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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFRspecific tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Kono SA Marshall ME Ware KE | 2009 | Drug Resist Update2009，12，45： | 1 |
| 3 | Abdominal obesity and peripheral vascular disease in men and women : a comparison of waist-to-thigh ratio and waist circ- umference as measures of abdominal obesity 显示文摘 | Lu B Zhou J Waring ME | 2010 | Atheresclerosis2010，208，1： | 1 |
| 4 | Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive rnanagemeng: one-year results from the ACUITY triall显示文摘 | Stone GW Ware JH Bertrand ME | 2007 | JAMA2007，298，21： | 1 |
| 5 | Cannabinoids for the treatment of chronic non- cancer pain:an updated systematic review of randomized controlled trials显示文摘 | Lynch ME Ware MA | 2015 | J Neuroimmune Pharmacol2015，10，2： | 1 |
| 6 | Rapidly Acquired Resistance to EGFR Tyrosine Kinas~ Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression 显示文摘 | Ware KE Marshall ME Heasley LR | 2010 | PLoS One2010，5，14： | 1 |
| 7 | Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure显示文摘 | Ware LB Snide ME | 2002 | Intensive Care Med2002，28，6： | 1 |
| 8 | The MOS 36-item shortfrom health survey (SF-36) : Psychometric and elinieal tests of validity in measuring physieal and mental health eonstants 显示文摘 | Me Homey CA Ware J Raezelk AE | 1993 | Medreare1993，3，3： | 1 |
| 9 | Aerosolized beta 2-adrenergic agonists achieve therapeutic Ievels in the pulmonary edema fluid of ventiIated patients with acute respiratory failure显示文摘 | Atabai K Ware LB Snide ME | 2002 | Intensive Care Med2002，28，6： | 1 |
| 10 | Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management:one-year results from the ACUITY trial显示文摘 | Stone GW WARE JH Bertrand ME | 2007 | JAMA2007，298，21： | 1 |
| 11 | Obesity and late-age survival without major disease or disability in older women显示文摘 | Rillamas-Sun E La Croix AZ Waring ME | 2014 | JAMA Intern Med2014，174，1： | 1 |
| 12 | The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Kono SA Marshall ME Ware KE | | 0，，4： | 1 |
| 13 | Incident diabetes in relation to weight patterns during middle age显示文摘 | Waring ME Eaton CB Lasater TM | 2010 | Am J Epidemiol2010，171，5： | 1 |
| 14 | Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management:One-year results from the ACUITY trial显示文摘 | Stone GW Ware JH Bertrand ME | 2007 | JAMA2007，298，21： | 1 |
| 15 | Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management one-year results from the ACUITY Trial显示文摘 | Stone GW Ware JH Bertrand ME | | Journal of the American Medical Association0，，： | 1 |
| 16 | Incident diabetez in relation to weight patterns during middle age显示文摘 | Waring ME Eaton CB Lasater TM | 2010 | Am J Epidemial2010，171，5： | 1 |
| 17 | Preaxial polydactyly caused byG- li3 haploinsufficiency is rescued by Zic3 loss of function in mice 显示文摘 | Quinn ME Haaning A Ware SM | 2012 | Hum Mol Genet2012，21，8： | 1 |
| 18 | Implications of new hyper-tension guidelines in the United States 显示文摘 | Bertoia ML Waring ME Gupta PS | 2011 | Hypertension2011，58，3： | 1 |
| 19 | Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression显示文摘 | Ware KE Marshall ME Heasley LR | 2010 | Plos One2010，5，14： | 1 |
| 20 | Antithrombotic strategiesin patients with acute coronary syndromes undergoing early invasivemanagement : one-year results from the ACUITY trial显示文摘 | Stone G W Ware J H Bertrand ME | 2007 | JAMA2007，298，21： | 1 |
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