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| 1 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 2 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Genetic contribution of the endothelial constitutive nitric oxide snythase gene to plasma nitric oxide levels显示文摘 | Mahaney MC Sim AS | 1997 | Arterioscler Thromb Vasc Biol1997，17，11： | 1 |
| 5 | Endoscopic management of cesarean scar pregnancy显示文摘 | Wang CJ Chao AS Yuen LT | 2006 | Fertil Steril2006，85，2： | 1 |
| 6 | Removal of ossified ligamentum flavum via a minimally invasive surgical approach显示文摘 | Wang VY Kanter AS Mummaneni PV | 2008 | Neurosurg Focus2008，25，2： | 1 |
| 7 | Caesarean scar preg- nancy successfully treated by operative hysteroscopy and suction curettage显示文摘 | Wang CJ Yuen LT Chao AS | 2005 | BJOG2005，112，6： | 1 |
| 8 | Endoscopic management of ce- sarean scar pregnancy显示文摘 | Wang C J Chao AS Yuen LT | 2006 | Fertility and Sterility2006，85，2： | 1 |
| 9 | Caesarean scar pregnancy successfully treated by operative hysteroscopy and suction curettage 显示文摘 | Wang CJ Yuen LT Chao AS | 2005 | Br J Obstet Gynaecol2005，112，6： | 1 |
| 10 | Describing and quantifying asthma comorbidity: a popula-tion study显示文摘 | Gershon AS Guan J Wang C | 2012 | Plos One2012，7，34： | 1 |
| 11 | TNF-α and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB显示文摘 | Wang CY Mayo MW Baldwin AS Jr | 1996 | Science1996，274，5288： | 1 |
| 12 | Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity显示文摘 | Wang XL Sire AS Wang MX | 2000 | FEBS Lett2000，471，： | 1 |
| 13 | Distribution in Healthy and Coronary Populations of the Methylenetetrahydrofolate Reductase(MTHFR) C677T Mutation 显示文摘 | Wilcken DEL Wang XL Sim AS | 1996 | Arterioscler Thromb Vasc Biol1996，16，： | 1 |
| 14 | Emerging Bcl-2 inhibitors for the treatment of cancer 显示文摘 | Azmi AS Wang Z Philip PA | 2011 | Expert Opin Emerg Drugs2011，16，1： | 1 |
| 15 | Outcomes for lung transplantation for lung cancer in the United Network for Organ Sharing Registry显示文摘 | Ahmad U Wang Z Bryant AS | 2012 | Ann Thorac Surg2012，94，3： | 1 |
| 16 | Inability to induce hypertension in normotensive rat expressing AT1 R antisense 显示文摘 | Wang H | 2000 | Circ Res2000，86，： | 1 |
| 17 | Endoscopic managementof ce- sarean scar pregnancy 显示文摘 | Wang CJ Chao AS Yuen LT | 2006 | Fertil Steril2006，85，2： | 1 |
| 18 | Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway显示文摘 | Hong-Bao Liu Qiu-Hong Meng Chen Huang Jian-Bo Wang Xiao-Wei Liu Matías Mosqueira | 2015 | Oxidative Medicine and Cellular Longevity2015，，： | 1 |
| 19 | Attenuation of streptozotocin-induced microvascular changes in the mouse retina with the endothelin receptor A antagonist atrasentan显示文摘 | Wang Z Yadav AS Leskova W | 2010 | Exp Eye Res2010，91，： | 1 |
| 20 | Endoscopic management of cesarean scar pregnancy显示文摘 | Wang C J Chao AS Yuen LT | 2006 | Fertility and Sterility2006，85，2： | 1 |
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