|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis显示文摘 | Heaney AP Horwitz GA Wang Z | 1999 | Nat Med1999，5，11： | 1 |
| 3 | Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis显示文摘 | Lu KH Patterson AP Wang L | 2004 | Clin Cancer Res2004，10，10： | 1 |
| 4 | Long-term effects of triptolide on spermatogenesis,epididymal sperm function and fertility in male rats显示文摘 | Huynh PN Hikim AP Wang C | | 0，，05： | 1 |
| 5 | Clinical implications of QRS duration in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction显示文摘 | Wang NC Maggioni AP Konstam MA | 2008 | JAMA2008，99，22： | 1 |
| 6 | Resequencing microarray probe design for typing genetically diverse viruses:human rhinoviruses and enteroviruses显示文摘 | Wang Z Malanoski AP Lin BC | | 0，，01： | 1 |
| 7 | Examining the small world phenomenon in the patent citation network: a case Study of the radio frequency identification (RFID) network 显示文摘 | Hung SW Wang AP | 2010 | SCIENTOMETRICS2010，82，1： | 1 |
| 8 | Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis 显示文摘 | Heaney AP Horwitz GA Wang Z | 1999 | Nat Med1999，5，11： | 1 |
| 9 | Correlation between neuronal injury and Caspase-3 after focal ischemia in human hippocampus 显示文摘 | Qi JP Wu AP Wang DS | 2008 | Chin ned (Engl)2008，117，10： | 1 |
| 10 | Functional role ofinducible nitric oxide synthase in the induction of male germcell apoptosis, regulation of sperm number, and determinationof testes size : evidence from null mutant mice 显示文摘 | Lue YH Sinha Hikim AP Wang C | 2003 | Endocrinology2003，144，7： | 1 |
| 11 | Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite显示文摘 | Singh AP Buscaglia CA Wang Q | 2007 | Cell2007，131，3： | 1 |
| 12 | Effects of aging on changing arterial compliance and left ventricalar load in a northern a Chinese urban community 显示文摘 | Avolio AP Chen SG Wang RP | 1983 | Circulation1983，68，： | 1 |
| 13 | Thymopentin-loaded pH-sensitive chitosan nanoparticles for oral adminis-tration:preparation,characterization,and pharmacodynamics显示文摘 | Zheng AP Wang JC Lu WL | 2006 | Journal of Nanoscienceand Nanotechnology2006，6，910： | 1 |
| 14 | Spontaneous germ cell apoptosis in humans:evidence for ethnic differences in the susceptibility of germ cell to programmed cell death显示文摘 | Wang C Lue Y | 1988 | Clin Endocrinol Metab1988，83，1： | 1 |
| 15 | Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model显示文摘 | Kao AP Wang KH Chang CC | | 0，，04： | 1 |
| 16 | Chimeric alphavirus vaccine candidates for chikungunya 显示文摘 | Wang E Volkova E Adams AP Forrester N Xiao SY Frolov I Weaver SC | 2008 | Vaccine2008，26，39： | 1 |
| 17 | Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis显示文摘 | Lu KH Patterson AP Wang L | 2004 | Clin Cancer Res2004，10，10： | 1 |
| 18 | fMRI for preoperative neurosurgical mapping of motor cortex and language in a clinical setting显示文摘 | Tomezak RJ Wunderlich AP Wang Y | 2000 | J Couput Assist Tomogr2000，24，6： | 1 |
| 19 | The evolutionary state of electresurgery: where are we now? 显示文摘 | Advineula AP Wang K | 2008 | Curr Opin Obstet Gynecol2008，20，4： | 1 |
| 20 | Sodium hydroxide pretreatment and enzymatic hydrolysis of coastal Bermuda grass 显示文摘 | Wang ZY Keshwani DR Redding AP Cheng JJ | 2010 | Bioresour Technol2010，101，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员