异性。已经发现睡眠紊乱与男性睾酮生成的变化和性腺功能低下有关,也可能与勃起功能障碍有关。睡眠紊乱与不育和精子参数的关系还有待研究。忠有性腺功能低下和不育的男性应该进行睡眠呼吸暂停症的筛查。对肥胖和睡眠呼吸暂停的治疗可以改善睾酮水平和勃起功能。 | Ahmad O Hammoud Douglas T Carrell Mark Gibson C Matthew Peterson A Wayne Meikle | 2012 | Asian Journal of Andrology2012，14，1： | 11 |
| 3 | Current updates on laboratory techniques for the diagnosis of male reproductive failure显示文摘导致不孕的男繁殖失败的发生,是否由于推迟的做家长,环境问题,基因因素,药,等等,在全世界正在增加。男 subfertility 的诊断和预后成为了挑战。当基本精液评价被执行许多年了时,很多研究询问传统的精液特征的价值。这是部分由于不适当的方法和标准化,为优秀保证的技术要求的有限知识,和一个精液评价能提供临床的信息的不完全的理解。当前执行精液和内分泌的评价表演伟人可变性的实验室。世界健康组织() 精液的评估的手册是在许多年在这个领域的进一步的开发帮助了的 andrology 和生育力评估的核心。这些包括精液,对精子计数的评价,活动性,活力,形态学,和精子和精液样品的功能的方面的物理外观。这些测试也由于氧化应力包括男内分泌的侧面,精液的生物化学的评估,在浆液的 antisperm 抗体的察觉,电脑辅助的精子分析(房屋) 的使用,精子 DNA 正直,和它的损坏。帮助繁殖技术(例如, IVF, ICSI ) 显示出大成功,但是是太昂贵的。与更新的技术在这块地里推进开发,广泛的火车 / 说明能改进精确性和还原剂可变性,因此维持如此的评估的质量和标准。有迫切需要标准化了训练中心并且为繁殖成功在 mens 健康的这个区域增加了了解。 | Suresh C Sikka Wayne JG Hellstrom | 2016 | Asian Journal of Andrology2016，18，3： | 9 |
| 4 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 5 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 6 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 7 | Stock market volatility, excess returns, and the role of investor sentiment显示文摘 | Wayne Y Lee Christine X Jiang Daniel C Indro | 2002 | Journal of Banking and Finance2002，，12： | 2 |
| 8 | Oil and gas in reservoirs with subnormal pressure显示文摘 | Prake A D Wayne C | 1977 | AAPG Bulletin1977，61，12： | 1 |
| 9 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease显示文摘 | Wayne A Ray C Michael Stein James R Daugherty Kathi Hall Patrick G Arbogast Marie R Griffin | 2002 | The Lancet2002，，9339： | 1 |
| 10 | In vivo response of polylactic acid-alginate scaffolds and bone marrow-derived cells for cartilage tissue engineering显示文摘 | Wayne J S McDowell C L Shields K J | 2005 | Tissue Eng2005，11，56： | 1 |
| 11 | 显示文摘 | Jason C Wayne D Mader J T | 1988 | J Bone Joint Surg (Am)1988，70，： | 1 |
| 12 | Exploring internet addiction:demographic characteristics and stereotypes of heavy internet users显示文摘 | Lori C Soul L Wayne Shell Betty A Kleen | 2003 | The Journal of Computer Information System2003，，3： | 1 |
| 13 | Treatment of severe chronic venous insufficiency using the subfascial endoscopic perforator vein procedure显示文摘 | Baron H G Wayne M G Santiago C | 2005 | Surg Endosc2005，19，1： | 1 |
| 14 | The impact of psychological contract breach on work-related outcomes:a meta-analysis显示文摘 | Zhao H Wayne S J Glibkowski B C | 2007 | Personnel Psychology2007，60，3： | 1 |
| 15 | An examina- tion of the mediating role of psychological empower- ment on the relations between the job,interpersonal relationships,and work outcomes显示文摘 | Liden R C Wayne S Sparrowe R T | 2000 | Journal of Ap- plied Psychology2000，85，3： | 1 |
| 16 | Treatment of severe chronic venous insufficiency using the subfascial endoscopic perforator vein procedure 显示文摘 | BARON H C WAYNE M G SANTIAGO C A | 2005 | Surg Endosc2005，19，1： | 1 |
| 17 | Landsat-4/5 band 6 relative radiometry 显示文摘 | Gyanesh Chander Dennis L Helder Wayne C Boncyk | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，1： | 1 |
| 18 | The im- pact of psychological contract breach on workrelated out- comes : a meta-analysis 显示文摘 | ZHAO Hao WAYNE S J GLIBKOWSKI C | 2007 | Personnel Psychology2007，60，3： | 1 |
| 19 | An overview of NSPCG:A nonsymmetric preconditioned conjugate gradient package显示文摘 | THOMAS C OPPE WAYNE D | | 0，，53： | 1 |
| 20 | Control and elimination of porcine reproductive and respiratory syndrome virus显示文摘 | Corzo C A Mondaca E Wayne S | | 0，，： | 1 |
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