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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | Key Technologies of Ultra-high Voltage Hybrid LCC-VSC MTDC Systems显示文摘The key technologies of ultra-high voltage hybrid LCC-VSC MTDC systems are investigated,focusing on the design of system configurations,converter topologies and the control and protection system.A double converter per pole of VSC connection is proposed along with the design of a 5000 MW VSC valve to develop a±800 kV/5000 MW large-capacity power transmission.The hybrid MMC topology capable of clearing the DC faults and the control strategy are developed to effectively improve the reliability in case of overhead line faults.The control and protection system of the LCC-VSC MTDC system is introduced to offer flexible operations under both normal and abnormal conditions,which includes voltage/current margin-based coordination,converter switch-in and switch-out,re-connection and drop-off of a third station.Simulations of an LCC-VSC MTDC system based on the LCC-VSC MTDC project are performed. | Hong Rao Yuebin Zhou Shukai Xu Xipeng Cai Wanyu Cao Yiliang Xu Chenglin Ren | 2019 | CSEE Journal of Power and Energy Systems2019，5，3： | 14 |
| 3 | Facile synthesis of yolk-shell Ni@void@SnO2(Ni3Sn2) ternary composites via galvanic replacement/Kirkendall effect and their enhanced microwave absorption properties显示文摘蛋黄壳第三的 composites 一个 Ni 范围核心和 SnO 2(Ni3 Sn 2) 壳被一个灵巧的二拍子的圆舞方法成功地准备。产生 composites 的尺寸,形态学,微观结构,和阶段纯净被扫描电子显微镜学描绘,精力散 X 光检查光谱学,传播电子显微镜学(TEM ) ,高分辨率的 TEM,精选区域的电子衍射,和粉末 X 光检查衍射。蛋黄壳结构的核心尺寸,空隙的空体积,和成分由改变反应时间变化了。机制为蛋黄壳结构的形成基于时间依赖者实验被建议。蛋黄壳结构被蚀刻的反应,流电的代替反应,和 Kirkendall 效果的 synergistic 联合形成。蛋黄壳第三的 SnO 2(Ni 3 Sn 2)@Ni composites 在 15 h 的一反应时间综合了显示出的优秀微波吸收性质。思考损失被发现作为在 6.1 GHz 的低 as-43 dB。提高的微波吸收性质可以被归因于好阻抗火柴,多重思考,由于在核心和壳之间的虚空散布,并且在电介质之间的有效补充损失和磁性的损失。因此,蛋黄壳第三的 composites 被期望为微波吸收应用,锂离子电池,和光催化正在答应候选人。 | Biao Zhao Xiaoqin Guo Wanyu Zhao Jiushuai Deng Bingbing Fan Gang Shao Zhongyi Bai Rui Zhang | 2017 | Nano Research2017，10，1： | 14 |
| 4 | Influences of working pressure on properties for TiO_2 films deposited by DC pulse magnetron sputtering显示文摘TiO2 films were deposited at room temperature by DC pulse magnetron sputtering system.The crystalline structures,morphological features and photocatalytic activity of TiO2 films were systematically investigated by X-ray diffraction(XRD),atomic force microscopy(AFM) and ultraviolet spectrophotometer,respectively.The results indicated that working pressure was the key deposition parameter in?uencing the TiO2 film phase composition at room temperature,which directly affected its photocatalytic activity.With increasing working pressure,the target self-bias decreases monotonously.Therefore,low temperature TiO2 phase(anatase) could be deposited with high working pressure.The anatase TiO2 films deposited with 1.4 Pa working pressure displayed the highest photocatalytic activity by the decomposition of Methyl Orange solution,which the degradation rate reached the maximum(35%) after irradiation by ultraviolet light for 1 h. | ZHANG Can DING Wanyu WANG Hualin CHAI Weiping JU Dongying | 2009 | Journal of Environmental Sciences2009，21，6： | 11 |
| 5 | Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy显示文摘Photodynamic therapy(PDT),as one of the noninvasive clinical cancer phototherapies,suffers from the key drawback associated with hypoxia at the tumor microenvironment(TME),which plays an important role in protecting tumor cells from damage caused by common treatments.High concentration of hydrogen peroxide(H2O2),one of the hallmarks of TME,has been recognized as a double-edged sword,posing both challenges,and opportunities for cancer therapy.The promising perspectives,strategies,and approaches for enhanced tumor therapies,including PDT,have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine.In this review,we outline the latest advances in H2O2-responsive materials,including organic and inorganic materials for enhanced PDT.Finally,the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned. | Nan Yang Wanyue Xiao Xuejiao Song Wenjun Wang Xiaochen Dong | 2020 | Nano-Micro Letters2020，12，1： | 11 |
| 6 | The role of micro RNAs in hepatocyte metabolism and hepatitis B virus replication显示文摘Though efficient vaccines against hepatitis B virus(HBV) and antiviral therapies are available,chronic HBV infection is still a global health problem. The process of HBV infection and HBV life cycle are extensively studied in last decades, however, the mechanisms of HBV-induced alterations of host cell metabolisms and host factors involved in modulating of viral replication are not fully understood. Thus, it is an important issue to examine these specific HBV-host interactions for development of novel strategies for antiviral therapies. Recently, microRNAs(miRNAs), a class of post-transcriptional regulatory small RNA, seem to be the relevant fine tuning factors of various cellular activities and pathways, including cell growth, metabolism, and viral replication. In this review, we summarize the up to date knowledge concerning the virus-host interactions and emphasizing on the role of miRNAs in regulation of HBV replication and host cell metabolism. | Wanyu Deng Mengji Lu | 2016 | Virologica Sinica2016，31，6： | 7 |
| 7 | Numerical Analysis of Flow Instability in the Water Wall of a Supercritical CFB Boiler with Annular Furnace显示文摘In order to expand the study on flow instability of supercritical circulating fluidized bed(CFB) boiler,a new numerical computational model considering the heat storage of the tube wall metal was presented in this paper.The lumped parameter method was proposed for wall temperature calculation and the single channel model was adopted for the analysis of flow instability.Based on the time-domain method,a new numerical computational program suitable for the analysis of flow instability in the water wall of supercritical CFB boiler with annular furnace was established.To verify the code,calculation results were respectively compared with data of commercial software.According to the comparisons,the new code was proved to be reasonable and accurate for practical engineering application in analysis of flow instability.Based on the new program,the flow instability of supercritical CFB boiler with annular furnace was simulated by time-domain method.When 1.2 times heat load disturbance was applied on the loop,results showed that the inlet flow rate,outlet flow rate and wall temperature fluctuated with time eventually remained at constant values,suggesting that the hydrodynamic flow was stable.The results also showed that in the case of considering the heat storage,the flow in the water wall is easier to return to stable state than without considering heat storage. | XIE Beibei YANG Dong XIE Haiyan NIE Xin LIU Wanyu | 2016 | Journal of Thermal Science2016，25，4： | 4 |
| 8 | Effectiveness of Qingre Lishi Yishen decoction on the glomerular fibrosis of immunoglobulin A nephropathy in a rat’s model显示文摘OBJECTIVE: To investigate the effect of the clinical effective prescription of Qingre Lishi Yishen decoction(QRLS) on the activation of mesangial cells in immunoglobulin A nephropathy(IgAN) rats.METHODS: IgAN rat’s model was established by combine with intragastric administration of bovine serum albumin(BSA) + intravenous injection of lipopolysaccharide(LPS) by + subcutaneous injection of carbon tetrachloride(CCL4). Then the animals were randomly divided into four groups: control group, IgAN model group, IgAN model with Valsartan(Val) treatment group and IgAN model with QRLS treatment group. To observe the indexes of 24-h urine protein, renal function, deposition of immune complexes, expression of activation factor, fibrosis marker and inflammatory cytokines in four different groups.RESULTS: The Val or QRLS treatment group:(a) it reduced the immune complexes deposition of IgA in glomerular mesangial and inhibited mesangial cell proliferation;(b) it decreased the expression of smooth muscle actin(α-SMA), fibronectin(FN) and tumor necrosis factor alpha(TNF-α).CONCLUSION: The study suggested that QRLS ameliorate renal structure and function in IgAN rat’s model. Furthermore, we also observed that QRLS alleviated mesangial cells activation and matrix accumulation partly by decreasing the α-SMA,then to downregulated the expression of FN and TNF-α. | Dang Wanyu Hou Linyi Yan Huimin Wu Xiaoming Zhen Xiaofang Hao Jing | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 2 |
| 9 | Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses显示文摘The surface glycoproteins of coronaviruses play an important role in receptor binding and cell entry. Different coronaviruses interact with their specific receptors to enter host cells. Lentiviruses pseudotyped with their spike proteins(S) were compared to analyze the entry efficiency of various coronaviruses. Our results indicated that S proteins from different coronaviruses displayed varied abilities to mediate pseudotyped virus infection. Furthermore, the cell tropisms of porcine epidemic diarrhea virus(PEDV) and transmissible gastroenteritis virus(TGEV) have been characterized by live and pseudotyped viruses. Both live and pseudoviruses could infected VeroCCL-81(monkey kidney), Huh-7(human liver), and PK-15(pig kidney) cells efficiently. CCL94(cat kidney) cells could be infected efficiently by TGEV but not PEDV. Overall, our study provides new insights into the mechanisms of viral entry and forms a basis for antiviral drug screening. | Jingjing Wang Feng Deng Gang Ye Wanyu Dong Anjun Zheng Qigai He Guiqing Peng | 2016 | Virologica Sinica2016，31，1： | 2 |
| 10 | Enhancing low-temperature NH_(3)-SCR performance of Fe-Mn/CeO_(2)catalyst by Al_(2)O_(3)modification显示文摘In the work,supported catalysts of FeO_(x) and MnO_(x) co-supported on aluminum-modified CeO_(2)was synthesized for low-temperature NH_(3)-selective catalytic reduction(NH_(3)-SCR)of NO.Impressively,the SCR activity of the obtained catalyst is markedly influenced by the adding amount of Al and the appropriate Ce/Al molar ratio is 1/2.The activity tests demonstrate that Fe-Mn/Ce1 Al2 catalyst shows over 90%NO conversion at 75-250℃and exhibits better SO_(2)resistance compared to Fe-Mn/CeO_(2).Fe-Mn/Ce1 Al2 shows the expected physicochemical characters of the ideal catalyst including the larger surface and increased active reaction active sites by controlling the amount of Al doping.Also,the better catalytic activity is well correlated with the present advantaged surface adsorption oxygen species,Mn^(4+)species,Ce^(3+)species and the enhanced reducibility of Fe-Mn/Ce1 Al2,which is superior to the Fe-Mn/CeO_(2)catalyst.More importantly,we further demonstrate that the amount and strength of surface acid sites are improved by Al-doping and more active intermediates(monodentate nitrate)is generated during NH_(3)-SCR reaction.This work provides certain insight into the rational creation of simple and practical denitration catalyst environmental purification. | Lulu Li Jiawei Ji Wei Tan Wang Song Xin Wang Xiaoqian Wei Kai Guo Wanyu Zhang Changjin Tang Lin Dong | 2022 | Journal of Rare Earths2022，40，9： | 2 |
| 11 | Effects of imazethapyr spraying on plant growth and leaf surface microbial communities in Arabidopsis thaliana显示文摘Imazethapyr (IM) is an acetolactate synthase (ALS)-inhibiting herbicide that has been widely used in recent years.However,IM spraying can lead to the accumulation of herbicide residues in leaves.Here,we determined the effects of IM spraying on the plant growth and leaf surface microbial communities of Arabidopsis thaliana after 7 and 14 days of exposure.The results suggested that IM spraying inhibited plant growth.Fresh weight decreased to 48% and 26% of the control value after 7 and 14 days,respectively,of 0.035 kg/ha IM exposure.In addition,anthocyanin content increased 9.2-fold and 37.2-fold relative to the control content after 7 and 14 days of treatment,respectively.Furthermore,IM spraying destroyed the cell structures of the leaves,as evidenced by increases in the number of starch granules and the stomatal closure rate.Reductions in photosynthetic efficiency and antioxidant enzyme activity were observed after IM spraying,especially after 14 days of exposure.The diversity and evenness of the leaf microbiota were not affected by IM treatment,but the composition of community structure at the genus level was altered by IM spraying.Imazethapyr application increased the abundance of Pseudomonas,a genus that includes species pathogenic to plants and humans,indicating that IM potentially increased the abundance of pathogenic bacteria on leaves.Our findings increase our understanding of the relationships between herbicide application and the microbial community structures on plant leaves,and they provide a new perspective for studying the ecological safety of herbicide usage. | Wanyue Liu Mingjing Ke Zhenyan Zhang Tao Lu Youchao Zhu Yan Li Xiangliang Pan Haifeng Qian | 2019 | Journal of Environmental Sciences2019，31，11： | 2 |
| 12 | Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial–mesenchymal transition显示文摘 | Bin Zhang Yan Yang Xiaoting Shi Wanyu Liao Min Chen Alfred Sze-Lok Cheng Hongli Yan Cheng Fang Shu Zhang Guifang Xu Shanshan Shen Shuling Huang Guangxia Chen Ying Lv Tingsheng Ling Xiaoqi Zhang Lei Wang Yuzheng Zhuge Xiaoping Zou | 2014 | Cancer Letters2014，，： | 2 |
| 13 | Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780显示文摘Background:Hypertrophic scars(HS)represent one of the most common clinical challenges due to unsatisfactory therapeutic results.HS formation is associated with the abnormal activation of fibroblasts and their excessive fibrotic behavior.Glycolysis dysregulation has been shown to participate in the incidence and progression of various fibrotic diseases and shows potential as a means of controlling HS formation.This work aimed to discuss the impact of augmented glycolysis on HS and to propose a method for controlling HS formation through glycolysis regulation.Methods:Here,augmented glycolysis was confirmed together with enhanced fibrotic activity in both HS fibroblasts(HFs)and HS tissues,and the suppression of glycolysis also attenuated fibroblast activation.We also introduced IR780,a heptamethine cyanine dye,to regulate glycolysis for the control of HS formation.Results:In vitro,cell studies indicated that IR780 significantly down-regulated glycolysis and suppressed the fibrotic activity of HFs.In vivo,the intralesional injection of IR780 into rabbit HS models led to the downregulation of glycolysis and the control of HS formation.Furthermore,IR780 accumulated preferentially in activated fibroblasts in both in vitro and in vivo studies,and thus specifically downregulated glycolysis and efficiently controlled fibrosis by targeting activated fibroblasts.Conclusions:This work identified a strategy for controlling fibrosis and HS formation from the perspective of glycolysis regulation with IR780 targeting of activated fibroblasts. | Xinxian Meng Zhixi Yu Wanyu Xu Jun Chai Shuo Fang Peiru Min Yunsheng Chen Yixin Zhang Zheng Zhang | 2022 | Burns & Trauma2022，10，1： | 2 |
| 14 | L-amino acid oxidase from Naja atra venom activates and binds to human platelets显示文摘L 氨基的酸 oxidase (LAAO ) , NA-LAAO,从 Naja atra 的毒液被净化。它有从另外的蛇毒液的 LAAO 的 N 终端顺序表演伟人类似。NA-LAAO dose-dependently 导致了洗的人的血小板的聚集。然而,它没在充满血小板的血浆在血小板上举办活动。NA-LAAO 的低集中极大地支持了氢过氧化物的效果,而氢每氧化物本身穿上小激活效果板让。NA-LAAO 包括 Src kinase,怒气酷氨酸 kinase,和 phospholipase C 2 导致了很多血小板蛋白质的酷氨酸 phosphorylation。不同于 convulxin, Fc 受体链和 T 淋巴细胞改编者蛋白质不是在 NA-LAAO-activated 血小板的 phosphorylated,建议与 glycoprotein VI 小径不同的激活机制。过氧化氢酶禁止了 NA-LAAO 导致的血小板聚集和血小板蛋白质 phosphorylation。NA-LAAO 跳了到固定血小板以及到西方的污点的血小板 lysates。而且, NA-LAAO-Sepharose 4B 列上的血小板蛋白质的亲密关系层析孤立一些血小板膜蛋白质,建议到血小板膜的 NA-LAAO 的那绑定可能起在它血小板上的行动的一个作用。 | Rui Li Shaowen Zhu Jianbo Wu Wanyu Wang Qiumin Lu Kenneth J. Clemetson | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 2 |
| 15 | Review on occupancy detection and prediction in building simulation显示文摘Energy simulation results for buildings have significantly deviated from actual consumption because of the uncertainty and randomness of occupant behavior.Such differences are mainly caused by the inaccurate estimation of occupancy in buildings.Therefore,the error between reality and prediction could be largely reduced by improving the accuracy level of occupancy prediction.Although various studies on occupancy have been conducted,there are still many differences in the approaches to detection,prediction,and validation.Reports published within this domain are reviewed in this article to discover the advantages and limitations of previous studies,and gaps in the research are identified for future investigation.Six methods of monitoring and their combinations are analyzed to provide effective guidance in choosing and applying a method.The advantages of deterministic schedules,stochastic schedules,and machine-learning methods for occupancy prediction are summarized and discussed to improve prediction accuracy in future work.Moreover,three applications of occupancy models—improving building simulation software,facilitating building operation control,and managing building energy use—are examined.This review provides theoretical guidance for building design and makes contributions to building energy conservation and thermal comfort through the implementation of intelligent control strategies based on occupancy monitoring and prediction. | Yan Ding Shuxue Han Zhe Tian Jian Yao Wanyue Chen Qiang Zhang | 2022 | Building Simulation2022，15，3： | 2 |
| 16 | Theory assisted design of N-doped tin oxides for enhanced electrochemical CO2 activation and reduction显示文摘Clearly understanding the structure-function relationship and rational design of efficient CO2 electrocatalysts are still the challenges.This article describes the molecular origin of high selectivity of formic acid on N-doped SnO2 nanoparticles,which obtained via thermal treatment of g-C3N4 and SnCl2·2H2O precursor.Combined with density functional theory(DFT)calculations,we discover that N-doping effectively introduces oxygen vacancies and increases the charge density of Sn sites,which plays a positive role in CO2 activation.In addition,N-doping further regulates the adsorption energy of^*OCHO,^*COOH,^*H and promotes HCOOH generation.Benefited from above modulation,the obtained N-doped SnO2 catalysts with oxygen vacancies(Ov-N-SnO2)exhibit faradaic efficiency of 93% for C1 formation,88% for HCOOH production and well-suppression of H2 evolution over a wide range of potentials. | Congling Hu Lei Zhang Lulu Li Wenjin Zhu Wanyu Deng Hao Dong Zhi-Jian Zhao Jinlong Gong | 2019 | Science China Chemistry2019，62，8： | 2 |
| 17 | A Hybrid Method of GA and BP for Short-term Economic Dispatch of Hydrothermal Power Systems 显示文摘 | Meng Xiangping Zhang Huaguang Tan Wanyu | 2000 | Mathematics and Computers in Simulation2000，51，3： | 1 |
| 18 | An Improved Aggregated One -Dependence Estimator: On Nonrigid Cross Validation 显示文摘 | Wanyu Deng Qinghua Zheng lin Chen | 2008 | IEEE CSCWD2008，，： | 1 |
| 19 | Incentive-based modeling and inference of attacker intent, objectives, and strategies显示文摘 | Peng Liu Wanyu Zang Meng Yu | 2005 | ACM Transactions on Information and System Security (TISSEC)2005，，1： | 1 |
| 20 | Amino acid substitutions at positions 122 and 145 of hepatitis b virus surface antigen (HBsAg) determine the antigenicity and immunogenicity of HBsAg and influence in vivo HBsAg clearance显示文摘 | Chunchen W Wanyu D Liu D | | 0，，08： | 1 |
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