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| 1 | Fetal brain tumors:Prenatal diagnosis by ultrasound and magnetic resonance imaging显示文摘Congenital central nervous system tumors diagnosed during pregnancy are rare, and often have a poor prognosis. The most frequent type is the teratoma. Use of ultrasound and magnetic resonance image allows the suspicion of brain tumors during pregnancy. However, the definitive diagnosis is only confirmed after birth by histology. The purpose of this mini-review article is to describe the general clinical aspects of intracranial tumors and describe the main fetal brain tumors. | Herbene Jose Milani Edward Araujo Junior Sergio Cavalheiro Patrícia Soares Oliveira Wagner Jou Hisaba Enoch Quindere Sa Barreto Maurício Mendes Barbosa Luciano Marcondes Nardozza Antonio Fernandes Moron | 2015 | World Journal of Radiology2015，7，1： | 7 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 4 | Rituximab-induced intersti- tial lung disease显示文摘 | Wagner SA Mehta AC Laber I)A | 2007 | Am J Hematol2007，82，10： | 1 |
| 5 | Teaching medical students dermatology research skills:six years of experience with the University of Texas Medical Branch dermatology non-degree research honors program,2001 -2006显示文摘 | Wagner RF Jr Lewis SA | 2006 | Dermatol Online J2006，12，4： | 1 |
| 6 | Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass显示文摘 | Povlsen LK Beli P Wagner SA | 2012 | Nat Cell Biol2012，14，10： | 1 |
| 7 | Rituximab-induced interstitial lung disease显示文摘 | Wagner SA Mehta AC Laber DA | 2007 | Am J Hematol2007，82，10： | 1 |
| 8 | Genetic architecture of the APM1 gene and its influence on atliponectin plasma levels and parameters of the metabolic syndrome in 1727 healthy Caucasians显示文摘 | Heid IM Wagner SA Gohlke H | 2006 | Diabetes2006，55，2： | 1 |
| 9 | Randomized, double-blind, phase I1 study of ruxolitinib or placebo in combination with capecitabine in patients with metastatic pancreatic cancer for whom therapy with gemcitabine has failed显示文摘 | Hurwitz HI Uppal N Wagner SA | 2015 | J C/in Oncol2015，33，34： | 1 |
| 10 | Acetylation site specific- ities of lysine deacetylase inhibitors in human cells 显示文摘 | Scholz C Weinert BT Wagner SA | 2015 | Nat Bio- technol2015，33，4： | 1 |
| 11 | Apoptin/VP3 contains a concentration-dependent nuclear localization signal(NLS), not a tumorigenic selective NLS显示文摘 | WadiaJS Wagner MV Ezhevsky SA | 2004 | J Virol2004，78，11： | 1 |
| 12 | Acetylation site specificities of lysine deacetylase inhibitors in human cells显示文摘 | Seholz C Weinert BT Wagner SA | 2015 | t Biotechnol2015，33，4： | 1 |
| 13 | Systems wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA damage bypass显示文摘 | Povlsen LK Beli P Wagner SA | 2012 | Nat Cell Biol2012，14，10： | 1 |
| 14 | A proteome-wide,quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles显示文摘 | Wagner SA Beli P Weinert BT | 2011 | Mol Cell Proteomics2011，10，01： | 1 |
| 15 | The nose revisited: a brief review of the comparative structure, function, and toxi- cologie pathology of the nasal epithelium, Toxicol显示文摘 | JR Harkema SA Carey JG Wagner | 2006 | Pathol2006，34，6： | 1 |
| 16 | Magnetic resonance imaging of atherosclerotic plaques using superparamagnetic iron oxide particles显示文摘 | Schmitz SA Taupitz M Wagner S | 2001 | J MRI2001，14，4： | 1 |
| 17 | BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury 显示文摘 | Hoh NZ Wagner AK Alexander SA | 2010 | J Neumtrauma2010，27，8： | 1 |
| 18 | A randomi zed trial of vitamin D supplementation in 2 community health center networks in South Carolina显示文摘 | Wagner CL McNeil R Hamilton SA | 2013 | Am 1 Obstet Gynecol2013，208，2： | 1 |
| 19 | Iron - oxide - enhanced magnetic resonance imaging of atherosclerotic plaques: postmortem analysis of accuracy, inter - observer agreement, and pitfalls 显示文摘 | Schmitz SA Taupitz M Wagner S | 2002 | Invest Radiol2002，37，7： | 1 |
| 20 | Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture显示文摘 | Lipton SA Wagner JA Madison RD | 1988 | Proc Natl Acad Sci USA1988，85，： | 1 |
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