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| 1 | Anti-inflammatory effect of resveratrol through the suppression of NF-KB and JAK/STAT signaling pathways显示文摘 | Chunfang Ma Yin Wang Lei Dong Minjing Li Wanru Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 17 |
| 2 | Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury显示文摘In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury(SCI). Currently,however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation(SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations,classification, potential underlying etiology, and currentchallenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed. | Qian Huang Wanru Duan Eellan Sivanesan Shuguang Liu Fei Yang Zhiyong Chen Neil C.Ford Xueming Chen Yun Guan | 2019 | Neuroscience Bulletin2019，35，3： | 13 |
| 3 | The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2显示文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions. | Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang | 2019 | Protein & Cell2019，10，6： | 6 |
| 4 | Isolation and identification of novel casein-derived bioactive peptides and potential functions in fermented casein with Lactobacillus helveticus显示文摘The present study here establishes a complete and effective method for isolating,purifying and identifying extracellular and intracellular peptides,and also describes the characters and bioactivities of peptides from fermented casein with Lactobacillus helveticus.Intracellular peptides are much larger in quantity and more complex in composition than extracellular peptides,between which the correlation reveals proteolytic and metabolic mechanisms.In addition,totally 241 different peptide sequences were identified by Nano LC–MS/MS from casein(212)and Lactobacillus helveticus proteins(29).These casein-derived peptides mostly originated from-casein,followed byS1-casein,-casein,andS2-casein,and came from extracell(69)and intracell(143),in which common peptides have a total of 27.Forty-four of the identified peptides were previously described as bioactive,including angiotensinconverting enzyme(ACE)-inhibitory,antioxidant,immunomodulating,antimicrobial,DPP-IV inhibitory,antiamnesic and anticancer effects and so on.Thirteen peptides with the potential of some biological activities are obtained,which were described in previous studies.A total of 47 novel peptides of 5 to 26 amino acids that were not disclosed were obtained.The new sources of natural bioactive peptides may have the very high application value as potential new peptide drugs for treatment human diseases.The product peptide DELQDKIHPF found in both extracell and intracell was quantitatively analyzed using the MRM mode of UPLC-U3Q,23.1 and 9.76 ng/mL,respectively.The quantitative analysis of the potential bioactive peptide may also advance the production of peptide products in the future. | Mengzhu Fan Tingting Guo Wanru Li Jing Chen Fushuo Li Chao Wang Yi Shi David Xi-an Li Shaohui Zhang | 2019 | Food Science and Human Wellness2019，8，2： | 5 |
| 5 | Multicomponent Nanoparticles Synergistic One-Dimensional Nanofibers as Heterostructure Absorbers for Tunable and Efficient Microwave Absorption显示文摘Application of novel radio technologies and equip-ment inevitably leads to electromagnetic pollution.One-dimensional polymer-based composite membrane structures have been shown to be an effective strategy to obtain high-performance microwave absorbers.Herein,we reported a one-dimensional N-doped carbon nanofibers material which encapsulated the hollow Co_(3)SnC_(0.7) nano-cubes in the fiber lumen by electrospinning.Space charge stacking formed between nanoparticles can be channeled by longitudinal fibrous structures.The dielectric constant of the fibers is highly related to the carbonization temperature,and the great impedance matching can be achieved by synergetic effect between Co_(3)SnC_(0.7) and carbon network.At 800℃,the necklace-like Co_(3)SnC_(0.7)/CNF with 5%low load achieves an excellent RL value of−51.2 dB at 2.3 mm and the effective absorption bandwidth of 7.44 GHz with matching thickness of 2.5 mm.The multiple electromagnetic wave(EMW)reflections and interfacial polarization between the fibers and the fibers internal contribute a major effect to attenuating the EMW.These strategies for regulating electromagnetic performance can be expanded to other electromagnetic functional materials which facilitate the development of emerging absorbers. | Chenxi Wang Yue Liu Zirui Jia Wanru Zhao Guanglei Wu | 2023 | Nano-Micro Letters2023，15，1： | 3 |
| 6 | Triggering in-plane defect cluster on MoS_(2) for accelerated dinitrogen electroreduction to ammonia显示文摘Electrochemical nitrogen reduction reaction (eNRR) is an alternative promising manner for sustainable N2 fixation with low-emission. The major challenge for developing an efficient electrocatalyst is the cleaving of the stable Ntriple bondN triple bonds. Herein, we design a new MoS_(2) with in-plane defect cluster through a bottom-up approach for the first time, where the defect cluster is composed of three adjacent S vacancies. The well-defined in-plane defect clusters could contribute to the strong chemical adsorption and activation towards inert nitrogen, achieving an excellent eNRR performance with an ammonia yield rate of 43.4 ± 3 μg h^(−1) mgcat.^(−1) and a Faradaic efficiency of 16.8 ± 2% at −0.3 V (vs. RHE). The performance is much higher than that of MoS_(2) with the edge defect. Isotopic labeling confirms that N atoms of produced NH4+ originate from N2. Furthermore, the in-plane defect clusters realized the alternate hydrogenation of nitrogen in a side-on way to synthesize ammonia. This work provides a prospecting strategy for fine-tuning in-plane defects in a catalyst, and also promotes the progress of eNRR. | Wanru Liao Ke Xie Lijuan Liu Xiuyun Wang Yu Luo Shijing Liang Fujian Liu Lilong Jiang | 2021 | Journal of Energy Chemistry2021，30，11： | 3 |
| 7 | Post-infectious cough of different syndromes treated by traditional Chinese medicines:A review显示文摘The application of traditional Chinese medicines(TCMs)has a history of more than 2000 years,which have the characteristics of multi-component,multi-target,and high safety.Post-infectious cough(PIC)is a respiratory disease with high incidence.It belongs to subacute cough and accounts for as much as40%–50%.Cough is the main clinical manifestation of PIC.PIC seriously affects people’s life quality because of complex etiology,long-term course of disease,treatment difficulties and other characteristics.Western medicines are based on the principle of symptomatic treatment,so they are often difficult to control PIC fundamentally.These factors could due to that PIC is prolonged and unable to heal repeatedly.TCMs have obvious advantages in treating PIC,with accurate curative effects,less side effects and adverse reactions and are effective in improving PIC-related symptoms and indicators,enhancing patients’life quality and reducing pain.TCMs,guided by holistic concept and syndrome differentiation,advocate determine treatment on the basis of pattern types,and have remarkable clinical treatment effects.As for TCMs etiology,pathogenesis and syndrome types of PIC,TCM scholars have not yet reached a unified standard.However,most of them think that wind pathogen can cause PIC alone,or it can be combined with other evils,which might be the main mechanism of PIC.This paper discusses the advantages and limitations of TCMs in PIC treatment from etiology,pathogenesis,distribution of syndrome types and treatment of TCMs.This article focuses on the treatment methods and pharmacodynamic material basis of wind pathogen,providing ideas in treating PIC of TCMs clinically and innovative drug development. | Wanru Jiang Jiaxin Qi Xu Li Gang Chen Di Zhou Wei Xiao Ning Li | 2022 | Chinese Herbal Medicines2022，14，4： | 3 |
| 8 | Tuning microwave absorption properties of Ti_(3)C_(2)T_(x) MXene-based materials:Component optimization and structure modulation显示文摘The current electromagnetic environment brings a growing demand for efficient microwave absorption(MA)materials.Ti_(3)C_(2)T_(x) MXene,one of the 2D transition-metal carbides,is considered to be a promising MA material owing to its superior dielectric properties and structural processability.In order to further improve the MA performance and environmental adaptability of Ti_(3)C_(2)T_(x) MXene,Ti_(3)C_(2)T_(x) MXene-based MA materials enhanced by composition and structure design have been extensively studied and the regu-lation ideas for its MA properties can be outlined as component optimization and structure manipulation strategies based on the microwave absorption mechanism.Herein,we briefly introduced the microwave absorption mechanism and focused on the design strategies of Ti_(3)C_(2)T_(x) MXene-based MA materials based on recent advances.In addition,the prospects of Ti_(3)C_(2)T_(x) MXene-based MA materials were also discussed. | Ming Chang Qingyu Li Zirui Jia Wanru Zhao Guanglei Wu | 2023 | Journal of Materials Science & Technology2023，，17： | 3 |
| 9 | Inhibition of Muscular Nociceptive Afferents via the Activation of Cutaneous Nociceptors in a Rat Model of Inflammatory Muscle Pain显示文摘Topical irritants such as capsaicin(CAP),peppermint oil(PO),and mustard oil(MO)are effective in relieving inflammatory muscle pain.We investigated the effects of topical irritants in a rat model of inflammatory muscle pain produced by injecting complete Freund's adjuvant(CFA)into the tibialis anterior muscle.CFAinduced mechanical hypersensitivity and the spontaneous activity of muscular nociceptive afferents,and decreased weight-bearing of the hindlimb were relieved by topical application of CAP,PO,or MO on the skin overlying the inflamed muscle.The effects of topical irritants were abolished when applied to the skin on the ipsilateral plantar region or on the contralateral leg,or when the relevant cutaneous nerve or dorsal root was transected.Our results demonstrated that topical irritants may alleviate inflammatory muscle pain via activating cutaneous nociceptors and subsequently inhibiting the abnormal activity of muscular nociceptive neurons. | Yehong Fang Jie Zhu Wanru Duan Yikuan Xie Chao Ma | 2020 | Neuroscience Bulletin2020，36，1： | 2 |
| 10 | Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation显示文摘Objective: To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Methods: Publicly available database of Cancer Cell Line Encyclopedia(CCLE) was used in bioinformatic analyses. Methylation of Cp G islands was detected by denaturing high performance liquid chromatography(DHPLC). Gene transcript levels were determined using quantitative real-time polymerase chain reaction(q RTPCR) assays. An engineered P16-specific transcription factor and DNA methyltransferase were used to induce P16-specific DNA demethylation and methylation.Results: The expression level of ANRIL was positively and significantly correlated with that of P16 but not with that of P15 in the CCLE database. This was confirmed in human cell lines and patient colon tissue samples. In addition, ANRIL was significantly upregulated in colon cancer tissues. Transcription of ANRIL and P16 was observed only in cell lines in which the P16 alleles were unmethylated and not in cell lines with fully methylated P16 alleles.Notably, P16-specific methylation significantly decreased transcription of P16 and ANRIL in BGC823 and GES1 cells. In contrast, P16-specific demethylation re-activated transcription of ANRIL and P16 in H1299 cells(P<0.001).Alteration of ANRIL expression was not induced by P16 expression changes.Conclusions: ANRIL and P16 are coordinately transcribed in human cells and regulated by the methylation status of the P16 Cp G islands around the transcription start site. | Ying Gan Wanru Ma Xiuhong Wang Juanli Qiao Baozhen Zhang Chenghua Cui Zhaojun Liu Dajun Deng | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 11 | Deformation mechanism of fine grained Mg-7Gd-5Y-l.2Nd-0.5Zr alloy under high temperature and high strain rates显示文摘Fine grained Mg-7Gd-5Y-1.2Nd-0.5Zr alloy was investigated by dynamic compression tests using a Split Hopkinson Pressure Bar under the strain rates in the range 1000-2000 s^(-1) and the temperature range 293-573 K along the normal direction.The microstructure was measured by optical microscopy,electron back-scattering diffraction,transmission electron microscopy and X-ray diffractometry.The results showed that Mg-7Gd-5Y-1.2Nd-0.5Zr alloy had the positive strain rate strengthening effect and thermal softening effect at high temperature.The solid solution of Gd and Y atoms in Mg-7Gd-5Y-1.2Nd-0.5Zr alloy reduced the asymmetry of α-Mg crystals and changed the critical shear stress of various deformation mechanisms.The main deformation mechanisms were prismatic slip and pyramidal(a)slip,{102}tension twinning,and dynamic recrystallization caused by local deformation such as particle-stimulated nucleation.c 2020 Published by Elsevier B.V.on behalf of Chongqing University. | Wanru Tang Zheng Liu Shimeng Liu Le Zhou Pingli Mao Hui Guo Xiaofang Sheng | 2020 | Journal of Magnesium and Alloys2020，8，4： | 2 |
| 12 | A mumps model with seasonality in China显示文摘Background:Mumps,an infectious viral disease,classically manifested by inflammation of salivary glands and is best known as a common childhood viral disease with no specific treatment.Although it can be protected by vaccine,there are more than 100,000 reported mumps cases according to the Chinese Center for Disease Control and Prevention.However,the factors and mechanisms behind the persistence and prevalence of mumps have not been well understood.Methods:A mumps model with seasonal fluctuation is formulated and investigated.We evaluate the basic reproduction numberℛ0 and analyze the dynamical behavior of the model.We also use the model to simulate the monthly data of mumps cases and carry out some sensitivity analysis ofℛ0 in terms of various model parameters.Results:It is shown that there exists only disease-free solution which is globally asymptotically stable ifℛ0<1,and there exists a positive periodic solution ifℛ0>1.ℛ0 is a threshold parameter,and its magnitude determines the extinction or persistence of the disease.Conclusion:Our analysis shows that vaccination rate and invalid vaccination rate play important roles in the spread of mumps.Hence,Our study suggests to increase the vaccine coverage and make two doses of MMR(Measles,mumps and rubella vaccine)vaccine freely available in China. | Qianqian Qu Cong Fang Le Zhang Wanru Jia Jie Weng Yong Li | 2017 | Infectious Disease Modelling2017，2，1： | 2 |
| 13 | Variation of the East Asian summer monsoon rainfall显示文摘 | CHEN Tsingchang WANG Shuhyu HUANG Wanru | | 0，，04： | 1 |
| 14 | Structure feature and antitumor activity of a novel polysaccharide isolated from Lactarius deliciosns Gray显示文摘 | DING Xiang HOU Yiling HOU Wanru | 2012 | Carbohydrate Polymers2012，89，2： | 1 |
| 15 | Structuralfeature and antitumor activity of a novel polysaccharideisolated from Lactarius deliciosus Gray显示文摘 | DING Xiang HOU Yiling HOU Wanru | 2012 | CarbohydPolym2012，89，： | 1 |
| 16 | CuXTomer Satisfaction: The Impact of Responsiveness, Promotion 37 Orientation, Service Quality and Relational Behavior 显示文摘 | Wanru Su | 1999 | Asia Pacific Advances in Consumer Research1999，，3： | 1 |
| 17 | Structure feature and antitumor activity of a novel polysaccharide isolated from Lactarius deliciosus Gray显示文摘 | Xiang Ding Yiling Hou Wanru Hou | 2012 | Carbohydrate Polymers2012，，2： | 1 |
| 18 | Injury of Muscular but not Cutaneous Nerve Drives Acute Neuropathic Pain in Rats显示文摘Acute pain is a common complication after injury of a peripheral nerve but the underlying mechanism is obscure.We established a model of acute neuropathic pain via pulling a pre-implanted suture loop to transect a peripheral nerve in awake rats.The tibial(both muscular and cutaneous),gastrocnemius-soleus(muscular only),and sural nerves(cutaneous only)were each transected.Transection of the tibial and gastrocnemius-soleus nerves,but not the sural nerve immediately evoked spontaneous pain and mechanical allodynia in the skin territories innervated by the adjacent intact nerves.Evans blue extravasation and cutaneous temperature of the intact skin territory were also significantly increased.In vivo electrophysiological recordings revealed that injury of a muscular nerve induced mechanical hypersensitivity and spontaneous activity in the nociceptive C-neurons in adjacent intact nerves.Our results indicate that injury of a muscular nerve,but not a cutaneous nerve,drives acute neuropathic pain. | Jie Zhu Zhiyong Chen Yehong Fang Wanru Duan Yikuan Xie Chao Ma | 2020 | Neuroscience Bulletin2020，36，5： | 1 |
| 19 | Nucleotide sequence of cDNA encoding the mitochondrial precursor protein of the ATPase inhibitor from the giant panda (Ailuropoda melanoleuca) 显示文摘 | Hou Wanru Du Yujie Chen Yu | 2007 | DNA Cell Biol2007，26，11： | 1 |
| 20 | Quantifying the effects of nitrogen on fruit growth and yield of cucumber crop in greenhouses显示文摘 | Jianfeng Dai Shanshan Liu Wanru Zhang Rui Xu Weihong Luo Shengfei Zhang Xinyou Yin Li Han Weiping Chen | 2011 | Scientia Horticulturae2011，，3： | 1 |
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