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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Combining bioinformatics and phylogenetics to identify large sets of single-copy orthologous genes (COSⅡ) for comparative, evolutionary and systematic studies: a test case in the euasterid plant clade显示文摘 | Wu F N Mueller L A Crouzillat D Petiard V Tanksley S D | 2006 | Genetics2006，174，： | 1 |
| 3 | Global patterns in leaf 13C discrimination and implications for studies of past and future climate 显示文摘 | Diefendorf A F Mueller K E Wing S L | 2010 | Proceedings of the National Academy of Sciences2010，107，13： | 1 |
| 4 | The cytokines IL-3 and GM CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation 显示文摘 | Johnson BS Mueller L Si J | 2002 | Blood2002，99，3： | 1 |
| 5 | A novel family of mammalian taste receptors显示文摘 | Adler E Hoon M A Mueller K L | 2000 | Cell2000，100，： | 1 |
| 6 | Computed tomographic scanning without oral contrast solution for blunt bowel and mesenteric injuries in abdominal trauma显示文摘 | Allen T L Mueller M T Bonk R T | 2004 | J Trauma2004，56，2： | 1 |
| 7 | Effect of SiO2 on densification and microstructure development in Nd:YAG transparent ceramics 显示文摘 | STEVENSON A J LI Xin MART1NEZ M A ANDERSON J M SUCHY D L KUPP E R DICKEY1 Z C MUELLER K T MESSING G L | 2011 | J Am Ceram Soc2011，94，： | 1 |
| 8 | Regulation of vascular endothelial growth factor(VEGF) gene transcription by estrogen receptors alpha and beta显示文摘 | MUELLER M D VIGNE J L MINCHENKO A | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 9 | Addition of chloride to a prepartal diet high in cations increase 1,25-dihydroxyvitamin D response to hypotalcemia preventing milk fever显示文摘 | Horst R L F J Mueller J K Miller | 1991 | Dairy science1991，，70： | 1 |
| 10 | Structure and function of claudins显示文摘 | Krause G Winkler L Mueller SL | 2008 | Biochim Biophys Acta2008，1778，3： | 1 |
| 11 | Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor显示文摘 | Villeneuve D L Mueller N D Martinovic D | 2009 | Environ Health Perspect2009，117，62： | 1 |
| 12 | CEO Character- istics and Firm RD Spending显示文摘 | BARKER III V L MUELLER G C | 2002 | Management Sci- ence2002，48，6： | 1 |
| 13 | Evidence that glucose metabohsm regulates leptin secretion from cultured rat adipocytes 显示文摘 | Mueller W M Gregoire F M Stanhope K L | 1998 | Endocrinology1998，139，： | 1 |
| 14 | RAS strategy for IBM S/390 G5 and G6 显示文摘 | M Mueller L C Alves W Fischer | 1999 | IBM Journal of Research and Development1999，43，56： | 1 |
| 15 | A common founder for the 35delG GJB2 gene mutation in connexin 26 hearing impairment显示文摘 | Van Laer L Coucke P Mueller RF | 2001 | J Med Genet2001，38，： | 1 |
| 16 | Validation of high sensitive troponin I in 2 hours diagnostic strategy to assess 30 day outcomes in emergency department patients with possible acute coronary syndrome 显示文摘 | Cullen L Mueller C Parsonage WA | 2013 | J Am Coil Cardiol2013，62，： | 1 |
| 17 | A Novel Approach to Determine the Glyphosate Tolerant Trait in Soybeans显示文摘 | MIAN C L PANTALONE V R MUELLER T C | 2004 | J Agric Food Chem2004，52，： | 1 |
| 18 | Addition of chloride to a prepartal diet high in cations increases 1,25-dihydmxyvitamin D response to hypocalcemia preventing milk fever显示文摘 | GOFF J P HORST R L MUELLER F J | 1991 | Dairy Sci1991，74，： | 1 |
| 19 | Progress and current status of percutaneous aortic valve replacement:results of three device generations of the CoreValve Revalving system显示文摘 | Grube E Buellesfeld L Mueller R | | 0，，： | 1 |
| 20 | Mu- tation of a new gene encoding a putative pyrin-like protein cau- ses familial cold autoinflammatory syndrome and Muckle- Wells syndrome显示文摘 | HOFFMAN H M MUELLER J L BROIDE D H | 2001 | Nat Genet2001，29，3： | 1 |
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