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| 1 | Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure显示文摘The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The main features of neurodegenerative diseases have been related with cellular and molecular events like neuronal loss, mitochondrial dysfunction and aberrant accumulation of misfolded proteins or peptides in specific areas of the brain. The most prevalent neurodegenerative diseases belonging to age-related pathologies are Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis. Interestingly, mitochondrial dysfunction has been observed to occur during the early onset of several neuropathological events associated to neurodegenerative diseases. The master regulator of mitochondrial quality control and energetic metabolism is the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α). Additionally, it has been observed that PGC-1α appears to be a key factor in maintaining neuronal survival and synaptic transmission. In fact, PGC-1α downregulation in different brain areas(hippocampus, substantia nigra, cortex, striatum and spinal cord) that occurs in function of neurological damage including oxidative stress, neuronal loss, and motor disorders has been seen in several animal and cellular models of neurodegenerative diseases. Current evidence indicates that PGC-1α upregulation may serve as a potent therapeutic approach against development and progression of neuronal damage. Remarkably, increasing evidence shows that PGC-1α deficient mice have neurodegenerative diseases-like features, as well as neurological abnormalities. Finally, we discuss recent studies showing novel specific PGC-1α isoforms in the central nervous system that appear to exert a key role in the age of onset of neurodegenerative diseases and have a neuroprotective function in the central nervous system, thus opening a new molecular strategy for treatment of neurodegenerative diseases. The purpose of this review is to provide an up-to-date overview of the PGC-1α role in the physiopathology of neurodegenerative diseases, as well as establish the importance of PGC-1α function in synaptic transmission and neuronal survival. | Jessica D.Panes Aline Wendt Oscar Ramirez-Molina Patricio A.Castro Jorge Fuentealba | 2022 | Neural Regeneration Research2022，17，2： | 6 |
| 2 | 上颌窦癌的术后放疗显示文摘副鼻窦癌在美国很少见,年发病率约为1/100000。由于发病隐匿,在诊断时往往已到中晚期。而副鼻窦又邻近重要器官,如眼眶、颅底、脑,彻底的肿瘤切除较为困难,满意的放疗设计也受到限制。所以,中晚期副鼻窦癌的治疗十分棘手。本文是回顾性分析,着重研究上颌窦癌的术后放疗。 | 蒋国樑 Ang KK Peters JL wendt CD Oswald MJ Ceopfer TH | 1991 | 中华放射肿瘤学杂志1991，0，3： | 5 |
| 3 | Expression of Tissue Factor in High-Grade Carotid Artery Stenosis: Association With Plaque Destabilization显示文摘 | Sebastian Jander Matthias Sitzer Angélique Wendt Michael Schroeter Martin Buchkremer Mario Siebler Wolfram Müller Wilhelm Sandmann Guido Stoll | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 3 |
| 4 | Sex-specific effects of inbreeding and early ife conditions on the adult oxidative balance显示文摘 | Raissa Anna DE BOER David COSTANTINI Giulia CASASOLE Hamada ABDELGAWAD Han ASARD Marcel EENS Wendt MIJLLER | 2018 | Current Zoology2018，64，5： | 2 |
| 5 | D.c. and r.f. (reactive) magnetron sputtering of ZnO:Al films from metallic and ceramic targets: a comparative study显示文摘 | K. Ellmer R. Wendt | 1997 | Surface & Coatings Technology1997，，1： | 2 |
| 6 | A new type of hydraulic actuator using electrorheological fluids显示文摘 | Wendt E Klaus K W | 1999 | International J Modern Physics B1999，，14： | 2 |
| 7 | Rescuing agroforestry as strategy for agriculture in Southern Brazil显示文摘Knowledge about agricultural ecosystems, as well as about ecological and social interactions that occur in an agricultural context, is essential to promote a balanced environment for production. Incorporating the forest landscape into farming systems has promoted the development of integrated production systems such as agroforestry. However, many aspects of the relationship between farming and the forest landscape have changed since the modernization of agriculture introduced by the Green Revolution. The objectives of this review are:(1) to contribute to the understanding of the changes in cultivation strategies and in the dynamics of agricultural systems,particularly in the context of farming in Santa Catarina State, Brazil;(2) to contribute to the understanding of agroforestry systems as a strategy to reintroduce the element of forestry into agricultural production systems; and(3) to compile a list of forest plant species that could be used in agroforestry. The approach adopted in this manuscript seeks to highlight the potential of agroforestry systems to conserve natural resources and thereby to support agricultural development by connecting environmental conservation with income for farmers. | Alexandre Siminski Karine Louise dos Santos Juliano Gil Nunes Wendt | 2016 | Journal of Forestry Research2016，27，4： | 2 |
| 8 | Specifications of Targeting Heterochromatin Modifications in Plants显示文摘植物编码专业化指向 cytosines 为的 DNA methyltransferases 的一个多样的全部剧目 ? 在特定的顺序上下文的 methylation。这些包括 de novo methyltransferase ,域重排 METHYLTRANSFERASE 2 ( DRM2 ),哪个在通过 指导RNA 的进程的所有顺序上下文的甲醇化物 cytosines , CHROMOMETHYLASES ( CMT ),哪个甲醇化物 CHH 和 CHG cytosines (在 H 是 A , T ,或 C 的地方),并且? METHYLTRANSFERASE 1 ( MET1 )它维持对称的 CG 上下文的 methylation 。在这评论,我们讨论顺序特性并且每这些小径指向。特别地,我们加亮显示 CMT 优先地指向 CWG 或 CWA/CAW 主题的最近的研究(在 W 是 A 或 T 的地方) ,并且讨论自我增强的反馈怎么在 heterochromatin 特征的 methyltransferases 和 histone 修正指定指向的 DNA 之间循环。最后,导致基因身体 methylation 的开始的事件作为说明不同 silencing 小径的相互依赖的指向怎么能加强的一个模型被讨论离开目标 epialleles 的建立。 | Jered M. Wendte Robert J. Schmitz | 2018 | Molecular Plant2018，11，3： | 2 |
| 9 | Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells显示文摘 | Lei J Wendt C H Fan D | 2007 | Am J Physiol Lung Cell Mol Physiol2007，292，1： | 1 |
| 10 | Response of Growing Pekin Ducks to Supplementation of Monobasic Calcium Phosphate to Low- Phosphorus Diets显示文摘 | Rodehutscord M Timmler R Wendt P | 2003 | Poult Sci2003，82，： | 1 |
| 11 | Partitioning of arsenic, selenium, and cadmium during the combustion of Pittsburgh and Illinois #6 coals in a self-sustained combustor显示文摘 | Wendt J O L | 2000 | Fuel Proc Technol2000，63，23： | 1 |
| 12 | AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration 显示文摘 | Autieri MV Kelemen SE Wendt KW | 2003 | Circ Res2003，92，10： | 1 |
| 13 | leadership and team cohesiveness across cultures显示文摘 | HEIN WENDT MARTIN C EUWEMA I J HETTY VAN EMMERIK | 2009 | The Leadership Quarterly2009，20，3： | 1 |
| 14 | Resistance to cusp fracture in endodonticallytreated teeth 显示文摘 | Wendt S L Jr Harris B M Hunt T E | 1987 | Dent Mater1987，3，5： | 1 |
| 15 | Implementing a Java-based image and report distribution system in a non-picture archiving and communication system environment显示文摘 | Wendt G Kulbago T Peppler W | 2000 | J Digit Imaging2000，13，21： | 1 |
| 16 | RAGE is a multiligand receptor of the immunoglobulin superfamily:implications for homeostasis and chronic disease显示文摘 | BUCCIARELLI L G WENDT T RONG L | 2002 | Cell Mol Life Sci2002，59，7： | 1 |
| 17 | Monitoring of glucose permeability in monkey skin in vivo using optical coherence tomography显示文摘 | Mohamad G Ghosn Narendran Sudheendran Mark Wendt | 2010 | J Biophotonics2010，3，12： | 1 |
| 18 | Preventability of trauma deaths in a Dutch Level-1 trauma centre 显示文摘 | Saltzherr TP Wendt KW Nieboer P | 2011 | Injury2011，42，9： | 1 |
| 19 | Inhalation Health Effects of Fine Particles from the Co-combustion of Coal and Refuse Derived Fuel显示文摘 | FERNANDEZ A WENDT J O L WOLSKI N | 2003 | Chemosphere2003，51，： | 1 |
| 20 | The dehydration of the lower fatty acids by extractive distillation 显示文摘 | LLOYD B SZABADOS R J WENDT K M | 1990 | Chem Eng Commun1990，89，1： | 1 |
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