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| 1 | A“T.E.S.T.”hydrogel bioadhesive assisted by corneal cross-linking for in situ sutureless corneal repair显示文摘Corneal transplantation is an effective clinical treatment for corneal diseases,which,however,is limited by donor corneas.It is of great clinical value to develop bioadhesive corneal patches with functions of“Transparency”and“Epithelium&Stroma generation”,as well as“Suturelessness”and“Toughness”.To simultaneously meet the“T.E.S.T.”requirements,a light-curable hydrogel is designed based on methacryloylated gelatin(GelMA),Pluronic F127 diacrylate(F127DA)&Aldehyded Pluronic F127(AF127)co-assembled bi-functional micelles and collagen type I(COL I),combined with clinically applied corneal cross-linking(CXL)technology for repairing damaged cornea.The patch formed after 5 min of ultraviolet irradiation possesses transparent,highly tough,and strongly bio-adhesive performance.Multiple cross-linking makes the patch withstand deformation near 600%and exhibit a burst pressure larger than 400 mmHg,significantly higher than normal intraocular pressure(10-21 mmHg).Besides,the slower degradation than GelMA-F127DA&AF127 hydrogel without COL I makes hydrogel patch stable on stromal beds in vivo,supporting the regrowth of corneal epithelium and stroma.The hydrogel patch can replace deep corneal stromal defects and well bio-integrate into the corneal tissue in rabbit models within 4 weeks,showing great potential in surgeries for keratoconus and other corneal diseases by combining with CXL. | Meiyan Li Ruoyan Wei Chang Liu Haowei Fang Weiming Yang Yunzhe Wang Yiyong Xian Kunxi Zhang Yong He Xingtao Zhou | 2023 | Bioactive Materials2023，，7： | 1 |
| 2 | The management of hepatocellular carcinoma around the world: a comparison of guidelines from 2001 to 2011显示文摘 | Peipei Song Ruoyan G. Tobe Yoshinori Inagaki Norihiro Kokudo Kiyoshi Hasegawa Yasuhiko Sugawara Wei Tang | 2012 | Liver Int2012，，7： | 1 |
| 3 | Electromagnetic Force Balanced Single-Wheel Robot显示文摘It is a challenging task to carry on the research concerning the lateral stabilization of Single wheel robot(SWR). The lateral dynamics of earlier flywheel stabilizing SWR is derived to explain the shortcomings of such a mechanism, and the recovery torque proportional to the acceleration and moment of inertia of the flywheel is proved. But as the motor being a speed server system,it is difficult to control its acceleration to actuate the flywheel to provide recovery torque for SWR; and the moment of inertia of the flywheel must be large enough to produce adequate recovery torque, which makes such a system rather cumbersome. We proposed a new mechanism to solve the problem by introducing an electromagnetic force. The proposed mechanism is described briefly, and the dynamic analyses of such a new SWR is given, then the stability analysis is also done. Three-dimensional(3D)multi-body simulation, numerical simulation and physical invented pendulum prototype experiments were conducted to verify the proposed mechanism. The experiment results verified that the proposed mechanism is feasible and have some advantages over the flywheel balanced SWR. | ZHU Xiaoqing RUAN Xiaogang CHEN Zhigang WEI Ruoyan XIAO Yao | 2016 | Chinese Journal of Electronics2016，25，3： | 0 |
| 4 | 基因组和转录组测序整合分析揭示混合型肝癌的不同分子亚型显示文摘文章简介原发性肝癌每年造成全球约70万病人死亡且过半死亡病例来自中国,其致死率在所有癌种中高居第二。肝癌主要分为3种类型:肝细胞癌(约80%)、肝内胆管癌(约15%)和混合型肝癌(约5%)。混合型肝癌兼具肝细胞癌和胆管细胞癌两种成分,是预后最差的一种肝癌。 | 薛瑞栋 陈璐 张冲 藤田征志 Ruoyan Li Shu-Mei Yan Choon Kiat Ong Xiwen Liao Qiang Gao Shota Sasagawa Yanmeng Li Jincheng Wang Hua Guo Qi-Tao Huang Qian Zhong Jing Tan Lisha Qi Wenchen Gong Zhixian Hong Meng Li Jingmin Zhao Tao Peng Yinying Lu Kiat Hon Tony Lim Arnoud Boot Atushi Ono Kazuaki Chayama Zemin Zhang Steve George Rozen Bin Tean Teh Xin Wei Wang Hidewaki Nakagawa 曾木圣 白凡 张宁 | 2020 | 科学新闻2020，，2： | 0 |
| 5 | Recent advances in small incision lenticule extraction(SMILE)-derived refractive lenticule preservation and clinical reuse显示文摘Small incision lenticule extraction(SMILE)has become one of the mainstream refractive surgeries in recent years,with satisfactory efficacy,safety,and predictability.SMILE-derived refractive lenticule,the byproduct of the surgery,holds great potential in clinical practice given its easy access and good biocompatibility.Numerous studies have been published to describe its applications in refractive correction,corneal ectasia diseases,and corneal defects.The feasibility and safety were validated in both animal models and clinical studies.Moreover,the preservation method is also crucial for its further promotion and application.Novel techniques are also evaluated and applied in lenticule preservation.We covered the recent advances in the preservation of corneal stromal lenticules and their clinical reuse in this review. | Xiaojun Hu Ruoyan Wei Chang Liu Yunzhe Wang Danjuan Yang Ling Sun Fei Xia Shengtao Liu Meiyan Li Xingtao Zhou | 2023 | Engineered Regeneration2023，4，2： | 0 |
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