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| 1 | Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning显示文摘AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length data.METHODS:A retrospective study was carried out in 56 patients who underwent curative esophagogastrectomy.Tumor lengths were measured on the immediate preoperative CT and on the post-operative resection specimens.Inter-and intra-observer variations in CT measurements were assessed.Survival data were collected.RESULTS:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length>5.6 cm was poorer than with smaller tumors,but the difference was not statistically significant.CONCLUSION:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy. | Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 10 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Taste-aversion conditioning of house mice (Mus domesticus) using the non-lethal repellent, cinnamamide显示文摘 | Watkins R W Gurney J E Cowan D P | 1998 | Appl Anim Behav Sci1998，，57： | 2 |
| 4 | The pain of being sick:implications of immune-to-brain communication for understanding pain 显示文摘 | Watkins L R Maier S F | 2000 | Annu Rev Psychol2000，，51： | 1 |
| 5 | Effects of oxygen stress on tobacco discoloration显示文摘 | Watkins R W Hassler F J | 1962 | Tobacco Science1962，，： | 1 |
| 6 | Glia: a novel drug discovery target for clinical pain 显示文摘 | Watkins L R Maier S F | 2003 | Nat Rev Drug Discov2003，2，12： | 1 |
| 7 | Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat显示文摘 | Watkins L R Martin D Ulrich P | 1997 | Pain1997，71，3： | 1 |
| 8 | Glial activa- tion and pathological pain 显示文摘 | Wieseler-Frank J Maier S F Watkins L R | 2004 | Neurochem Int2004，45，23： | 1 |
| 9 | HIF-- 1 mediates pathogenic inflammatory response to intestinal ischemia--reperfusion injury显示文摘 | Fernman R Deitch E A Watkins A C | 2010 | Am J Physiol2010，299，4： | 1 |
| 10 | Fine needle aspiration cytology of adrenocoaical oncocytic neoplasm: a case report显示文摘 | Chain E Watkin W Goldschmidt R | 2010 | Acta Cytol2010，54，4： | 1 |
| 11 | Antioxidant and antiproliferative activities of strawberries显示文摘 | MEYERS K J WATKINS C B RITTS M P LIU R H | 2003 | Journal of Agricultural and Food Chemistry2003，51，23： | 1 |
| 12 | Dynarrfic EMG analysis of torque transfer in professional baseball pitchers显示文摘 | WATKINS R G DENNIS S DILLIN W H | 1989 | Spine1989，14，4： | 1 |
| 13 | Diabetes, oxi- dative stress, and antioxidants: a review 显示文摘 | Maritim A C Sanders R A Watkins J B | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 14 | The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells显示文摘 | Al-Rawi M A Watkins G Mansel R E | 2005 | Int J Oncol2005，27，3： | 1 |
| 15 | Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin显示文摘 | Jessop C E Tavender T J Watkins R H | 2009 | Journal of Biological Chemistry2009，284，4： | 1 |
| 16 | Physical and mechanical changes in strawberry fruit after high carbondioxide treatments显示文摘 | Harker F R Elgar H J Watkins C B | 2000 | Postharvest Biology and Technology2000，19，2： | 1 |
| 17 | Attachmentof a histidine tag to the minimal zinc finger protein of theAapergillus nidulans gene regulatory protein Area causesa conformational change at DNA-binding site显示文摘 | Chant A Kraemer-pecore C M Watkin R | 2005 | ProteinExpr Purif2005，39，2： | 1 |
| 18 | Diabetes, oxidative stress, and antioxidants: a review显示文摘 | MARITIM A C SANDERS R A WATKINS J B 3rd | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 19 | The antiwear mechanisms of ZDDPs-Part Ⅰ 显示文摘 | Spedding H Watkins R C | 1982 | Tribology International1982，15，1： | 1 |
| 20 | Physical and mechanical changes in strawberry fruit after high carbondioxide treatments显示文摘 | HARKER F R ELGAR H J WATKINS C B | 2000 | Postharvest Biology and Technology2000，19，2： | 1 |
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