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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | An acorn squash (Cucurbita pepo ssp. ovifera) fruit and seed transcriptome as a resource for the study of fruit traits in Cucurbita显示文摘Acorn squash(Cucurbita pepo)is an iconic fall vegetable in the United States,known for its unique fruit shape and also prized for its culinary properties.Little is known about the metabolism that underlies the development of fruit quality attributes such as color,sweetness,texture and nutritional qualities in acorn squash,or any other winter squash grown worldwide.To provide insight into winter squash fruit and seed development and add to the genomic resources in the Cucurbita genus,RNA sequencing was used to generate an acorn squash fruit and seed transcriptome from the cultivar Sweet REBA at critical points throughout fruit development.141838600 high-quality paired-end Illumina reads were assembled into 55949 unigenes.85%of unigenes with predicted open reading frames had homology with previously identified genes and over 62%could be functionally annotated.Comparison with the watermelon and cucumber genomes provided confirmation that the unigenes are full-length and comprehensive,covering an average of 90%of the coding sequence of their homologs and 72%of the cucumber and watermelon exomes.Key candidate genes associated with carotenoid and carbohydrate metabolism were identified toward a resource for winter squash fruit quality trait dissection.This transcriptome represents a major advance in C.pepo genomics,providing significant new sequence information and revealing the repertoire of genes expressed throughout winter squash fruit and seed development.Future studies on the genetic basis of fruit quality and future breeding efforts will be enhanced by tools and insights developed from this resource. | Lindsay E Wyatt Susan R Strickler Lukas A Mueller Michael Mazourek | 2015 | Horticulture Research2015，2，1： | 11 |
| 3 | 旱作农区轮作和留茬处理方式对风蚀的影响——应用EPIC模型进行模拟和分析的武川案例显示文摘近一、二十年来 ,中国北方加剧的风蚀 ,气候恶化 ,西北和北京地区出现日益频繁的沙尘天气 ,也在迅速降低这些地区的土壤乃至农牧业的生产力。本研究首次引用美国农业部研究局系统开发的EPIC(environmentalpolicyintegrateclimate,考虑气候的环境决策 )模型 ,对位于农牧交错带的内蒙古武川县 ,评估其改进轮作和残留秸茬处理方式对风蚀的影响。模拟结果表明 ,收获后在田间保留作物秸茬、或推迟田间秸茬的处理 (移出 )时间 ,以及改进当前的轮作系统 ,即扩大玉米、油菜和莜麦的比例 ,相应减少杂豆等越冬和生长期地表裸露面积较大的作物 ,能有效地减少风蚀 ,从而逐步减轻中国北方地区沙尘暴的严重危害。长期保持表土有利于维持土地生产力 ,对改善此地区内农村贫困将有深远意义。 | 王尔大 Wyatte Harman 郑大玮 常欣 程序 | 2002 | 中国农业科学2002，35，11： | 10 |
| 4 | 医学模型分类及世界研发商显示文摘医学模型架起医学理论通往临床实践的桥梁。基础解剖示教模型、局部功能性模型、计算机互动模型、虚拟培训系统、生理驱动模拟系统,这五部分各自具有不同功能,在医学生培养中缺一不可。生理驱动模拟系统再造“真实临床环境”,帮助医学生最终实现临床梦想。 | Academy and marketing Department of Rizheng Huarui Enterprise LuSun Wyatt(Ri Zheng Hua Rui) China Co.,Ltd., No.9, Fangzhuang Nanlu, Fengtai District, Beijing, 100079, PRC | 2007 | 中国医院2007，11，4： | 7 |
| 5 | Comparative analysis of Cucurbita pepo metabolism throughout fruit development in acorn squash and oilseed pumpkin显示文摘Both the fruit mesocarp and the seeds of winter squash can be used for consumption,although the focus of breeding efforts varies by cultivar.Cultivars bred for fruit consumption are selected for fruit mesocarp quality traits such as carotenoid content,percent dry matter,and percent soluble solids,while these traits are essentially ignored in oilseed pumpkins.To compare fruit development in these two types of squash,we sequenced the fruit transcriptome of two cultivars bred for different purposes:an acorn squash,‘Sweet REBA’,and an oilseed pumpkin,‘Lady Godiva’.Putative metabolic pathways were developed for carotenoid,starch,and sucrose synthesis in winter squash fruit and squash homologs were identified for each of the structural genes in the pathways.Gene expression,especially of known rate-limiting and branch point genes,corresponded with metabolite accumulation both across development and between the two cultivars.Thus,developmental regulation of metabolite genes is an important factor in winter squash fruit quality. | Lindsay E Wyatt Susan R Strickler Lukas A Mueller Michael Mazourek | 2016 | Horticulture Research2016，3，1： | 7 |
| 6 | The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing显示文摘前列腺癌症是全球癌症相关的死亡的一个领先的原因,但是试图改善诊断并且开发新奇治疗被重要耐心的异质惊讶。在最近的年里,到几百个前列腺瘤的下一代的定序的应用程序定义新奇分子的子类型并且描绘了位于疾病开始和前进下面的广泛的 genomic 错误。在诊所观察的异质是由与复杂性流行的一处分子的风景的 underpinned,现在是清楚的,在 genomic 重新整理和稀罕变化联合放大 transcriptomic 差异的地方。这评论把我们前列腺癌症 ‘ 的当前的理解; omic 的包括拷贝数字变化的哨兵角色, oncogenic 熔化基因, chromothripsis 的潜在的影响,和在定义联系变化的子类型的突破的成长光谱。增加的证据建议损害经常在特定的细胞的功能和发信号的小径上集成的那 genomic,还周期性的基因错误显得稀罕。因此,我们继续定义单个瘤染色体,是批评的,特别在他们的表示 transcriptome 的上下文。仅仅通过到瘤可变性罐头的瘤的改进描述,我们前进到精确治疗和个性化的肿瘤学的年龄。 | Alexander W Wyatt Fan Mo Yuzhuo Wang Colin C Collins | 2013 | Asian Journal of Andrology2013，15，3： | 5 |
| 7 | 选择性头部降温在新生儿脑病后全身轻度低温中应用的多中心随机试验 | Gluckman P.D. Wyatt J.S. Azzopardi D. A. J. Gunn 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，8： | 4 |
| 8 | Survival outcomes of cemented compared to uncemented stems in primary total hip replacement显示文摘Total hip replacement(THR) is a successful and reliable operation for both relieving pain and improving function in patients who are disabled with end stage arthritis.The ageing population is predicted to significantly increase the requirement for THR in patients who have a higher functional demand than those of the past. Uncemented THR was introduced to improve the long term results and in particular the results in younger, higher functioning patients. There has been controversy about the value of uncemented compared to cemented THR although there has been a world-wide trend towards uncemented fixation. Uncemented acetabular fixation has gained wide acceptance, as seen in the increasing number of hybrid THR in joint registries, but there remains debate about the best mode of femoral fixation.In this article we review the history and current worldwide registry data, with an in-depth analysis of the New Zealand Joint Registry, to determine the results of uncemented femoral fixation in an attempt to provide an evidence-based answer as to the value of this form of fixation. | Michael Wyatt Gary Hooper Christopher Frampton Alastair Rothwell | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 9 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 10 | 社会创新如何运用设计思维显示文摘年轻的香提住在印度南部的海德拉巴城乡结合部。她每天要到离家300英尺的露天水井汲水,并将3加仑重的塑料水罐顶在头上运回家中。露天井水不如社区水站提供的经过处理的水源安全,时常导致家人生病,但她和丈夫却依然将它作为日常饮用和生活用水。 | Tim Brown Jocelyn Wyatt 王津旭 | 2015 | 中国社会组织2015，0，16： | 4 |
| 11 | 现代医学模拟实验室的建设、应用和管理显示文摘早在20世纪90年代,全英医学总会(GMC)就已经公布了医学教育的改革蓝图。呼吁通过设立医学理论知识、医患沟通技巧培养以及临床技能培训相结合的医学课程设置,减轻医学生的负担。同时,临床医学管理机构制定了医学保健从业人员的从业标准,这无疑对医学本科和研究生的培养模式产生了影响。针对上述各种情况,临床技能实验室、专科技能培训中心和医学模拟中心应运而生。他们成为医学院学生积累临床医学经验的场所。 | Academy and marketing Department of Rizheng Huarui Enterprise LuSun Wyatt(Ri Zheng Hua Rui) China Co.,Ltd., No.9, Fangzhuang Nanlu, Fengtai District, Beijing, 100079, PRC | 2007 | 中国医院2007，11，3： | 3 |
| 12 | Critical and subcritical ischaemia显示文摘 | J.H.N. Wolfe M.G. Wyatt | 1997 | European Journal of Vascular & Endovascular Surgery1997，，： | 2 |
| 13 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 14 | Resection margin in patients undergoing hepatectomy for colorectal liver metastasis: A critical appraisal of the 1cm rule显示文摘 | Z.Z.R. Hamady I.C. Cameron J. Wyatt R.K. Prasad G.J. Toogood J.P.A. Lodge | 2006 | European Journal of Surgical Oncology2006，，5： | 2 |
| 15 | Highly efficient 980 nm operation of an Yb3+-doped silica fibre laser显示文摘 | J R Armitage R Wyatt B J Ainslie | | 0，，： | 2 |
| 16 | Complications and Outcome After Acute Stroke: Does Dysphagia Matter?显示文摘 | D.G. Smithard NA O’Neill C. Park J. Morris R. Wyatt R. England D.F. Martin | 1996 | Stroke A Journal of Cerebral Circulation1996，，7： | 2 |
| 17 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 18 | Structures of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody显示文摘 | Wyatt R Robinson J | 1998 | Nature1998，393，： | 1 |
| 19 | Effects of a media campaign on back pain beliefs and its potential influence on management of low back pain in general practice显示文摘 | Buchbinder R Jolley D Wyatt M | 2001 | Spine2001，26，23： | 1 |
| 20 | IgA nephropathy: Long - term prognosis for pediatric patients显示文摘 | Wyatt R J Kritehevsky SB Woodford SY | 1995 | J Pediatr1995，127，91： | 1 |
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