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| 1 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 2 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 3 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 4 | Evaluation of an auto-CPAP device for treatment of obstructive sleep apnoea显示文摘 | Ficker JH Wiest GH Lehnert G | 1998 | Thorax1998，53，： | 1 |
| 5 | Bacterial transloeation(BT)in cirrhosis显示文摘 | Wiest R Garcia-Tsao G | 2005 | Hepatology2005，41，： | 1 |
| 6 | Bacterial translocation(BJ) in cirrhosis显示文摘 | Wiest R Garcia-Tsao G | 2005 | Hepatology2005，41，3： | 1 |
| 7 | Bacterial translocation up-regulates GTP-cyclohydrolase Ⅰ in mesenteric vasculature of cirrhotic rats 显示文摘 | WIEST R CADELINA G MILSTIEN S | 2003 | Hepatology2003，38，： | 1 |
| 8 | Lightweight Ti - basedbulk metallic glasses excluding late transition metals 显示文摘 | Duan G Wiest A Lind M L | 2008 | Scripta Materialia2008，58，6： | 1 |
| 9 | Bscterial translocation (BT) in cirrhosis显示文摘 | Wiest R Garcia T sao G | | 0，，03： | 1 |
| 10 | Vestibular function in severe bilateral vestibulopathy显示文摘 | WIEST G DEMER J L TIAN J | 2001 | J Neurol Neurosurg Psychiatry2001，71，： | 1 |
| 11 | A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia显示文摘 | Amann K Ritz E Wiest G | 1994 | J Am Soc Nephrol1994，4，： | 1 |
| 12 | DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH显示文摘 | Erwin G?bele Karin Dostert Claudia Hofmann Reiner Wiest Jürgen Sch?lmerich Claus Hellerbrand Florian Obermeier | 2011 | Journal of Hepatology2011，，6： | 1 |
| 13 | Gut microflora in the patho- genesis of the complications of cirrhosis显示文摘 | Garcia-Tsao G and R Wiest | 2004 | Best Praet Res Clin Gastroenterol2004，18，2： | 1 |
| 14 | A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia显示文摘 | Amann K Ritz E Wiest G | | 0，，： | 1 |
| 15 | Bacterial transloeation in cinhosis 显示文摘 | Wiest R Garcia-Tsao G | 2005 | Hepatology2005，41，3： | 1 |
| 16 | Recent trends and future prospects of soeio-spatial differentiation in urban regions of Central and Eastern Europe: A lull before the storm?显示文摘 | Brade I Herfert G and Wiest K | 2009 | Cities2009，26，： | 1 |
| 17 | A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia 显示文摘 | Amann K Ritz E Wiest G | 1994 | J Am Soc Nephrot1994，4，10： | 1 |
| 18 | Baeterial translocation(BT)incirrhosis显示文摘 | Wiest R Garcia Tsao G | 2005 | Hepatology2005，41，3： | 1 |
| 19 | Designing metallic glass matrix composites with high toughness and tensile ductility显示文摘 | HOFMANN D C SUH J Y WIEST A DUAN G LIND M L DEMETRIOU M D JOHNSON W L | 2008 | Nat Mater2008，451，： | 1 |
| 20 | Reduced capillary density in the myocardium of uremic rats - A stereological study显示文摘 | Amann K Wiest G Zimmer G | 1992 | Kidney Iht1992，42，： | 1 |
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