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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Preoperative diagnosis of malignant pulmonary nodules in lung cancer screening with a radiomics nomogram显示文摘Background:Lung cancer is the most commonly diagnosed cancer worldwide.Its survival rate can be significantly improved by early screening.Biomarkers based on radiomics features have been found to provide important physiological information on tumors and considered as having the potential to be used in the early screening of lung cancer.In this study,we aim to establish a radiomics model and develop a tool to improve the discrimination between benign and malignant pulmonary nodules.Methods:A retrospective study was conducted on 875 patients with benign or malignant pulmonary nodules who underwent computed tomography(CT)examinations between June 2013 and June 2018.We assigned 612 patients to a training cohort and 263 patients to a validation cohort.Radiomics features were extracted from the CT images of each patient.Least absolute shrinkage and selection operator(LASSO)was used for radiomics feature selection and radiomics score calculation.Multivariate logistic regression analysis was used to develop a classification model and radiomics nomogram.Radiomics score and clinical variables were used to distinguish benign and malignant pulmonary nodules in logistic model.The performance of the radiomics nomogram was evaluated by the area under the curve(AUC),calibration curve and Hosmer-Lemeshow test in both the training and validation cohorts.Results:A radiomics score was built and consisted of 20 features selected by LASSO from 1288 radiomics features in the training cohort.The multivariate logistic model and radiomics nomogram were constructed using the radiomics score and patients’age.Good discrimination of benign and malignant pulmonary nodules was obtained from the training cohort(AUC,0.836;95%confidence interval[CI]:0.793-0.879)and validation cohort(AUC,0.809;95%CI:0.745-0.872).The Hosmer-Lemeshow test also showed good performance for the logistic regression model in the training cohort(P=0.765)and validation cohort(P=0.064).Good alignment with the calibration curve indicated the good performance of the nomogram.Conclusions:The established radiomics nomogram is a noninvasive preoperative prediction tool for malignant pulmonary nodule diagnosis.Validation revealed that this nomogram exhibited excellent discrimination and calibration capacities,suggesting its clinical utility in the early screening of lung cancer. | Ailing Liu Zhiheng Wang Yachao Yang Jingtao Wang Xiaoyu Dai Lijie Wang Yuan Lu Fuzhong Xue | 2020 | Cancer Communications2020，40，1： | 22 |
| 3 | Isolation,Screening,and Optimization of the Fermentation Conditions of Highly Cellulolytic Bacteria from the Hindgut of Holotrichia parallela Larvae(Coleoptera:Scarabaeidae)显示文摘From the hindgut contents of Holotrichia parallela larvae,207 aerobic and facultatively anaerobic cellulolytic bacterial isolates were obtained.These bacterial isolates were assigned to 21 genotypes by amplified ribosomal DNA restriction analysis(ARDRA).A partial 16 S rDNA sequence analysis and standard biochemical and physiological tests were used for the assignment of the 21 representative isolates.Our results show that the cellulolytic bacterial community is dominated by the Proteobacteria(70.05%),followed by the Actinobacteria(24.15%),the Firmicutes(4.35%),and the Bacteroidetes(1.45%).And among the cellulolytic bacteria,some isolates,Siphonobacter aquaeclarae,Cellulosimicrobium funkei,Citrobacter freundii,Pseudomonas nitroreducens,and so on,are reported to be cellulolytic for the first time in this study.Among these isolates,a novel bacterium,designated Pseudomonas sp.HP207,with the highest endoglucanase productivity was selected for further study.The production of the endoglucanase was optimized by varying various physical culture conditions using a submerged fermentation method.Under the optimized fermentation conditions,the maximum endoglucanase activity of 1.432 U mL-1 in bacterial cultures was obtained,higher than those of the most widely studied bacteria and fungi,which are the attractive candidates for the commercial producer of cellulase.And the crude endoglucanase enzyme was also highly thermostable;approximately 55% of the original activity was maintained after pretreatment at 70°C for 1 h.Thus,from the present study,the bacterium can be added up to the database of cellulolytic bacteria,the scarab gut is an attractive source for the study of novel cellulolytic microorganisms and enzymes useful for cellulose degradation. | Ping Sheng Shengwei Huang Qi Wang Ailing Wang Hongyu Zhang | 2012 | 华中昆虫研究2012，，1： | 7 |
| 4 | Mitochondria-targeted antioxidant peptide SS-31 mediates neuroprotection in a rat experimental glaucoma model显示文摘To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce elevated intraocular pressure (IOP). After 6 weeks, electroretinography (ERG) and flash visual-evoked potentials (F-VEPs) were recorded to assess retinal function. Hematoxylin-eosin staining was performed on retinal cross-sections to measure ganglion cell complex (GCC) thickness. Apoptotic retinal cells were assessed by TUNEL staining. Brn3a-positive retinal ganglion cells (RGCs) were counted in retinal flat mounts via immunofluorescence. The retinal total SOD, SOD2, and MDA expression levels were assessed in retinal tissue homogenates. The cyt c, Baxz and Bcl-2 protein levels in rat retinas were detected by western blot analysis. Bax and Bcl-2 expressions were also evaluated using immunohistochemistry in paraffinized sections. Our results showed that the rats that received microsphere injection developed elevated IOP. SS-31 ameliorated the reductions in the a- and b-wave amplitudes on ERG and the F-VEP amplitude in glaucomatous eyes. GCC thickness was preserved, TUNEL-positive cells were decreased in the retina, and Brn3a-positive RGCs were in creased in the SS-31-treated glaucoma group compared with those in the non-treated glaucoma group. SS-31 significantly reduced MDA levels and increased SOD2 levels after glaucoma induction. Significant suppression of cyt c release, upregulation of Bcl-2, and downregulation of Bax were observed following SS-31 administration. In summary, SS-31 exerts neuroprotective effects in this experimental glaucoma model by inhibiting mitochondrial dysfunction and therefore represents a promising therapeutic agent for glaucoma. | Xiaoqiong Wu Yu Pang Zhilin Zhang Xiabin Li Chao Wang Yingqing Lei Ailing Li Ling Yu Jian Ye | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 7 |
| 5 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 6 | Theoretical and Experimental Study on Reaction Coupling: Dehydrogenation of Ethylbenzene in the Presence of Carbon Dioxide显示文摘到苯乙烯(圣) 的乙苯(EB ) 的除氢作用面对 CO2,在 EB,除氢作用被结合反向的水气体移动(RWGS ) ,通过理论分析和试验性的描述广泛地被调查。联合的反应证明了比在几个方面的单个除氢作用优异。热力学的分析建议 EB 的那平衡变换能被由于从除氢作用生产的氢的同时的消除联合的反应极大地改进。催化测试证明了与某些倡导者一起在活性炭或 Al2O3 上支持的那个熨斗和钒是为这个联合过程的潜在的催化剂。铁和钒的催化剂在反应机理是不同的,尽管圣产量总是在各种各样的催化剂上与 CO2 变换被联系。当一步舞小径在 V/Al2O3 上统治反应时,二拍子的圆舞小径在 Fe/Al2O3 上在联合过程起一个重要作用。科克免职和活跃部件的深减小是催化剂释放的主要原因。CO2 能通过在联合过程在高原子价保存活跃种类有效地减轻催化剂释放,尽管它不能压制焦炭免职。给词调音:联合的反应;乙苯除氢作用;苯乙烯;二氧化碳;水气体移动;反应机理; | Shuwei Chen Zhangfeng Qin Ailing Sun Jianguo Wang | 2006 | Journal of Natural Gas Chemistry2006，15，1： | 5 |
| 7 | Growth Characteristics and Kinetics of Niobium Carbide Coating Obtained on AISI 52100 by Thermal-reactive Diffusion Technique显示文摘Niobium carbide coating was produced by thermal-reactive diffusion technique on AISI 52100 steel in salt bath at 1 123 K, 1 173 K, and 1 223 K for 1, 2, 4, and 6 hours. The salt consisted of borax, sodium fl uoride, boron carbide, and niobium pentoxide. The presence of NbC phase on the steel surface was confi rmed by X-ray diffraction analysis. Microscopic observation showed that niobium carbide coating formed on the substrate was smooth and compact. There was a distinct and fl at interface between the coating and substrate. The micro-hardness of niobium carbide coating was 2892±145HV. The thickness of coating ranged from 1.6 μm to 14μm. The forming kinetics of niobium carbide coating was revealed. Moreover, a contour diagram derived from experimental data was graphed for correct selection of process parameters. Some mathematical equations were built for predicting the coating thickness with predetermined processing temperature and time. The results showed that these mathematical equations are very practical as well as the kinetics equation. | 严绍进 王洪福 SUN Qikun HE Peng PANG Chengang WANG Huachang WANG Ailing | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，4： | 5 |
| 8 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 9 | Tuning the intermolecular interaction of A_(2)-A_(1)-D-A_(1)-A_(2) type non-fullerene acceptors by substituent engineering for organic solar cells with ultrahigh V_(OC) of ~1.2 V显示文摘For non-fullerene acceptors(NFAs)with linear A_(2)-A_(1)-D-A_(1)-A_(2) backbone,there are three kinds of possible intermolecular interaction,A_(1)-A_(1),A_(1)-A_(2) and A_(2)-A_(2) stacking.Hence,it is a huge challenge to control this interaction and investigate the effect of intermolecular stacking model on the photovoltaic performance.Here,we adopt a feasible strategy,by utilizing different substituent groups on terminal A2 unit of dicyanomethylene rhodanine(RCN),to modulate this stacking model.According to theoretical calculation results,the molecule BTA3 with ethyl substituent packs via heterogeneous interaction between A_(2) and A_(1) unit in neighboring molecules.Surprisingly,the benzyl group can effectively transform the aggregation of BTA5 into homogeneous packing of A_(2)-A_(2) model,which might be driven by the strong interaction between benzyl and A1(benzotriazole)unit.However,different with benzyl,phenyl end group impedes the intermolecular interaction of BTA4 due to the large steric hindrance.When using a BTA-based D-π-A polymer J52-F as donor according to“Same-A-Strategy”,BTA3-5 could achieve ultrahigh open-circuit voltage(VOC)of 1.17–1.21 V.Finally,BTA5 with benzyl groups realized an improved power conversion efficiency(PCE)of 11.27%,obviously higher than that of BTA3(PCE=9.04%)and BTA4(PCE=5.61%).It is also worth noting that the same trend can be found when using other four classic p-type polymers of P3HT,PTB7,PTB7-Th and PBDB-T.This work not only investigates the intermolecular interaction of A_(2)-A_(1)-D-A_(1)-A_(2) type NFAs for the first time,but also provides a straightforward and universal method to change the interaction model and improve the photovoltaic performance. | Xiaochen Wang Ailing Tang Jing Yang Mengzhen Du Jianfeng Li Gongqiang Li Qiang Guo Erjun Zhou | 2020 | Science China Chemistry2020，63，11： | 5 |
| 10 | A 2-bp insertion(c.6768insCC) in MC1R causes recessive white coat color in Bama miniature pigs显示文摘Coat color is an important characteristic of various breeds of domestic animal species.Variation in farm animal coat color is of considerable interest for concealment,communication and protection against solar radiation(Slominski et al.,2004).It also plays an important role in the regulation of physiological processes(Miyagi and Terai,2013).Bama miniature pigs are a native breed | Qitao Jia Chunwei Cao Hai Tang Ying Zhang Qiantao Zheng Xiao Wang Rui Zhang Xianlong Wang Ailing Luo Hong Wei Anming Meng Qi Zhou Hongmei Wang Jianguo Zhao | 2017 | Journal of Genetics and Genomics2017，44，4： | 5 |
| 11 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 12 | Microstructure and penetration behavior of electroformed copper liners of shaped charges during explosive detonation deformation显示文摘The microstructure in the electroformed copper liners of shaped charges prepared with different electrolytes was studied by Scanning Electron Microscopy (SEM) and Electron Backscattering Kikuchi Pattern (EBSP) methods. SEM observations revealed the existence of columnar grains in electroformed copper liners of shaped charges formed by electrolyte without any additive and the average grain size is about 3 μm. When an additive is introduced to the electrolyte, the grains formed in the copper liners become equiaxed and finer. EBSP results show that the columnar grain grown during electroformation has the most preferential growth direction, whereas a micro-texture does not exit in the specimen prepared by electrolyte with the additive. Further, explosive detonation deformation experiments show that penetration depth is dramatically improved when the electroformed copper liners of shaped charges exhibit equiaxed grains. | Ailing Fan Wenhuai Tian Qi Sun Baoshen Wang | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 4 |
| 13 | Increment of antioxidase activity of transgenic tobacco with betaine aldehyde dehydrogenase显示文摘Superoxide dismutase (SOD) activity in the leaves of transgenic tobacco plants with betaine aldehyde dehydrogenase (BADH) gene was about 36% higher than that in the control plants (parent plants), activities of per-oxidase (POD) and catalase (Cat) increased by about 62% and 88% respectively. Activities of ascorbate peroxidase (AsSPOD), dehydroascorbate redutase (DAsAR) and glu-tathione reductase (GR) in ascorbate-glutothion pathway located at chloroplasts increased by 67.7%, 47.9% and 38.8% respectively. These results indicated that the H2O2 produced by SOD catalyzing superoxide anion radicals (O2-) could be fully decomposed, and could not derive to form the strongest toxicant radicals · OH. This is the first report to elucidate quantitatively that the activities of two kinds of antioxidative enzymes decomposed radicals and active oxygen were matched. Photoinhibition tolerant capacity of the transgenic tobacco plants was 35% higher than that in the parent plants. Increment of photoinhibition tolerant | LUO Ailing LIU Jaoyao MA Deqin WANG Xuechen LIANG Zheng | 2001 | Chinese Science Bulletin2001，46，6： | 4 |
| 14 | Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways显示文摘It has been demonstrated that prolonged graft survival can be achieved through inhibiting the activation of T cells, and addition of soluble CTLA4Ig and OX40Ig proteins to mixed lymphocyte reactions can effectively inhibit T cell proliferation. To explore the potential of this type of treatment in xenotransplantation, we infected streptozotocin-induced diabetic BalB/c mice (H-2d) (200 mg/kg, IV) with 5×108 pfu AdCTLA4Ig-IRES-OX40Ig on day 1 before islets trans-plantation through the tail vein. The results showed that this treatment prolonged the islet xeno-grafts survival significantly. The reaction to exogenous glucose stimulation was normal and the cytokine secretion of the type Th1 cells was inhibited. The AdCTLA4Ig-IRES-OX40Ig-mediated treatment effectively induced the T cells into anergy and the Th1/Th2 cells into deviation. These results strongly supported the therapeutic potential of blockade of costimulation by Ad-CTLA4Ig-IRES-OX40Ig genes transfer in inducing the organ transplantation tolerance. | WANG Guangming FENG Yougang HAO Jie LI Ailing GAO Xiang XIE Shusheng | 2005 | Science China(Life Sciences)2005，48，5： | 4 |
| 15 | Prevention of Mother-To-Child Transmission of HIV-China,2011-2020显示文摘ABSTRACT Introduction:Prevention of mother-to-child transmission(PMTCT)of human immunodeficiency virus(HIV)is a global health focus in most parts of the world.The World Health Organization(WHO)launched the dual Elimination of Mother-to-Child Transmission(EMTCT)of HIV and syphilis initiative and released global guidance on criteria and processes for validation of the EMTCT in 2014.The purpose of this report was to analyze the key validation indicators of EMTCT of HIV in China from 2011 to 2020 and to provide relevant basis information for the implementation of EMTCT action in China. | Xiaoyan Wang Qian Wang Changhe Wang Tong Zhang Zhixin Li Zhonghua Ma Ailing Wang | 2021 | China CDC weekly2021，3，48： | 3 |
| 16 | Stepwise synthesis of cuprous oxide nanoparticles with adjustable structures and growth model显示文摘By stepwise adding of reducer N2H4·H2O,cuprous oxide(Cu2O)nanoparticles(NPs)with adjustable structures were synthesized.The features of Cu2O NPs were characterized by XRD,TEM and UV-Vis absorption spectra.When the reducer was added into the reactant system at one time,the sizes of the Cu2O NPs are in the range of 120–140 nm.Most Cu2O NPs are solid spheres.As the reducer was divided into two equal parts and stepwisely added,almost all the NPs are hollow spheres with good size(150–170 nm)distribution and dispersity.But when the reducer was divided into three or four equal parts and stepwisely added,the NPs are hollow spheres,core-shell structures or solid spheres,and the sizes distribution of the products is deteriorated.The effect of sodium hydrate(NaOH)was also probed.Addition of NaOH speeded up the nucleation and growth processes of Cu2O NPs.With the alkalinity increase,the shells of the hollow spheres become compact and the thicknesses of the shells increase,but the size distribution of the NPs is deteriorated.The absorption spectra of the Cu2O NPs are tunable.With the shell thicknesses increase,the absorption peaks have red shifts.An inside-outside growth model of Cu2O NPs was proposed to explain the results.The Cu2O single crystalline grains grow not only in the reactant solution,but also inside of the hollow nanospheres.The new Cu2O nanocrystallines can not only aggregate onto the shells of the nano hollow spheres,but also inside and outside of the hollow spheres,which leads to increasing the shell thicknesses of the hollow spheres,forming core-shell structures or small solid spheres of Cu2O NPs,respectively. | YANG AiLing WANG YuJin LI ShunPin BAO XiChang YANG RenQiang | 2014 | Science China(Technological Sciences)2014，57，11： | 3 |
| 17 | Screening and Treatment of Syphilis for Pregnant Women—China,2011−2018显示文摘What is already known on this topic?The national program of prevention of mother-to-child transmission(PMTCT)of syphilis was initiated in 2011 and scaled to a national level since 2015.A better understanding of the implementation and outcomes of the program on PMTCT of syphilis is needed for future strategies to achieve the World Health Organization(WHO)goal of elimination of motherto-child transmission(EMTCT)of syphilis.What is added by this report Between 2011 and 2018,as the coverage of syphilis screening of pregnant women and treatment for syphilis-seropositive pregnant women and their infants have increased consistently,the incidence of congenital syphilis was significantly reduced from 91.6 cases per 100,000 live births to 18.4 cases per 100,000.Treatment rates and adequate treatment rates of syphilis-seropositive pregnant women were below the criteria of validation of EMTCT of syphilis and regional disparities were found.What are the implications for public health practice?We recommend continuing to strengthen the current PMTCT intervention strategies with further commitments to achieve the targets set by the WHO’s dual EMTCT of HIV and syphilis.Barriers to achieving high coverage of adequate treatment should be investigated and addressed at the provincial level to ensure prompt treatment for syphilis-seropositive pregnant women. | Yaping Qiao Xiaoyan Wang Qian Wang Zhen Li Xi Jin Ailing Wang | 2020 | China CDC weekly2020，2，26： | 2 |
| 18 | Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism-and inflammation-related gene expression显示文摘Administration of chicory polysaccharides(CP) can modify lipid metabolism, improve dyslipidemia, and reduce liver inflammation, all of which may help alleviate non-alcoholic fatty liver disease(NAFLD). However, the underlying mechanisms remain unclear. This study aimed to gain further understanding of the potential molecular mechanisms that mediate the protective effects of CP against NAFLD via transcriptomic and metabolomic analyses. Hepatic RNA-sequencing analysis demonstrated that long-term intake of CP restored expression of lipid metabolism-related genes Xbp1, Insig2, and Cth in NAFLD rats, thereby inhibiting de novo lipogenesis. Moreover, CP consumption restored expression levels of genes involved in pro-inflammatory responses, such as Irf1. In addition, metabolic data confirmed that CP treatment increased levels of L-palmitoylcarnitine and hexadecanoyl-Co A, implying that CP administration can promote hepatic fatty acid β-oxidation. The present results demonstrate the underlying mechanisms of CP in high-fat dietinduced NAFLD rats and suggest that CP treatment might provide a dietary therapeutic tool for the treatment of NAFLD in humans. | Shengjie Li Yulong Wu Haitao Jiang Feng Zhou Ailing Ben Renlei Wang Chun Hua | 2022 | Food Science and Human Wellness2022，11，4： | 2 |
| 19 | Incidence of persistent and high-risk human papillomavirus infection and associated factors among HIV-positive women in China, 2015-2016显示文摘Background:Persistent human papillomavirus(HPV)infection is the necessary factor for cervical cancer.Human immunodeficiency virus(HIV)-positive women are a high-risk population for cervical cancer,but little is known about persistent HPV infection among HIV-positive women in China.We aimed to investigate the persistence and incidence of infection with high-risk HPV(hrHPV)and associated factors among HIV-positive women in China.Method:Using a prospective observational study design,we collected data from 670 HIV-positive women in five counties of three provinces through interviews,medical record reviews,health examination,and laboratory tests at a baseline survey in 2015 and a follow-up survey in 2016.We tested HIVpositive women for hrHPV infection using the Cobas 4800 HPV test,and analyzed factors associated with persistence and new incidence of hrHPV infection using logistic regression.Results:After an average of 15 months at follow-up,the persistence and new incidence rates of hrHPV infection were 38.0%(46/121,95%CI:29.2%-46.8%)and 8.3%(35/420,95%CI:5.7%-11.1%),respectively.HIV-positive women in Yunnan and Guangxi were more likely to have persistent hrHPV infections than those in Xinjiang(aOR=3.18,95%CI:1.00-10.14,p=0.05;aOR=6.38,95%CI:2.29-17.77,p<0.001).Migrant women had a higher rate of new hrHPV incidence than local women(aOR=4.48,95%CI:1.65-12.15,p=0.003).HIV-positive women from Xinjiang were 6.5 times more likely to be newly infected with hrHPV than those from Yunnan(95%CI:2.40-17.60,p<0.001).HIV-positive women with HBV infection had a higher risk of being infected with hrHPV than those without HBV infection(aOR=3.48,95%CI:1.13-10.71,p=0.029).Conclusions:The persistence and new incidence rates of hrHPV infection among HIV-positive women were high and varied significantly between regions.HBV infection and being among the migrant population were associated with new hrHPV infection. | Yaping Qiao Ailing Wang Liwen Fang Linhong Wang | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，3： | 2 |
| 20 | Fluorescence enhancement of Tb^(3+) complexes by adding silica-coated silver nanoparticles显示文摘Six kinds of terbium ternary complexes with halo-benzoic acids were synthesized. Their compositions were determined by C, H elemental analyzer and EDTA titration. The infrared spectra, ultraviolet absorption spectra, and fluorescence spectra were also measured to identify the complexes. Elemental analysis showed that the compositions of these complexes were Tb(p-Br BA)3?H2O, Tb(p-Cl BA)3?2H2O, Tb(p-FBA)3?H2O, Tb(o-FBA)3?2H2O, Tb(o-Cl BA)3?H2O, and Tb(o-Br BA)3?H2O, respectively. The monodispersed Ag@Si O2 core-shell nanoparticles with silica thicknesses of 10, 15, and 25 nm were successfully prepared and characterized by transmission-electron microscopy. Fluorescence intensities of the complexes were detected before and after Ag@Si O2 core-shell nanoparticles were added; the enhancement times were related to the silica-shell thickness. The fluorescence enhancement times were largest when the thickness of the silica shell was 25 nm. The mechanism may be attributed to the localized surface-plasmon resonance. Furthermore, the enhancement effect of terbium fluoro-benzoate complexes was the strongest in these complexes. This result may be attributed to the hydrogen bond between the hydroxyl on the surface of the silica shell and the fluorine atom. | Dan Zhou Xuemei Lin Ailing Wang Jingjing Li Yanrong Qu Haibin Chu Yongliang Zhao | 2015 | Science China Chemistry2015，58，6： | 2 |
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